Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0071 | 0.3539 | 1 | |
Echinococcus granulosus | calpain A | 0.004 | 0.0999 | 0.0153 |
Giardia lamblia | Cathepsin B precursor | 0.0058 | 0.2425 | 0.5 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.015 | 1 | 1 |
Brugia malayi | calpain 7 | 0.004 | 0.0999 | 0.0999 |
Brugia malayi | Cathepsin L-like precursor | 0.0071 | 0.3539 | 0.3539 |
Schistosoma mansoni | calpain-7 (C02 family) | 0.004 | 0.0999 | 0.0153 |
Echinococcus multilocularis | hypothetical protein | 0.004 | 0.0999 | 0.0153 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0039 | 0.086 | 0.086 |
Entamoeba histolytica | cysteine protease, putative | 0.0039 | 0.086 | 0.243 |
Entamoeba histolytica | cysteine protease, putative | 0.0039 | 0.086 | 0.243 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0071 | 0.3539 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0039 | 0.086 | 0.243 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0071 | 0.3539 | 0.2931 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.1712 | 0.1712 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.3539 | 1 |
Leishmania major | cathepsin L-like protease | 0.0071 | 0.3539 | 1 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0039 | 0.086 | 0.243 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.3539 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0071 | 0.3539 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1712 | 0.1712 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0049 | 0.1712 | 0.0932 |
Schistosoma mansoni | calpain C (C02 family) | 0.004 | 0.0999 | 0.0153 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0071 | 0.3539 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Echinococcus multilocularis | calpain | 0.004 | 0.0999 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1712 | 0.1712 |
Entamoeba histolytica | cysteine protease, putative | 0.0071 | 0.3539 | 1 |
Echinococcus granulosus | cathepsin b | 0.015 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0071 | 0.3539 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0058 | 0.2425 | 0.6854 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0039 | 0.086 | 0.243 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0107 | 0.6488 | 0.6488 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.004 | 0.0999 | 0.0999 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Echinococcus granulosus | calpain 7 C02 family | 0.004 | 0.0999 | 0.0153 |
Brugia malayi | calpain family protein 1 | 0.0107 | 0.6488 | 0.6488 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0071 | 0.3539 | 0.3539 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0071 | 0.3539 | 0.3539 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.3539 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.3539 | 1 |
Leishmania major | cathepsin L-like protease | 0.0071 | 0.3539 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.3539 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.3539 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0071 | 0.3539 | 0.3539 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.004 | 0.0999 | 0.0999 |
Brugia malayi | Cathepsin L-like precursor | 0.0071 | 0.3539 | 0.3539 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C2, putative | 0.004 | 0.0999 | 0.2824 |
Trypanosoma brucei | calpain-like protein, putative | 0.004 | 0.0999 | 0.2824 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0071 | 0.3539 | 1 |
Onchocerca volvulus | 0.0071 | 0.3539 | 1 | |
Toxoplasma gondii | cathepsin CPL | 0.0071 | 0.3539 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0058 | 0.2425 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0071 | 0.3539 | 0.3539 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0039 | 0.086 | 0.243 |
Echinococcus multilocularis | cathepsin b | 0.015 | 1 | 1 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.004 | 0.0999 | 0.0999 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0039 | 0.086 | 0.243 |
Plasmodium vivax | calpain, putative | 0.004 | 0.0999 | 0.0521 |
Entamoeba histolytica | cysteine protease, putative | 0.0039 | 0.086 | 0.243 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.3539 | 1 |
Leishmania major | cathepsin L-like protease | 0.0071 | 0.3539 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0039 | 0.086 | 0.243 |
Leishmania major | cysteine peptidase A (CPA) | 0.0071 | 0.3539 | 1 |
Onchocerca volvulus | 0.0071 | 0.3539 | 1 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0071 | 0.3539 | 0.2931 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0071 | 0.3539 | 0.3539 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0049 | 0.1712 | 0.1712 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0071 | 0.3539 | 0.3539 |
Echinococcus granulosus | calpain | 0.004 | 0.0999 | 0.0153 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0049 | 0.1712 | 0.4839 |
Onchocerca volvulus | 0.0071 | 0.3539 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.0049 | 0.1712 | 0.0932 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0071 | 0.3539 | 0.3539 |
Trypanosoma brucei | antigen, putative | 0.004 | 0.0999 | 0.2824 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1712 | 0.1712 |
Trypanosoma cruzi | cysteine protease, putative | 0.0039 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.3539 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0039 | 0.086 | 0.086 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0122 | 0.7694 | 0.7477 |
Onchocerca volvulus | 0.0067 | 0.3163 | 0.7946 | |
Entamoeba histolytica | cysteine protease, putative | 0.0039 | 0.086 | 0.243 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0079 | 0.4163 | 0.3614 |
Leishmania major | cathepsin L-like protease | 0.0071 | 0.3539 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0071 | 0.3539 | 0.2931 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Onchocerca volvulus | 0.0071 | 0.3539 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.4163 | 0.4163 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.004 | 0.0999 | 0.2824 |
Trypanosoma cruzi | calpain cysteine peptidase, putative | 0.004 | 0.0999 | 0.0999 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0058 | 0.2425 | 0.1713 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0039 | 0.086 | 0.086 |
Echinococcus multilocularis | calpain 7 (C02 family) | 0.004 | 0.0999 | 0.0153 |
Brugia malayi | cathepsin L-like precursor | 0.0049 | 0.1712 | 0.1712 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0071 | 0.3539 | 0.2931 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.004 | 0.0999 | 0.0999 |
Entamoeba histolytica | cysteine protease, putative | 0.0039 | 0.086 | 0.243 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0039 | 0.086 | 0.086 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.015 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.015 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.015 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0039 | 0.086 | 0.243 |
Entamoeba histolytica | cysteine protease, putative | 0.0039 | 0.086 | 0.243 |
Loa Loa (eye worm) | cathepsin B | 0.0058 | 0.2425 | 0.2425 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1712 | 0.3182 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.6488 | 0.6488 |
Brugia malayi | Cathepsin L-like precursor | 0.0071 | 0.3539 | 0.3539 |
Plasmodium vivax | vivapain-2 | 0.0071 | 0.3539 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Leishmania major | cathepsin L-like protease | 0.0071 | 0.3539 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0071 | 0.3539 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0039 | 0.086 | 0.243 |
Echinococcus multilocularis | calpain 5 | 0.004 | 0.0999 | 0.0153 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0122 | 0.7694 | 0.7477 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0071 | 0.3539 | 0.3539 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.004 | 0.0999 | 0.0999 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.004 | 0.0999 | 0.0999 |
Onchocerca volvulus | 0.0071 | 0.3539 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0071 | 0.3539 | 0.3539 |
Entamoeba histolytica | cysteine protease, putative | 0.0039 | 0.086 | 0.243 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0058 | 0.2425 | 0.5844 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0071 | 0.3539 | 0.2931 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0107 | 0.6488 | 0.6157 |
Giardia lamblia | Cathepsin B precursor | 0.0058 | 0.2425 | 0.5 |
Loa Loa (eye worm) | fibroinase | 0.0071 | 0.3539 | 0.3539 |
Plasmodium vivax | vivapain-2 | 0.0071 | 0.3539 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0049 | 0.1712 | 0.3182 |
Trypanosoma brucei | calpain-like protein, putative | 0.004 | 0.0999 | 0.2824 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.5488 | 0.5488 |
Leishmania major | calpain, putative,cysteine peptidase, Clan CA, family C2, putative | 0.004 | 0.0999 | 0.2824 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0071 | 0.3539 | 1 |
Leishmania major | cathepsin L-like protease | 0.0071 | 0.3539 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0039 | 0.086 | 0.243 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0039 | 0.086 | 0.086 |
Trypanosoma brucei | calpain-like protein, putative | 0.004 | 0.0999 | 0.2824 |
Entamoeba histolytica | cysteine protease, putative | 0.0039 | 0.086 | 0.243 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0079 | 0.4163 | 0.4163 |
Brugia malayi | Cathepsin L-like precursor | 0.0049 | 0.1712 | 0.1712 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0039 | 0.086 | 0.243 |
Schistosoma mansoni | calpain (C02 family) | 0.004 | 0.0999 | 0.0153 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.004 | 0.0999 | 0.0999 |
Echinococcus multilocularis | cysteine protease | 0.0071 | 0.3539 | 0.2931 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0071 | 0.3539 | 0.2931 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0071 | 0.3539 | 0.2931 |
Echinococcus granulosus | cathepsin l1 | 0.0071 | 0.3539 | 0.2931 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3163 | 0.3163 |
Echinococcus multilocularis | cysteine protease | 0.0071 | 0.3539 | 0.2931 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.015 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0071 | 0.3539 | 1 |
Leishmania major | cathepsin L-like protease | 0.0071 | 0.3539 | 1 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.004 | 0.0999 | 0.2824 |
Echinococcus granulosus | cathepsin b | 0.015 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.3539 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.015 | 1 | 1 |
Echinococcus granulosus | calpain A | 0.0122 | 0.7752 | 0.754 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.3539 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0058 | 0.2425 | 0.2425 |
Echinococcus multilocularis | calpain A | 0.0122 | 0.7752 | 0.754 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0122 | 0.7694 | 0.7477 |
Loa Loa (eye worm) | calpain | 0.004 | 0.0999 | 0.0999 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0058 | 0.2425 | 0.6854 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0071 | 0.3539 | 1 |
Schistosoma mansoni | Mername-AA248 (C02 family) | 0.004 | 0.0999 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3539 | 0.3539 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0039 | 0.086 | 0.243 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.004 | 0.0999 | 0.2824 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0039 | 0.086 | 0.243 |
Brugia malayi | Cathepsin L-like precursor | 0.0071 | 0.3539 | 0.3539 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0039 | 0.086 | 0.243 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0071 | 0.3539 | 0.3539 |
Onchocerca volvulus | 0.0071 | 0.3539 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0071 | 0.3539 | 1 |
Brugia malayi | calpain family protein 1 | 0.0107 | 0.6488 | 0.6488 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0071 | 0.3539 | 0.3539 |
Schistosoma mansoni | calpain-7 (C02 family) | 0.004 | 0.0999 | 0.0153 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0039 | 0.086 | 0.086 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0122 | 0.7694 | 0.7477 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.004 | 0.0999 | 0.0999 |
Trypanosoma brucei | calpain-like protein, putative | 0.004 | 0.0999 | 0.2824 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0071 | 0.3539 | 0.2931 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.004 | 0.0999 | 0.0999 |
Echinococcus granulosus | calpain 5 | 0.004 | 0.0999 | 0.0153 |
Brugia malayi | Cathepsin L-like precursor | 0.0071 | 0.3539 | 0.3539 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0071 | 0.3539 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0049 | 0.1712 | 0.1712 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 50 uM | Inhibition of phosphorylation of a random glutamate/tyrosine copolymer in lysates of transfected Sf9 insect cells overexpressing mouse platelet-derived growth factor receptor beta | ChEMBL. | 9876115 |
IC50 (binding) | > 50 uM | Inhibition of phosphorylation of a random glutamate/tyrosine copolymer in lysates of transfected Sf9 insect cells overexpressing human fibroblast growth factor receptor 1 | ChEMBL. | 9876115 |
IC50 (binding) | > 50 uM | Inhibition of phosphorylation of a random glutamate/tyrosine copolymer in lysates of transfected Sf9 insect cells overexpressing mouse platelet-derived growth factor receptor beta | ChEMBL. | 9876115 |
IC50 (binding) | > 50 uM | Inhibition of phosphorylation of a random glutamate/tyrosine copolymer in lysates of transfected Sf9 insect cells overexpressing human fibroblast growth factor receptor 1 | ChEMBL. | 9876115 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.