Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0077 | 0.0125 |
Brugia malayi | mannose-6-phosphate isomerase, class I family protein | 0.0095 | 0.0864 | 0.1448 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.032 | 0.3833 | 0.7217 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0116 | 0.1142 | 0.3116 |
Echinococcus multilocularis | expressed conserved protein | 0.009 | 0.08 | 0.08 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0345 | 0.4156 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.0224 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.3833 | 0.7217 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0142 | 0.1486 | 0.3576 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0077 | 0.0145 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0077 | 0.0145 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0202 | 0.0338 |
Loa Loa (eye worm) | animal heme peroxidase | 0.032 | 0.3833 | 0.7217 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0202 | 0.0486 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.0122 | 0.0293 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0077 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0621 | 0.1169 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0046 | 0.0224 | 0.0967 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0071 | 0.0133 |
Entamoeba histolytica | aminopeptidase, putative | 0.0142 | 0.1486 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.032 | 0.3833 | 0.6422 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0621 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0224 | 0.0422 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.005 | 0.0274 | 0.2557 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0041 | 0.0162 | 0.0247 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.3833 | 0.7217 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0077 | 0.0042 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0142 | 0.1486 | 0.1486 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0295 | 0.3496 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0046 | 0.0224 | 0.2818 |
Echinococcus multilocularis | aminopeptidase N | 0.0482 | 0.5968 | 0.5968 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0046 | 0.0224 | 0.071 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0142 | 0.1486 | 0.1486 |
Toxoplasma gondii | phosphomannose isomerase type I protein | 0.0095 | 0.0864 | 0.739 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0035 | 0.0071 | 0.0099 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0142 | 0.1486 | 0.1486 |
Schistosoma mansoni | peroxidasin | 0.032 | 0.3833 | 0.9223 |
Leishmania major | puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.005 | 0.0274 | 0.0574 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0295 | 0.3496 | 1 |
Echinococcus granulosus | mannose 6 phosphate isomerase | 0.0095 | 0.0864 | 0.1448 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0116 | 0.1142 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 0.0224 | 0.043 |
Brugia malayi | hypothetical protein | 0.0089 | 0.0783 | 0.1311 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0116 | 0.1142 | 0.1142 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0046 | 0.0224 | 0.0967 |
Trypanosoma cruzi | phosphomannose isomerase, putative | 0.0095 | 0.0864 | 0.2303 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0138 | 0.0331 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0077 | 0.0125 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0142 | 0.1486 | 0.1486 |
Brugia malayi | ecdysteroid receptor | 0.0355 | 0.4294 | 0.7194 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.1452 | 0.4022 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0621 | 0.5102 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0076 | 0.0621 | 0.1493 |
Onchocerca volvulus | 0.0046 | 0.0224 | 0.0376 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0071 | 0.0133 |
Echinococcus granulosus | peptidase Clp S14 family | 0.005 | 0.0275 | 0.046 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0077 | 0.0145 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0077 | 0.0145 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.005 | 0.0274 | 0.0574 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0071 | 0.0133 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0621 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0142 | 0.1486 | 0.249 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0116 | 0.1142 | 0.3116 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0202 | 0.038 |
Onchocerca volvulus | 0.032 | 0.3833 | 0.6422 | |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0142 | 0.1486 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0041 | 0.0157 | 0.0263 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0202 | 0.0202 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.0122 | 0.0322 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0077 | 0.0129 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.032 | 0.3833 | 0.6422 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0345 | 0.4156 | 0.6963 |
Onchocerca volvulus | Dual oxidase homolog | 0.032 | 0.3833 | 0.6422 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0077 | 0.0125 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0077 | 0.0129 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.005 | 0.0275 | 0.091 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.4098 | 0.7717 |
Loa Loa (eye worm) | animal heme peroxidase | 0.032 | 0.3833 | 0.7217 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0116 | 0.1142 | 0.3116 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0077 | 0.0145 |
Schistosoma mansoni | patched 1 | 0.0041 | 0.0157 | 0.0378 |
Mycobacterium tuberculosis | Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho | 0.0051 | 0.0293 | 0.0982 |
Brugia malayi | hypothetical protein | 0.0142 | 0.1486 | 0.249 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0345 | 0.4156 | 0.4156 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0279 | 0.0525 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.0242 | 0.1546 |
Onchocerca volvulus | Peroxidasin homolog | 0.032 | 0.3833 | 0.6422 |
Brugia malayi | Animal haem peroxidase family protein | 0.032 | 0.3833 | 0.6422 |
Loa Loa (eye worm) | hypothetical protein | 0.0432 | 0.5311 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.0224 | 0.0376 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0077 | 0.0129 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0046 | 0.0224 | 0.1046 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0295 | 0.3496 | 1 |
Brugia malayi | Inositol-1 | 0.0038 | 0.0122 | 0.0204 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0621 | 0.104 |
Loa Loa (eye worm) | mannose-6-phosphate isomerase | 0.0095 | 0.0864 | 0.1628 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.0122 | 0.0229 |
Onchocerca volvulus | 0.005 | 0.0274 | 0.0458 | |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0038 | 0.0122 | 0.0418 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.0122 | 0.0316 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.005 | 0.0274 | 0.0574 |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.005 | 0.0274 | 0.2557 |
Brugia malayi | Animal haem peroxidase family protein | 0.032 | 0.3833 | 0.6422 |
Loa Loa (eye worm) | animal heme peroxidase | 0.032 | 0.3833 | 0.7217 |
Trypanosoma brucei | aminopeptidase, putative | 0.005 | 0.0274 | 0.0574 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0116 | 0.1142 | 0.1914 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.0162 | 0.0247 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0621 | 0.0621 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0077 | 0.0084 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0138 | 0.0331 |
Onchocerca volvulus | 0.0142 | 0.1486 | 0.249 | |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.3833 | 0.7217 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0046 | 0.0224 | 0.1046 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0202 | 0.0338 |
Onchocerca volvulus | 0.032 | 0.3833 | 0.6422 | |
Entamoeba histolytica | phosphomannose isomerase, putative | 0.0095 | 0.0864 | 0.5589 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0096 | 0.0877 | 0.1469 |
Trypanosoma brucei | phosphomannose isomerase | 0.0095 | 0.0864 | 0.2303 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0077 | 0.0042 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0202 | 0.0202 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.3833 | 0.7217 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0202 | 0.0486 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.3833 | 0.7217 |
Brugia malayi | Peptidase family M1 containing protein | 0.005 | 0.0274 | 0.0458 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0274 | 0.0515 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0077 | 0.0125 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0071 | 0.0133 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.0069 | 0.0092 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0202 | 0.0338 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.005 | 0.0274 | 0.0458 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0621 | 0.6929 |
Trypanosoma cruzi | phosphomannose isomerase, putative | 0.0095 | 0.0864 | 0.2303 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0092 | 0.0829 | 0.0829 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0041 | 0.0157 | 0.0296 |
Echinococcus granulosus | expressed conserved protein | 0.009 | 0.08 | 0.1341 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0046 | 0.0224 | 0.1046 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0224 | 0.2562 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0142 | 0.1486 | 0.4121 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0142 | 0.1486 | 0.249 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0077 | 0.0077 |
Entamoeba histolytica | mannose-6-phosphate isomerase, putative | 0.0043 | 0.0188 | 0.0787 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0116 | 0.1142 | 0.3116 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0077 | 0.0125 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0071 | 0.0133 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0142 | 0.1486 | 0.4121 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0157 | 0.0296 |
Mycobacterium leprae | probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO | 0.0051 | 0.0293 | 0.4061 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0295 | 0.3496 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0046 | 0.0224 | 0.0967 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.005 | 0.0274 | 0.0658 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 0.4294 | 0.8084 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0142 | 0.1486 | 0.249 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0274 | 0.0515 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0077 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.3833 | 0.7217 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.0224 | 0.0967 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.3833 | 0.7217 |
Mycobacterium ulcerans | mannose-6-phosphate isomerase ManA | 0.0095 | 0.0864 | 0.4996 |
Onchocerca volvulus | Peroxidase homolog | 0.032 | 0.3833 | 0.6422 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.0122 | 0.0204 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.0224 | 0.0967 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0621 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0041 | 0.0157 | 0.0157 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0116 | 0.1142 | 0.1914 |
Brugia malayi | TATA binding protein associated factor | 0.005 | 0.0274 | 0.0458 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0345 | 0.4156 | 0.6963 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0783 | 0.1474 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.005 | 0.0275 | 0.091 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0046 | 0.0224 | 0.071 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0077 | 0.0125 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0142 | 0.1486 | 0.1486 |
Onchocerca volvulus | 0.0035 | 0.0077 | 0.0129 | |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.3833 | 0.7217 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0355 | 0.4294 | 0.7194 |
Echinococcus multilocularis | peroxidasin | 0.032 | 0.3833 | 0.3833 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0046 | 0.0224 | 0.0967 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0621 | 0.3462 |
Onchocerca volvulus | 0.032 | 0.3833 | 0.6422 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0077 | 0.0153 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.005 | 0.0274 | 0.0515 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0138 | 0.0331 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.3833 | 0.7217 |
Brugia malayi | Probable ClpP-like protease | 0.0076 | 0.0621 | 0.104 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0137 | 0.1418 | 0.1418 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0077 | 0.0042 |
Brugia malayi | AMP-binding enzyme family protein | 0.0046 | 0.0224 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.3833 | 0.7217 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0076 | 0.0621 | 0.6929 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0142 | 0.1486 | 0.4121 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0116 | 0.1142 | 0.2749 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0122 | 0.013 |
Echinococcus multilocularis | protein dispatched 1 | 0.0047 | 0.0234 | 0.0234 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.0281 | 0.0596 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0076 | 0.0621 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0142 | 0.1486 | 0.4121 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.005 | 0.0275 | 0.3729 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0077 | 0.0125 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0122 | 0.013 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0155 | 0.166 | 0.6414 |
Toxoplasma gondii | aminopeptidase N protein | 0.005 | 0.0274 | 0.1843 |
Brugia malayi | Peroxidasin | 0.032 | 0.3833 | 0.6422 |
Echinococcus multilocularis | mannose 6 phosphate isomerase | 0.0095 | 0.0864 | 0.0864 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0077 | 0.0129 |
Onchocerca volvulus | Peroxidase homolog | 0.032 | 0.3833 | 0.6422 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.0122 | 0.0293 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0142 | 0.1486 | 0.4121 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 0.0122 | 0.0319 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.0122 | 0.0316 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0137 | 0.1418 | 0.2376 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0142 | 0.1486 | 0.3576 |
Echinococcus granulosus | peroxidasin | 0.032 | 0.3833 | 0.6422 |
Brugia malayi | Peptidase family M1 containing protein | 0.0482 | 0.5968 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 0.0224 | 0.043 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0077 | 0.0186 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0142 | 0.1486 | 0.1486 |
Echinococcus multilocularis | protein patched | 0.0041 | 0.0157 | 0.0157 |
Toxoplasma gondii | aminopeptidase n, putative | 0.005 | 0.0274 | 0.1843 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.005 | 0.0274 | 0.1394 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.005 | 0.0274 | 0.0574 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0077 | 0.0125 |
Schistosoma mansoni | Tata binding protein associated factor (M01 family) | 0.005 | 0.0274 | 0.0658 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0139 | 0.1452 | 0.4022 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.005 | 0.0274 | 0.0274 |
Loa Loa (eye worm) | aminopeptidase N | 0.0142 | 0.1486 | 0.2798 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.005 | 0.0274 | 0.0574 |
Schistosoma mansoni | family M1 non-peptidase homologue (M01 family) | 0.0092 | 0.0829 | 0.1994 |
Schistosoma mansoni | aminopeptidase A (M01 family) | 0.005 | 0.0274 | 0.0658 |
Onchocerca volvulus | 0.0482 | 0.5968 | 1 | |
Schistosoma mansoni | mannose-6-phosphate isomerase | 0.0095 | 0.0864 | 0.208 |
Brugia malayi | hypothetical protein | 0.032 | 0.3833 | 0.6422 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.3833 | 0.7217 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0041 | 0.0162 | 0.0247 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0096 | 0.0877 | 0.1469 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0224 | 0.0422 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0142 | 0.1486 | 0.4121 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0077 | 0.0125 |
Leishmania major | phosphomannose isomerase | 0.0095 | 0.0864 | 0.2303 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0077 | 0.0145 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0142 | 0.1486 | 0.4121 |
Mycobacterium ulcerans | hypothetical protein | 0.0155 | 0.166 | 1 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0142 | 0.1486 | 0.4121 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0077 | 0.0125 |
Brugia malayi | Animal haem peroxidase family protein | 0.032 | 0.3833 | 0.6422 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0077 | 0.0129 |
Trichomonas vaginalis | mannose-6-phosphate isomerase, putative | 0.0095 | 0.0864 | 0.5588 |
Plasmodium vivax | mannose-6-phosphate isomerase, putative | 0.0095 | 0.0864 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.1452 | 0.4022 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0096 | 0.0877 | 0.5677 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0116 | 0.1142 | 0.3116 |
Onchocerca volvulus | 0.0035 | 0.0077 | 0.0129 | |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0122 | 0.013 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0621 | 0.3462 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0274 | 0.0515 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.005 | 0.0275 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.3833 | 0.7217 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0202 | 0.0486 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0142 | 0.1486 | 0.249 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.005 | 0.0274 | 0.2557 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.005 | 0.0274 | 0.1278 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0345 | 0.4156 | 0.6963 |
Brugia malayi | Animal haem peroxidase family protein | 0.032 | 0.3833 | 0.6422 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0077 | 0.0185 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0345 | 0.4156 | 0.7825 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0077 | 0.0145 |
Toxoplasma gondii | aminopeptidase N, putative | 0.005 | 0.0274 | 0.1843 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.005 | 0.0274 | 0.0458 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0621 | 0.5102 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0046 | 0.0224 | 0.0967 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.039 | 0.4756 | 0.8955 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0142 | 0.1486 | 0.8908 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0046 | 0.0224 | 0.0967 |
Loa Loa (eye worm) | animal heme peroxidase | 0.032 | 0.3833 | 0.7217 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.005 | 0.0274 | 0.2557 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0077 | 0.0145 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0097 | 0.0896 | 0.2157 |
Onchocerca volvulus | 0.0035 | 0.0077 | 0.0129 | |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0829 | 0.156 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0621 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0157 | 0.0568 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0077 | 0.0042 |
Loa Loa (eye worm) | mannose-6-phosphate isomerase | 0.0095 | 0.0864 | 0.1628 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0224 | 0.0422 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0138 | 0.0331 |
Echinococcus granulosus | aminopeptidase N | 0.0482 | 0.5968 | 1 |
Brugia malayi | CHE-14 protein | 0.0041 | 0.0157 | 0.0263 |
Schistosoma mansoni | peroxidasin | 0.032 | 0.3833 | 0.9223 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0041 | 0.0157 | 0.0263 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0096 | 0.0877 | 0.0877 |
Plasmodium falciparum | mannose-6-phosphate isomerase, putative | 0.0095 | 0.0864 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.032 | 0.3833 | 0.6422 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0829 | 0.156 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0077 | 0.0185 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.005 | 0.0274 | 0.0458 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.3833 | 0.7217 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0046 | 0.0224 | 0.043 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.0162 | 0.0247 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0077 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0877 | 0.1651 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.0122 | 0.0316 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0077 | 0.0129 |
Loa Loa (eye worm) | TATA binding protein associated factor | 0.005 | 0.0274 | 0.0515 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0092 | 0.0829 | 0.2198 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0142 | 0.1486 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0077 | 0.0186 |
Brugia malayi | Peptidase family M1 containing protein | 0.0142 | 0.1486 | 0.249 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0077 | 0.0077 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.0122 | 0.0122 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0046 | 0.0224 | 0.2818 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.005 | 0.0274 | 0.0574 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0122 | 0.013 |
Brugia malayi | Animal haem peroxidase family protein | 0.032 | 0.3833 | 0.6422 |
Brugia malayi | hypothetical protein | 0.005 | 0.0274 | 0.0458 |
Brugia malayi | mannose-6-phosphate isomerase, class I family protein | 0.0095 | 0.0864 | 0.1448 |
Trypanosoma cruzi | aminopeptidase, putative | 0.005 | 0.0274 | 0.0574 |
Loa Loa (eye worm) | hypothetical protein | 0.032 | 0.3833 | 0.7217 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta HDL (functional) | = 320 % | Chronic in vivo activity of the compound was measured by the concentration of high density lipoproteins (HDL) in cholesterol fed rats | ChEMBL. | 8632431 |
Delta HDL (functional) | = 320 % | Chronic in vivo activity of the compound was measured by the concentration of high density lipoproteins (HDL) in cholesterol fed rats | ChEMBL. | 8632431 |
Delta TC (functional) | = -67 % | Acute in vivo activity measured by total plasma cholesterol concentration levels (TC) at 30 mg/kg dose | ChEMBL. | 8632431 |
Delta TC (functional) | = -46 % | Acute in vivo activity of the compound was measured by the total plasma cholesterol concentration levels(TC) at dose 3 mg/kg | ChEMBL. | 8632431 |
Delta TC (functional) | = -46 % | Acute in vivo activity of the compound was measured by the total plasma cholesterol concentration levels(TC) at dose 3 mg/kg | ChEMBL. | 8632431 |
Delta TC (functional) | = -37 % | Chronic in vivo activity of the compound was measured by the total cholesterol concentration levels in cholesterol fed rats | ChEMBL. | 8632431 |
Delta TC (functional) | = -37 % | Chronic in vivo activity of the compound was measured by the total cholesterol concentration levels in cholesterol fed rats | ChEMBL. | 8632431 |
IC50 (binding) | = 58 uM | In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 in microsomes of rat liver | ChEMBL. | 8632431 |
IC50 (binding) | = 58 uM | In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 in microsomes of rat liver | ChEMBL. | 8632431 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.