Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calpain 1, (mu/I) large subunit | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | calpain A | calpain 1, (mu/I) large subunit | 714 aa | 753 aa | 31.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | calpain A | 0.0069 | 0.025 | 0.0119 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0145 | 0.0688 | 0.0653 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1494 | 0.8465 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0753 | 0.4195 | 0.4056 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0069 | 0.025 | 0.0018 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0753 | 0.4195 | 0.4173 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0145 | 0.0688 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0753 | 0.4195 | 0.4046 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0066 | 0.0233 | 0.0144 |
Echinococcus multilocularis | thymidylate synthase | 0.0753 | 0.4195 | 0.4117 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0753 | 0.4195 | 0.4173 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0358 | 0.1919 | 0.1888 |
Loa Loa (eye worm) | thymidylate synthase | 0.0753 | 0.4195 | 0.4142 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1494 | 0.8465 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.176 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0133 | 0.0043 |
Onchocerca volvulus | 0.0753 | 0.4195 | 1 | |
Onchocerca volvulus | 0.0041 | 0.009 | 0.0214 | |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0233 | 0.0144 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0358 | 0.1919 | 0.5 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0069 | 0.025 | 0.0119 |
Mycobacterium ulcerans | thymidylate synthase | 0.0753 | 0.4195 | 0.4173 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1494 | 0.8465 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1494 | 0.8465 | 0.5 |
Brugia malayi | hypothetical protein | 0.0358 | 0.1919 | 0.1726 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1494 | 0.8465 | 0.5 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0145 | 0.0688 | 0.0653 |
Chlamydia trachomatis | dihydrofolate reductase | 0.176 | 1 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1494 | 0.8465 | 0.5 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0069 | 0.025 | 0.0018 |
Schistosoma mansoni | dihydrofolate reductase | 0.176 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0753 | 0.4195 | 0.4056 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.019 | 0.0101 |
Onchocerca volvulus | 0.0032 | 0.0037 | 0.0089 | |
Echinococcus multilocularis | dihydrofolate reductase | 0.176 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.176 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.176 | 1 | 1 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0048 | 0.0133 | 0.0043 |
Echinococcus granulosus | dihydrofolate reductase | 0.176 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.176 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.176 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11 nM | Inhibitory activity evaluated against recombinant human calpain 1 | ChEMBL. | No reference |
IC50 (binding) | = 11 nM | Inhibitory activity evaluated against recombinant human calpain 1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.