Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ankyrin repeat protein | 0.0313 | 0.9684 | 0.9684 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0055 | 0.1105 | 0.2273 |
Echinococcus multilocularis | protein prenyltransferase alpha subunit | 0.0044 | 0.0719 | 0.0719 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.0044 | 0.0719 | 0.1528 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0098 | 0.2549 | 0.2549 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0063 | 0.1362 | 0.28 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0529 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0529 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.0044 | 0.0719 | 0.1528 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0057 | 0.117 | 0.3427 |
Schistosoma mansoni | jumonji domain containing protein | 0.0057 | 0.1176 | 0.1214 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0098 | 0.2549 | 0.2549 |
Brugia malayi | amidase | 0.0098 | 0.2549 | 0.524 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0894 | 0.1838 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0894 | 0.1838 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0043 | 0.0708 | 0.0708 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0057 | 0.1176 | 0.1176 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0134 | 0.3731 | 0.7671 |
Brugia malayi | Animal haem peroxidase family protein | 0.003 | 0.0257 | 0.0529 |
Plasmodium falciparum | plasmepsin I | 0.0057 | 0.117 | 0.2405 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0043 | 0.0708 | 0.1505 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0055 | 0.1105 | 0.1105 |
Echinococcus multilocularis | geranylgeranyl transferase type 2 subunit alpha | 0.0044 | 0.0719 | 0.0719 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0043 | 0.0708 | 0.0708 |
Schistosoma mansoni | peroxidasin | 0.003 | 0.0257 | 0.0266 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0063 | 0.1362 | 0.28 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0043 | 0.0708 | 0.0731 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0168 | 0.4864 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1105 | 0.2273 |
Echinococcus granulosus | geranylgeranyl transferase type 2 subunit alpha | 0.0044 | 0.0719 | 0.0719 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0163 | 0.4703 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1418 | 0.1464 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1418 | 0.1464 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0134 | 0.3731 | 0.7935 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0043 | 0.0708 | 0.1455 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0163 | 0.4703 | 1 |
Entamoeba histolytica | Rab geranylgeranyltransferase alpha subunit, putative | 0.0044 | 0.0719 | 0.1477 |
Loa Loa (eye worm) | animal heme peroxidase | 0.003 | 0.0257 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.3731 | 0.7671 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0043 | 0.0708 | 0.1455 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0043 | 0.0708 | 0.1505 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0134 | 0.3731 | 0.7935 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0529 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.1418 | 0.1418 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0529 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.1418 | 0.2916 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0529 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0168 | 0.4864 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0044 | 0.0719 | 0.1477 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0043 | 0.0708 | 0.1455 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0124 | 0.3413 | 0.7017 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0529 |
Loa Loa (eye worm) | animal heme peroxidase | 0.003 | 0.0257 | 0.0529 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1418 | 0.1464 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0043 | 0.0708 | 0.0708 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1418 | 0.1464 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0055 | 0.1105 | 0.1105 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0055 | 0.1105 | 0.2273 |
Loa Loa (eye worm) | animal heme peroxidase | 0.003 | 0.0257 | 0.0529 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.0044 | 0.0719 | 0.1528 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.0708 | 0.1455 |
Leishmania major | protein farnesyltransferase alpha subunit, putative | 0.0044 | 0.0719 | 0.1528 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0055 | 0.1105 | 0.1142 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0043 | 0.0708 | 0.0731 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0134 | 0.3731 | 0.3853 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.1418 | 0.1464 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0043 | 0.0708 | 0.1505 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0043 | 0.0708 | 0.0708 |
Toxoplasma gondii | hypothetical protein | 0.0124 | 0.3413 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0057 | 0.1176 | 0.1176 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0708 | 0.1455 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0057 | 0.117 | 0.2405 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0322 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.003 | 0.0257 | 0.0529 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0057 | 0.1176 | 0.1214 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0529 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0168 | 0.4864 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0057 | 0.1176 | 0.1176 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0168 | 0.4864 | 0.5023 |
Onchocerca volvulus | 0.0044 | 0.0719 | 1 | |
Echinococcus multilocularis | protein patched | 0.0055 | 0.1105 | 0.1105 |
Echinococcus multilocularis | protein dispatched 1 | 0.0055 | 0.1105 | 0.1105 |
Toxoplasma gondii | hypothetical protein | 0.0044 | 0.0719 | 0.2106 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0055 | 0.1105 | 0.1105 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0529 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0055 | 0.1105 | 0.1105 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0894 | 0.1838 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0043 | 0.0708 | 0.0708 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0.0719 | 0.1528 |
Echinococcus multilocularis | peroxidasin | 0.003 | 0.0257 | 0.0257 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.1418 | 0.2916 |
Brugia malayi | hypothetical protein | 0.003 | 0.0257 | 0.0529 |
Schistosoma mansoni | amidase | 0.0098 | 0.2549 | 0.2632 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.1418 | 0.2916 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.1418 | 0.2916 |
Plasmodium falciparum | geranylgeranyl transferase type-2 subunit alpha, putative | 0.0044 | 0.0719 | 0.1477 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.2549 | 0.524 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0168 | 0.4864 | 1 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0057 | 0.117 | 0.3427 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0063 | 0.1362 | 0.28 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0134 | 0.3731 | 0.7935 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0168 | 0.4876 | 0.5035 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0134 | 0.3731 | 0.3731 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0057 | 0.117 | 0.1208 |
Echinococcus multilocularis | ankyrin repeat protein | 0.0313 | 0.9684 | 0.9684 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0529 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0168 | 0.4864 | 1 |
Echinococcus granulosus | protein prenyltransferase alpha subunit | 0.0044 | 0.0719 | 0.0719 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0044 | 0.0719 | 0.0742 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0168 | 0.4864 | 1 |
Trypanosoma brucei | protein farnesyltransferase alpha subunit, putative | 0.0044 | 0.0719 | 0.1528 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0057 | 0.1176 | 0.1176 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0168 | 0.4876 | 0.5035 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0379 | 0.0392 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0098 | 0.2549 | 0.2632 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0134 | 0.3731 | 0.7935 |
Schistosoma mansoni | peroxidasin | 0.003 | 0.0257 | 0.0266 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0057 | 0.117 | 0.2405 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0529 |
Brugia malayi | RNA binding protein | 0.0065 | 0.1418 | 0.2916 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0057 | 0.1176 | 0.2418 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0057 | 0.117 | 0.2405 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0 | 0.5 |
Plasmodium vivax | plasmepsin IV, putative | 0.0057 | 0.117 | 0.2405 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0134 | 0.3731 | 0.3731 |
Plasmodium falciparum | plasmepsin II | 0.0057 | 0.117 | 0.2405 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.1418 | 0.2916 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0044 | 0.0719 | 0.1477 |
Brugia malayi | Animal haem peroxidase family protein | 0.003 | 0.0257 | 0.0529 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0168 | 0.4864 | 0.4864 |
Brugia malayi | Peroxidasin | 0.003 | 0.0257 | 0.0529 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.1418 | 0.1418 |
Echinococcus granulosus | peroxidasin | 0.003 | 0.0257 | 0.0257 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0168 | 0.4864 | 1 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0043 | 0.0708 | 0.0708 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0057 | 0.117 | 0.117 |
Brugia malayi | CHE-14 protein | 0.0055 | 0.1105 | 0.2273 |
Brugia malayi | Animal haem peroxidase family protein | 0.003 | 0.0257 | 0.0529 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0379 | 0.078 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0098 | 0.2549 | 0.2549 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.4864 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0168 | 0.4864 | 1 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.0313 | 0.9684 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0168 | 0.4864 | 1 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0163 | 0.4703 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0.0719 | 0.1528 |
Brugia malayi | Animal haem peroxidase family protein | 0.003 | 0.0257 | 0.0529 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.0044 | 0.0719 | 0.1528 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0043 | 0.0708 | 0.1505 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0055 | 0.1105 | 0.1105 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.117 | 0.2405 |
Plasmodium vivax | protein prenyltransferase alpha subunit, putative | 0.0044 | 0.0719 | 0.1477 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0168 | 0.4864 | 0.4864 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0379 | 0.078 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0063 | 0.1362 | 0.28 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0894 | 0.1838 |
Plasmodium falciparum | plasmepsin VI | 0.0057 | 0.117 | 0.2405 |
Brugia malayi | jmjC domain containing protein | 0.0057 | 0.1176 | 0.2418 |
Brugia malayi | Blistered cuticle protein 3 | 0.003 | 0.0257 | 0.0529 |
Brugia malayi | jmjC domain containing protein | 0.0057 | 0.1176 | 0.2418 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0529 |
Schistosoma mansoni | patched 1 | 0.0055 | 0.1105 | 0.1142 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0044 | 0.0719 | 0.1528 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0163 | 0.4703 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0098 | 0.2549 | 0.2549 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0044 | 0.0719 | 0.1477 |
Loa Loa (eye worm) | animal heme peroxidase | 0.003 | 0.0257 | 0.0529 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0043 | 0.0708 | 0.1455 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0044 | 0.0719 | 0.1477 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0057 | 0.1176 | 0.1214 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0163 | 0.4703 | 1 |
Trypanosoma cruzi | Protein prenyltransferase alpha subunit repeat, putative | 0.0044 | 0.0719 | 0.1528 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0529 |
Plasmodium falciparum | plasmepsin IV | 0.0057 | 0.117 | 0.2405 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0134 | 0.3731 | 0.7935 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0043 | 0.0708 | 0.1455 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0163 | 0.4703 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0529 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.003 | 0.0257 | 0.0529 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0057 | 0.117 | 0.117 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | In vitro percent Inhibition of recombinant human prostaglandin G/H synthase 2 (COX-2) at a concentration of 1 microM | ChEMBL. | 14640557 |
Inhibition (binding) | = 0 % | In vitro percent Inhibition of recombinant human prostaglandin G/H synthase 2 (COX-2) at a concentration of 1 microM | ChEMBL. | 14640557 |
Inhibition (binding) | = 20 % | In vitro percent Inhibition of recombinant human prostaglandin G/H synthase 1 (COX-1) at a concentration of 100 microM | ChEMBL. | 14640557 |
Inhibition (binding) | = 20 % | In vitro percent Inhibition of recombinant human prostaglandin G/H synthase 2 (COX-2) at a concentration of 10 microM | ChEMBL. | 14640557 |
Inhibition (binding) | = 20 % | In vitro percent Inhibition of recombinant human prostaglandin G/H synthase 1 (COX-1) at a concentration of 100 microM | ChEMBL. | 14640557 |
Inhibition (binding) | = 20 % | In vitro percent Inhibition of recombinant human prostaglandin G/H synthase 2 (COX-2) at a concentration of 10 microM | ChEMBL. | 14640557 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.