Detailed information for compound 261037

Basic information

Technical information
  • TDR Targets ID: 261037
  • Name: 5-phenyl-2-(2,3,3-triiodoprop-2-enyl)tetrazol e
  • MW: 563.903 | Formula: C10H7I3N4
  • H donors: 0 H acceptors: 3 LogP: 4.86 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 2
  • SMILES: IC(=C(Cn1nnc(n1)c1ccccc1)I)I
  • InChi: 1S/C10H7I3N4/c11-8(9(12)13)6-17-15-10(14-16-17)7-4-2-1-3-5-7/h1-5H,6H2
  • InChiKey: QQNUCMKNUXKCPW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-phenyl-2-(2,3,3-triiodoallyl)tetrazole
  • 5-phenyl-2-(2,3,3-triiodoprop-2-enyl)-1,2,3,4-tetrazole
  • 2H-Tetrazole, 5-phenyl-2-(2,3,3-triiodo-2-propenyl)-
  • AIDS-154283
  • AIDS154283

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0013 0.0011
Schistosoma mansoni nuclear receptor 0.0015 0.0075 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.029 0.0335
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0559 0.0646
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.029 0.0335
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0098 0.0158
Echinococcus multilocularis protein C ets 2 0.001 0.0013 0.0011
Echinococcus multilocularis cpg binding protein 0.0032 0.0291 0.0289
Schistosoma mansoni hypothetical protein 0.0054 0.0579 0.1052
Schistosoma mansoni hypothetical protein 0.0016 0.0093 0.0149
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0335 0.5
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0093 0.0091
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0549 0.0634
Mycobacterium ulcerans lipase LipD 0.0035 0.0335 1
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0013 0.0021
Mycobacterium ulcerans beta-lactamase 0.0035 0.0335 1
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0013 0.0011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0453 0.0451
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0075 0.0115
Schistosoma mansoni hypothetical protein 0.0016 0.0093 0.0149
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0338 0.039
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.029 0.0536
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0075 0.0073
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.029 0.0289
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0477 0.0863
Schistosoma mansoni ap endonuclease 0.0018 0.0116 0.0193
Schistosoma mansoni hypothetical protein 0.0016 0.0093 0.0149
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.029 0.0334
Mycobacterium ulcerans hypothetical protein 0.0035 0.0335 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.029 0.0516
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0084
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0477 0.0882
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.029 0.0334
Loa Loa (eye worm) hypothetical protein 0.0032 0.029 0.0334
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0116 0.0115
Schistosoma mansoni coup transcription factor 0.0032 0.029 0.0516
Brugia malayi Fli-1 protein 0.0213 0.2625 0.3032
Loa Loa (eye worm) MBCTL1 0.0053 0.0559 0.0644
Schistosoma mansoni cpg binding protein 0.003 0.0269 0.0476
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1527 0.2815
Schistosoma mansoni hypothetical protein 0.0428 0.5393 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0098 0.0178
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0013 0.0015
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0477 0.0476
Mycobacterium tuberculosis Conserved protein 0.0035 0.0335 0.0822
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0453 0.0451
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0013 0.0021
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0075 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.029 0.0335
Loa Loa (eye worm) hypothetical protein 0.0053 0.0559 0.0644
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.029 0.0516
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0075 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1527 0.2815
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0075 0.0135
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0013 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.029 0.0334
Brugia malayi mbt repeat family protein 0.0046 0.0477 0.0551
Loa Loa (eye worm) hypothetical protein 0.0017 0.0098 0.0111
Loa Loa (eye worm) hypothetical protein 0.0035 0.0335 0.0386
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0075 0.0086
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.029 0.0536
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1527 0.2815
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0093 0.0169
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0335 0.0822
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.029 0.0536
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.029 0.0335
Brugia malayi Ets-domain containing protein 0.007 0.0785 0.0907
Brugia malayi conserved hypotetical protein 0.0015 0.0075 0.0086
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0075 0.0135
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0075 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.029 0.0335
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0075 0.0073
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0335 1
Trichomonas vaginalis esterase, putative 0.0035 0.0335 1
Schistosoma mansoni zinc finger protein 0.0015 0.0075 0.0115
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0335 0.0822
Brugia malayi hypothetical protein 0.0017 0.0098 0.0113
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0335 1
Onchocerca volvulus 0.0035 0.0335 0.0296
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0098 0.0113
Loa Loa (eye worm) hypothetical protein 0.0032 0.029 0.0334
Schistosoma mansoni cpg binding protein 0.0032 0.0291 0.0517
Loa Loa (eye worm) hypothetical protein 0.0046 0.0477 0.0549
Onchocerca volvulus 0.0046 0.0477 0.0457
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0075 0.0135
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0335 0.0599
Loa Loa (eye worm) hypothetical protein 0.0032 0.029 0.0334
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0084
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0075 0.0084
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0559 0.1035
Loa Loa (eye worm) fli-1 protein 0.0213 0.2625 0.3031
Loa Loa (eye worm) hypothetical protein 0.0017 0.0098 0.0111
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0559 0.1035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0453 0.0817
Loa Loa (eye worm) hypothetical protein 0.0035 0.0335 0.0386
Onchocerca volvulus 0.0035 0.0335 0.0296
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0093 0.0091
Brugia malayi nuclear receptor NHR-88 0.0015 0.0075 0.0086
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0084
Brugia malayi ecdysteroid receptor 0.0032 0.029 0.0335
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0013 0.0011
Brugia malayi tailless protein 0.0015 0.0075 0.0086
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.029 0.0516
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.029 0.0334
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.029 0.0289
Loa Loa (eye worm) hypothetical protein 0.0032 0.029 0.0334
Schistosoma mansoni hypothetical protein 0.0284 0.3547 0.6569
Brugia malayi beta-lactamase family protein 0.0035 0.0335 0.0387
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0013
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0116 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0106
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.029 0.0289
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0075 0.0073
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0084
Echinococcus multilocularis ets variant gene 4 0.001 0.0013 0.0011
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0116 0.0133
Loa Loa (eye worm) RNA binding protein 0.0128 0.1527 0.1763
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0093 0.0107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0453 0.0817
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0559 0.0558
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0013 0.0021
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0013 0.0021
Mycobacterium tuberculosis Conserved protein 0.0035 0.0335 0.0822
Brugia malayi hypothetical protein 0.0015 0.0075 0.0086
Loa Loa (eye worm) hypothetical protein 0.0035 0.0338 0.0388
Brugia malayi RNA binding protein 0.0128 0.1527 0.1764
Loa Loa (eye worm) hypothetical protein 0.0032 0.029 0.0334
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0269 0.0309
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.2275 0.2273
Brugia malayi nuclear hormone receptor 0.0681 0.8658 1
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0098 0.0113
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0477 0.0863
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0335 0.0822
Schistosoma mansoni ap endonuclease 0.0018 0.0116 0.0193
Echinococcus multilocularis tar DNA binding protein 0.0128 0.1527 0.1526
Echinococcus granulosus GPCR family 2 0.0016 0.0093 0.0169
Loa Loa (eye worm) beta-lactamase 0.0035 0.0335 0.0386
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0013 0.0011
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0116 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.029 0.0289
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.029 0.0335
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0453 0.0817
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0549 0.0632
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0098 0.0111
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0093 0.0169
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0084
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.029 0.0289
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.0785 0.0784
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0335 1
Mycobacterium leprae Probable lipase LipE 0.0035 0.0335 0.5
Loa Loa (eye worm) TAR-binding protein 0.0128 0.1527 0.1763
Schistosoma mansoni cpg binding protein 0.0032 0.0291 0.0517
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0013 0.0021
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0335 0.0387
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0075 0.0073
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0698 0.8874 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0116 0.0135
Echinococcus multilocularis GPCR, family 2 0.0016 0.0093 0.0091
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0075 0.0086
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.1527 0.1764
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.029 0.0334
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0075 0.0135
Brugia malayi nuclear receptor NHR-88 0.0032 0.029 0.0335
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0013 0.0013
Leishmania major hypothetical protein, conserved 0.0035 0.0335 1
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0075 0.0086
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0013 0.0013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.029 0.0289
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0335 0.0386
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.029 0.0516
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0703 0.1282
Schistosoma mansoni nuclear receptor 0.0015 0.0075 0.0115
Brugia malayi hypothetical protein 0.0017 0.0098 0.0113
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0013 0.0013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0075 0.0135
Brugia malayi steroid hormone receptor 0.0032 0.029 0.0335
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1527 0.2815
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.029 0.0536
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.029 0.0335
Loa Loa (eye worm) hypothetical protein 0.0035 0.0335 0.0386
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0453 0.0836
Echinococcus granulosus protein C ets 2 0.001 0.0013 0.0021
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0075 0.0086
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0335 0.0822
Brugia malayi transcription factor E74 isoform 0.001 0.0013 0.0015
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.029 0.0516
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0335 1
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0477 0.0476
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0335 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0084
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0084
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.029 0.0245
Toxoplasma gondii ABC1 family protein 0.0035 0.0335 0.439
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.029 0.0536
Echinococcus granulosus GA binding protein alpha chain 0.007 0.0785 0.1454
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0013 0.0011
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0093 0.0106
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0335 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0098 0.0111
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.0785 0.0906
Onchocerca volvulus 0.0032 0.029 0.0245
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0615 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0075 0.0115
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0335 0.0619
Mycobacterium tuberculosis Conserved protein 0.0035 0.0335 0.0822
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.029 0.0245
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0681 0.8658 1
Brugia malayi nuclear hormone receptor 0.0032 0.029 0.0335
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.029 0.0335
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.029 0.0335
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0453 0.0523
Schistosoma mansoni nuclear hormone receptor 0.0032 0.029 0.0516
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.029 0.0335
Loa Loa (eye worm) DR-78 0.0015 0.0075 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.029 0.0335
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.029 0.0536
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.029 0.0335
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0013 0.0021
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.2275 0.4216
Onchocerca volvulus 0.003 0.0269 0.0221
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0477 0.0863
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.029 0.0289
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.029 0.0335
Loa Loa (eye worm) hypothetical protein 0.0035 0.0335 0.0386
Echinococcus granulosus dnaJ subfamily B 0.0428 0.5393 1
Brugia malayi nuclear receptor RXR 0.0017 0.0098 0.0113
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.029 0.0516
Echinococcus granulosus tar DNA binding protein 0.0128 0.1527 0.283
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0098 0.0096
Schistosoma mansoni ets-related 0.0213 0.2625 0.4855
Brugia malayi Ets-domain containing protein 0.007 0.0785 0.0907
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.029 0.0516
Schistosoma mansoni hypothetical protein 0.0035 0.0338 0.0604
Schistosoma mansoni thyroid hormone receptor 0.0032 0.029 0.0516
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0084
Loa Loa (eye worm) hypothetical protein 0.0032 0.029 0.0334
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.029 0.0335
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0335 0.0822
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0335 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0335 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0084
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0075 0.0086
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0084
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.029 0.0536
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.029 0.0516
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0453 0.0521
Echinococcus granulosus FTZ F1 alpha 0.0032 0.029 0.0536
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0335 0.0599
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.029 0.0289
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0335 0.0822
Loa Loa (eye worm) hypothetical protein 0.0035 0.0335 0.0386
Loa Loa (eye worm) hypothetical protein 0.0032 0.029 0.0334
Brugia malayi nuclear receptor RXR 0.0015 0.0075 0.0086
Brugia malayi CXXC zinc finger family protein 0.003 0.0269 0.031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.029 0.0334
Brugia malayi ecdysone receptor 0.0015 0.0075 0.0086
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0559 0.0558
Loa Loa (eye worm) hypothetical protein 0.0017 0.0098 0.0111
Loa Loa (eye worm) hypothetical protein 0.006 0.0654 0.0754
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0335 0.0822
Brugia malayi Ets-domain containing protein 0.001 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0013
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0335 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0093 0.0107
Loa Loa (eye worm) hypothetical protein 0.0666 0.8465 0.9777
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0098 0.0158
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0335 1
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0075 0.0086
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0453 0.0836
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0559 0.1016
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0084
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0335 0.0334
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0075 0.0073
Schistosoma mansoni gabp alpha 0.007 0.0785 0.1436
Loa Loa (eye worm) hypothetical protein 0.0032 0.029 0.0334
Brugia malayi mbt repeat family protein 0.0046 0.0477 0.0551
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0084
Loa Loa (eye worm) hypothetical protein 0.0017 0.0098 0.0111
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0477 0.0549
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0116 0.0213
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0549 0.0634
Brugia malayi beta-lactamase family protein 0.0035 0.0335 0.0387
Brugia malayi hypothetical protein 0.0015 0.0075 0.0086
Schistosoma mansoni thyroid hormone receptor 0.0032 0.029 0.0516
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0075 0.0115
Brugia malayi TAR-binding protein 0.0128 0.1527 0.1764
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0116 0.5
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0477 0.0882
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.2779 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0335 0.0386
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.029 0.0536
Brugia malayi nuclear receptor NHR-67 0.0015 0.0075 0.0086
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0335 1
Echinococcus granulosus cpg binding protein 0.0032 0.0291 0.0537
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0116 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0075 0.0135
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.029 0.0516
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.029 0.0334
Loa Loa (eye worm) hypothetical protein 0.0052 0.0549 0.0632
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0477 0.0457
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0075 0.0115
Echinococcus multilocularis dnaJ subfamily B 0.0428 0.5393 0.5393
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.1527 0.1763
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0116 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.029 0.0335
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0084
Brugia malayi beta-lactamase 0.0035 0.0335 0.0387
Schistosoma mansoni hypothetical protein 0.0016 0.0093 0.0149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.029 0.0334
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.029 0.0289
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1527 0.2815
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.029 0.0335
Onchocerca volvulus 0.0035 0.0335 0.0296

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 1.56 ug ml-1 Antifungal activity towards Trichophyton mentagrophytes 530324 strain ChEMBL. 3546691
MIC (functional) = 3.13 ug ml-1 Antifungal activity towards Trichophyton interdigitale ChEMBL. 3546691
MIC (functional) = 6.25 ug ml-1 Antifungal activity against Aspergillus fumigatus Saito strain ChEMBL. 3546691
MIC (functional) = 12.5 ug ml-1 Antifungal activity against Candida albicans C-A-24 strain ChEMBL. 3546691
MIC (functional) = 12.5 ug ml-1 Antifungal activity against Cryptococcus neoformans Cr-1 strain ChEMBL. 3546691
MIC (functional) = 12.5 ug ml-1 Antifungal activity against Candida albicans C-A-24 strain ChEMBL. 3546691
MIC (functional) = 12.5 ug ml-1 Antifungal activity against Cryptococcus neoformans Cr-1 strain ChEMBL. 3546691

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.