Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0162 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0162 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0162 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0162 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0162 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0162 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0162 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0162 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0162 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0162 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 288 uM | In vitro cytotoxicity of the compound against human xeroderma pigmentosum fibroblast cells HMGZip (mer-) | ChEMBL. | 12459014 |
IC50 (functional) | > 500 uM | In vitro cytotoxicity of the compound against human xeroderma pigmentosum fibroblast cells HMGZAT (mer+) | ChEMBL. | 12459014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.