Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | carbonic anhydrase | 0.0171 | 0.2258 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0171 | 0.2258 | 0.1888 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0461 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0461 | 1 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0461 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0461 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.2258 | 0.1888 |
Echinococcus granulosus | carbonic anhydrase II | 0.0461 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.2258 | 0.1888 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.3643 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0461 | 1 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0461 | 1 | 0.5 |
Onchocerca volvulus | 0.0104 | 0.0457 | 0.0625 | |
Toxoplasma gondii | PAN domain-containing protein | 0.0304 | 0.5809 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0461 | 1 | 1 |
Toxoplasma gondii | PAN domain-containing protein | 0.0304 | 0.5809 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0171 | 0.2258 | 0.1888 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0171 | 0.2258 | 0.1888 |
Loa Loa (eye worm) | hypothetical protein | 0.0361 | 0.732 | 0.7191 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0171 | 0.2258 | 0.1888 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0361 | 0.732 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.2258 | 0.1888 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0171 | 0.2258 | 0.1888 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0461 | 1 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0361 | 0.732 | 0.7191 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0171 | 0.2258 | 0.1888 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0171 | 0.2258 | 0.1888 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.2258 | 0.1888 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0461 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0171 | 0.2258 | 0.1888 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0171 | 0.2258 | 0.1888 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0171 | 0.2258 | 0.1888 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0461 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Motility (functional) | = 31 | Antipsychotic effect was tested against motility scores in reserpinized mice at a control value of 11 | ChEMBL. | 4039368 |
Motility (functional) | = 914 | Antipsychotic effect was tested against motility scores in naive mice at a control value of 815 | ChEMBL. | 4039368 |
Motility (functional) | = 31 | Antipsychotic effect was tested against motility scores in reserpinized mice at a control value of 11 | ChEMBL. | 4039368 |
Motility (functional) | = 914 | Antipsychotic effect was tested against motility scores in naive mice at a control value of 815 | ChEMBL. | 4039368 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.