Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | skeletal muscle/kidney enriched inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0939 | 0.1916 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.2667 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.4678 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.2667 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.2667 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.2667 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.2667 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.2667 | 0.6023 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | Phospholipase C precursor, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.4678 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0634 | 0.0584 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.4678 | 0.465 |
Trichomonas vaginalis | ocrl type II inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.2667 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.2667 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.092 | 0.1996 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0939 | 0.2042 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0109 | 0.0056 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.2667 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.2667 | 1 |
Trichomonas vaginalis | type II inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.2667 | 0.6023 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.0634 | 0.1257 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.2667 | 0.2628 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.2667 | 0.2966 |
Trichomonas vaginalis | sphingomyelinase C 2 precursor, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Trichomonas vaginalis | type IV inositol 5-phosphatase, putative | 0.0004 | 0.0053 | 0.0199 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.2667 | 0.5651 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0939 | 0.1916 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 0.1969 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.4393 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.4393 | 0.4363 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.4393 | 1 |
Onchocerca volvulus | 0.0031 | 0.4393 | 1 | |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.4678 | 0.465 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.2667 | 0.2628 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.0634 | 0.1257 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.2667 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.2667 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0634 | 0.1257 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 0.1969 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.2667 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0634 | 0.1257 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0059 | 0.8867 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.2667 | 0.5 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0053 | 0.0199 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.2667 | 0.5651 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.2667 | 0.5 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0.0053 | 0.0199 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 10 uM | Inhibitory concentration against T cell proliferation using concanavalin A stimulated mice spleen cells | ChEMBL. | 11229767 |
IC50 (functional) | > 30 uM | Inhibitory concentration against TNF-alpha production from human peripheral blood mononuclear cells stimulated by LPS | ChEMBL. | 11229767 |
IC50 (functional) | > 30 uM | Inhibitory concentration against growth of LPS stimulated human peripheral blood mononuclear cells | ChEMBL. | 11229767 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.