TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 202.213 | Formula: C10H10N4O
H donors: 2 H acceptors: 1 LogP: 1.03 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: NC(=N)Nc1occ(n1)c1ccccc1
InChi: 1S/C10H10N4O/c11-9(12)14-10-13-8(6-15-10)7-4-2-1-3-5-7/h1-6H,(H4,11,12,13,14)
InChiKey: GEAJNHIOUJTLPX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0068	0.1206	0.0803
Echinococcus multilocularis	unc 13 (munc13)	0.0074	0.1385	0.1016
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1206	0.0714
Schistosoma mansoni	tyrosine kinase	0.0321	0.895	1
Schistosoma mansoni	titin	0.0068	0.1206	0.0803
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0048	0.0593	0.0075
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0146	0.361	1
Echinococcus granulosus	Immunoglobulin	0.0068	0.1191	0.1331
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.1524	1
Echinococcus granulosus	peroxidasin	0.0068	0.1206	0.1347
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1189	0.0696
Loa Loa (eye worm)	CAMK protein kinase	0.0048	0.0593	0.0067
Echinococcus multilocularis	tyrosine protein kinase otk	0.0068	0.1206	0.0803
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.007	0.1252	0.0858
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1189	0.0696
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0068	0.1206	0.0803
Schistosoma mansoni	vav2	0.0076	0.1434	0.1075
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0068	0.1206	0.0803
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0193	0.5047	0.477
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1191	0.0699
Brugia malayi	Protein kinase domain containing protein	0.007	0.1252	0.0858
Echinococcus granulosus	insulin growth factor binding	0.0046	0.053	0.0592
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.012	0.2804	0.2701
Brugia malayi	Prion-like-	0.0068	0.1206	0.0803
Entamoeba histolytica	protein kinase, putative	0.0074	0.1396	0.0855
Onchocerca volvulus		0.0074	0.1385	0.1189
Echinococcus multilocularis	hemicentin 1	0.0068	0.1206	0.0803
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.1396	0.1029
Echinococcus multilocularis	protein kinase c eta type	0.0068	0.1189	0.0783
Brugia malayi	Hr1 repeat family protein	0.0074	0.1396	0.1029
Schistosoma mansoni	serine/threonine protein kinase	0.0268	0.7352	0.8102
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0068	0.1189	0.0783
Schistosoma mansoni	nephrin	0.0114	0.2604	0.2464
Brugia malayi	hypothetical protein	0.0068	0.1191	0.0786
Schistosoma mansoni	septate junction protein	0.0068	0.1206	0.0803
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0068	0.1206	0.0714
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1206	0.0714
Brugia malayi	protein kinase C II.	0.0288	0.7966	0.8832
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1191	0.0699
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0068	0.1191	0.0786
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0068	0.1206	0.0803
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0071	0.1306	0.146
Echinococcus multilocularis	serine threonine protein kinase	0.0201	0.5279	0.5641
Loa Loa (eye worm)	hypothetical protein	0.028	0.7721	0.7593
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0068	0.1189	0.0783
Echinococcus granulosus	protein kinase c iota type	0.0226	0.6038	0.6747
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0048	0.0593	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1189	0.0696
Echinococcus granulosus	epidermal growth factor receptor	0.0321	0.895	1
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0074	0.1396	0.1029
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.1524	1
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0074	0.1396	0.1029
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1385	0.0903
Brugia malayi	RhoGAP domain containing protein	0.0068	0.1189	0.0783
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0068	0.1206	0.1347
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0068	0.1191	0.0786
Brugia malayi	Variant SH3 domain containing protein	0.0071	0.1306	0.0923
Schistosoma mansoni	vesicular amine transporter	0.0068	0.1191	0.0786
Brugia malayi	p70 ribosomal S6 kinase beta	0.0074	0.1396	0.1029
Brugia malayi	Furin-like cysteine rich region family protein	0.0321	0.895	1
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0074	0.1396	0.0915
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0078	0.1524	0.105
Echinococcus multilocularis	peroxidasin	0.0068	0.1206	0.0803
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0074	0.1396	0.0915
Echinococcus granulosus	unc 13 munc13	0.0074	0.1385	0.1547
Loa Loa (eye worm)	TK/INSR protein kinase	0.0114	0.2623	0.2211
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.1524	1
Schistosoma mansoni	serine/threonine protein kinase	0.0288	0.7966	0.8832
Loa Loa (eye worm)	hypothetical protein	0.028	0.7721	0.7593
Onchocerca volvulus		0.0048	0.0593	0.0088
Echinococcus granulosus	NDR protein kinase	0.0074	0.1396	0.156
Echinococcus granulosus	RNA directed DNA polymerase	0.012	0.2804	0.3133
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0074	0.1396	0.0915
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.1396	0.1029
Echinococcus granulosus	roundabout 2	0.0136	0.3281	0.3666
Schistosoma mansoni	tyrosine kinase	0.0161	0.4059	0.4192
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0074	0.1396	0.0915
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.1524	1
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0126	0.2975	0.2582
Echinococcus granulosus	protein kinase C gamma type	0.0201	0.5279	0.5899
Brugia malayi	Pleckstrin Homology Domain	0.0072	0.1317	0.0935
Echinococcus multilocularis	Immunoglobulin	0.0068	0.1191	0.0786
Echinococcus granulosus	titin	0.0046	0.053	0.0592
Brugia malayi	protein unc-22	0.0048	0.0593	0.0075
Schistosoma mansoni	protein kinase C mu	0.0068	0.1189	0.0783
Loa Loa (eye worm)	TK/ROR protein kinase	0.0065	0.1118	0.0621
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.007	0.1269	0.0781
Echinococcus granulosus	neuroglian	0.0068	0.1206	0.1347
Echinococcus multilocularis	hemicentin 1	0.0068	0.1206	0.0803
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0068	0.1206	0.0803
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0109	0.2456	0.2034
Schistosoma mansoni	hypothetical protein	0.0068	0.1189	0.0783
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0321	0.895	0.8891
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.1396	0.1029
Echinococcus granulosus	epidermal growth factor receptor	0.018	0.4648	0.5193
Echinococcus multilocularis	insulin receptor	0.0114	0.2623	0.2487
Echinococcus granulosus	N chimaerin	0.0071	0.1306	0.146
Echinococcus multilocularis	epidermal growth factor receptor	0.018	0.4648	0.4891
Echinococcus granulosus	protein kinase c epsilon type	0.0288	0.7966	0.8901
Brugia malayi	RhoGEF domain containing protein	0.0068	0.1189	0.0783
Brugia malayi	RhoGAP domain containing protein	0.0071	0.1306	0.0923
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0074	0.1396	0.156
Brugia malayi	diacylglycerol kinase	0.0068	0.1189	0.0783
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0046	0.053	0.0592
Echinococcus multilocularis	neuroglian	0.0114	0.2604	0.2464
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0068	0.1206	0.0803
Echinococcus multilocularis	roundabout 2	0.0136	0.3281	0.3267
Schistosoma mansoni	tyrosine kinase	0.0087	0.1794	0.1502
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1317	0.0832
Echinococcus granulosus	serine:threonine protein kinase N2	0.0074	0.1396	0.156
Echinococcus granulosus	Protein kinase C brain isozyme	0.0268	0.7352	0.8214
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0068	0.1191	0.0786
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0065	0.1118	0.0699
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0071	0.1306	0.0923
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0074	0.1385	0.1547
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0068	0.1206	0.0941
Loa Loa (eye worm)	hypothetical protein	0.0136	0.3281	0.2905
Schistosoma mansoni	tyrosine kinase	0.018	0.4648	0.4891
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0074	0.1396	0.156
Schistosoma mansoni	tyrosine kinase	0.0114	0.2623	0.2487
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0074	0.1396	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1191	0.0699
Onchocerca volvulus		0.0195	0.5112	0.6373
Schistosoma mansoni	nephrin	0.0068	0.1206	0.0803
Brugia malayi	Protein kinase c protein 2	0.0196	0.5135	0.547
Schistosoma mansoni	diacylglycerol kinase theta	0.0068	0.1189	0.0783
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1189	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1206	0.0714
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.1524	1
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0074	0.1396	0.1029
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0074	0.1396	0.1029
Brugia malayi	Protein kinase domain containing protein	0.0074	0.1396	0.1029
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0068	0.1189	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1191	0.0699
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.1524	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1189	0.0696
Schistosoma mansoni	roundabout	0.0068	0.1206	0.0803
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.016	0.4011	0.3676
Echinococcus multilocularis	roundabout 2	0.0068	0.1206	0.0803
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0065	0.1118	0.1249
Echinococcus granulosus	Rac GTPase activating protein 1	0.0068	0.1189	0.1329
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1189	0.0696
Echinococcus granulosus	lachesin	0.0068	0.1206	0.1347
Schistosoma mansoni	protein kinase C	0.0074	0.1385	0.1016
Trichomonas vaginalis	AGC family protein kinase	0.0074	0.1396	0.3308
Onchocerca volvulus		0.028	0.7721	1
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0129	0.3063	0.2675
Schistosoma mansoni	unc-13 (munc13)	0.0074	0.1385	0.1016
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.009	0.1868	0.2087
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1206	0.0714
Loa Loa (eye worm)	hypothetical protein	0.0188	0.4877	0.459
Loa Loa (eye worm)	hypothetical protein	0.012	0.2804	0.2402
Echinococcus granulosus	contactin	0.0068	0.1206	0.1347
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0068	0.1206	0.0803
Echinococcus multilocularis	lachesin	0.0068	0.1206	0.0803
Trichomonas vaginalis	AGC family protein kinase	0.0074	0.1396	0.3308
Loa Loa (eye worm)	hypothetical protein	0.009	0.1868	0.1413
Echinococcus multilocularis	Immunoglobulin	0.0068	0.1191	0.0786
Schistosoma mansoni	serine/threonine protein kinase	0.0268	0.7352	0.8102
Schistosoma mansoni	serine/threonine protein kinase	0.0087	0.1778	0.1482
Schistosoma mansoni	cell adhesion molecule	0.009	0.1868	0.1589
Echinococcus multilocularis	twitchin	0.0048	0.0593	0.0075
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0114	0.2623	0.2487
Echinococcus granulosus	serine:threonine protein kinase N2	0.0142	0.3482	0.3891
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0078	0.1524	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0114	0.2623	0.2931
Onchocerca volvulus		0.0191	0.4984	0.6195
Schistosoma mansoni	serine/threonine protein kinase	0.0048	0.0593	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1191	0.0699
Echinococcus granulosus	roundabout 2	0.0068	0.1206	0.1347
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0068	0.1206	0.0803
Echinococcus granulosus	tyrosine protein kinase otk	0.0068	0.1206	0.1347
Onchocerca volvulus		0.0124	0.2912	0.3313
Schistosoma mansoni	protein kinase C mu	0.0193	0.5047	0.5366
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.007	0.1252	0.1399
Schistosoma mansoni	tyrosine kinase	0.0161	0.4059	0.4192
Brugia malayi	Ras association domain family 1 isoform A	0.0068	0.1189	0.0783
Brugia malayi	Peroxidasin	0.0068	0.1206	0.0803
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0074	0.1396	0.156
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.1524	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0071	0.1306	0.0923
Echinococcus granulosus	Opioid binding protein:cell adhesion molecule	0.0046	0.053	0.0592
Echinococcus granulosus	twitchin	0.0116	0.2668	0.2981
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0068	0.1206	0.0803
Schistosoma mansoni	diacylglycerol kinase theta	0.0068	0.1189	0.0783
Schistosoma mansoni	cell adhesion molecule	0.0068	0.1206	0.0803
Schistosoma mansoni	neuroglian	0.0068	0.1206	0.0803
Brugia malayi	Fibronectin type III domain containing protein	0.0068	0.1191	0.0786
Echinococcus multilocularis	protein kinase c iota type	0.0226	0.6038	0.6542
Toxoplasma gondii	AGC kinase	0.0074	0.1396	1
Schistosoma mansoni	titin	0.0048	0.0593	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0348	0.9793	0.9782
Loa Loa (eye worm)	TK protein kinase	0.0065	0.1118	0.0621
Trichomonas vaginalis	AGC family protein kinase	0.0074	0.1396	0.3308
Echinococcus granulosus	protein kinase c eta type	0.0068	0.1189	0.1329
Loa Loa (eye worm)	hypothetical protein	0.0124	0.2912	0.2515
Echinococcus granulosus	roundabout 2	0.0068	0.1206	0.1347
Echinococcus multilocularis	myotubularin protein 13	0.0072	0.1317	0.0935
Echinococcus granulosus	Diacylglycerol kinase theta	0.0068	0.1189	0.1329
Brugia malayi	diacylglycerol kinase	0.0068	0.1189	0.0783
Echinococcus multilocularis	roundabout 2	0.0068	0.1206	0.0803
Entamoeba histolytica	protein kinase, putative	0.0078	0.1524	0.1383
Schistosoma mansoni	tyrosine kinase	0.018	0.4648	0.4891
Echinococcus granulosus	down syndrome cell adhesion	0.0046	0.053	0.0592
Schistosoma mansoni	atypical protein kinase C	0.0232	0.6227	0.6767
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0068	0.1206	0.0803
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.1396	0.1029
Echinococcus multilocularis	neuroglian	0.0068	0.1206	0.0803
Schistosoma mansoni	septate junction protein	0.0068	0.1206	0.0803
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0071	0.1306	0.0923
Loa Loa (eye worm)	hypothetical protein	0.0195	0.5112	0.4839
Schistosoma mansoni	serine/threonine protein kinase	0.007	0.1252	0.0858
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0087	0.1778	0.1482
Echinococcus granulosus	titin	0.0048	0.0593	0.0662
Echinococcus granulosus	neuroglian	0.0114	0.2604	0.291
Entamoeba histolytica	protein kinase, putative	0.0078	0.1524	0.1383
Echinococcus granulosus	titin	0.0046	0.053	0.0592
Schistosoma mansoni	serine/threonine kinase	0.0074	0.1396	0.1029
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0068	0.1191	0.0786
Brugia malayi	Protein kinase domain containing protein	0.0114	0.2623	0.2487
Loa Loa (eye worm)	raf kinase	0.0068	0.1189	0.0696
Brugia malayi	Protein kinase domain containing protein	0.0074	0.1396	0.1029
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0068	0.1206	0.0803
Echinococcus granulosus	leucine rich repeat containing protein 4	0.0046	0.053	0.0592
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0074	0.1385	0.1016
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0065	0.1118	0.0699
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0068	0.1206	0.0714
Echinococcus granulosus	titin	0.0048	0.0593	0.0662
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0071	0.1306	0.082
Entamoeba histolytica	protein kinase, putative	0.0074	0.1396	0.0855
Schistosoma mansoni	serine/threonine protein kinase	0.0048	0.0593	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0136	0.3281	0.2905
Loa Loa (eye worm)	hypothetical protein	0.028	0.7721	0.7593
Schistosoma mansoni	serine/threonine protein kinase	0.007	0.1252	0.0858
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0068	0.1206	0.0803
Echinococcus multilocularis	protein kinase c epsilon type	0.0288	0.7966	0.8832
Echinococcus multilocularis		0.0094	0.1994	0.174
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0215	0.5698	0.6138
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0109	0.2456	0.2288
Schistosoma mansoni	cell adhesion molecule	0.0068	0.1206	0.0803
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0193	0.5047	0.5366
Schistosoma mansoni	tyrosine kinase	0.0114	0.2623	0.2487
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0068	0.1206	0.0803
Echinococcus multilocularis	RNA directed DNA polymerase	0.012	0.2804	0.2701
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1206	0.0714
Echinococcus granulosus	titin	0.0046	0.053	0.0592
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0074	0.1396	0.0915
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0068	0.1189	0.0696
Brugia malayi	protein kinase C3,putative	0.0153	0.3822	0.391
Echinococcus granulosus	pro neuregulin 2 membrane bound	0.0046	0.053	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1191	0.0699
Echinococcus granulosus	leucine rich repeats and immunoglobulin	0.0046	0.053	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0124	0.2912	0.2515
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1206	0.0714
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0068	0.1189	0.0696
Echinococcus granulosus	nephrin	0.0046	0.053	0.0592
Echinococcus granulosus	raf serine:threonine protein kinase	0.0087	0.1778	0.1986
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1206	0.0714
Echinococcus granulosus	defective proboscis extension response	0.0068	0.1191	0.1331
Loa Loa (eye worm)	hypothetical protein	0.0191	0.4984	0.4704
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0268	0.7352	0.8102
Schistosoma mansoni	rac gtpase activating protein	0.0068	0.1189	0.0783
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.1524	1
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0288	0.7966	0.7852
Echinococcus granulosus	hemicentin 1	0.0068	0.1206	0.1347
Brugia malayi	C1-like domain containing protein	0.0193	0.5047	0.5366
Echinococcus granulosus	insulin receptor	0.0114	0.2623	0.2931
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0074	0.1396	0.1029
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1206	0.0714
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0068	0.1206	0.0803
Echinococcus multilocularis	N chimaerin	0.0071	0.1306	0.0923
Onchocerca volvulus	Tyrosine kinase homolog	0.0065	0.1118	0.0818
Echinococcus multilocularis	epidermal growth factor receptor	0.0321	0.895	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0068	0.1206	0.0803
Schistosoma mansoni	cell adhesion molecule	0.0068	0.1206	0.0803
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0068	0.1206	0.0714
Echinococcus multilocularis	titin	0.0048	0.0593	0.0075
Schistosoma mansoni	tyrosine kinase	0.0161	0.4059	0.4192
Echinococcus granulosus	myotubularin protein 13	0.0072	0.1317	0.1472
Brugia malayi	Protein kinase domain containing protein	0.0078	0.1524	0.1181
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0068	0.1206	0.0803
Schistosoma mansoni	unc-13 (munc13)	0.0074	0.1385	0.1016
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.018	0.4648	0.5193

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 0 %	Percent inhibition of gastric proton-pump enzyme H+/K+ ATPase was determined at 50 uM	ChEMBL.	2153817
Inhibition (binding)	= 0 %	Percent inhibition of gastric proton-pump enzyme H+/K+ ATPase was determined at 50 uM	ChEMBL.	2153817

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 261005