Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | phosphodiesterase 4A, cAMP specific | Starlite/ChEMBL | References |
Homo sapiens | phosphodiesterase 4D, cAMP-specific | Starlite/ChEMBL | References |
Mus musculus | phosphodiesterase 4D, cAMP specific | Starlite/ChEMBL | References |
Mus musculus | phosphodiesterase 4C, cAMP specific | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydrofolate reductase | 1.4745 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 1.4745 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 1.4745 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.1391 | 0.0518 | 0.0518 |
Onchocerca volvulus | 0.1391 | 0.0518 | 0.5 | |
Loa Loa (eye worm) | dihydrofolate reductase | 1.4745 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 1.4745 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.7379 | 0.477 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.7379 | 0.477 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 1.4745 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1391 | 0.0518 | 0.0518 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7379 | 0.477 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 1.4745 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7379 | 0.477 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 1.4745 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 1.4745 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.7379 | 0.477 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.7379 | 0.477 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1391 | 0.0518 | 0.0303 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0662 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.003 uM | Displacement of [3H]-rolipram from mouse brain homogenates | ChEMBL. | 8568798 |
IC50 (binding) | = 0.003 uM | Displacement of [3H]-rolipram from mouse brain homogenates | ChEMBL. | 8568798 |
IC50 (binding) | = 0.13 uM | Inhibition of Phosphodiesterase 4 | ChEMBL. | 8568798 |
IC50 (binding) | = 0.13 uM | Inhibition of Phosphodiesterase 4 | ChEMBL. | 8568798 |
IC50 (functional) | = 0.14 uM | Ability to block the release of TNF-alpha in human monocytes | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.