Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as production of hydrogen peroxide from p-tyramine at 100 uM after 15 mins by microplate fluorescence assay | ChEMBL. | 21872365 | |
Inhibition (binding) | Displacement of [3H]estradiol human recombinant 17beta-HSD2 expressed in Escherichia coli BL21 (DE3)-RIL at 0.6 uM by scintillation counting in presence of NAD+ | ChEMBL. | 21138273 | |
Inhibition (binding) | Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as production of hydrogen peroxide from p-tyramine at 100 uM after 15 mins by microplate fluorescence assay | ChEMBL. | 21872365 | |
Inhibition (binding) | Displacement of [3H]estradiol human recombinant 17beta-HSD2 expressed in Escherichia coli BL21 (DE3)-RIL at 6 uM by scintillation counting in presence of NAD+ | ChEMBL. | 21138273 | |
Inhibition (binding) | = 17 % | Displacement of [3H]estrone human recombinant 17beta-HSD1 expressed in Escherichia coli BL21 (DE3)-RIL at 6 uM by scintillation counting in presence of NADPH | ChEMBL. | 21138273 |
Ki (binding) | = 7.4 uM | Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF) | ChEMBL. | 11170644 |
Ki (binding) | = 7.4 uM | Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF) | ChEMBL. | 11170644 |
Ki (binding) | = 7.4 uM | Inhibition of human recombinant MIF tautomerase | ChEMBL. | 19090668 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
4 literature references were collected for this gene.