Detailed information for compound 261179

Basic information

Technical information
  • TDR Targets ID: 261179
  • Name: N-[[4-(4-chlorophenyl)phenyl]methyl]-4-[2-[(4 -fluorophenyl)methylsulfanyl]-5-[(2-methoxypy rimidin-5-yl)methyl]-4-oxopyrimidin-1-yl]-N-m ethylbutanamide
  • MW: 658.185 | Formula: C35H33ClFN5O3S
  • H donors: 0 H acceptors: 4 LogP: 6.05 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ncc(cn1)Cc1cn(CCCC(=O)N(Cc2ccc(cc2)c2ccc(cc2)Cl)C)c(nc1=O)SCc1ccc(cc1)F
  • InChi: 1S/C35H33ClFN5O3S/c1-41(21-24-5-9-27(10-6-24)28-11-13-30(36)14-12-28)32(43)4-3-17-42-22-29(18-26-19-38-34(45-2)39-20-26)33(44)40-35(42)46-23-25-7-15-31(37)16-8-25/h5-16,19-20,22H,3-4,17-18,21,23H2,1-2H3
  • InChiKey: KAOFBZKRQRATKQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[[4-(4-chlorophenyl)phenyl]methyl]-4-[2-[(4-fluorophenyl)methylsulfanyl]-5-[(2-methoxypyrimidin-5-yl)methyl]-4-oxo-pyrimidin-1-yl]-N-methyl-butanamide
  • N-[[4-(4-chlorophenyl)phenyl]methyl]-4-[2-[(4-fluorophenyl)methylthio]-5-[(2-methoxy-5-pyrimidinyl)methyl]-4-oxo-1-pyrimidinyl]-N-methylbutanamide
  • N-[4-(4-chlorophenyl)benzyl]-4-[2-[(4-fluorobenzyl)thio]-4-keto-5-[(2-methoxypyrimidin-5-yl)methyl]pyrimidin-1-yl]-N-methyl-butyramide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major phospholipase A1, putative Get druggable targets OG5_129351 All targets in OG5_129351
Leishmania infantum phospholipase A1, putative Get druggable targets OG5_129351 All targets in OG5_129351
Trypanosoma cruzi phospholipase A1, putative Get druggable targets OG5_129351 All targets in OG5_129351
Leishmania donovani phospholipase A2-like protein, putative Get druggable targets OG5_129351 All targets in OG5_129351
Trypanosoma brucei phospholipase A1, putative Get druggable targets OG5_129351 All targets in OG5_129351
Trypanosoma congolense phospholipase A1, putative Get druggable targets OG5_129351 All targets in OG5_129351
Trypanosoma cruzi phospholipase A1, putative Get druggable targets OG5_129351 All targets in OG5_129351
Leishmania braziliensis phospholipase A1, putative Get druggable targets OG5_129351 All targets in OG5_129351
Leishmania mexicana phospholipase A2-like protein, putative Get druggable targets OG5_129351 All targets in OG5_129351
Loa Loa (eye worm) platelet-activating factor acetylhydrolase Get druggable targets OG5_129351 All targets in OG5_129351
Trypanosoma brucei gambiense phospholipase A2-like protein, putative Get druggable targets OG5_129351 All targets in OG5_129351
Onchocerca volvulus Get druggable targets OG5_129351 All targets in OG5_129351
Onchocerca volvulus Get druggable targets OG5_129351 All targets in OG5_129351
Onchocerca volvulus Get druggable targets OG5_129351 All targets in OG5_129351
Brugia malayi Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein Get druggable targets OG5_129351 All targets in OG5_129351
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dnaJ subfamily B 0.2033 0.8 0.8
Echinococcus granulosus cyclin dependent kinase 0.0087 0.0152 0.0152
Onchocerca volvulus 0.008 0.0123 0.0668
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0732 0.2754 0.5003
Echinococcus multilocularis alpha 1A adrenergic receptor 0.008 0.0123 0.0153
Echinococcus multilocularis cyclins 0.0063 0.0054 0.0067
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.008 0.0123 0.0123
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0122 0.0295 0.5
Plasmodium falciparum protein kinase 5 0.0087 0.0152 0.4079
Onchocerca volvulus 0.008 0.0123 0.0668
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.008 0.0123 0.0153
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0065 0.0065 0.0082
Brugia malayi Protein kinase domain containing protein 0.0092 0.0174 0.0142
Onchocerca volvulus 0.008 0.0123 0.0668
Onchocerca volvulus 0.008 0.0123 0.0668
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0126 0.031 0.1246
Echinococcus granulosus Furin 1 0.0732 0.2754 0.2754
Brugia malayi Will die slowly protein 0.0067 0.0072 0.004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0123 0.0069
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0123 0.0153
Schistosoma mansoni amine GPCR 0.008 0.0123 0.0069
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.008 0.0123 0.0153
Brugia malayi G-protein coupled receptor 0.008 0.0123 0.0091
Loa Loa (eye worm) hypothetical protein 0.2529 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0089 0.011
Loa Loa (eye worm) hypothetical protein 0.0198 0.0601 0.0571
Brugia malayi Melatonin receptor type 1A 0.008 0.0123 0.0091
Trichomonas vaginalis cyclins, putative 0.0103 0.0215 0.0342
Schistosoma mansoni opsin-like receptor 0.008 0.0123 0.0069
Schistosoma mansoni hypothetical protein 0.0553 0.2033 0.199
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Trichomonas vaginalis conserved hypothetical protein 0.0553 0.2033 0.3679
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0152 0.0099
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0123 0.0153
Loa Loa (eye worm) follicle stimulating hormone receptor 0.008 0.0123 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.0295 0.0487
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0054 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0553 0.2033 0.3679
Leishmania major cyclin 0.015 0.0407 0.2008
Schistosoma mansoni neuropeptide F-like receptor 0.008 0.0123 0.0069
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0122 0.0295 0.0295
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0123 0.0153
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0123 0.0123
Trichomonas vaginalis cyclin A, putative 0.015 0.0407 0.0693
Trypanosoma cruzi cyclin, putative 0.015 0.0407 0.2008
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.1407 0.5475 0.6843
Echinococcus multilocularis 0.1975 0.7768 0.971
Echinococcus multilocularis serotonin receptor 0.0198 0.0601 0.0751
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0553 0.2033 0.3679
Loa Loa (eye worm) hypothetical protein 0.0215 0.067 0.0641
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Echinococcus multilocularis epidermal growth factor receptor 0.0296 0.0997 0.1246
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0087 0.0152 0.0121
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Toxoplasma gondii subtilisin SUB1 0.0122 0.0295 0.7101
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0123 0.0153
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.008 0.0123 0.0069
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.008 0.0123 0.0123
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0126 0.031 0.1246
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0057 0.0032 0.004
Toxoplasma gondii subtilisin SUB5 0.0122 0.0295 0.7101
Brugia malayi Cyclin, N-terminal domain containing protein 0.015 0.0407 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.0295 0.0487
Schistosoma mansoni neuropeptide f receptor 76f 0.008 0.0123 0.0069
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.0123 0.0069
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.008 0.0123 0.0153
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.008 0.0123 0.0668
Echinococcus granulosus wd40 repeat 0.0071 0.0089 0.0089
Schistosoma mansoni furin-1 (S08 family) 0.1244 0.482 0.4792
Trichomonas vaginalis cyclin B, putative 0.015 0.0407 0.0693
Onchocerca volvulus 0.008 0.0123 0.0668
Trichomonas vaginalis conserved hypothetical protein 0.0553 0.2033 0.3679
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.1407 0.5475 0.5475
Echinococcus granulosus hypothetical protein 0.008 0.0123 0.0123
Echinococcus multilocularis cyclins 0.0063 0.0054 0.0067
Brugia malayi hypothetical protein 0.008 0.0123 0.0091
Schistosoma mansoni neuropeptide receptor 0.008 0.0123 0.0069
Toxoplasma gondii subtilisin SUB8 0.0122 0.0295 0.7101
Echinococcus granulosus cyclin dependent kinase 1 0.0087 0.0152 0.0152
Echinococcus multilocularis G protein coupled receptor 139 0.008 0.0123 0.0153
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1407 0.5475 1
Brugia malayi G protein-coupled receptor 0.008 0.0123 0.0091
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Onchocerca volvulus 0.008 0.0123 0.0668
Onchocerca volvulus 0.008 0.0123 0.0668
Trichomonas vaginalis conserved hypothetical protein 0.0553 0.2033 0.3679
Schistosoma mansoni biogenic amine (5HT) receptor 0.008 0.0123 0.0069
Loa Loa (eye worm) endoprotease bli-4 0.2529 1 1
Loa Loa (eye worm) hypothetical protein 0.0198 0.0601 0.0571
Schistosoma mansoni opsin-like receptor 0.008 0.0123 0.0069
Echinococcus multilocularis protein will die slowly 0.0067 0.0072 0.009
Schistosoma mansoni neuropeptide receptor 0.008 0.0123 0.0069
Brugia malayi follicle stimulating hormone receptor 0.008 0.0123 0.0091
Schistosoma mansoni tyrosine kinase 0.0296 0.0997 0.0948
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.008 0.0123 0.0091
Echinococcus granulosus nmda type glutamate receptor 0.0058 0.0034 0.0034
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0122 0.0295 0.0368
Trichomonas vaginalis cyclin B, putative 0.015 0.0407 0.0693
Giardia lamblia G2/mitotic-specific cyclin B 0.015 0.0407 0.1309
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0126 0.031 0.1246
Brugia malayi hypothetical protein 0.008 0.0123 0.0091
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0732 0.2754 0.5003
Trichomonas vaginalis conserved hypothetical protein 0.0553 0.2033 0.3679
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Onchocerca volvulus 0.0067 0.0072 0.0303
Giardia lamblia Kinase, CMGC CDK 0.0087 0.0152 0.0364
Schistosoma mansoni hypothetical protein 0.0067 0.0072 0.0018
Brugia malayi Serotonin/octopamine receptor family protein 7 0.008 0.0123 0.0091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0123 0.0069
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Brugia malayi putative neuropeptide receptor 0.008 0.0123 0.0091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0123 0.0069
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0123 0.0069
Loa Loa (eye worm) cyclin domain-containing protein 0.0063 0.0054 0.0022
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0058 0.0034 0.0043
Echinococcus multilocularis cyclin dependent kinase 5 0.0087 0.0152 0.019
Loa Loa (eye worm) G-protein coupled receptor 0.008 0.0123 0.0091
Giardia lamblia Kinase, CMGC CDK 0.0087 0.0152 0.0364
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.008 0.0123 0.0069
Schistosoma mansoni biogenic amine receptor 0.008 0.0123 0.0069
Echinococcus granulosus neuropeptide receptor 0.008 0.0123 0.0123
Echinococcus granulosus glutamate receptor subunit protein glur 0.0057 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Schistosoma mansoni growth hormone secretagogue receptor 0.008 0.0123 0.0069
Onchocerca volvulus 0.0402 0.1421 1
Echinococcus multilocularis cyclin b3 0.0063 0.0054 0.0067
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.008 0.0123 0.0069
Trichomonas vaginalis cyclin B, putative 0.015 0.0407 0.0693
Loa Loa (eye worm) G-protein coupled receptor 0.008 0.0123 0.0091
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0223 0.0701 0.0651
Echinococcus granulosus neuropeptide Y receptor 0.008 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0777 0.2934 0.2911
Toxoplasma gondii subtilisin SUB12 0.0137 0.0353 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0732 0.2754 0.5003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Giardia lamblia High cysteine membrane protein Group 2 0.0731 0.275 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.008 0.0123 0.0123
Trichomonas vaginalis cyclins, putative 0.0063 0.0054 0.0045
Brugia malayi GnHR receptor homolog 0.008 0.0123 0.0091
Onchocerca volvulus 0.0402 0.1421 1
Schistosoma mansoni amine GPCR 0.008 0.0123 0.0069
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Echinococcus granulosus neuropeptide Y receptor 0.008 0.0123 0.0123
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0122 0.0295 0.5
Echinococcus multilocularis dnaJ subfamily B 0.2033 0.8 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.008 0.0123 0.0123
Echinococcus multilocularis cyclin dependent kinase 1 0.0087 0.0152 0.019
Echinococcus granulosus furin 0.2529 1 1
Trichomonas vaginalis retinoblastoma binding protein, putative 0.0071 0.0089 0.011
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Trichomonas vaginalis WD repeat domain, putative 0.0067 0.0072 0.0078
Toxoplasma gondii kringle domain-containing protein 0.0092 0.0174 0.1084
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0152 0.0099
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Brugia malayi Dopamine receptor 0.008 0.0123 0.0091
Echinococcus granulosus 7tm_1 domain containing protein 0.008 0.0123 0.0123
Entamoeba histolytica cyclin, putative 0.015 0.0407 1
Toxoplasma gondii subtilisin SUB7 0.0122 0.0295 0.7101
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.008 0.0123 0.0069
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0087 0.0152 0.0152
Onchocerca volvulus 0.008 0.0123 0.0668
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0732 0.2754 0.5003
Trichomonas vaginalis conserved hypothetical protein 0.0553 0.2033 0.3679
Schistosoma mansoni neuropeptide receptor 0.008 0.0123 0.0069
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.008 0.0123 0.0123
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0123 0.0123
Brugia malayi Trypsin family protein 0.0215 0.067 0.0641
Echinococcus multilocularis Furin 1 0.0732 0.2754 0.3442
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.0295 0.0487
Brugia malayi hypothetical protein 0.008 0.0123 0.0091
Echinococcus granulosus cyclins 0.0063 0.0054 0.0054
Echinococcus granulosus cyclins 0.0063 0.0054 0.0054
Entamoeba histolytica cell division protein kinase 2, putative 0.0087 0.0152 0.2782
Trichomonas vaginalis cyclin B, putative 0.0063 0.0054 0.0045
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1407 0.5475 1
Echinococcus multilocularis neuropeptides capa receptor 0.008 0.0123 0.0153
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Echinococcus multilocularis fmrfamide receptor 0.008 0.0123 0.0153
Plasmodium falciparum subtilisin-like protease 1 0.0122 0.0295 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Trichomonas vaginalis cyclins, putative 0.015 0.0407 0.0693
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0179 0.0522 0.0905
Brugia malayi Subtilase family protein 0.0122 0.0295 0.0264
Onchocerca volvulus 0.0122 0.0295 0.1904
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0122 0.0295 0.5
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Echinococcus multilocularis g protein coupled receptor 0.008 0.0123 0.0153
Echinococcus multilocularis sex peptide receptor 0.008 0.0123 0.0153
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0122 0.0295 0.0264
Echinococcus multilocularis g protein coupled receptor 0.008 0.0123 0.0153
Loa Loa (eye worm) TK/ROR protein kinase 0.0092 0.0174 0.0142
Schistosoma mansoni amine GPCR 0.008 0.0123 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0553 0.2033 0.3679
Onchocerca volvulus 0.0176 0.051 0.3449
Loa Loa (eye worm) hypothetical protein 0.015 0.0407 0.0376
Mycobacterium leprae Possible secreted protease 0.0122 0.0295 0.5
Echinococcus granulosus serotonin receptor 0.008 0.0123 0.0123
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0122 0.0295 0.0264
Onchocerca volvulus 0.008 0.0123 0.0668
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Schistosoma mansoni hypothetical protein 0.008 0.0123 0.0069
Echinococcus multilocularis serotonin receptor 0.0198 0.0601 0.0751
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0123 0.0153
Brugia malayi proprotein convertase 2 0.1854 0.7279 0.727
Schistosoma mansoni myosin xvIII 0.008 0.0123 0.0069
Echinococcus granulosus neuropeptide FF receptor 2 0.0777 0.2934 0.2934
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0179 0.0522 0.0471
Echinococcus granulosus biogenic amine 5HT receptor 0.0198 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Echinococcus multilocularis somatostatin receptor 0.008 0.0123 0.0153
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0063 0.0054 0.0067
Plasmodium vivax subtilisin-like protease 1 0.0122 0.0295 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Brugia malayi RE15519p 0.008 0.0123 0.0091
Echinococcus multilocularis cyclins 0.0063 0.0054 0.0067
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.008 0.0123 0.0069
Schistosoma mansoni opsin-like receptor 0.008 0.0123 0.0069
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0123 0.0123
Plasmodium vivax subtilisin-like serine protease, putative 0.0122 0.0295 1
Brugia malayi Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein 0.0402 0.1421 0.1393
Brugia malayi Furin-like cysteine rich region family protein 0.0296 0.0997 0.0968
Echinococcus multilocularis glutamate receptor 2 0.0057 0.0032 0.004
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0122 0.0295 0.5
Echinococcus granulosus neuroendocrine convertase 2 0.1854 0.7279 0.7279
Echinococcus granulosus cyclins 0.0063 0.0054 0.0054
Schistosoma mansoni biogenic amine receptor 0.008 0.0123 0.0069
Echinococcus granulosus tm gpcr rhodopsin 0.008 0.0123 0.0123
Brugia malayi hypothetical protein 0.008 0.0123 0.0091
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Brugia malayi Cyclin, N-terminal domain containing protein 0.0063 0.0054 0.0022
Echinococcus granulosus g protein coupled receptor 0.008 0.0123 0.0123
Brugia malayi neuroendocrine convertase 1 precursor 0.2211 0.8719 0.8715
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0184 0.0544 0.309
Echinococcus granulosus tm gpcr rhodopsin 0.008 0.0123 0.0123
Onchocerca volvulus 0.008 0.0123 0.0668
Trichomonas vaginalis hypothetical protein 0.0553 0.2033 0.3679
Trichomonas vaginalis cyclins, putative 0.015 0.0407 0.0693
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0123 0.0153
Echinococcus granulosus G protein coupled receptor 139 0.008 0.0123 0.0123
Onchocerca volvulus 0.008 0.0123 0.0668
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Trypanosoma cruzi subtilisin peptidase 0.0122 0.0295 0.1123
Trichomonas vaginalis cyclin B3, putative 0.0063 0.0054 0.0045
Echinococcus granulosus cyclins 0.0063 0.0054 0.0054
Echinococcus granulosus protein will die slowly 0.0067 0.0072 0.0072
Schistosoma mansoni biogenic amine receptor 0.008 0.0123 0.0069
Echinococcus multilocularis dro:myosuppressin receptor 0.008 0.0123 0.0153
Brugia malayi Kringle domain containing protein 0.0092 0.0174 0.0142
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.008 0.0123 0.0091
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.015 0.0407 0.2008
Trypanosoma brucei mitotic cyclin 6 0.015 0.0407 0.2008
Onchocerca volvulus 0.008 0.0123 0.0668
Trypanosoma brucei subtilisin peptidase 0.0122 0.0295 0.1123
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0063 0.0054 0.0054
Echinococcus multilocularis g protein coupled receptor 0.008 0.0123 0.0153
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Leishmania major subtilisin-like serine peptidase 0.0122 0.0295 0.1123
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0065 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0088 0.0154 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0553 0.2033 0.3679
Echinococcus multilocularis cyclin dependent kinase 0.0087 0.0152 0.019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0122 0.0295 0.5
Schistosoma mansoni hypothetical protein 0.0092 0.0174 0.0121
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.008 0.0123 0.0091
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Brugia malayi putative neuropeptide receptor NPR1 0.008 0.0123 0.0091
Echinococcus granulosus cyclin dependent kinase 5 0.0087 0.0152 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.0295 0.0487
Schistosoma mansoni hypothetical protein 0.0102 0.0214 0.0162
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.008 0.0123 0.0153
Echinococcus granulosus neuropeptides capa receptor 0.008 0.0123 0.0123
Echinococcus multilocularis cyclin B3 1 0.0063 0.0054 0.0067
Brugia malayi Tachykinin-like peptides receptor 99D 0.0777 0.2934 0.2911
Schistosoma mansoni hypothetical protein 0.008 0.0123 0.0069
Schistosoma mansoni peptide (allatostatin)-like receptor 0.008 0.0123 0.0069
Brugia malayi neuropeptide F receptor 0.008 0.0123 0.0091
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Loa Loa (eye worm) hypothetical protein 0.015 0.0407 0.0376
Leishmania major hypothetical protein, conserved 0.0092 0.0174 0.0171
Brugia malayi larval opioid receptor 0.008 0.0123 0.0091
Echinococcus multilocularis cyclins 0.0063 0.0054 0.0067
Brugia malayi sulfakinin receptor protein 0.008 0.0123 0.0091
Brugia malayi ORL1-like opioid receptor 0.008 0.0123 0.0091
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0215 0.067 0.0641
Echinococcus multilocularis fmrfamide receptor 0.008 0.0123 0.0153
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.008 0.0123 0.0153
Brugia malayi Protein kinase domain containing protein 0.0087 0.0152 0.0121
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.008 0.0123 0.0153
Echinococcus multilocularis neuropeptide s receptor 0.008 0.0123 0.0153
Trichomonas vaginalis cyclin B, putative 0.015 0.0407 0.0693
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0123 0.0123
Schistosoma mansoni hypothetical protein 0.008 0.0123 0.0069
Echinococcus multilocularis neuropeptide FF receptor 2 0.0777 0.2934 0.3667
Trypanosoma brucei RNA helicase, putative 0.0102 0.0214 0.0492
Echinococcus granulosus tachykinin peptides receptor 99D 0.008 0.0123 0.0123
Echinococcus multilocularis nmda type glutamate receptor 0.0058 0.0034 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0123 0.0069
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.0123 0.0069
Echinococcus multilocularis wd40 repeat 0.0071 0.0089 0.0112
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0123 0.0153
Loa Loa (eye worm) WD40 repeat protein 0.0067 0.0072 0.004
Echinococcus granulosus peptide allatostatin:somatostatin 0.008 0.0123 0.0123
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0122 0.0295 0.1123
Echinococcus multilocularis glutamate receptor 2 0.0065 0.0065 0.0082
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Trypanosoma cruzi phospholipase A1, putative 0.0402 0.1421 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.008 0.0123 0.0069
Trypanosoma cruzi phospholipase A1, putative 0.0402 0.1421 1
Leishmania major phospholipase A1, putative 0.0402 0.1421 1
Echinococcus granulosus tissue type plasminogen activator 0.0092 0.0174 0.0174
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Onchocerca volvulus 0.015 0.0407 0.2711
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Echinococcus granulosus glutamate receptor 2 0.0065 0.0065 0.0065
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0122 0.0295 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0123 0.0153
Trypanosoma cruzi cyclin, putative 0.015 0.0407 0.2008
Brugia malayi Dopamine receptor protein 2 0.008 0.0123 0.0091
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.008 0.0123 0.0069
Schistosoma mansoni hypothetical protein 0.2033 0.8 0.799
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.008 0.0123 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.0295 0.0487
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0215 0.067 0.062
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Echinococcus multilocularis cyclins 0.0063 0.0054 0.0067
Plasmodium falciparum cysteine repeat modular protein 1 0.0092 0.0174 0.4983
Loa Loa (eye worm) hypothetical protein 0.0092 0.0174 0.0142
Trypanosoma cruzi CYC2-like cyclin, putative 0.015 0.0407 0.2008
Trichomonas vaginalis CMGC family protein kinase 0.0087 0.0152 0.0225
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Brugia malayi hypothetical protein 0.008 0.0123 0.0091
Echinococcus granulosus sex peptide receptor 0.008 0.0123 0.0123
Schistosoma mansoni hypothetical protein 0.008 0.0123 0.0069
Echinococcus granulosus neuropeptide receptor 0.008 0.0123 0.0123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0123 0.0069
Loa Loa (eye worm) neuropeptide F receptor 0.008 0.0123 0.0091
Echinococcus granulosus cyclin b3 0.0063 0.0054 0.0054
Trichomonas vaginalis cyclin D, putative 0.0063 0.0054 0.0045
Toxoplasma gondii subtilisin SUB10 0.0122 0.0295 0.7101
Echinococcus multilocularis neuroendocrine convertase 2 0.1854 0.7279 0.9098
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0123 0.0123
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.008 0.0123 0.0091
Loa Loa (eye worm) TK/EGFR protein kinase 0.0296 0.0997 0.0968
Echinococcus multilocularis tachykinin peptides receptor 99D 0.008 0.0123 0.0153
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Echinococcus multilocularis neuropeptide Y receptor 0.008 0.0123 0.0153
Onchocerca volvulus Neuropeptide F receptor homolog 0.008 0.0123 0.0668
Giardia lamblia Furin precursor putative serine protease 0.061 0.2261 0.8185
Trichomonas vaginalis conserved hypothetical protein 0.0553 0.2033 0.3679
Loa Loa (eye worm) platelet-activating factor acetylhydrolase 0.0402 0.1421 0.1393
Onchocerca volvulus 0.008 0.0123 0.0668
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.2529 1 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0087 0.0152 0.0121
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0732 0.2754 0.5003
Schistosoma mansoni retinoblastoma binding protein 0.0071 0.0089 0.0036
Echinococcus multilocularis cyclins 0.0063 0.0054 0.0067
Echinococcus granulosus g-protein coupled receptor 0.008 0.0123 0.0123
Echinococcus granulosus dro:myosuppressin receptor 0.008 0.0123 0.0123
Trichomonas vaginalis cyclins, putative 0.015 0.0407 0.0693
Schistosoma mansoni amine GPCR 0.008 0.0123 0.0069
Echinococcus multilocularis cyclin B 0.015 0.0407 0.0508
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0087 0.0152 0.0121
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.0123 0.0069
Echinococcus multilocularis neuropeptide receptor 0.008 0.0123 0.0153
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Toxoplasma gondii subtilisin SUB4 0.0122 0.0295 0.7101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0123 0.0069
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.008 0.0123 0.0091
Brugia malayi G protein-coupled receptor F59B2.13 0.008 0.0123 0.0091
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Schistosoma mansoni neuropeptide F-like receptor 0.008 0.0123 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0553 0.2033 0.3679
Loa Loa (eye worm) TYRA-2 protein 0.008 0.0123 0.0091
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.008 0.0123 0.0153
Loa Loa (eye worm) hypothetical protein 0.1178 0.4554 0.4537
Echinococcus granulosus cyclin B3 1 0.0063 0.0054 0.0054
Entamoeba histolytica cell division protein kinase 2, putative 0.0087 0.0152 0.2782
Trichomonas vaginalis cyclins, putative 0.015 0.0407 0.0693
Trichomonas vaginalis CMGC family protein kinase 0.0087 0.0152 0.0225
Echinococcus granulosus neuropeptide s receptor 0.008 0.0123 0.0123
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0122 0.0295 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.008 0.0123 0.0123
Toxoplasma gondii subtilisin SUB2 0.0122 0.0295 0.7101
Onchocerca volvulus 0.008 0.0123 0.0668
Brugia malayi Serotonin receptor 0.008 0.0123 0.0091
Echinococcus granulosus neuropeptides capa receptor 0.008 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Loa Loa (eye worm) subtilase 0.0122 0.0295 0.0264
Schistosoma mansoni alpha-1 adrenergic receptor 0.008 0.0123 0.0069
Brugia malayi celfurPC protein 0.1975 0.7768 0.7761
Brugia malayi cell division control protein 2 homolog 0.0087 0.0152 0.0121
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0123 0.0069
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0123 0.0069
Echinococcus granulosus tm gpcr rhodopsin 0.008 0.0123 0.0123
Echinococcus granulosus cyclins 0.0063 0.0054 0.0054
Schistosoma mansoni neuropeptide receptor 0.008 0.0123 0.0069
Onchocerca volvulus 0.0215 0.067 0.4605
Echinococcus multilocularis cyclin dependent kinase 1 0.0087 0.0152 0.019
Echinococcus multilocularis orexin receptor type 2 0.008 0.0123 0.0153
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Toxoplasma gondii subtilisin SUB11 0.0122 0.0295 0.7101
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Echinococcus granulosus g protein coupled receptor 0.008 0.0123 0.0123
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.008 0.0123 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0553 0.2033 0.3679
Plasmodium falciparum subtilisin-like protease 2 0.0122 0.0295 1
Toxoplasma gondii subtilisin SUB6 0.0122 0.0295 0.7101
Loa Loa (eye worm) melatonin receptor type 1A 0.008 0.0123 0.0091
Onchocerca volvulus 0.0402 0.1421 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.008 0.0123 0.0123
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.008 0.0123 0.0091
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.008 0.0123 0.0153
Echinococcus multilocularis neuropeptide receptor A26 0.008 0.0123 0.0153
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0732 0.2754 0.2715
Echinococcus granulosus epidermal growth factor receptor 0.0296 0.0997 0.0997
Echinococcus granulosus neuropeptide receptor A26 0.008 0.0123 0.0123
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0122 0.0295 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0123 0.0123
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0184 0.0544 0.309
Onchocerca volvulus 0.008 0.0123 0.0668
Plasmodium vivax subtilisin-like protease 2, putative 0.0122 0.0295 1
Trichomonas vaginalis cyclin D, putative 0.0063 0.0054 0.0045
Onchocerca volvulus 0.008 0.0123 0.0668
Brugia malayi Dopamine receptor protein 1 0.008 0.0123 0.0091
Echinococcus multilocularis tissue type plasminogen activator 0.0092 0.0174 0.0217
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Echinococcus multilocularis G-protein coupled receptor, putative 0.008 0.0123 0.0153
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Echinococcus granulosus orexin receptor type 2 0.008 0.0123 0.0123
Echinococcus granulosus 7TM GPCR rhodopsin 0.008 0.0123 0.0123
Trypanosoma cruzi hypothetical protein, conserved 0.0092 0.0174 0.0171
Echinococcus granulosus biogenic amine 5HT receptor 0.008 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.008 0.0123 0.0069
Echinococcus granulosus fmrfamide receptor 0.008 0.0123 0.0123
Schistosoma mansoni amine GPCR 0.008 0.0123 0.0069
Brugia malayi hypothetical protein 0.008 0.0123 0.0091
Echinococcus multilocularis cyclins 0.0063 0.0054 0.0067
Schistosoma mansoni adenoreceptor 0.008 0.0123 0.0069
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Brugia malayi hypothetical protein 0.008 0.0123 0.0091
Brugia malayi neuropeptide F receptor 0.008 0.0123 0.0091
Loa Loa (eye worm) neuropeptide F receptor 0.008 0.0123 0.0091
Brugia malayi Hypothetical WD-repeat protein F21H12.1 in chromosome II 0.0071 0.0089 0.0058
Schistosoma mansoni cyclin B 0.015 0.0407 0.0355
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.008 0.0123 0.0153
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Echinococcus multilocularis g-protein coupled receptor 0.008 0.0123 0.0153
Echinococcus multilocularis biogenic amine (5HT) receptor 0.008 0.0123 0.0153
Echinococcus granulosus g protein coupled receptor 0.008 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0414 0.147 0.1443
Schistosoma mansoni biogenic amine (5HT) receptor 0.0198 0.0601 0.055
Loa Loa (eye worm) hypothetical protein 0.0071 0.0089 0.0058
Echinococcus multilocularis neuropeptide receptor 0.008 0.0123 0.0153
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0122 0.0295 0.0242
Brugia malayi hypothetical protein 0.008 0.0123 0.0091
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.061 0.2261 0.4098
Trypanosoma brucei phospholipase A1, putative 0.0402 0.1421 1
Plasmodium falciparum subtilisin-like protease 3 0.0122 0.0295 1
Echinococcus granulosus cyclin B 0.015 0.0407 0.0407
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.061 0.2261 0.4098
Loa Loa (eye worm) hypothetical protein 0.0086 0.0148 0.0117
Loa Loa (eye worm) hypothetical protein 0.0122 0.0295 0.0264
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0092 0.0174 0.1526
Trypanosoma cruzi cyclin 6, putative 0.015 0.0407 0.2008
Brugia malayi AKH receptor 0.008 0.0123 0.0091
Echinococcus granulosus membrane bound transcription factor site 1 0.0122 0.0295 0.0295
Echinococcus granulosus allatostatin A receptor 0.008 0.0123 0.0123
Echinococcus multilocularis allatostatin A receptor 0.008 0.0123 0.0153
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0122 0.0295 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.008 0.0123 0.0091
Schistosoma mansoni site-1 peptidase (S08 family) 0.0122 0.0295 0.0242
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0732 0.2754 0.5003
Brugia malayi G-protein coupled receptor 0.008 0.0123 0.0091
Brugia malayi gonadotropin-releasing hormone receptor 2 0.008 0.0123 0.0091
Brugia malayi hypothetical protein 0.008 0.0123 0.0091
Echinococcus multilocularis neuropeptide Y receptor 0.008 0.0123 0.0153
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.008 0.0123 0.0069
Echinococcus granulosus somatostatin receptor 0.008 0.0123 0.0123
Brugia malayi Cyclin, N-terminal domain containing protein 0.015 0.0407 0.0376
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Trichomonas vaginalis CMGC family protein kinase 0.0087 0.0152 0.0225
Brugia malayi hypothetical protein 0.008 0.0123 0.0091
Echinococcus multilocularis neuropeptides capa receptor 0.008 0.0123 0.0153
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Loa Loa (eye worm) proprotein convertase 2 0.0732 0.2754 0.2731
Schistosoma mansoni histamine h1 receptor 0.008 0.0123 0.0069
Toxoplasma gondii subtilisin SUB9 0.0122 0.0295 0.7101
Echinococcus multilocularis membrane bound transcription factor site 1 0.0122 0.0295 0.0368
Onchocerca volvulus 0.0092 0.0174 0.1036
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0122 0.0295 0.0487
Loa Loa (eye worm) hypothetical protein 0.008 0.0123 0.0091
Schistosoma mansoni site-1 peptidase (S08 family) 0.0122 0.0295 0.0242
Brugia malayi Serotonin receptor 0.008 0.0123 0.0091
Onchocerca volvulus 0.008 0.0123 0.0668

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5 nM Inhibitory activity against recombinant human Lp-PLA2 (Lp-PLA2). ChEMBL. 11738571
IC50 (binding) = 5 nM Inhibitory activity against recombinant human Lp-PLA2 (Lp-PLA2). ChEMBL. 11738571
Inhibition (binding) = 3 % Inhibition of non-specific binding effects in human plasma at a concentration of 10 nM ChEMBL. 11738571
Inhibition (binding) = 3 % Inhibition of non-specific binding effects in human plasma at a concentration of 10 nM ChEMBL. 11738571
Inhibition (binding) = 20 % Inhibition of non-specific binding effects in Watanabe hereditable hyperlipidaemic rabbit (WHHL rabbit) plasma at a concentration of 100 nM ChEMBL. 11738571
Inhibition (binding) = 20 % Inhibition of non-specific binding effects in Watanabe hereditable hyperlipidaemic rabbit (WHHL rabbit) plasma at a concentration of 100 nM ChEMBL. 11738571
Inhibition (binding) = 46 % Inhibition of non-specific binding effects in human plasma at a concentration of 100 nM ChEMBL. 11738571
Inhibition (binding) = 46 % Inhibition of non-specific binding effects in human plasma at a concentration of 100 nM ChEMBL. 11738571

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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