Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.1195 | 0.5 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0166 | 0.139 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0166 | 0.0123 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0995 | 0.1287 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0995 | 0.1188 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.5804 | 0.7856 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0667 | 0.0667 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.7374 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.1195 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.5804 | 0.7247 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.4446 | 0.4769 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.5804 | 0.7856 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.37 | 0.2845 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.1195 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0995 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0166 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0166 | 0.0123 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.7988 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.5804 | 0.7856 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0158 | 0.0114 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.7374 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.1195 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.5804 | 0.6243 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.5804 | 0.7856 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.5804 | 0.7247 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.1195 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.1195 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0166 | 0.0123 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.1401 | 0.0234 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.5804 | 0.7247 |
Onchocerca volvulus | 0.0024 | 0.1195 | 0.5 | |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0486 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1195 | 0.124 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.1195 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.5804 | 0.5234 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.1195 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.1195 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.1195 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0486 | 0.0592 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.1195 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.1195 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.1195 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.0166 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0667 | 0.0774 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1195 | 0.124 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.9266 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.4118 | 0.4413 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3712 | 0.3972 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.1195 | 1 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0486 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1195 | 0.124 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.1195 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.3293 | 0.4427 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0166 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.0166 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.3293 | 0.4427 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0166 | 0.0123 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 17 % | Percent inhibition of gastric proton-pump enzyme H+/K+ ATPase was determined at 50 uM | ChEMBL. | 2153817 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.