Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | oxidoreductase | 0.0321 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0321 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0321 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0321 | 1 | 1 |
Plasmodium vivax | aldehyde reductase, putative | 0.0093 | 0.1592 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0321 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0321 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0321 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0321 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0321 | 1 | 1 |
Onchocerca volvulus | 0.0321 | 1 | 1 | |
Leishmania major | guanosine monophosphate reductase | 0.0095 | 0.1661 | 0.0082 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0321 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0321 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0321 | 1 | 1 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 0.1661 | 0.0082 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0321 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0321 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0321 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0321 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0095 | 0.1661 | 0.5 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0321 | 1 | 1 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 0.1661 | 0.0082 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0321 | 1 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0095 | 0.1661 | 0.0082 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0321 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0321 | 1 | 1 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.1661 | 0.0082 |
Giardia lamblia | Aldose reductase | 0.0321 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0321 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0321 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0321 | 1 | 1 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0093 | 0.1592 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0321 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0321 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0321 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0321 | 1 | 0.5 |
Onchocerca volvulus | 0.0321 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0321 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0321 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0321 | 1 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.0228 | 0.6572 | 0.5922 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0321 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0321 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0321 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0321 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0321 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0321 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0093 | 0.1592 | 0.1592 |
Loa Loa (eye worm) | oxidoreductase | 0.0321 | 1 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0228 | 0.6572 | 0.5922 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0321 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0321 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0321 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0321 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0321 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0321 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0321 | 1 | 1 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.1661 | 0.0082 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0321 | 1 | 1 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0093 | 0.1592 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0321 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0321 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0321 | 1 | 1 |
Onchocerca volvulus | 0.0321 | 1 | 1 | |
Toxoplasma gondii | IMP dehydrogenas | 0.0095 | 0.1661 | 0.0082 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.1661 | 0.0082 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0095 | 0.1661 | 0.1661 |
Trypanosoma brucei | prostaglandin f synthase | 0.0321 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0321 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0321 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0321 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0228 | 0.6572 | 0.6572 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0095 | 0.1661 | 0.0243 |
Trypanosoma brucei | GMP reductase | 0.0095 | 0.1661 | 0.0082 |
Onchocerca volvulus | 0.0321 | 1 | 1 | |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0321 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0321 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0321 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0321 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0321 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0321 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0093 | 0.1592 | 0.0163 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.1661 | 0.0082 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0321 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0321 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0321 | 1 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.1661 | 0.0082 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0321 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0321 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.1661 | 0.0082 |
Echinococcus multilocularis | aldo keto reductase | 0.0321 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0321 | 1 | 1 |
Mycobacterium leprae | Possible oxidoreductase | 0.0093 | 0.1592 | 0.1592 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0095 | 0.1661 | 0.0082 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0321 | 1 | 1 |
Onchocerca volvulus | 0.0321 | 1 | 1 | |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0095 | 0.1661 | 0.0082 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0321 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0321 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0321 | 1 | 1 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0093 | 0.1592 | 1 |
Onchocerca volvulus | 0.0321 | 1 | 1 | |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0321 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0321 | 1 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.0321 | 1 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.1661 | 0.0082 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0095 | 0.1661 | 0.1661 |
Entamoeba histolytica | aldose reductase, putative | 0.0321 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.