Detailed information for compound 261673

Basic information

Technical information
  • TDR Targets ID: 261673
  • Name: N-[(2S)-1-[[(S)-cyano(phenyl)methyl]amino]-4- methyl-1-oxopentan-2-yl]morpholine-4-carboxam ide
  • MW: 358.435 | Formula: C19H26N4O3
  • H donors: 2 H acceptors: 3 LogP: 1.73 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C[C@H](c1ccccc1)NC(=O)[C@@H](NC(=O)N1CCOCC1)CC(C)C
  • InChi: 1S/C19H26N4O3/c1-14(2)12-16(22-19(25)23-8-10-26-11-9-23)18(24)21-17(13-20)15-6-4-3-5-7-15/h3-7,14,16-17H,8-12H2,1-2H3,(H,21,24)(H,22,25)/t16-,17+/m0/s1
  • InChiKey: XCZAXNGSRFVDGR-DLBZAZTESA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(1S)-1-[[(S)-cyano(phenyl)methyl]carbamoyl]-3-methyl-butyl]morpholine-4-carboxamide
  • N-[(1S)-1-[[[(S)-cyano(phenyl)methyl]amino]-oxomethyl]-3-methylbutyl]-4-morpholinecarboxamide
  • N-[(2S)-1-[[(S)-cyano(phenyl)methyl]amino]-4-methyl-1-oxo-pentan-2-yl]morpholine-4-carboxamide
  • N-[(2S)-1-[[(S)-cyano-phenylmethyl]amino]-4-methyl-1-oxopentan-2-yl]morpholine-4-carboxamide
  • N-[(1S)-1-[[(S)-cyano-phenyl-methyl]carbamoyl]-3-methyl-butyl]morpholine-4-carboxamide
  • N-[(1S)-1-[[[(S)-cyano-phenylmethyl]amino]-oxomethyl]-3-methylbutyl]-4-morpholinecarboxamide
  • N-[(2S)-1-[[(S)-cyano-phenyl-methyl]amino]-4-methyl-1-oxo-pentan-2-yl]morpholine-4-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin S Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0165 0.0165
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 1 1
Brugia malayi RE15519p 0.0014 0.0165 0.0165
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.3182 0.3182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0165 0.0165
Plasmodium vivax vivapain-2 0.0027 1 1
Leishmania major cathepsin L-like protease 0.0027 1 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 1 1
Echinococcus multilocularis cysteine protease 0.0027 1 1
Echinococcus granulosus g protein coupled receptor 0.0014 0.0165 0.0165
Brugia malayi G protein-coupled receptor F59B2.13 0.0014 0.0165 0.0165
Echinococcus granulosus neuropeptide receptor 0.0014 0.0165 0.0165
Echinococcus granulosus sex peptide receptor 0.0014 0.0165 0.0165
Schistosoma mansoni neuropeptide receptor 0.0014 0.0165 0.0165
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0165 0.0165
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0165 0.0165
Brugia malayi hypothetical protein 0.0014 0.0165 0.0165
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0165 0.0165
Onchocerca volvulus Cathepsin L homolog 0.0027 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0027 1 1
Echinococcus granulosus neuropeptide s receptor 0.0014 0.0165 0.0165
Plasmodium falciparum cysteine proteinase falcipain 3 0.0027 1 1
Brugia malayi hypothetical protein 0.0014 0.0165 0.0165
Brugia malayi larval opioid receptor 0.0014 0.0165 0.0165
Trypanosoma cruzi cysteine peptidase, putative 0.0027 1 1
Loa Loa (eye worm) fibroinase 0.0027 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0014 0.0165 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 1 1
Echinococcus multilocularis sex peptide receptor 0.0014 0.0165 0.0165
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0165 0.0165
Trypanosoma cruzi cruzipain precursor, putative 0.0027 1 1
Leishmania major cathepsin L-like protease 0.0027 1 0.5
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0018 0.3182 0.3182
Brugia malayi Dopamine receptor protein 2 0.0014 0.0165 0.0165
Echinococcus multilocularis serotonin receptor 0.0014 0.0165 0.0165
Brugia malayi cathepsin L-like precursor 0.0018 0.3182 0.3182
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0014 0.0165 0.0165
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0165 0.0165
Onchocerca volvulus Cathepsin L homolog 0.0027 1 1
Schistosoma mansoni amine GPCR 0.0014 0.0165 0.0165
Echinococcus granulosus dro:myosuppressin receptor 0.0014 0.0165 0.0165
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0165 0.0165
Brugia malayi hypothetical protein 0.0014 0.0165 0.0165
Echinococcus multilocularis neuropeptide receptor A26 0.0014 0.0165 0.0165
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.3182 0.3068
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0014 0.0165 0.0165
Schistosoma mansoni alpha-1 adrenergic receptor 0.0014 0.0165 0.0165
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0165 0.0165
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0165 0.0165
Echinococcus granulosus tachykinin peptides receptor 99D 0.0014 0.0165 0.0165
Echinococcus granulosus somatostatin receptor 0.0014 0.0165 0.0165
Brugia malayi sulfakinin receptor protein 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0027 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 1 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.3182 0.3182
Schistosoma mansoni cathepsin F (C01 family) 0.0027 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0027 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0165 0.0165
Schistosoma mansoni biogenic amine receptor 0.0014 0.0165 0.0165
Schistosoma mansoni histamine h1 receptor 0.0014 0.0165 0.0165
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0165 0.0165
Brugia malayi Cathepsin L-like precursor 0.0027 1 1
Schistosoma mansoni opsin-like receptor 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 1 1
Leishmania major cathepsin L-like protease 0.0027 1 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0165 0.0165
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0014 0.0165 0.0165
Trypanosoma cruzi cysteine peptidase, putative 0.0027 1 1
Echinococcus granulosus cathepsin l1 0.0018 0.3182 0.3182
Brugia malayi Tachykinin-like peptides receptor 99D 0.0014 0.0165 0.0165
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 1 1
Brugia malayi G protein-coupled receptor 0.0014 0.0165 0.0165
Loa Loa (eye worm) ctsf protein 0.0027 1 1
Brugia malayi G-protein coupled receptor 0.0014 0.0165 0.0165
Loa Loa (eye worm) cysteine protease 0.0027 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0165 0.0165
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0165 0.0165
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0014 0.0165 0.0165
Trypanosoma cruzi cysteine peptidase, putative 0.0027 1 1
Schistosoma mansoni amine GPCR 0.0014 0.0165 0.0165
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0014 0.0165 0.0165
Schistosoma mansoni biogenic amine receptor 0.0014 0.0165 0.0165
Echinococcus granulosus peptide allatostatin:somatostatin 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 1 1
Schistosoma mansoni hypothetical protein 0.0014 0.0165 0.0165
Schistosoma mansoni amine GPCR 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.3182 0.3182
Echinococcus granulosus neuropeptide receptor 0.0014 0.0165 0.0165
Brugia malayi hypothetical protein 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 1 1
Leishmania major cathepsin L-like protease 0.0027 1 0.5
Brugia malayi Dopamine receptor 0.0014 0.0165 0.0165
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0165 0.0165
Leishmania major cysteine peptidase A (CPA) 0.0027 1 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0165 0.0165
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0165 0.0165
Echinococcus granulosus G protein coupled receptor 139 0.0014 0.0165 0.0165
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0027 1 1
Echinococcus granulosus fmrfamide receptor 0.0014 0.0165 0.0165
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0165 0.0165
Echinococcus multilocularis neuropeptide s receptor 0.0014 0.0165 0.0165
Schistosoma mansoni hypothetical protein 0.0014 0.0165 0.0165
Schistosoma mansoni neuropeptide receptor 0.0014 0.0165 0.0165
Echinococcus multilocularis somatostatin receptor 0.0014 0.0165 0.0165
Echinococcus multilocularis neuropeptide FF receptor 2 0.0014 0.0165 0.0165
Brugia malayi AKH receptor 0.0014 0.0165 0.0165
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0165 0.0165
Brugia malayi Cathepsin L-like precursor 0.0027 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0014 0.0165 0.0165
Echinococcus multilocularis orexin receptor type 2 0.0014 0.0165 0.0165
Echinococcus granulosus serotonin receptor 0.0014 0.0165 0.0165
Echinococcus multilocularis allatostatin A receptor 0.0014 0.0165 0.0165
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.3182 0.3182
Onchocerca volvulus 0.0027 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0027 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0014 0.0165 0.0165
Echinococcus granulosus allatostatin A receptor 0.0014 0.0165 0.0165
Leishmania major cathepsin L-like protease 0.0027 1 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0165 0.0165
Brugia malayi follicle stimulating hormone receptor 0.0014 0.0165 0.0165
Onchocerca volvulus 0.0027 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 1 1
Schistosoma mansoni opsin-like receptor 0.0014 0.0165 0.0165
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0165 0.0165
Brugia malayi ORL1-like opioid receptor 0.0014 0.0165 0.0165
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0165 0.0165
Brugia malayi hypothetical protein 0.0014 0.0165 0.0165
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0027 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0014 0.0165 0.0165
Brugia malayi Cathepsin L-like precursor 0.0018 0.3182 0.3182
Schistosoma mansoni neuropeptide receptor 0.0014 0.0165 0.0165
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0014 0.0165 0.0165
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0014 0.0165 0.0165
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0165 0.0165
Onchocerca volvulus 0.0027 1 1
Brugia malayi G-protein coupled receptor 0.0014 0.0165 0.0165
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 1 1
Plasmodium vivax vivapain-2 0.0027 1 1
Leishmania major cathepsin L-like protease 0.0027 1 0.5
Schistosoma mansoni neuropeptide receptor 0.0014 0.0165 0.0165
Schistosoma mansoni amine GPCR 0.0014 0.0165 0.0165
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0165 0.0165
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0014 0.0165 0.0165
Brugia malayi hypothetical protein 0.0014 0.0165 0.0165
Entamoeba histolytica cysteine protease, putative 0.0027 1 1
Onchocerca volvulus 0.0018 0.3182 0.3068
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0165 0.0165
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 1 1
Echinococcus granulosus orexin receptor type 2 0.0014 0.0165 0.0165
Brugia malayi hypothetical protein 0.0014 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0018 0.3182 0.3068
Leishmania major cathepsin L-like protease 0.0027 1 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0165 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0014 0.0165 0.0165
Brugia malayi Serotonin receptor 0.0014 0.0165 0.0165
Schistosoma mansoni opsin-like receptor 0.0014 0.0165 0.0165
Onchocerca volvulus Cathepsin F homolog 0.0027 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0165 0.0165
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0165 0.0165
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0014 0.0165 0.0165
Echinococcus granulosus g-protein coupled receptor 0.0014 0.0165 0.0165
Echinococcus multilocularis cysteine protease 0.0027 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0018 0.3182 0.3068
Leishmania major cathepsin L-like protease 0.0027 1 0.5
Schistosoma mansoni hypothetical protein 0.0014 0.0165 0.0165
Onchocerca volvulus 0.0027 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0165 0.0165
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0027 1 1
Brugia malayi GnHR receptor homolog 0.0014 0.0165 0.0165
Brugia malayi putative neuropeptide receptor NPR1 0.0014 0.0165 0.0165
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0014 0.0165 0.0165
Brugia malayi hypothetical protein 0.0014 0.0165 0.0165
Schistosoma mansoni myosin xvIII 0.0014 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0027 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0165 0.0165
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0014 0.0165 0.0165
Schistosoma mansoni growth hormone secretagogue receptor 0.0014 0.0165 0.0165
Onchocerca volvulus 0.0027 1 1
Brugia malayi Serotonin receptor 0.0014 0.0165 0.0165
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.3182 0.3182
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0165 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 1 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0014 0.0165 0.0165
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0014 0.0165 0.0165
Brugia malayi neuropeptide F receptor 0.0014 0.0165 0.0165
Echinococcus granulosus alpha 1A adrenergic receptor 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0027 1 1
Echinococcus multilocularis serotonin receptor 0.0014 0.0165 0.0165
Echinococcus granulosus neuropeptide receptor A26 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 1 1
Brugia malayi Cathepsin L-like precursor 0.0027 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0014 0.0165 0.0165
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0165 0.0165
Schistosoma mansoni hypothetical protein 0.0014 0.0165 0.0165
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0165 0.0165
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0165 0.0165
Onchocerca volvulus 0.0027 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0018 0.3182 0.3182
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0165 0.0165
Echinococcus multilocularis G protein coupled receptor 139 0.0014 0.0165 0.0165
Echinococcus multilocularis dro:myosuppressin receptor 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0014 0.0165 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0165 0.0165
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0165 0.0165
Brugia malayi hypothetical protein 0.0014 0.0165 0.0165
Entamoeba histolytica cysteine proteinase, putative 0.0027 1 1
Brugia malayi putative neuropeptide receptor 0.0014 0.0165 0.0165
Echinococcus granulosus cathepsin l cysteine peptidase 0.0027 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0014 0.0165 0.0165
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0165 0.0165
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0014 0.0165 0.0165
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0014 0.0165 0.0165
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0165 0.0165
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0165 0.0165
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0165 0.0165
Schistosoma mansoni biogenic amine receptor 0.0014 0.0165 0.0165
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0165 0.0165
Echinococcus granulosus neuropeptide FF receptor 2 0.0014 0.0165 0.0165
Brugia malayi Cathepsin L-like precursor 0.0027 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0165 0.0165
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0165 0.0165
Brugia malayi Cathepsin L-like precursor 0.0027 1 1
Brugia malayi neuropeptide F receptor 0.0014 0.0165 0.0165
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0165 0.0165
Toxoplasma gondii cathepsin CPL 0.0027 1 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0014 0.0165 0.0165
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 1 1
Echinococcus granulosus g protein coupled receptor 0.0014 0.0165 0.0165
Echinococcus granulosus hypothetical protein 0.0014 0.0165 0.0165
Schistosoma mansoni adenoreceptor 0.0014 0.0165 0.0165
Brugia malayi Dopamine receptor protein 1 0.0014 0.0165 0.0165
Echinococcus granulosus g protein coupled receptor 0.0014 0.0165 0.0165
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0165 0.0165
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0165 0.0165
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0165 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 1 1
Onchocerca volvulus 0.0027 1 1
Echinococcus multilocularis g-protein coupled receptor 0.0014 0.0165 0.0165
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0165 0.0165
Brugia malayi Melatonin receptor type 1A 0.0014 0.0165 0.0165
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0165 0.0165
Brugia malayi hypothetical protein 0.0014 0.0165 0.0165
Schistosoma mansoni amine GPCR 0.0014 0.0165 0.0165
Echinococcus granulosus cathepsin l1 0.0027 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0014 0.0165 0.0165

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 51 nM Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirus ChEMBL. 12459015
IC50 (binding) = 51 nM Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirus ChEMBL. 12459015
Kd (binding) = 4 nM Equilibrium dissocation constant determined using fluorescence based competitive binding assay towards Cathepsin S ChEMBL. 12459015
Kd (binding) = 4 nM Equilibrium dissocation constant determined using fluorescence based competitive binding assay towards Cathepsin S ChEMBL. 12459015
p10 MIC (functional) = 5000 nM MIC (minimum inhibitory concentration) of the compound at which P10 band (cathepsin S) can be detected ChEMBL. 12459015

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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