TDR Targets

Basic information

Technical information

TDR Targets ID: 260238
Name: (3S)-3-[[(3R)-1-(1-piperidin-4-ylpiperidine-4 -carbonyl)piperidine-3-carbonyl]amino]-3-pyri din-3-ylpropanoic acid
MW: 471.592 | Formula: C25H37N5O4
H donors: 3 H acceptors: 5 LogP: -2.21 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C[C@@H](c1cccnc1)NC(=O)[C@@H]1CCCN(C1)C(=O)C1CCN(CC1)C1CCNCC1
InChi: 1S/C25H37N5O4/c31-23(32)15-22(19-3-1-9-27-16-19)28-24(33)20-4-2-12-30(17-20)25(34)18-7-13-29(14-8-18)21-5-10-26-11-6-21/h1,3,9,16,18,20-22,26H,2,4-8,10-15,17H2,(H,28,33)(H,31,32)/t20-,22+/m1/s1
InChiKey: OSWCPUORIOBICX-IRLDBZIGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(3S)-3-[[(3R)-1-[1-(4-piperidyl)piperidine-4-carbonyl]piperidine-3-carbonyl]amino]-3-(3-pyridyl)propanoic acid
(3S)-3-[[oxo-[(3R)-1-[oxo-[1-(4-piperidinyl)-4-piperidinyl]methyl]-3-piperidinyl]methyl]amino]-3-(3-pyridyl)propanoic acid
(3S)-3-[[(3R)-1-(1-piperidin-4-ylpiperidin-4-yl)carbonylpiperidin-3-yl]carbonylamino]-3-pyridin-3-yl-propanoic acid
(3S)-3-[[(3R)-1-[1-(4-piperidyl)isonipecotoyl]nipecotoyl]amino]-3-(3-pyridyl)propionic acid
(3S)-3-[[(3R)-1-[1-(4-piperidyl)piperidine-4-carbonyl]piperidine-3-carbonyl]amino]-3-(3-pyridyl)propionic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)		References
Homo sapiens	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	integrin alpha pat-2	Get druggable targets OG5_129341	All targets in OG5_129341
Echinococcus granulosus	integrin beta 2	Get druggable targets OG5_127959	All targets in OG5_127959
Schistosoma mansoni	integrin beta subunit	Get druggable targets OG5_127959	All targets in OG5_127959
Brugia malayi	Integrin beta pat-3 precursor	Get druggable targets OG5_127959	All targets in OG5_127959
Schistosoma mansoni	integrin alpha	Get druggable targets OG5_129341	All targets in OG5_129341
Schistosoma japonicum	Integrin beta-PS precursor, putative	Get druggable targets OG5_127959	All targets in OG5_127959
Schistosoma japonicum	Integrin beta-3 precursor, putative	Get druggable targets OG5_127959	All targets in OG5_127959
Loa Loa (eye worm)	integrin beta-2	Get druggable targets OG5_127959	All targets in OG5_127959
Echinococcus multilocularis	integrin beta 2	Get druggable targets OG5_127959	All targets in OG5_127959
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129341	All targets in OG5_129341
Echinococcus granulosus	integrin alpha 3	Get druggable targets OG5_129341	All targets in OG5_129341
Schistosoma japonicum	IPR013513,Integrin alpha chain, C-terminal cytoplasmic region,domain-containing	Get druggable targets OG5_129341	All targets in OG5_129341
Brugia malayi	Integrin alpha pat-2 precursor	Get druggable targets OG5_129341	All targets in OG5_129341
Schistosoma japonicum	ko:K06476 integrin alpha 2B, putative	Get druggable targets OG5_129341	All targets in OG5_129341
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129341	All targets in OG5_129341
Echinococcus multilocularis	integrin alpha 3	Get druggable targets OG5_129341	All targets in OG5_129341
Schistosoma japonicum	ko:K06464 integrin beta 2, putative	Get druggable targets OG5_127959	All targets in OG5_127959

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Fructose-bisphosphate aldolase	0.0327	0.3991	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0331	0.4043	0.4863
Loa Loa (eye worm)	hypothetical protein	0.0296	0.3551	0.436
Brugia malayi	hypothetical protein	0.0296	0.3551	0.4247
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0296	0.3551	0.3551
Schistosoma mansoni	integrin alpha-ps	0.0083	0.0598	0.0734
Loa Loa (eye worm)	hypothetical protein	0.0296	0.3551	0.436
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.014	0.1387	0.1537
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0331	0.4043	0.4964
Onchocerca volvulus	Bile acid receptor homolog	0.0627	0.8145	1
Loa Loa (eye worm)	hypothetical protein	0.0296	0.3551	0.436
Schistosoma mansoni	integrin alpha	0.0185	0.2011	0.247
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0627	0.8145	0.8145
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.3991	0.5
Loa Loa (eye worm)	hypothetical protein	0.0331	0.4043	0.4964
Brugia malayi	conserved hypotetical protein	0.0296	0.3551	0.4247
Brugia malayi	ecdysone receptor	0.0296	0.3551	0.4247
Echinococcus granulosus	ecdysone induced protein 78C	0.0627	0.8145	0.8145
Schistosoma mansoni	cellular tumor antigen P53	0.0111	0.0994	0.122
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0627	0.8145	1
Echinococcus multilocularis	FTZ F1 alpha	0.0627	0.8145	0.8145
Brugia malayi	hypothetical protein	0.0331	0.4043	0.4863
Loa Loa (eye worm)	hypothetical protein	0.0296	0.3551	0.436
Schistosoma mansoni	zinc finger protein	0.0296	0.3551	0.436
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0627	0.8145	1
Loa Loa (eye worm)	steroid hormone receptor	0.0627	0.8145	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.3991	0.5
Onchocerca volvulus		0.0627	0.8145	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0627	0.8145	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0331	0.4043	0.4043
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0331	0.4043	0.4043
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.3991	0.5
Brugia malayi	nuclear receptor RXR	0.0331	0.4043	0.4863
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0627	0.8145	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0627	0.8145	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0627	0.8145	1
Brugia malayi	nuclear hormone receptor	0.0627	0.8145	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0627	0.8145	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0296	0.3551	0.3551
Brugia malayi	nuclear receptor NHR-88	0.0296	0.3551	0.4247
Brugia malayi	nuclear receptor NHR-67	0.0296	0.3551	0.4247
Schistosoma mansoni	thyroid hormone receptor	0.0627	0.8145	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.3991	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.016	0.016
Loa Loa (eye worm)	hypothetical protein	0.0296	0.3551	0.436
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0057	0.0247	0.0303
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0627	0.8145	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0627	0.8145	1
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.016	0.1668	0.5
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0296	0.3551	0.3551
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0627	0.8145	0.8145
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0627	0.8145	0.8145
Echinococcus granulosus	thyroid hormone receptor alpha	0.0296	0.3551	0.3551
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0296	0.3551	0.3551
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0296	0.3551	0.436
Brugia malayi	Steroid receptor seven-up type 2	0.0627	0.8145	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0296	0.3551	0.3551
Loa Loa (eye worm)	hypothetical protein	0.0331	0.4043	0.4964
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0296	0.3551	0.436
Schistosoma mansoni	coup transcription factor	0.0627	0.8145	1
Loa Loa (eye worm)	hypothetical protein	0.0627	0.8145	1
Loa Loa (eye worm)	integrin beta-2	0.0378	0.4697	0.5767
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.016	0.0197
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0627	0.8145	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0627	0.8145	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0627	0.8145	0.8145
Loa Loa (eye worm)	hypothetical protein	0.0627	0.8145	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0627	0.8145	1
Brugia malayi	nuclear receptor NHR-88	0.0627	0.8145	1
Brugia malayi	Integrin alpha pat-2 precursor	0.0185	0.2011	0.2318
Loa Loa (eye worm)	hypothetical protein	0.0296	0.3551	0.436
Treponema pallidum	fructose-bisphosphate aldolase	0.0327	0.3991	0.5
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0627	0.8145	0.8145
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0627	0.8145	1
Loa Loa (eye worm)	hypothetical protein	0.0627	0.8145	1
Schistosoma mansoni	nuclear receptor	0.0296	0.3551	0.436
Brugia malayi	hypothetical protein	0.0057	0.0247	0.0108
Schistosoma mansoni	nuclear hormone receptor	0.0627	0.8145	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.3991	0.5
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0296	0.3551	0.3551
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.016	0.0197
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0627	0.8145	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0296	0.3551	0.4247
Brugia malayi	photoreceptor-specific nuclear receptor	0.0627	0.8145	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0331	0.4043	0.4964
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0327	0.3991	0.5
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0627	0.8145	0.8145
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.016	0.1668	0.5
Loa Loa (eye worm)	hypothetical protein	0.0627	0.8145	1
Brugia malayi	Kelch motif family protein	0.0057	0.0247	0.0108
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0627	0.8145	0.8145
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0627	0.8145	1
Schistosoma mansoni	nuclear receptor	0.0296	0.3551	0.436
Schistosoma mansoni	nuclear receptor nhr-48	0.0296	0.3551	0.436
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0296	0.3551	0.3551
Loa Loa (eye worm)	hypothetical protein	0.0296	0.3551	0.436
Loa Loa (eye worm)	hypothetical protein	0.0296	0.3551	0.436
Brugia malayi	tailless protein	0.0296	0.3551	0.4247
Brugia malayi	Nuclear hormone receptor E75	0.0296	0.3551	0.4247
Loa Loa (eye worm)	hypothetical protein	0.0296	0.3551	0.436
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.016	0.0197
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0627	0.8145	1
Onchocerca volvulus		0.0296	0.3551	0.3576
Echinococcus granulosus	FTZ F1 alpha	0.0627	0.8145	0.8145
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0627	0.8145	1
Loa Loa (eye worm)	hypothetical protein	0.0296	0.3551	0.436
Loa Loa (eye worm)	nuclear hormone receptor	0.0296	0.3551	0.436
Echinococcus multilocularis	tumor protein p63	0.076	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.016	0.016
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0627	0.8145	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0247	0.0303
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.3991	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0331	0.4043	0.4964
Onchocerca volvulus	Protein ultraspiracle homolog	0.0627	0.8145	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0863	0.1059
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0627	0.8145	0.8145
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0296	0.3551	0.3576
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0296	0.3551	0.436
Loa Loa (eye worm)	hypothetical protein	0.014	0.1387	0.1703
Loa Loa (eye worm)	hypothetical protein	0.0296	0.3551	0.436
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0296	0.3551	0.3551
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0627	0.8145	1
Brugia malayi	ecdysteroid receptor	0.0627	0.8145	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0627	0.8145	1
Schistosoma mansoni	nuclear hormone receptor	0.0296	0.3551	0.436
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0296	0.3551	0.4247
Brugia malayi	orphan nuclear receptor NR2E1	0.0296	0.3551	0.4247
Loa Loa (eye worm)	hypothetical protein	0.0331	0.4043	0.4964
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0296	0.3551	0.3576
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0627	0.8145	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0627	0.8145	1
Loa Loa (eye worm)	hypothetical protein	0.0627	0.8145	1
Schistosoma mansoni	nuclear hormone receptor	0.0296	0.3551	0.436
Echinococcus multilocularis	integrin beta 2	0.028	0.3337	0.3337
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0627	0.8145	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0627	0.8145	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0627	0.8145	0.8145
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0296	0.3551	0.3551
Brugia malayi	Nuclear hormone receptor E75	0.0296	0.3551	0.4247
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0296	0.3551	0.4247
Brugia malayi	nuclear hormone receptor	0.0296	0.3551	0.4247
Loa Loa (eye worm)	hypothetical protein	0.0627	0.8145	1
Loa Loa (eye worm)	hypothetical protein	0.0331	0.4043	0.4964
Brugia malayi	hypothetical protein	0.0331	0.4043	0.4863
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0627	0.8145	1
Brugia malayi	steroid hormone receptor	0.0627	0.8145	1
Brugia malayi	nuclear receptor RXR	0.0296	0.3551	0.4247
Echinococcus granulosus	integrin alpha 3	0.0142	0.1413	0.1413
Echinococcus multilocularis	integrin alpha ps	0.0083	0.0598	0.0598
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0627	0.8145	1
Echinococcus multilocularis	integrin alpha ps	0.0083	0.0598	0.0598
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.016	0.1668	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0627	0.8145	0.8145
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.016	0.016
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0627	0.8145	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0296	0.3551	0.436
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0994	0.122
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0627	0.8145	0.8145
Echinococcus multilocularis	integrin alpha 3	0.0142	0.1413	0.1413
Echinococcus granulosus	integrin alpha ps	0.0083	0.0598	0.0598
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0627	0.8145	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0296	0.3551	0.3551
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0627	0.8145	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.3991	0.5
Loa Loa (eye worm)	DR-78	0.0296	0.3551	0.436
Schistosoma mansoni	thyroid hormone receptor	0.0627	0.8145	1
Loa Loa (eye worm)	hypothetical protein	0.0627	0.8145	1
Loa Loa (eye worm)	hypothetical protein	0.0331	0.4043	0.4964
Echinococcus granulosus	integrin beta 2	0.028	0.3337	0.3337
Onchocerca volvulus		0.0296	0.3551	0.3576
Loa Loa (eye worm)	hypothetical protein	0.0627	0.8145	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0627	0.8145	0.8145
Loa Loa (eye worm)	integrin alpha pat-2	0.0285	0.3399	0.4173
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0627	0.8145	0.8145
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0627	0.8145	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0047	0.0058
Brugia malayi	hypothetical protein	0.0296	0.3551	0.4247
Brugia malayi	Nuclear hormone receptor-like 1	0.0331	0.4043	0.4863
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0627	0.8145	1
Brugia malayi	Integrin beta pat-3 precursor	0.0378	0.4697	0.5682
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.016	0.016
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0296	0.3551	0.3551
Echinococcus multilocularis	ecdysone induced protein 78C	0.0627	0.8145	0.8145
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1461	0.1794
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0327	0.3991	0.5
Loa Loa (eye worm)	hypothetical protein	0.0296	0.3551	0.436
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0327	0.3991	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0627	0.8145	0.8145
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.016	0.0197
Schistosoma mansoni	integrin alpha-ps	0.0043	0.0047	0.0058
Schistosoma mansoni	integrin beta subunit	0.0223	0.254	0.3118
Loa Loa (eye worm)	hypothetical protein	0.0296	0.3551	0.436

Activities

Activity type	Activity value	Assay description	Source	Reference
Duration (functional)	= 180 min	Ex vivo duration of inhibition of ADP-induced canine platelet aggregation by 3 mg/kg.	ChEMBL.	10602710
IC50 (binding)	= 0.65 nM	In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor.	ChEMBL.	10602710
IC50 (binding)	= 0.65 nM	In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor.	ChEMBL.	10602710
IC50 (functional)	= 0.45 uM	In vitro inhibitory potency against human gel filtered platelet (GFP) aggregation	ChEMBL.	10602710
IC50 (functional)	= 0.45 uM	In vitro inhibitory potency against human gel filtered platelet (GFP) aggregation	ChEMBL.	10602710

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	10602710

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL357593
PubChem: 10790594

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 260238