Detailed information for compound 260622

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 228.329 | Formula: C16H20O
  • H donors: 1 H acceptors: 1 LogP: 4.97 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)C12C[C@@H]3C[C@H](C2)C[C@H](C1)C3
  • InChi: 1S/C16H20O/c17-15-3-1-14(2-4-15)16-8-11-5-12(9-16)7-13(6-11)10-16/h1-4,11-13,17H,5-10H2/t11-,12+,13-,16?
  • InChiKey: KZMYFIUFUAOZHP-SIPHMOLBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0026 0.0166 0.0166
Loa Loa (eye worm) carboxylesterase 0.0082 0.0824 0.2246
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0271 0.1536
Schistosoma mansoni cytochrome P450 0.0019 0.008 0.0176
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0387 0.0852
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0026 0.0166 0.0416
Echinococcus granulosus ring and YY1 binding protein 0.0013 0.0017 0.0037
Brugia malayi SWIB/MDM2 domain containing protein 0.0038 0.0304 0.0798
Brugia malayi brahma associated protein 60 kDa 0.0038 0.0304 0.0798
Schistosoma mansoni hypothetical protein 0.0397 0.4542 1
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0271 0.0694
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0112 0.1183 0.3244
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Echinococcus granulosus tar DNA binding protein 0.0061 0.0584 0.1286
Mycobacterium ulcerans hypothetical protein 0.0141 0.1523 0.4183
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0141 0.1523 0.3353
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0176
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0105 0.0245
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0318 0.3611 1
Brugia malayi Carboxylesterase family protein 0.0082 0.0824 0.2246
Onchocerca volvulus 0.0141 0.1523 0.4191
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.008 0.019
Loa Loa (eye worm) hypothetical protein 0.0104 0.109 0.2985
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0155 0.0384
Echinococcus granulosus expressed conserved protein 0.0098 0.1015 0.2235
Brugia malayi FAD binding domain containing protein 0.0026 0.0166 0.0416
Giardia lamblia Nitric oxide synthase, inducible 0.0023 0.0131 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0431 0.0431
Brugia malayi Tachykinin-like peptides receptor 99D 0.0112 0.1183 0.3244
Schistosoma mansoni hypothetical protein 0.0043 0.0368 0.081
Onchocerca volvulus 0.0014 0.0022 0.0013
Loa Loa (eye worm) hypothetical protein 0.0045 0.0387 0.103
Echinococcus multilocularis ring and YY1 binding protein 0.0013 0.0017 0.0017
Leishmania major p450 reductase, putative 0.0026 0.0166 0.0416
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0019 0.008 0.0162
Onchocerca volvulus 0.0112 0.1183 0.3244
Echinococcus multilocularis BC026374 protein (S09 family) 0.0014 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0112 0.1183 0.2604
Schistosoma mansoni hypothetical protein 0.0165 0.1799 0.396
Onchocerca volvulus 0.0014 0.0022 0.0013
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0026 0.0166 0.0416
Echinococcus granulosus g-protein coupled receptor 0.0112 0.1183 0.2604
Brugia malayi Trypsin family protein 0.0141 0.1523 0.4191
Schistosoma mansoni neuropeptide F-like receptor 0.0112 0.1183 0.2604
Schistosoma mansoni hypothetical protein 0.0038 0.0304 0.0669
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0105 0.0105
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0082 0.0824 0.1814
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0141 0.1523 0.3353
Loa Loa (eye worm) hypothetical protein 0.0055 0.0506 0.136
Schistosoma mansoni hypothetical protein 0.0043 0.0368 0.081
Onchocerca volvulus 0.0025 0.0155 0.0384
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0318 0.3611 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0019 0.008 0.0162
Echinococcus granulosus neuropeptide receptor 0.0112 0.1183 0.2604
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0271 0.0694
Loa Loa (eye worm) hypothetical protein 0.0035 0.0271 0.0706
Schistosoma mansoni diflavin oxidoreductase 0.0013 0.0011 0.0025
Echinococcus granulosus methionine synthase reductase 0.0016 0.0049 0.0107
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0112 0.1183 0.2604
Echinococcus granulosus g protein coupled receptor 0.0112 0.1183 0.2604
Brugia malayi hypothetical protein 0.0112 0.1183 0.3244
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0019 0.008 0.0162
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0112 0.1183 0.3244
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Brugia malayi hypothetical protein 0.0021 0.0105 0.0245
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Schistosoma mansoni rab6-interacting 0.0021 0.0105 0.0232
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.1183 0.2604
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Echinococcus granulosus BC026374 protein S09 family 0.0014 0.0022 0.0048
Schistosoma mansoni BC026374 protein (S09 family) 0.0014 0.0022 0.0048
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0038 0.0304 0.0304
Brugia malayi G protein-coupled receptor F59B2.13 0.0112 0.1183 0.3244
Schistosoma mansoni lipoxygenase 0.0125 0.1334 0.2936
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Loa Loa (eye worm) FAD binding domain-containing protein 0.0026 0.0166 0.0416
Onchocerca volvulus 0.0035 0.0271 0.0706
Brugia malayi neuropeptide F receptor 0.0112 0.1183 0.3244
Onchocerca volvulus 0.0141 0.1523 0.4191
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0174 0.0437
Echinococcus multilocularis transmembrane protease serine 3 0.0141 0.1523 0.1523
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0019 0.008 0.0162
Echinococcus granulosus neuropeptide Y receptor 0.0112 0.1183 0.2604
Echinococcus multilocularis neuropeptide Y receptor 0.0112 0.1183 0.1183
Brugia malayi hypothetical protein 0.0112 0.1183 0.3244
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0013
Echinococcus multilocularis Niemann Pick C1 protein 0.0104 0.109 0.109
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0013
Schistosoma mansoni hypothetical protein 0.0112 0.1183 0.2604
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0019 0.008 0.0162
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0125 0.1334 0.2936
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0019 0.008 0.0162
Brugia malayi hypothetical protein 0.0112 0.1183 0.3244
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0387 0.103
Brugia malayi hypothetical protein 0.0112 0.1183 0.3244
Echinococcus granulosus neuroligin 0.0014 0.0022 0.0048
Loa Loa (eye worm) hypothetical protein 0.0025 0.0155 0.0384
Brugia malayi ORL1-like opioid receptor 0.0112 0.1183 0.3244
Loa Loa (eye worm) hypothetical protein 0.0082 0.0824 0.2246
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0023 0.0131 0.0676
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0026 0.0166 0.0416
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0318 0.3611 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0155 0.0372
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0318 0.3611 0.795
Echinococcus granulosus serotonin receptor 0.0112 0.1183 0.2604
Brugia malayi Niemann-Pick C1 protein precursor 0.0104 0.109 0.2985
Loa Loa (eye worm) hypothetical protein 0.0035 0.0271 0.0706
Onchocerca volvulus 0.0035 0.0271 0.0706
Schistosoma mansoni biogenic amine receptor 0.0112 0.1183 0.2604
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0019 0.008 0.0162
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0105 0.0105
Echinococcus multilocularis protein patched 0.0045 0.0387 0.0387
Echinococcus multilocularis Mastin 0.0141 0.1523 0.1523
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0176
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Echinococcus granulosus thymidylate synthase 0.0318 0.3611 0.795
Brugia malayi hypothetical protein 0.0017 0.0062 0.0126
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.0437
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0038 0.0304 0.0812
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0019 0.008 0.0162
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0019 0.008 0.0162
Echinococcus multilocularis neuropeptide receptor 0.0112 0.1183 0.1183
Echinococcus granulosus dro:myosuppressin receptor 0.0112 0.1183 0.2604
Brugia malayi Trypsin family protein 0.0141 0.1523 0.4191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.1183 0.2604
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0112 0.1183 0.2604
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0026 0.0166 0.0244
Loa Loa (eye worm) hypothetical protein 0.0141 0.1523 0.4191
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0174 0.0437
Onchocerca volvulus 0.0112 0.1183 0.3244
Brugia malayi beta-lactamase family protein 0.0035 0.0271 0.0706
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0013
Schistosoma mansoni lipoxygenase 0.0087 0.089 0.1959
Plasmodium falciparum nitric oxide synthase, putative 0.0026 0.0166 0.0416
Echinococcus granulosus sex peptide receptor 0.0112 0.1183 0.2604
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.1183 0.2604
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Brugia malayi Serotonin receptor 0.0112 0.1183 0.3244
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0584 0.1286
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0271 0.1536
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0016 0.0049 0.0107
Loa Loa (eye worm) neuropeptide F receptor 0.0112 0.1183 0.3244
Loa Loa (eye worm) hypothetical protein 0.0021 0.0105 0.0245
Schistosoma mansoni cercarial elastase (S01 family) 0.0141 0.1523 0.3353
Loa Loa (eye worm) hypothetical protein 0.0025 0.0155 0.0384
Schistosoma mansoni polycystin 1-related 0.0021 0.0105 0.0232
Brugia malayi Dopamine receptor 0.0112 0.1183 0.3244
Loa Loa (eye worm) TYRA-2 protein 0.0112 0.1183 0.3244
Schistosoma mansoni cercarial elastase (S01 family) 0.0141 0.1523 0.3353
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0112 0.1183 0.1183
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0187 0.0474
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0019 0.008 0.0162
Mycobacterium leprae Probable lipase LipE 0.0035 0.0271 0.0541
Toxoplasma gondii ran binding protein 0.0013 0.0017 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0155 0.0372
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0112 0.1183 0.2604
Onchocerca volvulus 0.0112 0.1183 0.3244
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0482 0.1306
Onchocerca volvulus 0.0112 0.1183 0.3244
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0189 0.048
Echinococcus granulosus carboxylesterase 5A 0.0082 0.0824 0.1814
Echinococcus granulosus Niemann Pick C1 protein 0.0104 0.109 0.2399
Echinococcus granulosus glycoprotein Antigen 5 0.0141 0.1523 0.3353
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.1183 0.1183
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0019 0.008 0.0162
Loa Loa (eye worm) cytochrome P450 0.0019 0.008 0.0175
Echinococcus multilocularis SWI:SNF matrix associated 0.0038 0.0304 0.0304
Brugia malayi thymidylate synthase 0.0318 0.3611 1
Echinococcus multilocularis 0.0019 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0112 0.1183 0.2604
Schistosoma mansoni cercarial elastase (S01 family) 0.0141 0.1523 0.3353
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0112 0.1183 0.1183
Echinococcus granulosus peptide allatostatin:somatostatin 0.0112 0.1183 0.2604
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0584 0.0584
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0271 0.0706
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.1183 0.2604
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0271 0.0596
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0318 0.3611 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0019 0.008 0.0162
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0019 0.008 0.0162
Echinococcus granulosus tachykinin peptides receptor 99D 0.0112 0.1183 0.2604
Echinococcus multilocularis sex peptide receptor 0.0112 0.1183 0.1183
Mycobacterium ulcerans beta-lactamase 0.0035 0.0271 0.0694
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0038 0.0304 0.0633
Echinococcus multilocularis dro:myosuppressin receptor 0.0112 0.1183 0.1183
Echinococcus multilocularis para nitrobenzyl esterase 0.0014 0.0022 0.0022
Brugia malayi hypothetical protein 0.0151 0.1644 0.4526
Brugia malayi Carboxylesterase family protein 0.0014 0.0022 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0068 0.0129
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Loa Loa (eye worm) hypothetical protein 0.0021 0.0105 0.0245
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0141 0.1523 0.1523
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0112 0.1183 0.1183
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0271 0.1536
Echinococcus granulosus tm gpcr rhodopsin 0.0112 0.1183 0.2604
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0019 0.008 0.0162
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0141 0.1523 0.1523
Onchocerca volvulus 0.0112 0.1183 0.3244
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Giardia lamblia Hypothetical protein 0.0023 0.0131 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0431 0.0948
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0176
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0112 0.1183 0.2604
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0155 0.0213
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0026 0.0166 0.0366
Loa Loa (eye worm) hypothetical protein 0.0141 0.1523 0.4191
Onchocerca volvulus 0.0141 0.1523 0.4191
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0112 0.1183 0.3244
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0014 0.0022 0.0022
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0112 0.1183 0.3244
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Loa Loa (eye worm) trypsin family protein 0.0141 0.1523 0.4191
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0584 0.1578
Brugia malayi Trypsin family protein 0.0141 0.1523 0.4191
Schistosoma mansoni hypothetical protein 0.0038 0.0304 0.0669
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0038 0.0304 0.0798
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.1183 0.2604
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0112 0.1183 0.1183
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0019 0.008 0.0162
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0112 0.1183 0.1183
Schistosoma mansoni biogenic amine receptor 0.0112 0.1183 0.2604
Brugia malayi Carboxylesterase family protein 0.0082 0.0824 0.2246
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.008 0.1233
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0019 0.008 0.0162
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Schistosoma mansoni hypothetical protein 0.0043 0.0368 0.081
Schistosoma mansoni amine GPCR 0.0112 0.1183 0.2604
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0026 0.0166 0.0166
Echinococcus multilocularis G-protein coupled receptor, putative 0.0112 0.1183 0.1183
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0105 0.0232
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0271 0.0706
Onchocerca volvulus 0.0014 0.0022 0.0013
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0557 0.1503
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0155 0.0213
Loa Loa (eye worm) hypothetical protein 0.0141 0.1523 0.4191
Echinococcus multilocularis neuropeptide s receptor 0.0112 0.1183 0.1183
Onchocerca volvulus 0.0141 0.1523 0.4191
Onchocerca volvulus 0.0112 0.1183 0.3244
Leishmania major cytochrome p450-like protein 0.0028 0.0189 0.048
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0019 0.008 0.0162
Brugia malayi CXXC zinc finger family protein 0.0028 0.0187 0.0474
Schistosoma mansoni growth hormone secretagogue receptor 0.0112 0.1183 0.2604
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0038 0.0304 0.0812
Echinococcus multilocularis neuropeptides capa receptor 0.0112 0.1183 0.1183
Leishmania major hypothetical protein, conserved 0.0027 0.0174 0.0437
Echinococcus granulosus allatostatin A receptor 0.0112 0.1183 0.2604
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0125 0.1334 0.1334
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.1183 0.2604
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0189 0.048
Echinococcus granulosus geminin 0.0165 0.1799 0.396
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0271 0.054
Loa Loa (eye worm) hypothetical protein 0.0141 0.1523 0.4191
Echinococcus granulosus orexin receptor type 2 0.0112 0.1183 0.2604
Mycobacterium ulcerans lipase LipD 0.0035 0.0271 0.0694
Loa Loa (eye worm) thymidylate synthase 0.0318 0.3611 1
Schistosoma mansoni gliotactin 0.0014 0.0022 0.0048
Mycobacterium ulcerans thymidylate synthase 0.0318 0.3611 1
Loa Loa (eye worm) G-protein coupled receptor 0.0112 0.1183 0.3244
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0112 0.1183 0.3244
Echinococcus multilocularis thymidylate synthase 0.0318 0.3611 0.3611
Loa Loa (eye worm) hypothetical protein 0.0141 0.1523 0.4191
Loa Loa (eye worm) hypothetical protein 0.0141 0.1523 0.4191
Schistosoma mansoni opsin-like receptor 0.0112 0.1183 0.2604
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0019 0.008 0.0162
Brugia malayi brahma associated protein 60 kDa 0.0038 0.0304 0.0798
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0013 0.0017 0.0017
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0271 0.0271
Echinococcus granulosus tm gpcr rhodopsin 0.0112 0.1183 0.2604
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0019 0.008 0.0162
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0155 0.0384
Onchocerca volvulus 0.0038 0.0304 0.0798
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0019 0.008 0.0162
Brugia malayi hypothetical protein 0.0014 0.0022 0.0013
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Onchocerca volvulus 0.0141 0.1523 0.4191
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0141 0.1523 0.3353
Echinococcus multilocularis neuropeptides capa receptor 0.0112 0.1183 0.1183
Onchocerca volvulus 0.0141 0.1523 0.4191
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0026 0.0166 0.0416
Echinococcus granulosus neuropeptides capa receptor 0.0112 0.1183 0.2604
Brugia malayi hypothetical protein 0.0112 0.1183 0.3244
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0387 0.2252
Brugia malayi CHE-14 protein 0.0045 0.0387 0.103
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.008 0.0175
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.1183 0.2604
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0189 0.048
Echinococcus granulosus cpg binding protein 0.0029 0.0206 0.0454
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.4542 0.4542
Echinococcus granulosus neuropeptide receptor A26 0.0112 0.1183 0.2604
Brugia malayi Cytochrome P450 family protein 0.0028 0.0189 0.048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.1183 0.1183
Echinococcus multilocularis g protein coupled receptor 0.0112 0.1183 0.1183
Echinococcus multilocularis neuropeptide Y receptor 0.0112 0.1183 0.1183
Echinococcus granulosus alpha 1A adrenergic receptor 0.0112 0.1183 0.2604
Echinococcus multilocularis g-protein coupled receptor 0.0112 0.1183 0.1183
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0431 0.1151
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.1644 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0271 0.0706
Brugia malayi beta-lactamase family protein 0.0035 0.0271 0.0706
Schistosoma mansoni histamine h1 receptor 0.0112 0.1183 0.2604
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0155 0.0372
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0068 0.0129
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Brugia malayi Trypsin-like protease protein 5 0.0141 0.1523 0.4191
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0271 0.0694
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0105 0.0071
Mycobacterium tuberculosis Conserved protein 0.0035 0.0271 0.0694
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.008 0.0176
Schistosoma mansoni hypothetical protein 0.0112 0.1183 0.2604
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0584 0.1286
Echinococcus multilocularis glycoprotein Antigen 5 0.0141 0.1523 0.1523
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0431 0.1151
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0019 0.008 0.0162
Schistosoma mansoni adenoreceptor 0.0112 0.1183 0.2604
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Mycobacterium ulcerans hypothetical protein 0.0035 0.0271 0.0694
Loa Loa (eye worm) hypothetical protein 0.0035 0.0271 0.0706
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0141 0.1523 0.3353
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.1183 0.2604
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0019 0.008 0.0162
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0019 0.008 0.0162
Brugia malayi G protein-coupled receptor 0.0112 0.1183 0.3244
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0112 0.1183 0.1183
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Onchocerca volvulus 0.0112 0.1183 0.3244
Brugia malayi hypothetical protein 0.0112 0.1183 0.3244
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0013 0.0017 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.1183 0.2604
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0013 0.0017 0.0037
Brugia malayi putative neuropeptide receptor NPR1 0.0112 0.1183 0.3244
Schistosoma mansoni alpha-1 adrenergic receptor 0.0112 0.1183 0.2604
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Loa Loa (eye worm) G-protein coupled receptor 0.0112 0.1183 0.3244
Echinococcus granulosus dnaJ subfamily B 0.0397 0.4542 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0112 0.1183 0.1183
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0155 0.0384
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0112 0.1183 0.2604
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0387 0.0852
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0105 0.0232
Brugia malayi Serotonin receptor 0.0112 0.1183 0.3244
Onchocerca volvulus 0.0112 0.1183 0.3244
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0271 0.0694
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0584 0.1578
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.1183 0.2604
Schistosoma mansoni cercarial elastase (S01 family) 0.0141 0.1523 0.3353
Echinococcus multilocularis RUN 0.0021 0.0105 0.0105
Schistosoma mansoni hypothetical protein 0.0043 0.0368 0.081
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0112 0.1183 0.2604
Brugia malayi Cytochrome P450 family protein 0.0028 0.0189 0.048
Schistosoma mansoni neuroligin 3 (S09 family) 0.0014 0.0022 0.0048
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0155 0.0372
Echinococcus granulosus 7TM GPCR rhodopsin 0.0112 0.1183 0.2604
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.1183 0.1183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.1183 0.2604
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0556 0.1224
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0112 0.1183 0.3244
Echinococcus multilocularis G protein coupled receptor 139 0.0112 0.1183 0.1183
Schistosoma mansoni cpg binding protein 0.0028 0.0187 0.0413
Mycobacterium tuberculosis Hypothetical protein 0.0151 0.1644 0.4519
Onchocerca volvulus 0.0112 0.1183 0.3244
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0112 0.1183 0.1183
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0112 0.1183 0.3244
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Echinococcus granulosus fmrfamide receptor 0.0112 0.1183 0.2604
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0019 0.008 0.0162
Schistosoma mansoni loxhd1 0.0021 0.0105 0.0232
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0112 0.1183 0.1183
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0271 0.0694
Onchocerca volvulus 0.0035 0.0271 0.0706
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0112 0.1183 0.2604
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0038 0.0304 0.0798
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0318 0.3611 1
Loa Loa (eye worm) FAD binding domain-containing protein 0.0016 0.0049 0.0088
Schistosoma mansoni cercarial elastase (S01 family) 0.0141 0.1523 0.3353
Schistosoma mansoni acetylcholinesterase 0.0014 0.0022 0.0048
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0271 0.1536
Echinococcus multilocularis somatostatin receptor 0.0112 0.1183 0.1183
Echinococcus multilocularis methionine synthase reductase 0.0016 0.0049 0.0049
Brugia malayi hypothetical protein 0.0112 0.1183 0.3244
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0105 0.0245
Echinococcus multilocularis enteropeptidase 0.0141 0.1523 0.1523
Loa Loa (eye worm) neuropeptide F receptor 0.0112 0.1183 0.3244
Echinococcus multilocularis acetylcholinesterase 0.0082 0.0824 0.0824
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0141 0.1523 0.3353
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.1183 0.1183
Echinococcus multilocularis neuropeptide receptor A26 0.0112 0.1183 0.1183
Brugia malayi hypothetical protein 0.0112 0.1183 0.3244
Brugia malayi hypothetical protein 0.0112 0.1183 0.3244
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0112 0.1183 0.3244
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0141 0.1523 0.3353
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0068 0.0129
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0318 0.3611 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0106 0.1109 0.2441
Trypanosoma cruzi p450 reductase, putative 0.0026 0.0166 0.0416
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.008 0.0163
Schistosoma mansoni neuropeptide receptor 0.0112 0.1183 0.2604
Echinococcus granulosus neuropeptide Y receptor 0.0112 0.1183 0.2604
Echinococcus granulosus biogenic amine 5HT receptor 0.0112 0.1183 0.2604
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0174 0.0437
Mycobacterium tuberculosis Conserved protein 0.0035 0.0271 0.0694
Onchocerca volvulus 0.0112 0.1183 0.3244
Loa Loa (eye worm) brahma associated protein 0.0038 0.0304 0.0798
Echinococcus multilocularis allatostatin A receptor 0.0112 0.1183 0.1183
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Schistosoma mansoni biogenic amine (5HT) receptor 0.0112 0.1183 0.2604
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0584 0.1286
Brugia malayi hypothetical protein 0.0021 0.0105 0.0245
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0176
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Onchocerca volvulus 0.0112 0.1183 0.3244
Echinococcus multilocularis SWI:SNF matrix associated 0.0038 0.0304 0.0304
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.1183 0.1183
Echinococcus multilocularis acetylcholinesterase 0.0082 0.0824 0.0824
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.008 0.0175
Echinococcus granulosus SWI:SNF matrix associated 0.0038 0.0304 0.0669
Brugia malayi Carboxylesterase family protein 0.0014 0.0022 0.0013
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0026 0.0166 0.0366
Schistosoma mansoni cytochrome P450 reductase 0.0026 0.0166 0.0366
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0271 0.0541
Chlamydia trachomatis DNA topoisomerase I 0.0038 0.0304 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0141 0.1523 0.3353
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0038 0.0304 0.0669
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0151 0.1644 0.4526
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0112 0.1183 0.2604
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0112 0.1183 0.3244
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0155 0.0372
Loa Loa (eye worm) acetylcholinesterase 1 0.0082 0.0824 0.2246
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.1183 0.2604
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0019 0.008 0.0162
Echinococcus granulosus acetylcholinesterase 0.0082 0.0824 0.1814
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0141 0.1523 0.3353
Echinococcus multilocularis neuroligin 0.0014 0.0022 0.0022
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0155 0.0372
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0155 0.0372
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0112 0.1183 0.2604
Onchocerca volvulus 0.0112 0.1183 0.3244
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0271 0.1536
Echinococcus granulosus hypothetical protein 0.0112 0.1183 0.2604
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0112 0.1183 0.1183
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0112 0.1183 0.3244
Schistosoma mansoni hypothetical protein 0.0019 0.008 0.0176
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0019 0.008 0.0162
Brugia malayi Trypsin family protein 0.0141 0.1523 0.4191
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.008 0.0163
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0141 0.1523 0.4191
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0318 0.3611 1
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0174 0.0451
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0155 0.0372
Onchocerca volvulus Neuropeptide F receptor homolog 0.0112 0.1183 0.3244
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Echinococcus multilocularis protein dispatched 1 0.0051 0.0462 0.0462
Schistosoma mansoni hypothetical protein 0.0141 0.1523 0.3353
Brugia malayi G-protein coupled receptor 0.0112 0.1183 0.3244
Schistosoma mansoni NADPH flavin oxidoreductase 0.0013 0.0014 0.003
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0176
Onchocerca volvulus 0.0028 0.0187 0.0474
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0112 0.1183 0.2604
Brugia malayi Doublecortin family protein 0.0021 0.0105 0.0245
Brugia malayi Carboxylesterase family protein 0.0014 0.0022 0.0013
Mycobacterium ulcerans hypothetical protein 0.0025 0.0155 0.0372
Brugia malayi follicle stimulating hormone receptor 0.0112 0.1183 0.3244
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0105 0.0105
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0112 0.1183 0.3244
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0019 0.008 0.0162
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0155 0.0372
Echinococcus multilocularis zinc finger protein Ran binding 0.0013 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0013
Schistosoma mansoni cercarial elastase (S01 family) 0.0141 0.1523 0.3353
Echinococcus granulosus acetylcholinesterase 0.0082 0.0824 0.1814
Onchocerca volvulus 0.0112 0.1183 0.3244
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0019 0.008 0.0162
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.1183 0.2604
Brugia malayi larval opioid receptor 0.0112 0.1183 0.3244
Schistosoma mansoni amine GPCR 0.0112 0.1183 0.2604
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0019 0.008 0.0162
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.1183 0.1183
Echinococcus granulosus Zinc finger RanBP2 type 0.0013 0.0017 0.0037
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0112 0.1183 0.1183
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0105 0.0232
Schistosoma mansoni amine GPCR 0.0112 0.1183 0.2604
Brugia malayi neuropeptide F receptor 0.0112 0.1183 0.3244
Brugia malayi RNA binding protein 0.0061 0.0584 0.1578
Loa Loa (eye worm) hypothetical protein 0.0082 0.0824 0.2246
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0019 0.008 0.0162
Loa Loa (eye worm) hypothetical protein 0.0035 0.0271 0.0706
Schistosoma mansoni neuropeptide receptor 0.0112 0.1183 0.2604
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.1183 0.2604
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0019 0.008 0.0162
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.1183 0.2604
Schistosoma mansoni zinc finger protein 0.0013 0.0017 0.0037
Schistosoma mansoni fusion 0.0013 0.0017 0.0037
Brugia malayi Cytochrome P450 family protein 0.0019 0.008 0.0175
Echinococcus granulosus biogenic amine 5HT receptor 0.0112 0.1183 0.2604
Onchocerca volvulus 0.0021 0.0105 0.0245
Schistosoma mansoni hypothetical protein 0.0021 0.0105 0.0232
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0155 0.0384
Echinococcus multilocularis serotonin receptor 0.0112 0.1183 0.1183
Echinococcus multilocularis orexin receptor type 2 0.0112 0.1183 0.1183
Schistosoma mansoni cercarial elastase (S01 family) 0.0141 0.1523 0.3353
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.008 0.0175
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0304 0.0633
Schistosoma mansoni amine GPCR 0.0112 0.1183 0.2604
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Brugia malayi Dopamine receptor protein 2 0.0112 0.1183 0.3244
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0174 0.0437
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0271 0.0596
Schistosoma mansoni cpg binding protein 0.0029 0.0206 0.0454
Schistosoma mansoni hypothetical protein 0.0141 0.1523 0.3353
Loa Loa (eye worm) hypothetical protein 0.0025 0.0155 0.0384
Loa Loa (eye worm) beta-lactamase 0.0035 0.0271 0.0706
Schistosoma mansoni hypothetical protein 0.0165 0.1799 0.396
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0431 0.0431
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0026 0.0166 0.0416
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0112 0.1183 0.1183
Schistosoma mansoni neuropeptide receptor 0.0112 0.1183 0.2604
Loa Loa (eye worm) RNA binding protein 0.0061 0.0584 0.1578
Echinococcus multilocularis g protein coupled receptor 0.0112 0.1183 0.1183
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.008 0.0175
Echinococcus granulosus G protein coupled receptor 139 0.0112 0.1183 0.2604
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0019 0.008 0.0162
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0019 0.008 0.0162
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0013
Schistosoma mansoni rab6-interacting 0.0021 0.0105 0.0232
Echinococcus granulosus neuropeptide receptor 0.0112 0.1183 0.2604
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0431 0.0948
Loa Loa (eye worm) hypothetical protein 0.0026 0.0166 0.0416
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0155 0.0384
Echinococcus granulosus neuropeptide FF receptor 2 0.0112 0.1183 0.2604
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0026 0.0166 0.0416
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0026 0.0166 0.0416
Echinococcus multilocularis expressed conserved protein 0.0098 0.1015 0.1015
Brugia malayi hypothetical protein 0.0112 0.1183 0.3244
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0013
Schistosoma mansoni cercarial elastase (S01 family) 0.0141 0.1523 0.3353
Echinococcus multilocularis carboxylesterase 5A 0.0082 0.0824 0.0824
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0019 0.008 0.0162
Schistosoma mansoni myosin xvIII 0.0112 0.1183 0.2604
Echinococcus granulosus RUN 0.0021 0.0105 0.0232
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0013 0.0017 0.0016
Echinococcus granulosus para nitrobenzyl esterase 0.0014 0.0022 0.0048
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0112 0.1183 0.1183
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0387 0.0387
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0189 0.048
Echinococcus granulosus transmembrane protease serine 3 0.0141 0.1523 0.3353
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0038 0.0304 0.0798
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0014 0.0022 0.0048
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0318 0.3611 1
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0174 0.0265
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0019 0.008 0.0162
Schistosoma mansoni RNA binding protein 0.0013 0.0017 0.0037
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0019 0.008 0.0162
Onchocerca volvulus 0.0318 0.3611 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0584 0.1286
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0026 0.0166 0.0416
Schistosoma mansoni cercarial elastase (S01 family) 0.0141 0.1523 0.3353
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0431 0.0948
Brugia malayi putative neuropeptide receptor 0.0112 0.1183 0.3244
Echinococcus granulosus zinc finger protein Ran binding 0.0013 0.0017 0.0037
Brugia malayi hypothetical protein 0.0141 0.1523 0.4191
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0271 0.0706
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0014 0.0022 0.0048
Onchocerca volvulus 0.0014 0.0022 0.0013
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0019 0.008 0.0162
Brugia malayi flavodoxin family protein 0.0026 0.0166 0.0416
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0112 0.1183 0.2604
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0112 0.1183 0.2604
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0189 0.048
Brugia malayi cytochrome P450 0.0019 0.008 0.0175
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0013
Brugia malayi FAD binding domain containing protein 0.0016 0.0049 0.0088
Brugia malayi Cytochrome P450 family protein 0.0059 0.0557 0.1503
Toxoplasma gondii ABC1 family protein 0.0035 0.0271 0.0721
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0112 0.1183 0.1183
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Schistosoma mansoni hypothetical protein 0.0013 0.0017 0.0037
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0271 0.0596
Mycobacterium tuberculosis Conserved protein 0.0035 0.0271 0.0694
Echinococcus multilocularis neuropeptide FF receptor 2 0.0112 0.1183 0.1183
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0141 0.1523 0.3353
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.1183 0.2604
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0584 0.1286
Schistosoma mansoni cercarial elastase (S01 family) 0.0141 0.1523 0.3353
Echinococcus multilocularis SWI:SNF matrix associated 0.0038 0.0304 0.0304
Schistosoma mansoni opsin-like receptor 0.0112 0.1183 0.2604
Onchocerca volvulus 0.0014 0.0022 0.0013
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0189 0.0467
Echinococcus multilocularis neuropeptide receptor 0.0112 0.1183 0.1183
Brugia malayi AKH receptor 0.0112 0.1183 0.3244
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0304 0.1739
Echinococcus multilocularis cpg binding protein 0.0029 0.0206 0.0206
Chlamydia trachomatis SWIB complex protein 0.0038 0.0304 1
Brugia malayi GnHR receptor homolog 0.0112 0.1183 0.3244
Schistosoma mansoni patched 1 0.0045 0.0387 0.0852
Echinococcus granulosus 7tm_1 domain containing protein 0.0112 0.1183 0.2604
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0019 0.008 0.0162
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0019 0.008 0.0162
Echinococcus multilocularis Niemann Pick C1 protein 0.0149 0.1618 0.1618
Echinococcus multilocularis serotonin receptor 0.0112 0.1183 0.1183
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.008 0.0175
Onchocerca volvulus 0.0112 0.1183 0.3244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0431 0.0948
Schistosoma mansoni amine GPCR 0.0112 0.1183 0.2604
Brugia malayi Dopamine receptor protein 1 0.0112 0.1183 0.3244
Echinococcus granulosus neuropeptides capa receptor 0.0112 0.1183 0.2604
Loa Loa (eye worm) melatonin receptor type 1A 0.0112 0.1183 0.3244
Schistosoma mansoni hypothetical protein 0.0112 0.1183 0.2604
Echinococcus multilocularis fmrfamide receptor 0.0112 0.1183 0.1183
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0019 0.008 0.0162
Trichomonas vaginalis esterase, putative 0.0035 0.0271 0.1536
Schistosoma mansoni hypothetical protein 0.0038 0.0304 0.0669
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.1183 0.1183
Brugia malayi G-protein coupled receptor 0.0112 0.1183 0.3244
Echinococcus granulosus somatostatin receptor 0.0112 0.1183 0.2604
Schistosoma mansoni neuropeptide F-like receptor 0.0112 0.1183 0.2604
Echinococcus granulosus enteropeptidase 0.0141 0.1523 0.3353
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0141 0.1523 0.3353
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.1183 0.1183
Schistosoma mansoni biogenic amine (5HT) receptor 0.0112 0.1183 0.2604
Onchocerca volvulus 0.0112 0.1183 0.3244
Loa Loa (eye worm) hypothetical protein 0.0141 0.1523 0.4191
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0104 0.109 1
Brugia malayi sulfakinin receptor protein 0.0112 0.1183 0.3244
Onchocerca volvulus 0.0112 0.1183 0.3244
Schistosoma mansoni opsin-like receptor 0.0112 0.1183 0.2604
Echinococcus granulosus Niemann Pick C1 protein 0.0149 0.1618 0.3563
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.1183 0.2604
Schistosoma mansoni biogenic amine receptor 0.0112 0.1183 0.2604
Onchocerca volvulus 0.0021 0.0105 0.0245
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0068 0.0129
Echinococcus multilocularis fmrfamide receptor 0.0112 0.1183 0.1183
Echinococcus granulosus neuropeptide s receptor 0.0112 0.1183 0.2604
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0112 0.1183 0.2604
Echinococcus granulosus tm gpcr rhodopsin 0.0112 0.1183 0.2604
Brugia malayi beta-lactamase 0.0035 0.0271 0.0706
Brugia malayi Carboxylesterase family protein 0.0014 0.0022 0.0013
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0271 0.0694
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0584 0.1578
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.1183 0.2604
Schistosoma mansoni cercarial elastase (S01 family) 0.0141 0.1523 0.3353
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0174 0.0437
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0112 0.1183 0.2604
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0271 0.0706
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.1183 0.2604
Echinococcus multilocularis g protein coupled receptor 0.0112 0.1183 0.1183
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0271 0.0694
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0271 0.0694
Schistosoma mansoni neuropeptide f receptor 76f 0.0112 0.1183 0.2604
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0026 0.0166 0.0403
Echinococcus granulosus g protein coupled receptor 0.0112 0.1183 0.2604
Trichomonas vaginalis sulfite reductase, putative 0.0026 0.0166 0.0892
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0014 0.0022 0.0048
Brugia malayi hypothetical protein 0.0027 0.0174 0.0437
Echinococcus granulosus Mastin 0.0141 0.1523 0.3353
Onchocerca volvulus 0.0112 0.1183 0.3244
Loa Loa (eye worm) carboxylesterase 0.0014 0.0022 0.0013
Schistosoma mansoni TRABID protein (C64 family) 0.0013 0.0017 0.0037
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0189 0.048
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0155 0.0384
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0112 0.1183 0.2604
Leishmania major cytochrome P450 reductase, putative 0.0023 0.0131 0.0319
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0431 0.0948
Loa Loa (eye worm) hypothetical protein 0.0035 0.0271 0.0706
Leishmania major cytochrome p450-like protein 0.0019 0.008 0.0175
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0271 0.0694
Schistosoma mansoni brg-1 associated factor 0.0038 0.0304 0.0669
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Echinococcus multilocularis geminin 0.0165 0.1799 0.1799
Leishmania major cytochrome p450-like protein 0.0019 0.008 0.0175
Loa Loa (eye worm) carboxylesterase 0.0014 0.0022 0.0013
Echinococcus granulosus g protein coupled receptor 0.0112 0.1183 0.2604
Brugia malayi RE15519p 0.0112 0.1183 0.3244
Loa Loa (eye worm) hypothetical protein 0.0112 0.1183 0.3244
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0271 0.0706
Schistosoma mansoni neuropeptide receptor 0.0112 0.1183 0.2604
Schistosoma mansoni cpg binding protein 0.0029 0.0206 0.0454
Leishmania major hypothetical protein, conserved 0.0035 0.0271 0.0706
Plasmodium vivax flavodoxin domain containing protein 0.0023 0.0131 0.0145
Brugia malayi Melatonin receptor type 1A 0.0112 0.1183 0.3244
Brugia malayi TAR-binding protein 0.0061 0.0584 0.1578
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0014 0.0022 0.0048
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2493 0.6884
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.008 0.0176

Activities

Activity type Activity value Assay description Source Reference
Km (binding) = 0.001 mM Apparent Michaelis constant (Km) against Arylsulfotransferase (AST IV) ChEMBL. 12459019
Km (binding) = 0.001 mM Apparent Michaelis constant (Km) against Arylsulfotransferase (AST IV) ChEMBL. 12459019
Ratio (binding) = 1600 Ratio of kcat/Km determined for catalytic efficiency of the compound in sulfonation against AST IV ChEMBL. 12459019
Vmax (binding) = 47.2 nM min-1 Maximal velocity of the compound (Vmax) against Arylsulfotransferase (AST IV) ChEMBL. 12459019
Vmax (binding) = 47.2 nM min-1 Maximal velocity of the compound (Vmax) against Arylsulfotransferase (AST IV) ChEMBL. 12459019

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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