Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, muscarinic 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0438 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0438 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0438 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0438 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0438 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0438 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0438 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0438 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0438 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0438 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0438 | 0.5 | 0.5 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0438 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0438 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0438 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0438 | 0.5 | 0.5 | |
Echinococcus multilocularis | peroxidasin | 0.0438 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0438 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0438 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0438 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0438 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0438 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0438 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0438 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0438 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0438 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 80 % | Percent of Parent compound remaining after 20 min incubation with human liver microsomes (Human microsomal stability) | ChEMBL. | 12459007 |
Activity (functional) | = 80 % | Percent of Parent compound remaining after 20 min incubation with human liver microsomes (Human microsomal stability) | ChEMBL. | 12459007 |
clogP | = 2.8 | Calculated partition coefficient (clogP) | ChEMBL. | 12459007 |
Ki (binding) | = 32 nM | Binding affinity for human Muscarinic acetylcholine receptor M2 | ChEMBL. | 12459007 |
Ki (binding) | = 32 nM | Binding affinity for human Muscarinic acetylcholine receptor M2 | ChEMBL. | 12459007 |
Selectivity (binding) | = 8 | Selectivity as ratio of Ki for M1 anad M2 receptors | ChEMBL. | 12459007 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.