Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear receptor NHR-88 | 0.0006 | 0.431 | 0.431 |
Trypanosoma cruzi | cytochrome P450, putative | 0.001 | 1 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.001 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.001 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0006 | 0.431 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0006 | 0.431 | 0.431 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0006 | 0.431 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.431 | 0.431 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0006 | 0.431 | 0.431 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.001 | 1 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0006 | 0.431 | 0.431 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0006 | 0.431 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.431 | 0.431 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.431 | 0.431 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.431 | 0.431 |
Onchocerca volvulus | 0.0006 | 0.431 | 0.5 | |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0006 | 0.431 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0006 | 0.431 | 0.431 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.431 | 0.431 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0006 | 0.431 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0006 | 0.431 | 0.431 |
Brugia malayi | nuclear hormone receptor | 0.0006 | 0.431 | 0.431 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0006 | 0.431 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0006 | 0.431 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0006 | 0.431 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0006 | 0.431 | 0.431 |
Brugia malayi | Cytochrome P450 family protein | 0.001 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0006 | 0.431 | 0.431 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0006 | 0.431 | 0.431 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.431 | 0.431 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0006 | 0.431 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.431 | 0.431 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0006 | 0.431 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0006 | 0.431 | 0.431 |
Leishmania major | cytochrome p450-like protein | 0.001 | 1 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0006 | 0.431 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0006 | 0.431 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0006 | 0.431 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0006 | 0.431 | 0.431 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0006 | 0.431 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0006 | 0.431 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0006 | 0.431 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.001 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.001 | 1 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0006 | 0.431 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0006 | 0.431 | 0.431 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0006 | 0.431 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0006 | 0.431 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0006 | 0.431 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0006 | 0.431 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0006 | 0.431 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0006 | 0.431 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0006 | 0.431 | 0.431 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.5734 | 0.5734 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0006 | 0.431 | 0.431 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0006 | 0.431 | 0.431 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0006 | 0.431 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0006 | 0.431 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0006 | 0.431 | 0.431 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0006 | 0.431 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0006 | 0.431 | 0.431 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0006 | 0.431 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0006 | 0.431 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0006 | 0.431 | 0.431 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0006 | 0.431 | 0.431 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0006 | 0.431 | 0.431 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0006 | 0.431 | 0.431 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.431 | 0.431 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0006 | 0.431 | 0.431 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0006 | 0.431 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0006 | 0.431 | 0.431 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0006 | 0.431 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0006 | 0.431 | 0.431 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0006 | 0.431 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.001 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0006 | 0.431 | 0.431 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0006 | 0.431 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0006 | 0.431 | 0.431 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0006 | 0.431 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0006 | 0.431 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0006 | 0.431 | 0.431 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 0.46 mM l-1 | In vitro antitumor activity against human erythroleukemia K-562 cells | ChEMBL. | 7086837 |
ID50 (functional) | = 0.46 mM l-1 | In vitro antitumor activity against human erythroleukemia K-562 cells | ChEMBL. | 7086837 |
ID50 (functional) | > 1 mM l-1 | In vitro antitumor activity against human erythroleukemia K-562 cells | ChEMBL. | 7086837 |
ID50 (functional) | > 1 mM l-1 | In vitro antitumor activity against human erythroleukemia K-562 cells | ChEMBL. | 7086837 |
ID50 (functional) | > 1.01 mM l-1 | In vitro antitumor activity against mouse myeloid leukemia L1210 cells | ChEMBL. | 7086837 |
ID50 (functional) | > 1.01 mM l-1 | In vitro antitumor activity against mouse myeloid leukemia L1210 cells | ChEMBL. | 7086837 |
ID50 (functional) | = 1.4 mM l-1 | In vitro antitumor activity (tumor cell growth inhibition) against MDAY-D2 cells | ChEMBL. | 7086837 |
ID50 (functional) | = 1.4 mM l-1 | In vitro antitumor activity (tumor cell growth inhibition) against MDAY-D2 cells | ChEMBL. | 7086837 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.