Detailed information for compound 260144

Basic information

Technical information
  • TDR Targets ID: 260144
  • Name: 2-(2,6-dichlorophenyl)-3-pyridin-4-yl-1,3-thi azolidin-4-one
  • MW: 325.213 | Formula: C14H10Cl2N2OS
  • H donors: 0 H acceptors: 2 LogP: 3.55 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CSC(N1c1ccncc1)c1c(Cl)cccc1Cl
  • InChi: 1S/C14H10Cl2N2OS/c15-10-2-1-3-11(16)13(10)14-18(12(19)8-20-14)9-4-6-17-7-5-9/h1-7,14H,8H2
  • InChiKey: YEAFOWNMNHUOMH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2,6-dichlorophenyl)-3-(4-pyridyl)thiazolidin-4-one
  • 2-(2,6-dichlorophenyl)-3-(4-pyridyl)-4-thiazolidinone
  • 2-(2,6-Dichloro-phenyl)-3-pyridin-4-yl-thiazolidin-4-one
  • AIDS-162725
  • AIDS162725

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0136 0.1477 1
Echinococcus granulosus tyrosine protein kinase shark 0.0136 0.1477 0.1477
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0209 0.5132 0.5132
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0209 0.5132 0.5132
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0136 0.1477 0.1477
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0307 1 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0307 1 1
Echinococcus granulosus tyrosine protein kinase Srms 0.0136 0.1477 0.1477
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0307 1 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0174 0.3391 0.3391
Brugia malayi Variant SH3 domain containing protein 0.0209 0.5132 0.5132
Echinococcus multilocularis tyrosine kinase 0.0136 0.1477 0.1477
Brugia malayi Sex muscle abnormal protein 5 0.0209 0.5132 0.5132
Echinococcus granulosus tyrosine protein kinase Blk 0.0204 0.4868 0.4868
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.1477 0.1477
Schistosoma mansoni nck2/grb4 0.0209 0.5132 0.5132
Echinococcus granulosus tyrosine protein kinase Src64B 0.0307 1 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0307 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0204 0.4868 0.4868
Loa Loa (eye worm) hypothetical protein 0.0209 0.5132 0.5132
Loa Loa (eye worm) TK/ABL protein kinase 0.0136 0.1477 0.1477
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.1477 0.1477
Loa Loa (eye worm) hypothetical protein 0.0136 0.1477 0.1477
Onchocerca volvulus 0.0136 0.1477 1
Brugia malayi Protein kinase domain containing protein 0.0136 0.1477 0.1477
Schistosoma mansoni growth factor receptor-bound protein 0.0209 0.5132 0.5132
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.1477 0.1477
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0209 0.5132 0.5132
Onchocerca volvulus 0.0136 0.1477 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0239 0.6609 0.6609
Onchocerca volvulus 0.0136 0.1477 1
Brugia malayi SH2 domain containing protein 0.0136 0.1477 0.1477
Onchocerca volvulus 0.0136 0.1477 1
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.1347 0.1347
Echinococcus granulosus tyrosine protein kinase Src42A 0.0307 1 1
Schistosoma mansoni growth factor receptor-bound protein 0.0209 0.5132 0.5132
Brugia malayi protein-tyrosine kinase 0.0204 0.4868 0.4868
Schistosoma mansoni tyrosine kinase 0.0136 0.1477 0.1477
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0204 0.4868 0.4868
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.1477 0.1477
Brugia malayi Protein kinase domain containing protein 0.0136 0.1477 0.1477
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.1477 0.1477
Echinococcus multilocularis tyrosine protein kinase Blk 0.0204 0.4868 0.4868
Schistosoma mansoni tyrosine kinase 0.0239 0.6609 0.6609
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0307 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0307 1 1
Echinococcus multilocularis NCK adaptor protein 0.0209 0.5132 0.5132
Schistosoma mansoni adapter molecule crk 0.0209 0.5132 0.5132
Echinococcus granulosus NCK adaptor protein 0.0209 0.5132 0.5132
Echinococcus granulosus tyrosine protein kinase Fyn 0.0307 1 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0239 0.6609 0.6609
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.1477 0.1477
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0239 0.6609 0.6609
Echinococcus granulosus growth factor receptor bound protein 2 0.0209 0.5132 0.5132
Brugia malayi SH2 domain containing protein 0.0136 0.1477 0.1477
Brugia malayi hypothetical protein 0.0136 0.1477 0.1477
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0136 0.1477 0.1477
Echinococcus multilocularis tyrosine protein kinase shark 0.0136 0.1477 0.1477
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.1477 0.1477
Brugia malayi Protein kinase domain containing protein 0.0136 0.1477 0.1477
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0307 1 1
Schistosoma mansoni tyrosine kinase 0.0307 1 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0239 0.6609 0.6609
Echinococcus granulosus tyrosine kinase 0.0136 0.1477 0.1477
Echinococcus multilocularis growth factor receptor bound protein 2 0.0209 0.5132 0.5132
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0307 1 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0307 1 1
Loa Loa (eye worm) SRC-1 0.0307 1 1
Schistosoma mansoni tyrosine kinase 0.0136 0.1477 0.1477
Schistosoma mansoni tyrosine kinase 0.0307 1 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0204 0.4868 0.4868
Echinococcus granulosus tyrosine protein kinase ABL1 0.0136 0.1477 0.1477
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0136 0.1477 0.1477
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0307 1 1
Brugia malayi Protein kinase domain containing protein 0.0136 0.1477 0.1477
Echinococcus granulosus tyrosine kinase 0.0204 0.4868 0.4868
Echinococcus granulosus tyrosine protein kinase Src42A 0.0174 0.3391 0.3391
Echinococcus multilocularis c src tyrosine kinase 0.0239 0.6609 0.6609
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0239 0.6609 0.6609
Brugia malayi Protein kinase domain containing protein 0.0136 0.1477 0.1477
Schistosoma mansoni tyrosine kinase 0.0239 0.6609 0.6609
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0307 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.1477 0.1477
Echinococcus granulosus c src tyrosine kinase 0.0239 0.6609 0.6609
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0307 1 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0307 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.1477 0.1477
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.1477 0.1477
Brugia malayi Variant SH3 domain containing protein 0.0209 0.5132 0.5132
Loa Loa (eye worm) TK protein kinase 0.0204 0.4868 0.4868
Onchocerca volvulus 0.0136 0.1477 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0136 0.1477 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0307 1 1

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) = 10 uM Cytotoxic concentration (anti-HIV activity) required to reduce HIV-1 induced viability by 50% in MT-4 cells ChEMBL. 12431069
NA (functional) 0 Effective concentration (anti-HIV activity) required to reduce HIV-1 induced cytopathic effect by 50% in MT-4 cells; NA is Not Active. ChEMBL. 12431069
ND (functional) 0 Selectivity index of the compound as the ratio of CC50 to that of EC50 value in MT cells;ND means no data. ChEMBL. 12431069

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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