TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 255.721 | Formula: C12H16ClN2O2-
H donors: 1 H acceptors: 1 LogP: 1.77 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: NC1CCc2c1cccc2OC(=O)N(C)C.[Cl-]
InChi: 1S/C12H16N2O2.ClH/c1-14(2)12(15)16-11-5-3-4-8-9(11)6-7-10(8)13;/h3-5,10H,6-7,13H2,1-2H3;1H/p-1
InChiKey: QIWKNGJLQDONON-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	protoporphyrinogen oxidase	0.0025	0.0354	0.2818
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0058	0.1255	0.7447
Echinococcus granulosus	carboxylesterase 5A	0.0164	0.4114	0.4762
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0534	0.3167
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0083	0.0126
Trichomonas vaginalis	ap endonuclease, putative	0.0058	0.1255	0.1255
Loa Loa (eye worm)	hypothetical protein	0.0164	0.4114	0.6252
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0032	0.0534	0.1161
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.1339	0.1462
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0025	0.0354	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0419	0.0637
Mycobacterium tuberculosis	Possible oxidoreductase	0.0025	0.0354	0.0406
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0979	0.1488
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0649	0.0745
Loa Loa (eye worm)	acetylcholinesterase 1	0.0164	0.4114	0.6252
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0032	0.0534	0.3167
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0359	0.2133
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0058	0.1255	0.6697
Brugia malayi	Carboxylesterase family protein	0.0028	0.0419	0.0637
Toxoplasma gondii	exonuclease III APE	0.0058	0.1255	0.7898
Loa Loa (eye worm)	hypothetical protein	0.0094	0.2208	0.3357
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0649	0.0745
Schistosoma mansoni	cpg binding protein	0.0031	0.0501	0.0547
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0354	0.0537
Treponema pallidum	quinoline 2-oxidoreductase	0.006	0.1308	0.9595
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0056	0.1177	0.5329
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0649	0.0745
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0354	0.0537
Echinococcus granulosus	GPCR family 2	0.0015	0.0083	0.0096
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0359	0.2133
Echinococcus granulosus	tar DNA binding protein	0.0075	0.1709	0.1978
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0354	0.0537
Schistosoma mansoni	aldehyde dehydrogenase	0.0071	0.1589	0.1734
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0359	0.2133
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0026	0.0382	0.0407
Schistosoma mansoni	gabp alpha	0.007	0.1572	0.1716
Echinococcus granulosus	cpg binding protein	0.0031	0.0501	0.058
Loa Loa (eye worm)	MBCTL1	0.0063	0.1386	0.2106
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0094	0.2208	0.2411
Brugia malayi	RNA binding protein	0.0075	0.1709	0.2597
Treponema pallidum	hypothetical protein	0.0051	0.1051	0.6929
Echinococcus granulosus	neuroligin	0.0028	0.0419	0.0485
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0025	0.0354	0.2099
Brugia malayi	Carboxylesterase family protein	0.0164	0.4114	0.6252
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0251	0.6475	0.7496
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0649	0.0987
Onchocerca volvulus		0.0028	0.0419	0.1897
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0028	0.0419	0.0481
Loa Loa (eye worm)	carboxylesterase	0.0028	0.0419	0.0637
Onchocerca volvulus		0.0094	0.2208	1
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0056	0.1177	0.1362
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0058	0.1255	0.1907
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0649	0.0709
Schistosoma mansoni	hypothetical protein	0.035	0.9162	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0251	0.6475	0.7496
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0649	0.3854
Echinococcus granulosus	acetylcholinesterase	0.0164	0.4114	0.4762
Echinococcus multilocularis	survival motor neuron protein 1	0.0255	0.658	0.7617
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0981	0.1071
Schistosoma mansoni	rotamase	0.0033	0.0555	0.0605
Brugia malayi	hypothetical protein	0.0025	0.0359	0.0546
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0083	0.0126
Onchocerca volvulus		0.0036	0.0649	0.294
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0649	0.0745
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0083	0.0126
Schistosoma mansoni	hypothetical protein	0.0166	0.4169	0.455
Mycobacterium ulcerans	carboxylesterase, LipT	0.0028	0.0419	0.0446
Brugia malayi	hypothetical protein	0.0016	0.0114	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0419	0.0637
Onchocerca volvulus		0.0028	0.0419	0.1897
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0649	0.0649
Leishmania major	UDP-galactopyranose mutase	0.0025	0.0354	0.2099
Echinococcus multilocularis	polycomb protein SCMH1	0.0056	0.1177	0.1362
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0083	0.0096
Schistosoma mansoni	hypothetical protein	0.0033	0.0564	0.0616
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.2859	0.4346
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (small chain)	0.0073	0.164	0.1881
Schistosoma mansoni	hypothetical protein	0.0015	0.0083	0.009
Schistosoma mansoni	gliotactin	0.0028	0.0419	0.0457
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0649	0.0745
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0231	0.5935	0.6871
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0083	0.0096
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0063	0.1386	0.1604
Schistosoma mansoni	cpg binding protein	0.0029	0.0456	0.0498
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0025	0.0354	0.2818
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0094	0.2208	0.3357
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0649	0.0649
Brugia malayi	MH2 domain containing protein	0.0118	0.2859	0.4346
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0074	0.1685	0.1839
Leishmania major	phosphopantetheinyl transferase-like protein	0.0026	0.0382	0.2269
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0058	0.1255	0.1334
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0028	0.0419	0.0457
Mycobacterium ulcerans	hypothetical protein	0.0062	0.1347	0.1432
Mycobacterium ulcerans	carbon monoxyde dehydrogenase small chain CoxS	0.0073	0.164	0.1744
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0028	0.0419	0.0481
Brugia malayi	beta-lactamase family protein	0.0036	0.0649	0.0987
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.007	0.1572	0.239
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0058	0.1255	0.7447
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0359	0.2263
Brugia malayi	Ets-domain containing protein	0.007	0.1572	0.239
Echinococcus multilocularis	expressed protein	0.0033	0.0555	0.0642
Loa Loa (eye worm)	mbt repeat family protein	0.0056	0.1177	0.1789
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0026	0.0382	0.0407
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0359	0.2865
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0649	0.0745
Echinococcus granulosus	polycomb protein SCMH1	0.0056	0.1177	0.1362
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0026	0.0382	0.3047
Leishmania major	hypothetical protein, conserved	0.0036	0.0649	0.3854
Onchocerca volvulus		0.0052	0.1078	0.488
Schistosoma mansoni	hypothetical protein	0.0052	0.1078	0.1176
Plasmodium vivax	hypothetical protein, conserved	0.0025	0.0354	0.2818
Toxoplasma gondii	aldehyde dehydrogenase	0.0071	0.1589	1
Echinococcus multilocularis	tumor protein p63	0.033	0.8638	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0083	0.0096
Plasmodium vivax	hypothetical protein, conserved	0.0025	0.0354	0.2818
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0649	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0028	0.0419	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0419	0.0637
Echinococcus granulosus	survival motor neuron protein 1	0.0255	0.658	0.7617
Loa Loa (eye worm)	hypothetical protein	0.0164	0.4114	0.6252
Echinococcus multilocularis	tar DNA binding protein	0.0075	0.1709	0.1978
Echinococcus granulosus	acetylcholinesterase	0.0164	0.4114	0.4762
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0032	0.0534	0.3167
Brugia malayi	Ets-domain containing protein	0.007	0.1572	0.239
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0074	0.1685	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0534	0.3167
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0419	0.0637
Loa Loa (eye worm)	TAR-binding protein	0.0075	0.1709	0.2597
Mycobacterium ulcerans	monoamine oxidase	0.0025	0.0354	0.0376
Loa Loa (eye worm)	carboxylesterase	0.0164	0.4114	0.6252
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0359	0.0546
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0025	0.0354	0.0406
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0063	0.1386	0.1513
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0251	0.6475	0.7067
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0058	0.1255	0.1439
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0026	0.0382	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0649	0.0987
Mycobacterium ulcerans	carbon monoxide dehydrogenase	0.0252	0.6512	0.6923
Trichomonas vaginalis	ap endonuclease, putative	0.0058	0.1255	0.1255
Trichomonas vaginalis	spcc417.12 protein, putative	0.0028	0.0419	0.0419
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0028	0.0419	0.0485
Schistosoma mansoni	survival motor neuron protein	0.0052	0.1078	0.1176
Schistosoma mansoni	amine oxidase	0.0025	0.0354	0.0386
Trichomonas vaginalis	rotamase, putative	0.0032	0.0534	0.0534
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0025	0.0354	0.0409
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0649	0.5175
Brugia malayi	amine oxidase, flavin-containing family protein	0.0025	0.0354	0.0537
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0231	0.5939	0.6811
Schistosoma mansoni	hypothetical protein	0.0015	0.0083	0.009
Echinococcus multilocularis	cpg binding protein	0.0031	0.0501	0.058
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0251	0.6475	0.7496
Onchocerca volvulus		0.0029	0.0456	0.2064
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0083	0.0126
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0074	0.1685	0.1951
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0025	0.0354	0.9247
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0649	1
Schistosoma mansoni	sex comb on midleg homolog	0.0056	0.1177	0.1285
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0649	0.069
Echinococcus multilocularis	acetylcholinesterase	0.0164	0.4114	0.4762
Schistosoma mansoni	tar DNA-binding protein	0.0075	0.1709	0.1865
Echinococcus granulosus	L aminoadipate semialdehyde	0.0094	0.2208	0.2557
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0555	0.0555
Trichomonas vaginalis	xanthine dehydrogenase, putative	0.038	1	1
Mycobacterium ulcerans	lipase LipD	0.0036	0.0649	0.069
Schistosoma mansoni	aldehyde dehydrogenase	0.0071	0.1589	0.1734
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0025	0.0354	0.0376
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0028	0.0419	0.0457
Loa Loa (eye worm)	hypothetical protein	0.006	0.1296	0.197
Echinococcus multilocularis	para nitrobenzyl esterase	0.0028	0.0419	0.0485
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0649	0.069
Trichomonas vaginalis	aldehyde oxidase, putative	0.038	1	1
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0028	0.0419	0.0485
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0025	0.0354	0.0409
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0251	0.6475	0.7067
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0058	0.1255	1
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0026	0.0382	0.2407
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0025	0.0354	0.2818
Echinococcus granulosus	histone acetyltransferase MYST2	0.0063	0.1386	0.1604
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0649	0.3854
Trypanosoma brucei	hypothetical protein, conserved	0.0026	0.0382	0.2269
Brugia malayi	Carboxylesterase family protein	0.0028	0.0419	0.0637
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0056	0.1177	0.1285
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0456	0.0693
Toxoplasma gondii	ABC1 family protein	0.0036	0.0649	0.4087
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0026	0.0382	0.3047
Brugia malayi	hypothetical protein	0.0025	0.0354	0.0537
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0058	0.1255	1
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (large chain)	0.0179	0.4539	0.5206
Schistosoma mansoni	ap endonuclease	0.0058	0.1255	0.137
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0063	0.1386	0.1604
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0649	0.0745
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0251	0.6475	0.9841
Leishmania major	hypothetical protein, conserved	0.0025	0.0359	0.2133
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0058	0.1255	1
Schistosoma mansoni	tar DNA-binding protein	0.0075	0.1709	0.1865
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0025	0.0354	0.0409
Schistosoma mansoni	tar DNA-binding protein	0.0075	0.1709	0.1865
Schistosoma mansoni	BC026374 protein (S09 family)	0.0028	0.0419	0.0457
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0063	0.1386	0.1604
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0649	0.0987
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0354	0.0537
Treponema pallidum	hypothetical protein	0.0062	0.1347	1
Echinococcus multilocularis	geminin	0.0166	0.4169	0.4826
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0649	0.0987
Trichomonas vaginalis	rotamase, putative	0.0033	0.0555	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0419	0.0637
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0354	0.0537
Brugia malayi	Fli-1 protein	0.0213	0.545	0.8283
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0649	0.0752
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0028	0.0419	0.0485
Onchocerca volvulus		0.0036	0.0649	0.294
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0071	0.1589	0.9429
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0025	0.0354	0.2818
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0058	0.1255	0.9041
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0359	0.9406	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0649	0.0987
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0649	0.0649
Schistosoma mansoni	tar DNA-binding protein	0.0075	0.1709	0.1865
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0649	0.0987
Brugia malayi	beta-lactamase	0.0036	0.0649	0.0987
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0649	0.0649
Echinococcus granulosus	transcription factor Dp 1	0.0043	0.0835	0.0967
Trichomonas vaginalis	esterase, putative	0.0036	0.0649	0.0649
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0026	0.0382	0.2407
Onchocerca volvulus		0.0028	0.0419	0.1897
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0074	0.1685	0.2561
Brugia malayi	RNA recognition motif domain containing protein	0.0075	0.1709	0.2597
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0074	0.1685	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0058	0.1255	0.7447
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0419	0.0637
Brugia malayi	exodeoxyribonuclease III family protein	0.0058	0.1255	0.1907
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0058	0.1255	0.1453
Schistosoma mansoni	hypothetical protein	0.0015	0.0083	0.009
Brugia malayi	SWIRM domain containing protein	0.0025	0.0354	0.0537
Mycobacterium ulcerans	carbon monoxyde dehydrogenase large chain CoxL	0.0179	0.4539	0.4826
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0063	0.1386	0.2106
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0033	0.0555	0.0843
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0456	0.0693
Echinococcus multilocularis	acetylcholinesterase	0.0164	0.4114	0.4762
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0058	0.1255	0.1453
Schistosoma mansoni	hypothetical protein	0.0166	0.4169	0.455
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0028	0.0419	0.0419
Schistosoma mansoni	hypothetical protein	0.0015	0.0083	0.009
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0074	0.1685	1
Mycobacterium ulcerans	oxidoreductase	0.0025	0.0354	0.0376
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0979	0.1488
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1177	0.1789
Loa Loa (eye worm)	carboxylesterase	0.0028	0.0419	0.0637
Schistosoma mansoni	amine oxidase	0.0025	0.0354	0.0386
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.1589	0.1689
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0071	0.1589	0.1839
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1386	0.2106
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0026	0.0382	0.0439
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0649	0.0745
Onchocerca volvulus		0.0025	0.0354	0.1601
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0251	0.6475	0.7067
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0359	0.2865
Mycobacterium ulcerans	carbon monoxyde dehydrogenase medium chain CoxM	0.0128	0.3156	0.3355
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0649	0.069
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0333	0.872	1
Loa Loa (eye worm)	RNA binding protein	0.0075	0.1709	0.2597
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0033	0.0555	0.0843
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0649	0.0745
Schistosoma mansoni	sex comb on midleg homolog	0.0056	0.1177	0.1285
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0231	0.5935	0.6871
Onchocerca volvulus		0.0048	0.0981	0.4441
Toxoplasma gondii	peptidylprolyl isomerase	0.0032	0.0534	0.3359
Schistosoma mansoni	ets-related	0.0213	0.545	0.5949
Loa Loa (eye worm)	hypothetical protein	0.0255	0.658	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0979	0.1488
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0074	0.1685	1
Onchocerca volvulus		0.0036	0.0649	0.294
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0359	0.2865
Echinococcus granulosus	GA binding protein alpha chain	0.007	0.1572	0.182
Mycobacterium ulcerans	carbon monoxyde dehydrogenase small chain CoxS	0.0073	0.164	0.1744
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.1161	0.7306
Brugia malayi	beta-lactamase family protein	0.0036	0.0649	0.0987
Onchocerca volvulus		0.0028	0.0419	0.1897
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0164	0.4114	0.449
Brugia malayi	mbt repeat family protein	0.0056	0.1177	0.1789
Brugia malayi	Carboxylesterase family protein	0.0028	0.0419	0.0637
Echinococcus granulosus	geminin	0.0166	0.4169	0.4826
Echinococcus granulosus	expressed protein	0.0033	0.0555	0.0642
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0071	0.1589	0.1839
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0025	0.0354	0.2099
Schistosoma mansoni	acetylcholinesterase	0.0028	0.0419	0.0457
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0981	0.1491
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0027	0.0402	0.2528
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0649	0.0987
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0025	0.0354	0.0409
Schistosoma mansoni	tar DNA-binding protein	0.0075	0.1709	0.1865
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0649	0.0987
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0074	0.1685	0.2561
Brugia malayi	mbt repeat family protein	0.0056	0.1177	0.1789
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0028	0.0419	0.0457
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0058	0.1255	1
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxL_2	0.0179	0.4539	0.4826
Echinococcus multilocularis		0.0025	0.0354	0.0409
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxM_2	0.0128	0.3156	0.3355
Toxoplasma gondii	histone lysine-specific demethylase	0.0025	0.0354	0.2226
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0026	0.0382	0.3047
Schistosoma mansoni	cpg binding protein	0.0031	0.0501	0.0547
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0354	0.0537
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.1589	0.1689
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0564	0.0857
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0359	0.9406	1
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0028	0.0419	0.0457
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0074	0.1685	0.1951
Echinococcus multilocularis	carboxylesterase 5A	0.0164	0.4114	0.4762
Brugia malayi	TAR-binding protein	0.0075	0.1709	0.2597
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.1589	0.1689
Echinococcus granulosus	BC026374 protein S09 family	0.0028	0.0419	0.0485
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0649	0.0752
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0094	0.2208	0.2557
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0075	0.1709	0.2597
Brugia malayi	hypothetical protein	0.0255	0.658	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0649	0.3854
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0025	0.0354	0.0386
Echinococcus multilocularis	neuroligin	0.0028	0.0419	0.0485
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0074	0.1685	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.1078	0.1638
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.2859	0.4346
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0564	0.0857
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0649	0.069
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0083	0.0096
Brugia malayi	Carboxylesterase family protein	0.0028	0.0419	0.0637
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0058	0.1255	0.7447
Brugia malayi	Carboxylesterase family protein	0.0164	0.4114	0.6252
Echinococcus multilocularis	transcription factor Dp 1	0.0043	0.0835	0.0967
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0025	0.0354	0.2818
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0419	0.0637
Loa Loa (eye worm)	fli-1 protein	0.0213	0.545	0.8283
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0083	0.0096
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0649	0.0649
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0649	0.0987
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0071	0.1589	0.1822
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0028	0.0419	0.0481
Brugia malayi	hypothetical protein	0.0028	0.0419	0.0637
Onchocerca volvulus		0.0056	0.1177	0.5329
Schistosoma mansoni	ap endonuclease	0.0058	0.1255	0.137
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0649	0.0745
Echinococcus multilocularis	GA binding protein alpha chain	0.007	0.1572	0.182
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0251	0.6475	0.9841
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0649	0.0709
Mycobacterium ulcerans	dehydrogenase	0.0025	0.0354	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0979	0.1488
Mycobacterium leprae	conserved hypothetical protein	0.0026	0.0382	0.0973
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (medium chain)	0.0128	0.3156	0.3619
Echinococcus granulosus	SAM and MBT domain containing protein	0.0056	0.1177	0.1362
Mycobacterium ulcerans	carbon monoxyde dehydrogenase large chain CoxL	0.0113	0.273	0.2903
Onchocerca volvulus		0.0028	0.0419	0.1897
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0251	0.6475	0.7496
Echinococcus granulosus	tumor protein p63	0.033	0.8638	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.009 uM	In vitro inhibitory concentration against purified Acetylcholinesterase of human erythrocytes; value ranges from 0.008-0.012	ChEMBL.	12431053
IC50 (binding)	= 0.014 uM	In vitro inhibitory concentration against Butyrylcholinesterase of horse serum; value ranges from 0.009-0.024	ChEMBL.	12431053
IC50 (binding)	= 9.8 uM	In vitro inhibitory concentration against Monoamine oxidase A of rat brain homogenates; value ranges from 7.6-12.5	ChEMBL.	12431053
IC50 (binding)	> 1000 uM	In vitro inhibitory concentration against Monoamine oxidase B of rat brain homogenates	ChEMBL.	12431053
Ratio (binding)	= 0.64	Ratio of the IC50 value against AChE of human erythrocytes to that of BuChE of horse serum	ChEMBL.	12431053

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 348946

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 260120