Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neurokinin 1 receptor | Starlite/ChEMBL | No references |
Cavia porcellus | Neurokinin 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04224 tachykinin receptor 3, putative | Get druggable targets OG5_137770 | All targets in OG5_137770 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.017 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.017 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.017 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.017 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.017 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.017 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.017 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.017 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.017 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.017 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.017 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.017 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.017 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.017 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.017 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.017 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.017 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.017 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.017 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.017 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.017 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.017 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.017 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.017 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.017 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.017 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.017 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.017 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.017 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.017 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.017 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.017 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.017 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.017 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.017 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.017 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.017 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.017 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.017 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.017 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.017 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.017 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.017 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.017 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.017 | 0.5 | 0.5 |
Onchocerca volvulus | 0.017 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.017 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.017 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.017 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.017 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.017 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.017 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 160 nM | Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]-SP as the radioligand | ChEMBL. | No reference |
IC50 (binding) | = 160 nM | Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]-SP as the radioligand | ChEMBL. | No reference |
IC50 (binding) | = 7200 nM | Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand | ChEMBL. | No reference |
IC50 (binding) | = 7200 nM | Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligand | ChEMBL. | No reference |
IC50 (binding) | >= 100000 nM | Ability to displace the binding of [125I]-iodohistidyl-NKA to Tachykinin receptor 2 in hamster urinary bladder membranes was determined. | ChEMBL. | No reference |
IC50 (binding) | >= 100000 nM | Ability to displace the binding of [3H]-Senktide to Tachykinin receptor 3 in rat cerebral cortex membranes was determined. | ChEMBL. | No reference |
IC50 (binding) | >= 100000 nM | Ability to displace the binding of [125I]-iodohistidyl-NKA to Tachykinin receptor 2 in hamster urinary bladder membranes was determined. | ChEMBL. | No reference |
IC50 (binding) | >= 100000 nM | Ability to displace the binding of [3H]-Senktide to Tachykinin receptor 3 in rat cerebral cortex membranes was determined. | ChEMBL. | No reference |
Ratio (binding) | = 45 | Ratio of binding affinity for NK1 receptor in guinea pig to that of rat was determined | ChEMBL. | No reference |
Ratio (binding) | = 45 | Ratio of binding affinity for NK1 receptor in guinea pig to that of rat was determined | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.