Detailed information for compound 260125

Basic information

Technical information
  • TDR Targets ID: 260125
  • Name: N-(4-oxo-3-propan-2-yl-2H-indeno[1,2-c]pyrazo l-5-yl)acetamide
  • MW: 269.299 | Formula: C15H15N3O2
  • H donors: 2 H acceptors: 3 LogP: 2.28 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1cccc2c1C(=O)c1c2[nH]nc1C(C)C
  • InChi: 1S/C15H15N3O2/c1-7(2)13-12-14(18-17-13)9-5-4-6-10(16-8(3)19)11(9)15(12)20/h4-7H,1-3H3,(H,16,19)(H,17,18)
  • InChiKey: XZJJYGFJFWJWDZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-isopropyl-4-oxo-2H-indeno[1,2-c]pyrazol-5-yl)acetamide
  • N-(4-oxo-3-propan-2-yl-2H-indeno[1,2-c]pyrazol-5-yl)ethanamide
  • N-(3-isopropyl-4-keto-2H-indeno[1,2-c]pyrazol-5-yl)acetamide
  • Indenopyrazole 13d

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin E2 Starlite/ChEMBL References
Homo sapiens cyclin D1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.2744 0.2311
Echinococcus granulosus aldo keto reductase 0.0229 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0104 0.2744 0.2311
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.2744 0.2311
Onchocerca volvulus 0.0133 0.4414 0.4414
Echinococcus granulosus somatostatin receptor 0.0104 0.2744 0.2311
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0229 1 1
Schistosoma mansoni amine GPCR 0.0104 0.2744 0.2311
Onchocerca volvulus 0.0104 0.2744 0.2744
Brugia malayi hypothetical protein 0.0104 0.2744 0.2744
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.2744 0.2311
Echinococcus granulosus tm gpcr rhodopsin 0.0104 0.2744 0.2311
Echinococcus multilocularis fmrfamide receptor 0.0104 0.2744 0.2311
Schistosoma mansoni opsin-like receptor 0.0104 0.2744 0.2311
Brugia malayi follicle stimulating hormone receptor 0.0104 0.2744 0.2744
Trichomonas vaginalis aldo-keto reductase, putative 0.0229 1 1
Brugia malayi hypothetical protein 0.0104 0.2744 0.2744
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0104 0.2744 0.2311
Echinococcus multilocularis neuropeptide s receptor 0.0104 0.2744 0.2311
Trichomonas vaginalis aldo-keto reductase, putative 0.0229 1 1
Giardia lamblia Aldose reductase 0.0229 1 0.5
Loa Loa (eye worm) oxidoreductase 0.0229 1 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.1128 0.1128
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0229 1 1
Echinococcus granulosus hypothetical protein 0.0104 0.2744 0.2311
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0104 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0076 0.1128 0.1128
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0104 0.2744 0.2311
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0229 1 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Onchocerca volvulus 0.0229 1 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0229 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0104 0.2744 0.2744
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0076 0.1128 0.1128
Echinococcus multilocularis neuropeptide FF receptor 2 0.0104 0.2744 0.2311
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0229 1 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0229 1 1
Brugia malayi hypothetical protein 0.0104 0.2744 0.2744
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0229 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0229 1 1
Brugia malayi Dopamine receptor 0.0104 0.2744 0.2744
Trichomonas vaginalis aldo-keto reductase, putative 0.0066 0.0563 0.0563
Brugia malayi sulfakinin receptor protein 0.0104 0.2744 0.2744
Echinococcus granulosus tm gpcr rhodopsin 0.0104 0.2744 0.2311
Schistosoma mansoni opsin-like receptor 0.0104 0.2744 0.2311
Loa Loa (eye worm) hypothetical protein 0.0229 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0104 0.2744 0.2311
Giardia lamblia Aldose reductase 0.0229 1 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.0104 0.2744 0.2311
Echinococcus granulosus neuropeptide receptor 0.0104 0.2744 0.2311
Brugia malayi G protein-coupled receptor 0.0104 0.2744 0.2744
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0066 0.0563 0.0563
Echinococcus multilocularis orexin receptor type 2 0.0104 0.2744 0.2311
Brugia malayi AKH receptor 0.0104 0.2744 0.2744
Onchocerca volvulus 0.0229 1 1
Onchocerca volvulus 0.0133 0.4414 0.4414
Echinococcus multilocularis neuropeptides capa receptor 0.0104 0.2744 0.2311
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.2744 0.2311
Echinococcus granulosus 7TM GPCR rhodopsin 0.0104 0.2744 0.2311
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0104 0.2744 0.2311
Brugia malayi larval opioid receptor 0.0104 0.2744 0.2744
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0133 0.4414 0.4414
Schistosoma mansoni neuropeptide receptor 0.0104 0.2744 0.2311
Echinococcus multilocularis neuropeptide receptor 0.0104 0.2744 0.2311
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0563 0.0563
Loa Loa (eye worm) hypothetical protein 0.0133 0.4414 0.4414
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0104 0.2744 0.2311
Leishmania major aldo-keto reductase-like protein 0.0229 1 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Onchocerca volvulus 0.0133 0.4414 0.4414
Onchocerca volvulus 0.0133 0.4414 0.4414
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.2744 0.2311
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Schistosoma mansoni amine GPCR 0.0104 0.2744 0.2311
Leishmania major prostaglandin f synthase, putative 0.0229 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0104 0.2744 0.2311
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0229 1 1
Echinococcus granulosus g-protein coupled receptor 0.0104 0.2744 0.2311
Echinococcus granulosus hypothetical protein 0.0229 1 1
Schistosoma mansoni aldo-keto reductase 0.0229 1 1
Brugia malayi hypothetical protein 0.0104 0.2744 0.2744
Loa Loa (eye worm) G-protein coupled receptor 0.0104 0.2744 0.2744
Toxoplasma gondii aldose reductase, putative 0.0229 1 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Brugia malayi GnHR receptor homolog 0.0104 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Brugia malayi Serotonin receptor 0.0104 0.2744 0.2744
Echinococcus multilocularis g protein coupled receptor 0.0104 0.2744 0.2311
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Echinococcus multilocularis neuropeptide receptor A26 0.0104 0.2744 0.2311
Trichomonas vaginalis aldo-keto reductase, putative 0.0066 0.0563 0.0563
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.2744 0.2311
Brugia malayi G protein-coupled receptor F59B2.13 0.0104 0.2744 0.2744
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0104 0.2744 0.2311
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0066 0.0563 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0104 0.2744 0.2311
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0229 1 1
Onchocerca volvulus 0.0104 0.2744 0.2744
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0104 0.2744 0.2311
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0229 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0229 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0104 0.2744 0.2311
Loa Loa (eye worm) hypothetical protein 0.0076 0.1128 0.1128
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0229 1 1
Brugia malayi G-protein coupled receptor 0.0104 0.2744 0.2744
Brugia malayi ORL1-like opioid receptor 0.0104 0.2744 0.2744
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.2744 0.2311
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0104 0.2744 0.2311
Onchocerca volvulus 0.0133 0.4414 0.4414
Echinococcus granulosus aldo keto reductase 0.0229 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0229 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.2744 0.2311
Echinococcus granulosus allatostatin A receptor 0.0104 0.2744 0.2311
Mycobacterium ulcerans oxidoreductase 0.0229 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0104 0.2744 0.2744
Schistosoma mansoni hypothetical protein 0.0104 0.2744 0.2311
Echinococcus granulosus g protein coupled receptor 0.0104 0.2744 0.2311
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0104 0.2744 0.2311
Brugia malayi Dopamine receptor protein 2 0.0104 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Schistosoma mansoni biogenic amine (5HT) receptor 0.0104 0.2744 0.2311
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.2744 0.2311
Echinococcus granulosus alpha 1A adrenergic receptor 0.0104 0.2744 0.2311
Brugia malayi Melatonin receptor type 1A 0.0104 0.2744 0.2744
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0104 0.2744 0.2311
Mycobacterium tuberculosis Probable oxidoreductase 0.0229 1 1
Loa Loa (eye worm) oxidoreductase 0.0229 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0104 0.2744 0.2311
Trypanosoma brucei aldo-keto reductase, putative 0.0229 1 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0104 0.2744 0.2311
Echinococcus multilocularis fmrfamide receptor 0.0104 0.2744 0.2311
Trypanosoma brucei prostaglandin f synthase 0.0229 1 1
Onchocerca volvulus 0.0104 0.2744 0.2744
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0229 1 1
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0076 0.1128 0.1128
Onchocerca volvulus 0.0133 0.4414 0.4414
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0104 0.2744 0.2311
Echinococcus multilocularis g protein coupled receptor 0.0104 0.2744 0.2311
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.2744 0.2311
Schistosoma mansoni hypothetical protein 0.0104 0.2744 0.2311
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Schistosoma mansoni histamine h1 receptor 0.0104 0.2744 0.2311
Echinococcus multilocularis serotonin receptor 0.0104 0.2744 0.2311
Onchocerca volvulus 0.0076 0.1128 0.1128
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0104 0.2744 0.2311
Onchocerca volvulus 0.0104 0.2744 0.2744
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.2744 0.2311
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.2744 0.2311
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Brugia malayi hypothetical protein 0.0104 0.2744 0.2744
Echinococcus granulosus serotonin receptor 0.0104 0.2744 0.2311
Schistosoma mansoni pol-related 0.0229 1 1
Schistosoma mansoni neuropeptide receptor 0.0104 0.2744 0.2311
Echinococcus granulosus neuropeptides capa receptor 0.0104 0.2744 0.2311
Schistosoma mansoni amine GPCR 0.0104 0.2744 0.2311
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0104 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Schistosoma mansoni hypothetical protein 0.0104 0.2744 0.2311
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Plasmodium vivax aldehyde reductase, putative 0.0066 0.0563 0.5
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0066 0.0563 0.0563
Plasmodium falciparum aldo-keto reductase, putative 0.0066 0.0563 0.5
Trichomonas vaginalis aldo/keto reductase, putative 0.0229 1 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Echinococcus multilocularis aldo keto reductase 0.0229 1 1
Echinococcus multilocularis aldo keto reductase 0.0229 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0229 1 1
Onchocerca volvulus 0.0133 0.4414 0.4414
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0133 0.4414 0.4414
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0104 0.2744 0.2311
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Echinococcus multilocularis allatostatin A receptor 0.0104 0.2744 0.2311
Onchocerca volvulus 0.0104 0.2744 0.2744
Trichomonas vaginalis aldo-keto reductase, putative 0.0229 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.2744 0.2311
Echinococcus granulosus tm gpcr rhodopsin 0.0104 0.2744 0.2311
Echinococcus granulosus neuropeptide receptor 0.0104 0.2744 0.2311
Echinococcus granulosus dro:myosuppressin receptor 0.0104 0.2744 0.2311
Mycobacterium leprae Conserved hypothetical protein 0.0163 0.6152 0.5922
Echinococcus multilocularis aldehyde reductase 0.0163 0.6152 0.5922
Loa Loa (eye worm) oxidoreductase 0.0229 1 1
Brugia malayi hypothetical protein 0.0076 0.1128 0.1128
Echinococcus multilocularis G protein coupled receptor 139 0.0104 0.2744 0.2311
Echinococcus granulosus neuropeptide receptor A26 0.0104 0.2744 0.2311
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Echinococcus granulosus biogenic amine 5HT receptor 0.0104 0.2744 0.2311
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0229 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0104 0.2744 0.2744
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0104 0.2744 0.2311
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0104 0.2744 0.2744
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0104 0.2744 0.2311
Schistosoma mansoni biogenic amine receptor 0.0104 0.2744 0.2311
Echinococcus multilocularis neuropeptides capa receptor 0.0104 0.2744 0.2311
Onchocerca volvulus 0.0133 0.4414 0.4414
Trichomonas vaginalis aldo-keto reductase, putative 0.0229 1 1
Onchocerca volvulus 0.0229 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0229 1 1
Schistosoma mansoni amine GPCR 0.0104 0.2744 0.2311
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0104 0.2744 0.2744
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0104 0.2744 0.2744
Brugia malayi hypothetical protein 0.0104 0.2744 0.2744
Trichomonas vaginalis aldo-keto reductase, putative 0.0229 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0104 0.2744 0.2311
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0229 1 1
Echinococcus granulosus orexin receptor type 2 0.0104 0.2744 0.2311
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Schistosoma mansoni neuropeptide F-like receptor 0.0104 0.2744 0.2311
Loa Loa (eye worm) oxidoreductase 0.0229 1 1
Onchocerca volvulus 0.0229 1 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Echinococcus granulosus aldehyde reductase 0.0163 0.6152 0.5922
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0229 1 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0104 0.2744 0.2744
Echinococcus granulosus neuropeptide Y receptor 0.0104 0.2744 0.2311
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Brugia malayi hypothetical protein 0.0104 0.2744 0.2744
Schistosoma mansoni neuropeptide F-like receptor 0.0104 0.2744 0.2311
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0104 0.2744 0.2311
Onchocerca volvulus 0.0104 0.2744 0.2744
Trichomonas vaginalis aldo/keto reductase, putative 0.0229 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0104 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Schistosoma mansoni neuropeptide receptor 0.0104 0.2744 0.2311
Onchocerca volvulus 0.0104 0.2744 0.2744
Brugia malayi hypothetical protein 0.0104 0.2744 0.2744
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0104 0.2744 0.2311
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.2744 0.2311
Echinococcus granulosus biogenic amine 5HT receptor 0.0104 0.2744 0.2311
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0104 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Onchocerca volvulus 0.0104 0.2744 0.2744
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.2744 0.2311
Loa Loa (eye worm) hypothetical protein 0.0076 0.1128 0.1128
Schistosoma mansoni hypothetical protein 0.0104 0.2744 0.2311
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.2744 0.2311
Schistosoma mansoni neuropeptide receptor 0.0104 0.2744 0.2311
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0104 0.2744 0.2311
Echinococcus granulosus sex peptide receptor 0.0104 0.2744 0.2311
Echinococcus granulosus peptide allatostatin:somatostatin 0.0104 0.2744 0.2311
Echinococcus multilocularis aldo keto reductase 0.0229 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0104 0.2744 0.2311
Onchocerca volvulus 0.0104 0.2744 0.2744
Onchocerca volvulus 0.0104 0.2744 0.2744
Schistosoma mansoni myosin xvIII 0.0104 0.2744 0.2311
Loa Loa (eye worm) oxidoreductase 0.0229 1 1
Onchocerca volvulus 0.0066 0.0563 0.0563
Brugia malayi putative neuropeptide receptor 0.0104 0.2744 0.2744
Brugia malayi G-protein coupled receptor 0.0104 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0104 0.2744 0.2311
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0104 0.2744 0.2311
Trichomonas vaginalis aldo-keto reductase, putative 0.0229 1 1
Schistosoma mansoni opsin-like receptor 0.0104 0.2744 0.2311
Entamoeba histolytica aldose reductase, putative 0.0229 1 1
Onchocerca volvulus 0.0104 0.2744 0.2744
Schistosoma mansoni amine GPCR 0.0104 0.2744 0.2311
Onchocerca volvulus 0.0104 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.2744 0.2311
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0133 0.4414 0.4414
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.2744 0.2311
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0229 1 1
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0076 0.1128 0.1128
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0104 0.2744 0.2311
Schistosoma mansoni biogenic amine receptor 0.0104 0.2744 0.2311
Onchocerca volvulus 0.0104 0.2744 0.2744
Onchocerca volvulus 0.0104 0.2744 0.2744
Onchocerca volvulus 0.0076 0.1128 0.1128
Echinococcus granulosus G protein coupled receptor 139 0.0104 0.2744 0.2311
Onchocerca volvulus 0.0104 0.2744 0.2744
Loa Loa (eye worm) neuropeptide F receptor 0.0104 0.2744 0.2744
Onchocerca volvulus 0.0229 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.2744 0.2311
Onchocerca volvulus 0.0229 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0229 1 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0104 0.2744 0.2311
Brugia malayi Dopamine receptor protein 1 0.0104 0.2744 0.2744
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0104 0.2744 0.2311
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Brugia malayi hypothetical protein 0.0076 0.1128 0.1128
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0229 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0229 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.2744 0.2311
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Schistosoma mansoni adenoreceptor 0.0104 0.2744 0.2311
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Entamoeba histolytica aldose reductase, putative 0.0229 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0104 0.2744 0.2311
Entamoeba histolytica aldose reductase, putative 0.0229 1 1
Plasmodium falciparum aldehyde reductase, putative 0.0066 0.0563 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0104 0.2744 0.2311
Echinococcus granulosus neuropeptide Y receptor 0.0104 0.2744 0.2311
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0104 0.2744 0.2311
Echinococcus granulosus neuropeptide s receptor 0.0104 0.2744 0.2311
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Brugia malayi RE15519p 0.0104 0.2744 0.2744
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0076 0.1128 0.1128
Echinococcus granulosus g protein coupled receptor 0.0104 0.2744 0.2311
Echinococcus multilocularis neuropeptide receptor 0.0104 0.2744 0.2311
Loa Loa (eye worm) neuropeptide F receptor 0.0104 0.2744 0.2744
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0104 0.2744 0.2311
Echinococcus granulosus g protein coupled receptor 0.0104 0.2744 0.2311
Echinococcus granulosus fmrfamide receptor 0.0104 0.2744 0.2311
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0229 1 1
Loa Loa (eye worm) TYRA-2 protein 0.0104 0.2744 0.2744
Echinococcus granulosus neuropeptide FF receptor 2 0.0104 0.2744 0.2311
Trichomonas vaginalis aldo-keto reductase, putative 0.0229 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0229 1 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.1128 0.1128
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0066 0.0563 0.0563
Schistosoma mansoni biogenic amine receptor 0.0104 0.2744 0.2311
Echinococcus multilocularis G-protein coupled receptor, putative 0.0104 0.2744 0.2311
Echinococcus multilocularis neuropeptide Y receptor 0.0104 0.2744 0.2311
Echinococcus granulosus aldo keto reductase 0.0229 1 1
Echinococcus multilocularis somatostatin receptor 0.0104 0.2744 0.2311
Brugia malayi hypothetical protein 0.0104 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Trichomonas vaginalis aldo-keto reductase, putative 0.0229 1 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.2744 0.2744
Echinococcus multilocularis neuropeptide Y receptor 0.0104 0.2744 0.2311
Trypanosoma cruzi aldo-keto reductase 0.0229 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0104 0.2744 0.2744
Brugia malayi neuropeptide F receptor 0.0104 0.2744 0.2744
Echinococcus multilocularis aldo keto reductase 0.0229 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0104 0.2744 0.2311
Brugia malayi putative neuropeptide receptor NPR1 0.0104 0.2744 0.2744
Schistosoma mansoni aldo-keto reductase 0.0229 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0229 1 1
Echinococcus multilocularis serotonin receptor 0.0104 0.2744 0.2311
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.2744 0.2311
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0229 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0229 1 1
Onchocerca volvulus 0.0104 0.2744 0.2744
Trichomonas vaginalis aldo-keto reductase, putative 0.0229 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0104 0.2744 0.2311
Brugia malayi Serotonin receptor 0.0104 0.2744 0.2744
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0104 0.2744 0.2744
Echinococcus multilocularis rhodopsin orphan GPCR 0.0104 0.2744 0.2311
Schistosoma mansoni growth hormone secretagogue receptor 0.0104 0.2744 0.2311
Brugia malayi hypothetical protein 0.0104 0.2744 0.2744
Echinococcus multilocularis g protein coupled receptor 0.0104 0.2744 0.2311
Schistosoma mansoni alpha-1 adrenergic receptor 0.0104 0.2744 0.2311
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0076 0.1128 0.1128
Echinococcus granulosus neuropeptides capa receptor 0.0104 0.2744 0.2311
Trypanosoma cruzi aldo/keto reductase, putative 0.0229 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0104 0.2744 0.2311
Onchocerca volvulus 0.0104 0.2744 0.2744
Brugia malayi NADH-dependent xylose reductase 0.0066 0.0563 0.0563
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0133 0.4414 0.4414
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0104 0.2744 0.2311
Trichomonas vaginalis aldo-keto reductase, putative 0.0066 0.0563 0.0563
Trichomonas vaginalis aldo-keto reductase, putative 0.0229 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0104 0.2744 0.2311
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0104 0.2744 0.2744
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0229 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0229 1 1
Echinococcus multilocularis sex peptide receptor 0.0104 0.2744 0.2311
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0229 1 1
Brugia malayi neuropeptide F receptor 0.0104 0.2744 0.2744
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0104 0.2744 0.2744

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 840 nM Inhibitory concentration of the compound against Cyclin-dependent kinase 2-cyclin E ChEMBL. 12431051
IC50 (binding) = 840 nM Inhibitory concentration of the compound against Cyclin-dependent kinase 2-cyclin E ChEMBL. 12431051
IC50 (binding) > 3700 nM Inhibitory concentration against Cyclin-dependent kinase 4-cyclin D1 ChEMBL. 12431051
IC50 (binding) > 3700 nM Inhibitory concentration against Cyclin-dependent kinase 4-cyclin D1 ChEMBL. 12431051

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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