Detailed information for compound 26147

Basic information

Technical information
  • TDR Targets ID: 26147
  • Name: 1,4,6,7-tetramethylquinoxaline-2,3-dione
  • MW: 218.252 | Formula: C12H14N2O2
  • H donors: 0 H acceptors: 2 LogP: 1.54 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc2n(C)c(=O)c(=O)n(c2cc1C)C
  • InChi: 1S/C12H14N2O2/c1-7-5-9-10(6-8(7)2)14(4)12(16)11(15)13(9)3/h5-6H,1-4H3
  • InChiKey: ULYODVJBZANZDF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,4,6,7-tetramethylquinoxaline-2,3-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Tubulin beta 2C chain 0.0503 0.9716 0.9716
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0174 0.0115
Loa Loa (eye worm) tubulin beta chain 0.0503 0.9716 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0688 0.0647
Plasmodium falciparum tubulin gamma chain 0.0284 0.5338 0.5465
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0688 0.0647
Schistosoma mansoni alpha tubulin 0.0394 0.7552 0.7552
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0063 0.0065
Leishmania major beta tubulin 0.0503 0.9716 1
Loa Loa (eye worm) Smad1 0.0033 0.0324 0.0334
Leishmania major beta tubulin 0.0503 0.9716 1
Trichomonas vaginalis tubulin beta chain, putative 0.0394 0.7552 0.7759
Trypanosoma cruzi zeta tubulin, putative 0.0123 0.2132 0.2143
Echinococcus multilocularis isocitrate dehydrogenase 0.0048 0.0634 0.0634
Loa Loa (eye worm) hypothetical protein 0.0234 0.4346 0.4473
Loa Loa (eye worm) tubulin beta-4 chain 0.0503 0.9716 1
Leishmania major beta tubulin 0.0503 0.9716 1
Trichomonas vaginalis tubulin, putative 0.0503 0.9716 1
Brugia malayi Tubulin beta-1 chain 0.0503 0.9716 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0394 0.7552 0.7552
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0271 0.5092 0.5241
Echinococcus multilocularis lamin dm0 0.0026 0.0197 0.0197
Brugia malayi Tubulin beta chain 0.0123 0.2132 0.2194
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0048 0.0634 0.2761
Trypanosoma brucei unspecified product 0.0039 0.0446 0.0396
Echinococcus multilocularis tubulin subunit beta 0.0503 0.9716 0.9716
Echinococcus multilocularis dna polymerase eta 0.0065 0.0971 0.0971
Echinococcus multilocularis Tubulin alpha 1 chain 0.0394 0.7552 0.7552
Trichomonas vaginalis tubulin beta chain, putative 0.0394 0.7552 0.7759
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0446 0.0396
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.1809 0.1809
Schistosoma mansoni DNA polymerase eta 0.0065 0.0971 0.0971
Leishmania major DNA polymerase eta, putative 0.0065 0.0971 0.0941
Trypanosoma brucei epsilon tubulin 0.0284 0.5338 0.5465
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0284 0.5338 0.5465
Loa Loa (eye worm) hypothetical protein 0.0036 0.0381 0.0392
Trypanosoma brucei tubulin gamma chain 0.0284 0.5338 0.5465
Toxoplasma gondii beta-tubulin, putative 0.0503 0.9716 1
Loa Loa (eye worm) BEN-1 protein 0.0503 0.9716 1
Loa Loa (eye worm) tubulin alpha 2 0.0271 0.5092 0.5241
Schistosoma mansoni hypothetical protein 0.0036 0.0381 0.0381
Plasmodium falciparum tubulin delta chain, putative 0.0123 0.2132 0.2143
Schistosoma mansoni tubulin subunit alpha 0.0394 0.7552 0.7552
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0446 0.1849
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0587 0.0587
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0446 0.1849
Echinococcus multilocularis tubulin alpha 3 chain 0.0394 0.7552 0.7552
Trichomonas vaginalis tubulin alpha chain, putative 0.016 0.2878 0.2916
Trypanosoma brucei beta tubulin 0.0503 0.9716 1
Echinococcus granulosus tubulin alpha 1C chain 0.0394 0.7552 0.7552
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0174 0.0115
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0381 0.0392
Trypanosoma cruzi tubulin delta chain 0.0123 0.2132 0.2143
Echinococcus granulosus alpha tubulin 0.0394 0.7552 0.7552
Schistosoma mansoni tubulin subunit beta 0.0503 0.9716 0.9716
Brugia malayi Tubulin alpha chain 0.0123 0.2132 0.2194
Echinococcus granulosus tubulin alpha 3 chain 0.0394 0.7552 0.7552
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0205 0.0147
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0174 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0446 0.0396
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0587 0.0587
Leishmania major alpha tubulin 0.0394 0.7552 0.7759
Schistosoma mansoni tubulin subunit beta 0.0503 0.9716 0.9716
Mycobacterium tuberculosis Cell division protein FtsZ 0.0123 0.2132 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0446 0.0396
Echinococcus granulosus Smad4 0.0033 0.0324 0.0324
Leishmania major alpha tubulin 0.0394 0.7552 0.7759
Schistosoma mansoni tubulin subunit beta 0.0503 0.9716 0.9716
Entamoeba histolytica tubulin gamma chain 0.0284 0.5338 0.5465
Giardia lamblia Delta tubulin 0.0123 0.2132 0.2143
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0446 0.0396
Loa Loa (eye worm) hypothetical protein 0.0065 0.0971 0.1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0446 0.0459
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0324 0.0324
Brugia malayi MH2 domain containing protein 0.0033 0.0324 0.0334
Leishmania major zeta tubulin, putative 0.0123 0.2132 0.2143
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0446 0.0396
Toxoplasma gondii alpha tubulin TUBA1 0.0394 0.7552 0.7759
Echinococcus multilocularis hypothetical protein 0.0394 0.7552 0.7552
Loa Loa (eye worm) tubulin alpha 2 0.0271 0.5092 0.5241
Leishmania major alpha tubulin 0.0394 0.7552 0.7759
Trypanosoma cruzi zeta tubulin, putative 0.0123 0.2132 0.2143
Echinococcus granulosus smad 0.0033 0.0324 0.0324
Leishmania major alpha tubulin 0.0394 0.7552 0.7759
Echinococcus multilocularis Tubulin beta 2C chain 0.0503 0.9716 0.9716
Trichomonas vaginalis tubulin alpha chain, putative 0.016 0.2878 0.2916
Leishmania major beta tubulin 0.0503 0.9716 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0587 0.0587
Echinococcus multilocularis tubulin alpha chain 0.0394 0.7552 0.7552
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0446 0.0396
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0634 0.0592
Plasmodium falciparum alpha tubulin 1 0.0394 0.7552 0.7759
Schistosoma mansoni tubulin subunit beta 0.0123 0.2132 0.2132
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0446 0.0396
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0437 0.0387
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0634 0.0592
Plasmodium falciparum alpha tubulin 2 0.0394 0.7552 0.7759
Leishmania major beta tubulin 0.0503 0.9716 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0048 0.0634 0.0592
Echinococcus granulosus tubulin alpha chain 0.0394 0.7552 0.7552
Trichomonas vaginalis tubulin gamma chain, putative 0.0503 0.9716 1
Loa Loa (eye worm) hypothetical protein 0.0271 0.5092 0.5241
Plasmodium vivax tubulin alpha chain, putative 0.0394 0.7552 0.7759
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0063 0.0063
Loa Loa (eye worm) tubulin beta-1 chain 0.0503 0.9716 1
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0446 0.1849
Schistosoma mansoni tubulin subunit beta 0.0503 0.9716 0.9716
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0634 0.0592
Brugia malayi Flap endonuclease-1 0.0025 0.0174 0.0179
Loa Loa (eye worm) isocitrate dehydrogenase 0.0048 0.0634 0.0653
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0446 0.0396
Trypanosoma brucei unspecified product 0.0027 0.0205 0.0147
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0197 0.0203
Leishmania major beta tubulin 0.0503 0.9716 1
Leishmania major DNA polymerase eta, putative 0.0038 0.0437 0.0387
Treponema pallidum cell division protein FtsZ 0.0123 0.2132 1
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0174 0.0174
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.071 0.0731
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0174 0.0115
Entamoeba histolytica tubulin alpha chain, putative 0.0394 0.7552 0.7759
Brugia malayi hypothetical protein 0.0107 0.1809 0.1862
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0446 0.0396
Echinococcus multilocularis tubulin delta chain 0.0123 0.2132 0.2132
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0587 0.0604
Onchocerca volvulus 0.016 0.2878 0.6433
Schistosoma mansoni tubulin subunit epsilon 0.0284 0.5338 0.5338
Leishmania major alpha tubulin 0.0394 0.7552 0.7759
Loa Loa (eye worm) tubulin alpha-3 chain 0.0234 0.4346 0.4473
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0174 0.0115
Echinococcus granulosus Tubulin beta 2C chain 0.0503 0.9716 0.9716
Echinococcus multilocularis beta tubulin 0.0503 0.9716 0.9716
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0324 0.0324
Echinococcus multilocularis Smad4 0.0033 0.0324 0.0324
Leishmania major beta tubulin 0.0503 0.9716 1
Schistosoma mansoni tubulin subunit alpha 0.0123 0.2132 0.2132
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0446 0.0396
Loa Loa (eye worm) transcription factor SMAD2 0.0479 0.9253 0.9524
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0048 0.0634 0.0592
Schistosoma mansoni lamin 0.0026 0.0197 0.0197
Brugia malayi MH1 domain containing protein 0.0033 0.0324 0.0334
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0324 0.0334
Brugia malayi MH1 domain containing protein 0.0018 0.0032 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.2132 0.2143
Loa Loa (eye worm) BEN-1 protein 0.0503 0.9716 1
Echinococcus multilocularis geminin 0.0517 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0234 0.4346 0.4437
Echinococcus granulosus peroxisome assembly protein 26 0.0394 0.7552 0.7552
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0048 0.0634 0.0634
Brugia malayi MH2 domain containing protein 0.0479 0.9253 0.9524
Schistosoma mansoni ap endonuclease 0.002 0.0063 0.0063
Trichomonas vaginalis tubulin beta chain, putative 0.0394 0.7552 0.7759
Loa Loa (eye worm) beta-tubulin 0.0503 0.9716 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0284 0.5338 0.5465
Brugia malayi MH1 domain containing protein 0.0018 0.0032 0.0033
Echinococcus multilocularis Tubulin beta 2C chain 0.0503 0.9716 0.9716
Brugia malayi Tubulin beta chain 0.016 0.2878 0.2962
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0324 0.0324
Schistosoma mansoni alpha tubulin 0.0394 0.7552 0.7552
Schistosoma mansoni alpha tubulin 0.0394 0.7552 0.7552
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0446 0.0446
Trypanosoma brucei zeta tubulin 0.0123 0.2132 0.2143
Echinococcus granulosus tubulin subunit TubB 0.0394 0.7552 0.7552
Leishmania major alpha tubulin 0.0394 0.7552 0.7759
Mycobacterium ulcerans cell division protein FtsZ 0.0123 0.2132 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0032 0.0033
Trypanosoma brucei alpha tubulin 0.0394 0.7552 0.7759
Echinococcus granulosus tubulin alpha 1C chain 0.0394 0.7552 0.7552
Schistosoma mansoni Smad4 0.0033 0.0324 0.0324
Loa Loa (eye worm) nuclear factor I 0.0018 0.0032 0.0033
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0688 0.0647
Loa Loa (eye worm) tubulin alpha chain 0.0394 0.7552 0.7773
Echinococcus multilocularis tubulin alpha chain 0.0394 0.7552 0.7552
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0446 0.0446
Echinococcus granulosus tubulin alpha chain 0.0394 0.7552 0.7552
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0446 0.0396
Trichomonas vaginalis tubulin epsilon chain, putative 0.0503 0.9716 1
Echinococcus granulosus dna polymerase kappa 0.0039 0.0446 0.0446
Brugia malayi Pax transcription factor protein 2 0.0235 0.4364 0.4492
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0634 0.0634
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0587 0.0587
Trypanosoma cruzi epsilon tubulin, putative 0.0284 0.5338 0.5465
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0063 0.0065
Echinococcus multilocularis tubulin subunit TubB 0.0394 0.7552 0.7552
Leishmania major gamma-tubulin 0.0284 0.5338 0.5465
Leishmania major hypothetical protein, conserved 0.0051 0.0688 0.0647
Echinococcus multilocularis Tubulin beta 2C chain 0.0503 0.9716 0.9716
Entamoeba histolytica tubulin family protein 0.0503 0.9716 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0123 0.2132 0.2143
Schistosoma mansoni smad 0.0033 0.0324 0.0324
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0324 0.0324
Trypanosoma brucei alpha tubulin 0.0394 0.7552 0.7759
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0503 0.9716 0.9716
Loa Loa (eye worm) tubulin beta chain 0.0123 0.2132 0.2194
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0205 0.0147
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0123 0.2132 0.2143
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.071 0.0731
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0174 0.0115
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.0971 0.1
Trichomonas vaginalis tubulin beta chain, putative 0.0503 0.9716 1
Echinococcus granulosus Tubulin beta 2C chain 0.0503 0.9716 0.9716
Brugia malayi Tubulin gamma chain 0.0284 0.5338 0.5495
Echinococcus granulosus lamin 0.0026 0.0197 0.0197
Echinococcus multilocularis tubulin epsilon chain 0.0284 0.5338 0.5338
Echinococcus multilocularis peroxisome assembly protein 26 0.0394 0.7552 0.7552
Trypanosoma brucei beta tubulin 0.0284 0.5338 0.5465
Brugia malayi isocitrate dehydrogenase 0.0048 0.0634 0.0653
Echinococcus granulosus Tubulin alpha 1 chain 0.0394 0.7552 0.7552
Brugia malayi intermediate filament protein 0.0026 0.0197 0.0203
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0446 0.0396
Trichomonas vaginalis tubulin beta chain, putative 0.0394 0.7552 0.7759
Schistosoma mansoni hypothetical protein 0.0517 1 1
Echinococcus granulosus tubulin alpha 0.0284 0.5338 0.5338
Trichomonas vaginalis tubulin gamma chain, putative 0.0284 0.5338 0.5465
Leishmania major beta tubulin 0.0503 0.9716 1
Brugia malayi Smad1 0.0033 0.0324 0.0334
Echinococcus granulosus tubulin gamma 1 chain 0.0284 0.5338 0.5338
Brugia malayi Tubulin alpha chain 0.0394 0.7552 0.7773
Trypanosoma brucei zeta tubulin, putative 0.0123 0.2132 0.2143
Trichomonas vaginalis tubulin, putative 0.0123 0.2132 0.2143
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0127 0.0127
Schistosoma mansoni tubulin subunit beta 0.0503 0.9716 0.9716
Echinococcus granulosus tubulin beta 4A class IVa 0.0503 0.9716 0.9716
Loa Loa (eye worm) alpha-tubulin 0.0394 0.7552 0.7773
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0688 0.0647
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0446 0.0446
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0446 0.0446
Loa Loa (eye worm) MH2 domain-containing protein 0.0479 0.9253 0.9524
Echinococcus multilocularis Tubulin alpha 1 chain 0.0394 0.7552 0.7552
Loa Loa (eye worm) hypothetical protein 0.0052 0.071 0.0731
Trypanosoma brucei beta tubulin 0.0503 0.9716 1
Toxoplasma gondii alpha-tubulin I, putative 0.0394 0.7552 0.7759
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0688 0.0647
Leishmania major alpha tubulin 0.0394 0.7552 0.7759
Trichomonas vaginalis tubulin epsilon chain, putative 0.0394 0.7552 0.7759
Trichomonas vaginalis tubulin beta chain, putative 0.0394 0.7552 0.7759
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0446 0.0396
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0048 0.0634 0.0592
Giardia lamblia Beta tubulin 0.0503 0.9716 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0446 0.0446
Echinococcus granulosus tubulin alpha chain 0.0394 0.7552 0.7552
Echinococcus multilocularis Tubulin alpha 1 chain 0.0394 0.7552 0.7552
Echinococcus granulosus tubulin alpha chain 0.0394 0.7552 0.7552
Brugia malayi Isocitrate dehydrogenase 0.0048 0.0634 0.0653
Brugia malayi tubulin alpha chain - mouse 0.0394 0.7552 0.7773
Leishmania major alpha tubulin 0.0394 0.7552 0.7759
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.1809 0.1809
Schistosoma mansoni intermediate filament proteins 0.0026 0.0197 0.0197
Leishmania major beta tubulin 0.0503 0.9716 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0394 0.7552 0.7759
Trypanosoma cruzi tubulin delta chain 0.0123 0.2132 0.2143
Schistosoma mansoni ap endonuclease 0.002 0.0063 0.0063
Giardia lamblia Beta tubulin 0.0503 0.9716 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0503 0.9716 1
Echinococcus multilocularis tubulin alpha chain 0.0394 0.7552 0.7552
Plasmodium falciparum tubulin beta chain 0.0503 0.9716 1
Trypanosoma cruzi tubulin gamma chain 0.0284 0.5338 0.5465
Plasmodium vivax tubulin epsilon chain, putative 0.0284 0.5338 0.5465
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0197 0.0203
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0587 0.0587
Trichomonas vaginalis tubulin alpha chain, putative 0.0503 0.9716 1
Giardia lamblia DINP protein human, muc B family 0.0039 0.0446 0.0396
Echinococcus granulosus tubulin beta 1 chain 0.0503 0.9716 0.9716
Onchocerca volvulus 0.0235 0.4364 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0503 0.9716 1
Schistosoma mansoni tubulin subunit delta 0.0123 0.2132 0.2132
Echinococcus multilocularis tubulin beta 1 chain 0.0503 0.9716 0.9716
Trypanosoma cruzi epsilon tubulin, putative 0.0284 0.5338 0.5465
Loa Loa (eye worm) tubulin alpha-2 chain 0.0394 0.7552 0.7773
Loa Loa (eye worm) tubulin alpha chain 0.0394 0.7552 0.7773
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0048 0.0634 0.0592
Echinococcus multilocularis tubulin alpha 1C chain 0.0394 0.7552 0.7552
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0587 0.0604
Trypanosoma brucei epsilon tubulin 0.0284 0.5338 0.5465
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0048 0.0634 0.0634
Brugia malayi Cell division protein ftsZ 0.0123 0.2132 0.2194
Leishmania major alpha tubulin 0.0394 0.7552 0.7759
Schistosoma mansoni smad1 5 8 and 0.0033 0.0324 0.0324
Plasmodium falciparum flap endonuclease 1 0.0025 0.0174 0.0115
Trypanosoma brucei tubulin delta chain 0.0123 0.2132 0.2143
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0446 0.0396
Schistosoma mansoni hypothetical protein 0.0517 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0394 0.7552 0.7552
Mycobacterium leprae cell division protein FtsZ 0.0123 0.2132 0.5
Loa Loa (eye worm) pax transcription factor protein 2 0.0235 0.4364 0.4492
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.2132 0.2143
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0446 0.0396
Leishmania major beta tubulin 0.0503 0.9716 1
Trichomonas vaginalis tubulin beta chain, putative 0.0394 0.7552 0.7759
Echinococcus granulosus Tubulin beta 2C chain 0.0503 0.9716 0.9716
Plasmodium vivax tubulin alpha chain, putative 0.0394 0.7552 0.7759
Schistosoma mansoni tubulin subunit alpha 0.0394 0.7552 0.7552
Plasmodium falciparum tubulin epsilon chain, putative 0.0284 0.5338 0.5465
Leishmania major beta tubulin 0.0503 0.9716 1
Echinococcus granulosus flap endonuclease 1 0.0025 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0026 0.0188 0.0193
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0634 0.0634
Plasmodium vivax delta tubulin, putative 0.0123 0.2132 0.2143
Trichomonas vaginalis tubulin alpha chain, putative 0.016 0.2878 0.2916
Brugia malayi hypothetical protein 0.0051 0.0688 0.0708
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0446 0.0396
Entamoeba histolytica hypothetical protein 0.0107 0.1809 0.1809
Echinococcus multilocularis tubulin alpha chain 0.0394 0.7552 0.7552
Giardia lamblia Gamma tubulin 0.0284 0.5338 0.5465
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0048 0.0634 0.0634
Loa Loa (eye worm) alpha-tubulin 0.0394 0.7552 0.7773
Echinococcus granulosus intermediate filament protein 0.0026 0.0197 0.0197
Leishmania major beta tubulin 0.0503 0.9716 1
Toxoplasma gondii isocitrate dehydrogenase 0.0048 0.0634 0.0592
Echinococcus multilocularis smad 0.0033 0.0324 0.0324
Echinococcus multilocularis Tubulin beta 2C chain 0.0503 0.9716 0.9716
Leishmania major delta tubulin, putative 0.0123 0.2132 0.2143
Echinococcus granulosus dna polymerase eta 0.0065 0.0971 0.0971
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0587 0.0587
Schistosoma mansoni hypothetical protein 0.0107 0.1809 0.1809
Trypanosoma brucei epsilon tubulin 0.0284 0.5338 0.5465
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0197 0.0203
Giardia lamblia Beta tubulin 0.0503 0.9716 1
Loa Loa (eye worm) tubulin gamma chain 0.0284 0.5338 0.5495
Echinococcus granulosus tubulin alpha 3 chain 0.0394 0.7552 0.7552
Plasmodium vivax tubulin beta chain, putative 0.0503 0.9716 1
Echinococcus multilocularis tubulin gamma 1 chain 0.0284 0.5338 0.5338
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0446 0.1849
Trichomonas vaginalis tubulin gamma chain, putative 0.0123 0.2132 0.2143
Entamoeba histolytica tubulin alpha-1 chain 0.0394 0.7552 0.7759
Brugia malayi tubulin alpha-2 chain 0.0394 0.7552 0.7773
Echinococcus multilocularis musashi 0.0026 0.0197 0.0197
Trichomonas vaginalis tubulin beta chain, putative 0.016 0.2878 0.2916
Schistosoma mansoni hypothetical protein 0.0023 0.0127 0.0127
Echinococcus multilocularis beta tubulin 0.0503 0.9716 0.9716
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0203
Trypanosoma brucei beta tubulin 0.0503 0.9716 1
Trypanosoma cruzi beta tubulin, putative 0.0503 0.9716 1
Leishmania major epsilon tubulin, putative 0.0284 0.5338 0.5465
Schistosoma mansoni tubulin subunit gamma 0.0284 0.5338 0.5338
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0446 0.0396
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.071 0.0731
Leishmania major beta tubulin 0.0503 0.9716 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0437 0.0387
Schistosoma mansoni smad1 5 8 and 0.0033 0.0324 0.0324
Giardia lamblia Epsilon tubulin 0.0123 0.2132 0.2143
Schistosoma mansoni tubulin subunit beta 0.0503 0.9716 0.9716
Trichomonas vaginalis tubulin, putative 0.016 0.2878 0.2916
Entamoeba histolytica hypothetical protein 0.0107 0.1809 0.1809
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0446 0.0396
Echinococcus granulosus tubulin alpha chain 0.0394 0.7552 0.7552
Brugia malayi beta-tubulin, identical 0.0503 0.9716 1
Schistosoma mansoni smad1 5 8 and 0.0033 0.0324 0.0324
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0123 0.2132 0.2143
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0324 0.0324
Giardia lamblia Alpha-tubulin 0.0394 0.7552 0.7759
Leishmania major alpha tubulin 0.0394 0.7552 0.7759
Trypanosoma brucei alpha tubulin 0.0394 0.7552 0.7759
Plasmodium vivax tubulin gamma chain, putative 0.0284 0.5338 0.5465
Leishmania major beta tubulin 0.0503 0.9716 1
Echinococcus multilocularis lamin 0.0026 0.0197 0.0197
Echinococcus multilocularis tubulin alpha 0.0284 0.5338 0.5338
Trypanosoma brucei alpha tubulin, putative 0.016 0.2878 0.2916
Brugia malayi Tubulin alpha-2 chain 0.0394 0.7552 0.7773
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0174 0.0115
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0688 0.0647
Leishmania major beta tubulin 0.0503 0.9716 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0065 0.0971 0.0941
Schistosoma mansoni lamin 0.0026 0.0197 0.0197
Leishmania major beta tubulin 0.0503 0.9716 1
Echinococcus granulosus tubulin subunit beta 0.0503 0.9716 0.9716
Trichomonas vaginalis tubulin, putative 0.016 0.2878 0.2916
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0446 0.0396
Leishmania major alpha tubulin 0.0394 0.7552 0.7759
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0048 0.0634 0.0592
Echinococcus granulosus beta tubulin 0.0503 0.9716 0.9716
Loa Loa (eye worm) hypothetical protein 0.0394 0.7552 0.7773
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0324 0.0334
Toxoplasma gondii beta tubulin 0.0503 0.9716 1
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0123 0.2132 0.2143
Echinococcus multilocularis tubulin alpha 1C chain 0.0394 0.7552 0.7552
Echinococcus granulosus beta tubulin 0.0503 0.9716 0.9716
Echinococcus granulosus tubulin delta chain 0.0123 0.2132 0.2132
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0174 0.0179
Echinococcus multilocularis tubulin alpha chain 0.0394 0.7552 0.7552
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0048 0.0634 0.0634
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0446 0.0396
Echinococcus granulosus Tubulin alpha 1 chain 0.0394 0.7552 0.7552
Schistosoma mansoni tubulin subunit alpha 0.0394 0.7552 0.7552
Schistosoma mansoni flap endonuclease-1 0.0023 0.0126 0.0126
Giardia lamblia Alpha-tubulin 0.0394 0.7552 0.7759
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0271 0.5092 0.521
Loa Loa (eye worm) tubulin alpha 2 0.0111 0.1885 0.194
Trichomonas vaginalis tubulin alpha chain, putative 0.0284 0.5338 0.5465
Leishmania major beta tubulin 0.0503 0.9716 1
Trypanosoma cruzi alpha tubulin, putative 0.0394 0.7552 0.7759
Trypanosoma brucei unspecified product 0.0027 0.0205 0.0147
Entamoeba histolytica hypothetical protein 0.0107 0.1809 0.1809
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0205 0.0147
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0688 0.0647
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0394 0.7552 0.7759
Echinococcus granulosus tubulin epsilon chain 0.0284 0.5338 0.5338
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0446 0.0396
Echinococcus multilocularis Tubulin beta 2C chain 0.0503 0.9716 0.9716
Leishmania major alpha tubulin 0.0394 0.7552 0.7759
Echinococcus granulosus lamin dm0 0.0026 0.0197 0.0197
Echinococcus granulosus Tubulin beta 2C chain 0.0503 0.9716 0.9716
Leishmania major DNA polymerase kappa, putative 0.0039 0.0446 0.0396
Brugia malayi hypothetical protein 0.0033 0.0328 0.0337
Toxoplasma gondii beta-1 tubulin, putative 0.0503 0.9716 1
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0446 0.0459
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0174 0.0115
Loa Loa (eye worm) hypothetical protein 0.0051 0.0688 0.0708
Entamoeba histolytica hypothetical protein 0.0107 0.1809 0.1809
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.1809 0.1809
Trypanosoma brucei alpha tubulin 0.0394 0.7552 0.7759
Brugia malayi MH2 domain containing protein 0.0033 0.0324 0.0334
Entamoeba histolytica tubulin family protein 0.0503 0.9716 1
Trypanosoma brucei beta tubulin 0.0503 0.9716 1
Brugia malayi Tubulin alpha-2 chain 0.0394 0.7552 0.7773
Trypanosoma brucei DNA polymerase eta, putative 0.0065 0.0971 0.0941
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0127 0.0127
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0063 0.0063
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0123 0.2132 1
Brugia malayi alpha-tubulin 0.0394 0.7552 0.7773
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0587 0.0587
Brugia malayi MH1 domain containing protein 0.0033 0.0324 0.0334
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.016 0.2878 0.2916
Leishmania major beta tubulin 0.0503 0.9716 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 100 uM Inhibition of [3H]-glycine binding to glycine site of N-methyl-D-aspartate glutamate receptor in rat cortical membranes ChEMBL. 1826744
IC50 (binding) > 100 uM Inhibition of [3H]-glycine binding to glycine site of N-methyl-D-aspartate glutamate receptor in rat cortical membranes ChEMBL. 1826744

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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