Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0188 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0188 | 1 | 1 |
Onchocerca volvulus | 0.0149 | 0.7606 | 0.5 | |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.7606 | 0.7606 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0135 | 0.6767 | 0.6767 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0188 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0149 | 0.7606 | 0.7606 |
Loa Loa (eye worm) | TAR-binding protein | 0.0188 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0188 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0188 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0135 | 0.6767 | 0.6767 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0188 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 45 % | Percent inhibition [3H]-Ro-15-1788 binding to Benzodiazepine receptor from bovine brain membrane at 10 uM | ChEMBL. | 12477354 |
Inhibition (binding) | = 45 % | Percent inhibition [3H]-Ro-15-1788 binding to Benzodiazepine receptor from bovine brain membrane at 10 uM | ChEMBL. | 12477354 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.