Detailed information for compound 262129

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 340.368 | Formula: C17H24O7
  • H donors: 3 H acceptors: 4 LogP: -1.49 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@]12C[C@H](O)C(=C[C@H]1O[C@H]1[C@]3([C@]2(C)[C@H](OC(=O)C)[C@H]1O)CO3)C
  • InChi: 1S/C17H24O7/c1-8-4-11-16(6-18,5-10(8)20)15(3)13(23-9(2)19)12(21)14(24-11)17(15)7-22-17/h4,10-14,18,20-21H,5-7H2,1-3H3/t10-,11+,12+,13+,14+,15+,16+,17-/m0/s1
  • InChiKey: CSYVMZMEBKUDRQ-BNWDXEGFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica P-glycoprotein-1 0.0021 0.0509 0.2388
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0013 0.0038 0.5
Trichomonas vaginalis taga, putative 0.0021 0.0509 1
Echinococcus multilocularis multidrug resistance associated protein 7 0.0046 0.2103 0.644
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0046 0.2103 0.6706
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0509 1
Loa Loa (eye worm) ABC transporter 0.0013 0.0038 0.0038
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0228 0.0616
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.3117 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0228 0.0676
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0038 0.0585
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0228 0.4377
Echinococcus multilocularis ATP binding cassette sub family B 0.002 0.048 0.1394
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.3117 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0509 1
Echinococcus multilocularis 0.0013 0.0038 0.0021
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0509 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0509 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0228 0.0228
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0509 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.0038 0.0021
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.3117 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.0038 0.0021
Loa Loa (eye worm) fibroinase 0.0016 0.0228 0.0228
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0509 1
Toxoplasma gondii hypothetical protein 0.0173 1 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0123 0.0123
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.3117 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0228 0.0611
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.3117 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0509 1
Entamoeba histolytica P-glyco protein 6, putative 0.0021 0.0509 0.2388
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0509 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0228 0.0676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0228 0.4377
Trichomonas vaginalis abcb9, putative 0.0021 0.0509 1
Echinococcus granulosus intermediate filament protein 0.0028 0.0923 0.2822
Loa Loa (eye worm) hypothetical protein 0.0028 0.0923 0.0923
Brugia malayi hypothetical protein 0.0013 0.0038 0.009
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0509 0.1544
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0509 0.1544
Brugia malayi TAR-binding protein 0.0065 0.3248 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.3117 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.2103 0.2103
Brugia malayi Cathepsin L-like precursor 0.0016 0.0228 0.0676
Schistosoma mansoni multidrug resistance protein 0.0021 0.0509 0.1544
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0228 0.4377
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.3117 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0021 0.0509 0.0473
Leishmania major cathepsin L-like protease 0.0016 0.0228 0.0616
Echinococcus granulosus multidrug resistance associated protein 7 0.0046 0.2103 0.6465
Leishmania major cathepsin L-like protease 0.0016 0.0228 0.0616
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0509 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0228 0.4377
Loa Loa (eye worm) TAR-binding protein 0.0065 0.3248 0.3248
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0046 0.2103 0.6706
Toxoplasma gondii cathepsin CPL 0.0016 0.0228 0.019
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.3248 1
Loa Loa (eye worm) cysteine protease 0.0016 0.0228 0.0228
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0228 0.4028
Entamoeba histolytica P-glycoprotein-2, putative 0.0021 0.0509 0.2388
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0228 0.0611
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0509 0.0509
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.002 0.048 0.1453
Brugia malayi ABC transporter family protein 0.0021 0.0509 0.1544
Leishmania major cathepsin L-like protease 0.0016 0.0228 0.0616
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0046 0.2103 0.6706
Onchocerca volvulus 0.0028 0.0923 1
Echinococcus granulosus ATP binding cassette sub family B 0.0013 0.0038 0.009
Loa Loa (eye worm) multidrug resistance-associated protein 0.0033 0.1294 0.1294
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0228 0.4377
Echinococcus granulosus cathepsin l1 0.0016 0.0228 0.0676
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0509 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0509 0.1485
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.3117 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.2777 0.8896
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0509 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0509 0.1485
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.3117 1
Echinococcus granulosus multidrug resistance associated protein 4 0.0033 0.1265 0.3876
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0013 0.0038 0.5
Trypanosoma brucei multidrug resistance protein E 0.0046 0.2103 0.6706
Echinococcus multilocularis multidrug resistance associated protein 4 0.0033 0.1265 0.3833
Brugia malayi ABC transporter 0.0013 0.0038 0.009
Loa Loa (eye worm) multidrug resistance protein 3 0.0021 0.0509 0.0509
Entamoeba histolytica ATP-binding cassette protein, putative 0.0046 0.2103 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.3117 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0509 0.0509
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0013 0.0038 0.5
Leishmania major p-glycoprotein e 0.0046 0.2103 0.6706
Giardia lamblia MRP-like ABC transporter 0.0046 0.2103 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0032 0.0032
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0923 0.0923
Brugia malayi Cytochrome P450 family protein 0.003 0.1098 0.3361
Schistosoma mansoni smdr1 0.0013 0.0038 0.009
Echinococcus granulosus lamin dm0 0.0028 0.0923 0.2822
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0228 0.4377
Loa Loa (eye worm) hypothetical protein 0.0173 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0228 0.4377
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0228 0.4377
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.3117 1
Schistosoma mansoni lamin 0.0028 0.0923 0.2822
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.0038 0.0021
Entamoeba histolytica ATP-binding cassette protein, putative 0.0046 0.2103 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0509 1
Entamoeba histolytica P-glycoprotein 6, putative 0.0013 0.0038 0.014
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0228 0.1045
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0923 0.0923
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0509 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0509 0.1544
Trypanosoma cruzi multidrug resistance protein E, putative 0.0046 0.2103 0.6706
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0509 1
Echinococcus multilocularis cysteine protease 0.0016 0.0228 0.0611
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0021 0.0509 1
Trypanosoma brucei p-glycoprotein 0.0046 0.2103 0.6706
Loa Loa (eye worm) ABC transporter 0.0013 0.0038 0.0038
Entamoeba histolytica P-glycoprotein 5, putative 0.0021 0.0509 0.2388
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0509 1
Schistosoma mansoni intermediate filament proteins 0.0028 0.0923 0.2822
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0228 0.0676
Schistosoma mansoni tar DNA-binding protein 0.0065 0.3248 1
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0228 0.0676
Schistosoma mansoni smdr2 0.0021 0.0509 0.1544
Loa Loa (eye worm) hypothetical protein 0.0013 0.0038 0.0038
Brugia malayi intermediate filament protein 0.0028 0.0923 0.2822
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0228 0.4377
Entamoeba histolytica P-glycoprotein-5 0.0021 0.0509 0.2388
Echinococcus granulosus tar DNA binding protein 0.0065 0.3248 1
Leishmania major cathepsin L-like protease 0.0063 0.3117 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0046 0.2103 1
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0013 0.0038 0.5
Leishmania major p-glycoprotein 0.0021 0.0509 0.1529
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0509 0.1544
Giardia lamblia Multidrug resistance-associated protein 1 0.0046 0.2074 0.986
Brugia malayi Cathepsin L-like precursor 0.0016 0.0228 0.0676
Brugia malayi multidrug resistance protein 3 0.0021 0.0509 0.1544
Echinococcus granulosus ATP binding cassette sub family B 0.0013 0.0038 0.009
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.1098 0.1098
Loa Loa (eye worm) RNA binding protein 0.0065 0.3248 0.3248
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0046 0.2103 0.6706
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0228 0.0611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0228 0.4377
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0046 0.2103 0.6706
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.3117 1
Brugia malayi ABC transporter transmembrane region family protein 0.0013 0.0038 0.009
Plasmodium falciparum multidrug resistance protein 1 0.0021 0.0509 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0228 0.4377
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0509 0.1485
Brugia malayi multidrug resistance related protein 1 0.0046 0.2103 0.6465
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0013 0.0038 0.009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0228 0.4377
Schistosoma mansoni multidrug resistance protein 0.0046 0.2103 0.6465
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0509 0.1544
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0509 1
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0228 0.0616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0228 0.4377
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0046 0.2103 0.6706
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0228 0.0676
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0509 0.1485
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0123 0.0352
Trichomonas vaginalis abcb9, putative 0.0021 0.0509 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0228 0.4377
Schistosoma mansoni lamin 0.0028 0.0923 0.2822
Echinococcus multilocularis lamin 0.0028 0.0923 0.2772
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0046 0.2103 0.6706
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0021 0.0509 0.5
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0509 1
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0228 0.1045
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0046 0.2103 0.2073
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.2279 0.7277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0228 0.4377
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0509 0.1485
Entamoeba histolytica hypothetical protein 0.0046 0.2103 1
Echinococcus multilocularis cysteine protease 0.0016 0.0228 0.0611
Schistosoma mansoni multidrug resistance protein 0.0021 0.0509 0.1544
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0228 0.4377
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0013 0.0038 0.5
Brugia malayi ABC transporter family protein 0.0013 0.0038 0.009
Loa Loa (eye worm) ABC transporter 0.0013 0.0038 0.0038
Entamoeba histolytica P-glycoprotein-2 0.0021 0.0509 0.2388
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.0038 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.3117 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0228 0.0228
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0228 0.0611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0228 0.4377
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0509 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.3117 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0228 0.0676
Schistosoma mansoni multidrug resistance protein 0.0046 0.2103 0.6465
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0228 0.4377
Entamoeba histolytica P-glycoprotein 6, putative 0.0013 0.0038 0.014
Onchocerca volvulus 0.0028 0.0923 1
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0509 0.1544
Brugia malayi P-glycoprotein-like protein 0.0013 0.0038 0.009
Entamoeba histolytica P-glycoprotein-2 0.0021 0.0509 0.2388
Brugia malayi RNA binding protein 0.0065 0.3248 1
Schistosoma mansoni multidrug resistance protein 0.0013 0.0038 0.009
Loa Loa (eye worm) hypothetical protein 0.0046 0.2103 0.2103
Leishmania major pentamidine resistance protein 1 0.0046 0.2103 0.6706
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0013 0.0038 0.5
Schistosoma mansoni multidrug resistance protein 0.0021 0.0509 0.1544
Echinococcus granulosus multidrug resistance associated protein 1 0.0046 0.2103 0.6465
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0509 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0228 0.4377
Leishmania major cathepsin L-like protease 0.0016 0.0228 0.0616
Schistosoma mansoni tar DNA-binding protein 0.0065 0.3248 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.2074 0.2074
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0509 0.0473
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0228 0.4028
Leishmania major cathepsin L-like protease 0.0063 0.3117 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.3248 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0509 0.1485
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0021 0.0509 0.0509
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0013 0.0038 0.5
Giardia lamblia Multidrug resistance-associated protein 1 0.0046 0.2103 1
Leishmania major cathepsin L-like protease 0.0016 0.0228 0.0616
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0509 0.1544
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0021 0.0509 0.1529
Schistosoma mansoni tar DNA-binding protein 0.0065 0.3248 1
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0923 0.2822
Plasmodium vivax vivapain-2 0.0016 0.0228 0.4028
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0509 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0228 0.0676
Entamoeba histolytica cysteine protease, putative 0.0016 0.0228 0.1045
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0013 0.0038 0.5
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0046 0.2103 0.6706
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0228 0.4377
Giardia lamblia ABC transporter, putative 0.0046 0.2103 1
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0046 0.2103 0.2103
Echinococcus granulosus lamin 0.0028 0.0923 0.2822
Entamoeba histolytica multidrug resistance protein, putative 0.0046 0.2103 1
Echinococcus multilocularis tar DNA binding protein 0.0065 0.3248 1
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0013 0.0038 0.009
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0009
Brugia malayi ABC transporter transmembrane region family protein 0.0046 0.2103 0.6465
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0509 0.1485
Loa Loa (eye worm) hypothetical protein 0.002 0.048 0.048
Entamoeba histolytica ATP-binding cassette protein, putative 0.0046 0.2103 1
Schistosoma mansoni multidrug resistance protein 0.0046 0.2103 0.6465
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0228 0.4377
Loa Loa (eye worm) hypothetical protein 0.0027 0.0892 0.0892
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0509 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0509 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0228 0.4377
Trichomonas vaginalis abcb9, putative 0.0021 0.0509 1
Echinococcus multilocularis lamin dm0 0.0028 0.0923 0.2772
Brugia malayi ABC transporter family protein 0.0013 0.0038 0.009
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0032 0.0069
Onchocerca volvulus 0.0021 0.0509 0.4044
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0509 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0228 0.0228
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0228 0.4028
Leishmania major ABC-thiol transporter 0.0046 0.2103 0.6706
Entamoeba histolytica ABC transporter, putative 0.0046 0.2103 1
Trypanosoma cruzi hypothetical protein 0.0033 0.1265 0.3982
Schistosoma mansoni tar DNA-binding protein 0.0065 0.3248 1
Plasmodium vivax vivapain-2 0.0016 0.0228 0.4028
Echinococcus multilocularis musashi 0.0028 0.0923 0.2772
Loa Loa (eye worm) ctsf protein 0.0016 0.0228 0.0228
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0173 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0228 0.4377
Giardia lamblia Multidrug resistance-associated protein 1 0.0046 0.2103 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0509 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.3248 0.3248
Brugia malayi Cathepsin L-like precursor 0.0016 0.0228 0.0676
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0509 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0509 1
Leishmania major cathepsin L-like protease 0.0063 0.3117 1
Echinococcus multilocularis multidrug resistance associated protein 1 0.0046 0.2103 0.644
Schistosoma mansoni multidrug resistance protein 0.0046 0.2103 0.6465
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.3117 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0228 0.4377
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0228 0.4377
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0228 0.0676
Brugia malayi ABC transporter family protein 0.0013 0.0038 0.009
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0013 0.0038 0.5
Plasmodium vivax multidrug resistance protein 1, putative 0.0021 0.0509 1

Activities

Activity type Activity value Assay description Source Reference
LC50 (ADMET) = 20 ng ml-1 Cytotoxicity, assayed on L5178Y mouse lymphoma cells ChEMBL. 2918501
LC50 (ADMET) = 20 ng ml-1 Cytotoxicity, assayed on L5178Y mouse lymphoma cells ChEMBL. 2918501

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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