Detailed information for compound 26194

Basic information

Technical information
  • TDR Targets ID: 26194
  • Name: (E)-3-(4-fluorophenyl)-N-methyl-N-(naphthalen -1-ylmethyl)prop-2-en-1-amine
  • MW: 305.389 | Formula: C21H20FN
  • H donors: 0 H acceptors: 0 LogP: 5.25 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(Cc1cccc2c1cccc2)C/C=C/c1ccc(cc1)F
  • InChi: 1S/C21H20FN/c1-23(15-5-6-17-11-13-20(22)14-12-17)16-19-9-4-8-18-7-2-3-10-21(18)19/h2-14H,15-16H2,1H3/b6-5+
  • InChiKey: LGOJCTYWHXPMQJ-AATRIKPKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-3-(4-fluorophenyl)-N-methyl-N-(1-naphthylmethyl)prop-2-en-1-amine
  • (E)-3-(4-fluorophenyl)-N-methyl-N-(1-naphthalenylmethyl)-2-propen-1-amine
  • [(E)-3-(4-fluorophenyl)allyl]-methyl-(1-naphthylmethyl)amine
  • [(E)-3-(4-fluorophenyl)prop-2-enyl]-methyl-(1-naphthylmethyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis neuropeptide receptor A26 0.0447 0.4701 0.4701
Schistosoma mansoni hypothetical protein 0.0015 0.0078 0.0078
Schistosoma mansoni RAR-like nuclear receptor 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Brugia malayi Nuclear hormone receptor-like 1 0.0498 0.5243 0.5235
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0445 0.4672 0.4672
Brugia malayi beta-NAC-like protein 0.0034 0.0277 0.026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0943 1 1
Schistosoma mansoni cpg binding protein 0.0029 0.0229 0.0229
Echinococcus multilocularis ecdysone induced protein 78C 0.0943 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0943 1 1
Schistosoma mansoni glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) 0.0769 0.8139 0.8139
Schistosoma mansoni coup transcription factor 0.0943 1 1
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1461 0.1461
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.4148 0.4148
Schistosoma mansoni nuclear hormone receptor 0.0943 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0943 1 1
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0078 0.0061
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0018 0.0018
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0212 0.0194
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.023 0.023
Onchocerca volvulus Bile acid receptor homolog 0.0943 1 1
Schistosoma mansoni hypothetical protein 0.0033 0.0267 0.0267
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.023 0.023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0943 1 1
Loa Loa (eye worm) DR-78 0.0445 0.4672 0.4662
Brugia malayi Muscleblind-like protein 0.0145 0.1461 0.1446
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0078 0.0078
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0277 0.0246
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0445 0.4672 0.4672
Onchocerca volvulus Protein ultraspiracle homolog 0.0943 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0943 1 1
Schistosoma mansoni nuclear receptor 0.0445 0.4672 0.4672
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Schistosoma mansoni hypothetical protein 0.0164 0.1669 0.1669
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 0.0494 0.5205 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0267 0.025
Brugia malayi glutamine synthetase 0.0274 0.285 0.2837
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0943 1 1
Echinococcus granulosus GPCR family 2 0.0015 0.0078 0.0078
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0498 0.5243 0.5243
Brugia malayi hypothetical protein 0.0498 0.5243 0.5235
Loa Loa (eye worm) hypothetical protein 0.0943 1 1
Schistosoma mansoni thyroid hormone receptor 0.0943 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0943 1 1
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0277 0.0387
Loa Loa (eye worm) hypothetical protein 0.0943 1 1
Echinococcus multilocularis cpg binding protein 0.0029 0.0229 0.0229
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0943 1 1
Leishmania major basic transcription factor 3a, putative 0.0034 0.0277 0.0246
Brugia malayi nuclear receptor RXR 0.0498 0.5243 0.5235
Brugia malayi hypothetical protein 0.0445 0.4672 0.4663
Echinococcus multilocularis glutamine synthetase 0.0769 0.8139 0.8139
Brugia malayi nuclear receptor NHR-88 0.0445 0.4672 0.4663
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0078 0.0078
Schistosoma mansoni nuclear hormone receptor 0.0445 0.4672 0.4672
Onchocerca volvulus 0.0943 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.023 0.0213
Mycobacterium ulcerans glutamine synthetase 0.0494 0.5205 1
Mycobacterium ulcerans glutamine synthetase GlnA1 0.0494 0.5205 1
Loa Loa (eye worm) hypothetical protein 0.0498 0.5243 0.5234
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0445 0.4672 0.4672
Brugia malayi photoreceptor-specific nuclear receptor 0.0943 1 1
Trichomonas vaginalis glutamine synthetase, putative 0.0194 0.199 0.8175
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0277 0.0246
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0078 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0943 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.023 0.023
Echinococcus granulosus neuropeptide s receptor 0.0447 0.4701 0.4701
Schistosoma mansoni glutamine synthetase bacteria 0.0194 0.199 0.199
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0445 0.4672 0.4557
Trypanosoma cruzi glutamine synthetase, putative 0.0769 0.8139 1
Brugia malayi Pre-SET motif family protein 0.0029 0.023 0.0214
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) 0.0494 0.5205 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0445 0.4672 0.4672
Schistosoma mansoni nuclear hormone receptor 0.0445 0.4672 0.4672
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0018 0.0018
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.0396 0.4148 0.4148
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Loa Loa (eye worm) hypothetical protein 0.0498 0.5243 0.5234
Entamoeba histolytica glutamine synthetase, putative 0.0194 0.199 1
Loa Loa (eye worm) hypothetical protein 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0445 0.4672 0.4672
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0445 0.4672 0.4663
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0943 1 1
Brugia malayi hypothetical protein 0.0498 0.5243 0.5235
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0943 1 1
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0277 0.0246
Schistosoma mansoni hypothetical protein 0.0164 0.1669 0.1669
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0445 0.4672 0.4672
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0557 0.0557
Loa Loa (eye worm) steroid hormone receptor 0.0943 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0943 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.023 0.023
Toxoplasma gondii glutamine synthetase, type I, putative 0.0494 0.5205 1
Echinococcus granulosus glutamine synthetase 0.0769 0.8139 0.8139
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0498 0.5243 0.5243
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0212 0.0212
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0943 1 1
Plasmodium vivax glutamine synthetase, putative 0.0494 0.5205 1
Schistosoma mansoni hypothetical protein 0.0015 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0015 0.0078 0.006
Brugia malayi Nuclear hormone receptor-like 1 0.0498 0.5243 0.5235
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.023 0.023
Brugia malayi steroid hormone receptor 0.0943 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0943 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0943 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0943 1 1
Echinococcus multilocularis muscleblind protein 0.0145 0.1461 0.1461
Echinococcus granulosus ecdysone induced protein 78C 0.0943 1 1
Trichomonas vaginalis set domain proteins, putative 0.023 0.2373 1
Schistosoma mansoni glutamine synthetase bacteria 0.0194 0.199 0.199
Echinococcus granulosus dnaJ subfamily B 0.0396 0.4148 0.4148
Entamoeba histolytica glutamine synthetase, putative 0.0194 0.199 1
Echinococcus multilocularis neuropeptide s receptor 0.0447 0.4701 0.4701
Onchocerca volvulus Glutamine synthetase homolog 0.0494 0.5205 0.5101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0943 1 1
Brugia malayi nuclear hormone receptor 0.0943 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0943 1 1
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) 0.0194 0.199 0.373
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Echinococcus multilocularis nuclear receptor nhr 48 0.0445 0.4672 0.4672
Brugia malayi nuclear receptor NHR-88 0.0943 1 1
Trichomonas vaginalis glutamine synthetase-bacteria, putative 0.0194 0.199 0.8175
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2075 0.2061
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0078 0.0078
Brugia malayi nuclear receptor RXR 0.0445 0.4672 0.4663
Onchocerca volvulus 0.0029 0.023 0.0019
Brugia malayi isocitrate dehydrogenase 0.0015 0.0078 0.0061
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0277 0.0387
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0943 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0943 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0943 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Schistosoma mansoni transcription factor btf3 0.0034 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Loa Loa (eye worm) hypothetical protein 0.0943 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0943 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.023 0.0296
Loa Loa (eye worm) hypothetical protein 0.0498 0.5243 0.5234
Loa Loa (eye worm) hypothetical protein 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0498 0.5243 0.5234
Loa Loa (eye worm) hypothetical protein 0.0498 0.5243 0.5234
Brugia malayi nuclear hormone receptor family member odr-7 0.0445 0.4672 0.4663
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0943 1 1
Brugia malayi conserved hypotetical protein 0.0445 0.4672 0.4663
Schistosoma mansoni nuclear receptor nhr-48 0.0445 0.4672 0.4672
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Echinococcus granulosus Nuclear hormone receptor HR96 0.0445 0.4672 0.4672
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0943 1 1
Plasmodium falciparum glutamine synthetase, putative 0.0494 0.5205 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0498 0.5243 0.5243
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0445 0.4672 0.4672
Schistosoma mansoni hypothetical protein 0.0015 0.0078 0.0078
Onchocerca volvulus 0.023 0.2373 0.2208
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0489 0.0802
Loa Loa (eye worm) nuclear hormone receptor 0.0445 0.4672 0.4662
Schistosoma mansoni zinc finger protein 0.0445 0.4672 0.4672
Loa Loa (eye worm) hypothetical protein 0.0048 0.0431 0.0413
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0943 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0943 1 1
Echinococcus multilocularis transcription factor btf3 0.0034 0.0277 0.0277
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.023 0.023
Echinococcus multilocularis thyroid hormone receptor alpha 0.0943 1 1
Brugia malayi hypothetical protein 0.0445 0.4672 0.4663
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0943 1 1
Echinococcus granulosus FTZ F1 alpha 0.0943 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0447 0.4701 0.4701
Brugia malayi tailless protein 0.0445 0.4672 0.4663
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0078 0.0061
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0431 0.0414
Leishmania major glutamine synthetase, putative 0.0769 0.8139 1
Echinococcus granulosus muscleblind protein 0.0145 0.1461 0.1461
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0943 1 1
Brugia malayi Nuclear hormone receptor E75 0.0445 0.4672 0.4663
Plasmodium vivax SET domain protein, putative 0.0029 0.023 0.0296
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0943 1 1
Echinococcus granulosus transcription factor btf3 0.0034 0.0277 0.0277
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0498 0.5243 0.5234
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0078 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0943 1 1
Echinococcus granulosus cpg binding protein 0.0029 0.0229 0.0229
Trypanosoma cruzi glutamine synthetase, putative 0.0769 0.8139 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0431 0.0414
Onchocerca volvulus 0.0445 0.4672 0.4557
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Echinococcus granulosus Nuclear hormone receptor HR96 0.0445 0.4672 0.4672
Loa Loa (eye worm) hypothetical protein 0.0445 0.4672 0.4662
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0943 1 1
Schistosoma mansoni cpg binding protein 0.0028 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0145 0.1461 0.1445
Echinococcus granulosus nuclear receptor nhr 48 0.0445 0.4672 0.4672
Schistosoma mansoni hypothetical protein 0.0015 0.0078 0.0078
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0445 0.4672 0.4557
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0078 0.0061
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0078 0.0078
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0943 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0445 0.4672 0.4662
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0277 0.0387
Echinococcus granulosus thyroid hormone receptor alpha 0.0445 0.4672 0.4672
Echinococcus multilocularis FTZ F1 alpha 0.0943 1 1
Echinococcus multilocularis GPCR, family 2 0.0015 0.0078 0.0078
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0078 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0943 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.0445 0.4672 0.4663
Schistosoma mansoni thyroid hormone receptor 0.0943 1 1
Brugia malayi nuclear receptor NHR-67 0.0445 0.4672 0.4663
Echinococcus multilocularis geminin 0.0164 0.1669 0.1669
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0943 1 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0212 0.0195
Brugia malayi ecdysone receptor 0.0445 0.4672 0.4663
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0445 0.4672 0.4672
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0431 0.0413
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0943 1 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0078 0.006
Schistosoma mansoni cpg binding protein 0.0029 0.0229 0.0229
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0078 0.0078
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0078 0.006
Brugia malayi Nuclear hormone receptor E75 0.0445 0.4672 0.4663
Brugia malayi Pre-SET motif family protein 0.0202 0.2075 0.2062
Brugia malayi nuclear hormone receptor family member nhr-6 0.0445 0.4672 0.4663
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0445 0.4672 0.4662
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0277 0.0259
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0445 0.4672 0.4672
Schistosoma mansoni nuclear receptor 0.0445 0.4672 0.4672
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0078 0.0078
Brugia malayi nuclear hormone receptor 0.0445 0.4672 0.4663
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0943 1 1
Trypanosoma brucei glutamine synthetase, putative 0.0769 0.8139 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0267 0.0251
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0943 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.023 0.023
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0784 0.8307 0.8307
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0498 0.5243 0.5243
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.1461 0.1445
Loa Loa (eye worm) Gln-2 protein 0.0494 0.5205 0.5196
Echinococcus granulosus geminin 0.0164 0.1669 0.1669
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0078 0.0078
Onchocerca volvulus 0.0445 0.4672 0.4557
Schistosoma mansoni retinoic acid receptor RXR 0.0943 1 1
Wolbachia endosymbiont of Brugia malayi glutamine synthetase 0.0194 0.199 0.5

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 21 % In vivo antifungal activity by topical treatment of guinea pig dermatophytosis caused by Trichophyton mentagrophytes at a dose of 0.1% ChEMBL. 3510297
Activity (functional) = 82 % In vivo antifungal activity by topical treatment of guinea pig dermatophytosis caused by Trichophyton mentagrophytes at a dose of 0.5% ChEMBL. 3510297
Activity (functional) = 100 % In vivo antifungal activity by topical treatment of guinea pig dermatophytosis caused by Trichophyton mentagrophytes at a dose of 2% ChEMBL. 3510297
MIC (functional) = 0.1 ug ml-1 Antifungal activity measured against Trichophyton mentagrophytes ChEMBL. 3510297
MIC (functional) = 0.1 ug ml-1 Antifungal activity against Epidermophyton floccosum. ChEMBL. 3510297
MIC (functional) = 0.2 ug ml-1 Antifungal activity against Microsporum canis ChEMBL. 3510297
MIC (functional) = 1.6 ug ml-1 Antifungal activity measured against Sporothrix schenck ii. ChEMBL. 3510297
MIC (functional) = 3.1 ug ml-1 Antifungal activity against Candida parapsilosis. ChEMBL. 3510297
MIC (functional) = 25 ug ml-1 Antifungal activity measured against Aspergillus fumigatus ChEMBL. 3510297

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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