TDR Targets

Basic information

Technical information

TDR Targets ID: 262724
Name: 6-[8-hydroxy-3-[6-[3-(4-methylpiperazin-1-yl) propylamino]-6-oxohexyl]-1,4-dioxonaphthalen- 2-yl]-N-[3-(4-methylpiperazin-1-yl)propyl]hex anamide
MW: 680.92 | Formula: C38H60N6O5
H donors: 3 H acceptors: 5 LogP: 3.97 Rotable bonds: 22
Rule of 5 violations (Lipinski): 2
SMILES: CN1CCN(CC1)CCCNC(=O)CCCCCC1=C(CCCCCC(=O)NCCCN2CCN(CC2)C)C(=O)c2c(C1=O)c(O)ccc2
InChi: 1S/C38H60N6O5/c1-41-22-26-43(27-23-41)20-10-18-39-34(46)16-7-3-5-12-30-31(38(49)36-32(37(30)48)14-9-15-33(36)45)13-6-4-8-17-35(47)40-19-11-21-44-28-24-42(2)25-29-44/h9,14-15,45H,3-8,10-13,16-29H2,1-2H3,(H,39,46)(H,40,47)
InChiKey: DBLAAUCCCYMOJJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-[8-hydroxy-3-[6-[3-(4-methylpiperazin-1-yl)propylamino]-6-oxo-hexyl]-1,4-dioxo-2-naphthyl]-N-[3-(4-methylpiperazin-1-yl)propyl]hexanamide
6-[8-hydroxy-3-[6-[3-(4-methyl-1-piperazinyl)propylamino]-6-oxohexyl]-1,4-dioxo-2-naphthyl]-N-[3-(4-methyl-1-piperazinyl)propyl]hexanamide
6-[8-hydroxy-3-[6-[3-(4-methylpiperazin-1-yl)propylamino]-6-oxo-hexyl]-1,4-dioxo-naphthalen-2-yl]-N-[3-(4-methylpiperazin-1-yl)propyl]hexanamide
6-[8-hydroxy-1,4-diketo-3-[6-keto-6-[3-(4-methylpiperazino)propylamino]hexyl]-2-naphthyl]-N-[3-(4-methylpiperazino)propyl]hexanamide
6-[8-hydroxy-1,4-diketo-3-[6-keto-6-[3-(4-methylpiperazin-1-yl)propylamino]hexyl]-2-naphthyl]-N-[3-(4-methylpiperazin-1-yl)propyl]hexanamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma cruzi	trypanothione reductase, putative	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium falciparum	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Toxoplasma gondii	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Cryptosporidium hominis	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Neospora caninum	Glutathione reductase, related	Get druggable targets OG5_126785	All targets in OG5_126785
Candida albicans	similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase	Get druggable targets OG5_126785	All targets in OG5_126785
Babesia bovis	thiodoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus granulosus	thioredoxin glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania braziliensis	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium berghei	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma cruzi	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania donovani	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Loa Loa (eye worm)	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma brucei	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus multilocularis	thioredoxin glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium knowlesi	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania major	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania infantum	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma brucei gambiense	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium yoelii	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium knowlesi	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Loa Loa (eye worm)	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Candida albicans	similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase	Get druggable targets OG5_126785	All targets in OG5_126785
Neospora caninum	MGC84926 protein, related	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium yoelii	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium berghei	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Theileria parva	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania mexicana	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium vivax	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Brugia malayi	Thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium vivax	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Schistosoma japonicum	ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma congolense	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium falciparum	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Cryptosporidium parvum	thioredoxin reductase 1	Get druggable targets OG5_126785	All targets in OG5_126785

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	trypanothione reductase, putative	492 aa	548 aa	21.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0038	0.0023	0.0071
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0354	0.063	0.063
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0051	0.0153
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0792	0.1473	0.4598
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0014	0.0045
Mycobacterium tuberculosis	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)	0.0354	0.063	0.063
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.1691	0.3203	0.3203
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.1691	0.3203	0.3203
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0354	0.063	0.063
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0279	0.0486	0.0486
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0279	0.0486	0.1516
Toxoplasma gondii	hypothetical protein	0.0053	0.0051	0.0051
Toxoplasma gondii	GAF domain-containing protein	0.0513	0.0936	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0312	0.055	0.177
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.1631	0.3088	0.964
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0279	0.0486	0.0486
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0279	0.0486	0.0486
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0312	0.055	0.1717
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0279	0.0486	0.0486
Trichomonas vaginalis	hypothetical protein	0.5223	1	1
Echinococcus granulosus	ectonucleotide	0.0029	0.0004	0.0013
Mycobacterium leprae	conserved hypothetical protein	0.0513	0.0936	0.0936
Loa Loa (eye worm)	norepinephrine transporter	0.0312	0.055	0.177
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0053	0.0051	0.016
Mycobacterium ulcerans	short chain dehydrogenase	0.0354	0.063	0.063
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0053	0.0051	0.016
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.1691	0.3203	0.3203
Plasmodium falciparum	transporter, putative	0.0053	0.0051	0.0051
Loa Loa (eye worm)	TK protein kinase	0.0034	0.0015	0.0037
Mycobacterium ulcerans	short chain dehydrogenase	0.0354	0.063	0.063
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0279	0.0486	0.1516
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0053	0.0051	0.0051
Echinococcus multilocularis	ectonucleotide	0.0029	0.0004	0.0013
Schistosoma mansoni	tyrosine kinase	0.0038	0.0023	0.0071
Toxoplasma gondii	hypothetical protein	0.0053	0.0051	0.0051
Leishmania major	hypothetical protein, conserved	0.0279	0.0486	0.1516
Brugia malayi	glutathione reductase	0.0076	0.0096	0.031
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0354	0.063	0.204
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0354	0.063	0.1966
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0354	0.063	0.2029
Loa Loa (eye worm)	PDE1B protein	0.1631	0.3088	1
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.1691	0.3203	1
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0354	0.063	0.1966
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0038	0.0023	0.0071
Trichomonas vaginalis	conserved hypothetical protein	0.1412	0.2667	0.2667
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0051	0.0153
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.1691	0.3203	0.3203
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	0.0354	0.063	0.063
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0038	0.0023	0.0071
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0029	0.0004	0.0013
Mycobacterium ulcerans	short chain dehydrogenase	0.0354	0.063	0.063
Trypanosoma brucei	pteridine reductase 1	0.0354	0.063	0.1966
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0354	0.063	0.1966
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0279	0.0486	0.0486
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0279	0.0486	0.0486
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0279	0.0486	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0279	0.0486	0.1562
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0279	0.0486	0.1516
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.1691	0.3203	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0279	0.0486	0.0486
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0279	0.0486	0.0486
Brugia malayi	SRC-1	0.0038	0.0023	0.0073
Toxoplasma gondii	3-ketoacyl-(acyl-carrier-protein) reductase	0.0354	0.063	0.063
Trichomonas vaginalis	conserved hypothetical protein	0.1412	0.2667	0.2667
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0354	0.063	0.063
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.1691	0.3203	0.3203
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0279	0.0486	0.1516
Mycobacterium ulcerans	short chain dehydrogenase	0.0354	0.063	0.063
Toxoplasma gondii	hypothetical protein	0.0513	0.0936	0.0936
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.1691	0.3203	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0279	0.0486	0.1516
Plasmodium falciparum	glutathione reductase	0.0076	0.0096	0.0096
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.1691	0.3203	0.3203
Mycobacterium ulcerans	short chain dehydrogenase	0.0354	0.063	0.063
Mycobacterium ulcerans	putative regulatory protein	0.0513	0.0936	0.0936
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0354	0.063	0.063
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.1691	0.3203	0.3203
Leishmania major	pteridine reductase 1	0.0354	0.063	0.1966
Loa Loa (eye worm)	serotonin transporter b	0.0312	0.055	0.177
Brugia malayi	Thioredoxin reductase	0.0076	0.0096	0.031
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0014	0.0045
Mycobacterium ulcerans	short chain dehydrogenase	0.0354	0.063	0.063
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0279	0.0486	0.0486
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0279	0.0486	0.0486
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0354	0.063	0.063
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0312	0.055	0.1781
Leishmania major	3-oxoacyl-ACP reductase, putative	0.0354	0.063	0.1966
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0279	0.0486	0.1562
Trypanosoma cruzi	hypothetical protein, conserved	0.0279	0.0486	0.1516
Toxoplasma gondii	hypothetical protein	0.0513	0.0936	0.0936
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0038	0.0023	0.0071
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.1691	0.3203	0.3203
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0053	0.0051	0.0153
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.1691	0.3203	0.3203
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0014	0.0045
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0279	0.0486	0.0486
Echinococcus granulosus	thioredoxin glutathione reductase	0.0076	0.0096	0.0299
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0279	0.0486	0.0486
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0038	0.0023	0.0071
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0279	0.0486	0.1516
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0792	0.1473	0.477
Loa Loa (eye worm)	hypothetical protein	0.0312	0.055	0.177
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0053	0.0051	0.0051
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0053	0.0051	0.016
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0354	0.063	0.063
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0014	0.0033
Mycobacterium ulcerans	short chain dehydrogenase	0.0354	0.063	0.063
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0354	0.063	0.1966
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0034	0.0015	0.0048
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0279	0.0486	0.0486
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0053	0.0051	0.016
Treponema pallidum	sodium- and chloride- dependent transporter	0.0312	0.055	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0076	0.0096	0.0096
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0279	0.0486	0.0486
Trypanosoma cruzi	hypothetical protein, conserved	0.0279	0.0486	0.1516
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0053	0.0051	0.0166
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0279	0.0486	0.1516
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.1691	0.3203	0.3203
Mycobacterium ulcerans	short chain dehydrogenase	0.0354	0.063	0.063
Echinococcus granulosus	serotonin transporter	0.0312	0.055	0.1717
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0354	0.063	0.1966
Loa Loa (eye worm)	hypothetical protein	0.0279	0.0486	0.1562
Trypanosoma cruzi	hypothetical protein, conserved	0.0279	0.0486	0.1516
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.5223	1	1
Loa Loa (eye worm)	hypothetical protein	0.0279	0.0486	0.1562
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.1631	0.3088	0.964
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0053	0.0051	0.0051
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0038	0.0023	0.0071
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0279	0.0486	0.0486
Loa Loa (eye worm)	SRC-1	0.0038	0.0023	0.006
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0279	0.0486	0.1516
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0354	0.063	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0053	0.0051	0.016
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0792	0.1473	0.477
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0038	0.0023	0.0071
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0354	0.063	0.063
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.1691	0.3203	0.3203
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.1691	0.3203	0.3203
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0038	0.0023	0.0071
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0076	0.0096	0.0299
Chlamydia trachomatis	oxoacy-ACP reductase	0.0354	0.063	0.063
Mycobacterium ulcerans	short chain dehydrogenase	0.0354	0.063	0.063
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0038	0.0023	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0792	0.1473	0.4763
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0053	0.0051	0.016
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0029	0.0004	0.0013
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0279	0.0486	0.1516
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0354	0.063	0.063
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] reductase, putative	0.0354	0.063	0.063
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0279	0.0486	0.1573
Mycobacterium ulcerans	oxidoreductase	0.0354	0.063	0.063
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.5223	1	1
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0354	0.063	0.063
Brugia malayi	Thrombospondin type 1 domain containing protein	0.0073	0.009	0.0291
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.1691	0.3203	0.3203
Giardia lamblia	Hypothetical protein	0.0279	0.0486	1
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0034	0.0014	0.0045
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.5223	1	1
Onchocerca volvulus		0.0354	0.063	1
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.0354	0.063	0.1966
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0354	0.063	0.1966
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0279	0.0486	0.0486
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0279	0.0486	0.0486
Mycobacterium tuberculosis	Possible oxidoreductase	0.0354	0.063	0.063
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0279	0.0486	0.1516
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0354	0.063	0.063
Trypanosoma cruzi	hypothetical protein, conserved	0.0279	0.0486	0.1516
Plasmodium vivax	phosphodiesterase gamma, putative	0.0279	0.0486	0.0486
Trypanosoma cruzi	hypothetical protein, conserved	0.0279	0.0486	0.1516
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0033	0.0013	0.0042
Mycobacterium tuberculosis	Possible oxidoreductase	0.0354	0.063	0.063
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.1691	0.3203	0.3203
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.1691	0.3203	1
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0014	0.0045
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0279	0.0486	0.1516
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.1178	0.2216	0.6918
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0279	0.0486	0.0486
Mycobacterium ulcerans	20-beta-hydroxysteroid dehydrogenase FabG3	0.0354	0.063	0.063
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0279	0.0486	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0053	0.0051	0.0166
Schistosoma mansoni	sodium/chloride dependent transporter	0.0053	0.0051	0.016
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0033	0.0013	0.0042
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.1691	0.3203	1
Onchocerca volvulus		0.0053	0.0051	0.0598
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0279	0.0486	0.1516
Trichomonas vaginalis	conserved hypothetical protein	0.0279	0.0486	0.0486
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0034	0.0015	0.0048
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0038	0.0023	0.0071
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.5223	1	1
Echinococcus multilocularis	serotonin transporter	0.0312	0.055	0.1717
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0513	0.0936	0.0936
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0513	0.0936	0.0936
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.1691	0.3203	0.3203
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0279	0.0486	0.0486
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0014	0.0045
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.1691	0.3203	0.3203
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0053	0.0051	0.0153
Plasmodium vivax	hypothetical protein, conserved	0.0513	0.0936	0.0936
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0034	0.0014	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0279	0.0486	0.0486
Echinococcus granulosus	sodium and chloride dependent glycine	0.0053	0.0051	0.016
Trypanosoma brucei	trypanothione reductase	0.0076	0.0096	0.0299
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0279	0.0486	0.0486
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0354	0.063	0.1966
Leishmania major	trypanothione reductase	0.0076	0.0096	0.0299
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.1631	0.3088	1
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0354	0.063	0.063
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0034	0.0014	0.0045
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.1691	0.3203	0.3203
Brugia malayi	hypothetical protein	0.0053	0.0051	0.0166
Schistosoma mansoni	dihydropteridine reductase	0.0354	0.063	0.1966
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.1691	0.3203	1
Onchocerca volvulus		0.0312	0.055	0.8702
Onchocerca volvulus		0.0354	0.063	1
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0792	0.1473	0.4598
Plasmodium falciparum	thioredoxin reductase	0.0076	0.0096	0.0096
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0279	0.0486	0.1573
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0014	0.0045
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0034	0.0015	0.0048
Mycobacterium leprae	POSSIBLE OXIDOREDUCTASE	0.0354	0.063	0.063
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0279	0.0486	0.0486
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0354	0.063	0.063
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0792	0.1473	0.1473
Plasmodium vivax	glutathione reductase, putative	0.0076	0.0096	0.0096
Mycobacterium tuberculosis	Probable oxidoreductase	0.0354	0.063	0.063
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0279	0.0486	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0051	0.0153
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0354	0.063	0.204
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0354	0.063	0.1966
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0053	0.0051	0.0166
Trichomonas vaginalis	conserved hypothetical protein	0.1691	0.3203	0.3203
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0279	0.0486	0.1516
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.1691	0.3203	0.3203
Trypanosoma brucei	oxidoreductase-like protein	0.0354	0.063	0.1966
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0053	0.0051	0.016
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0014	0.0045
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0354	0.063	0.063
Loa Loa (eye worm)	thioredoxin reductase	0.0076	0.0096	0.0297
Trypanosoma cruzi	hypothetical protein, conserved	0.0279	0.0486	0.1516
Trypanosoma cruzi	trypanothione reductase, putative	0.0076	0.0096	0.0299
Plasmodium falciparum	enoyl-acyl carrier reductase	0.5223	1	1
Loa Loa (eye worm)	hypothetical protein	0.0312	0.055	0.177
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0014	0.0045
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0279	0.0486	0.1516
Plasmodium vivax	thioredoxin reductase, putative	0.0076	0.0096	0.0096
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0053	0.0051	0.0166
Leishmania major	hypothetical protein, conserved	0.0279	0.0486	0.1516
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0354	0.063	0.063
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.5223	1	1
Plasmodium falciparum	phosphodiesterase delta, putative	0.0279	0.0486	0.0486
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.1691	0.3203	0.3203
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0053	0.0051	0.0051
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0279	0.0486	0.1573
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0792	0.1473	0.1473
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0354	0.063	0.063
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0053	0.0051	0.016
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0354	0.063	0.2029
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0279	0.0486	0.1516
Echinococcus granulosus	tyrosine protein kinase HCK	0.0031	0.0008	0.0025
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0038	0.0023	0.0071
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0034	0.0014	0.0045
Toxoplasma gondii	hypothetical protein	0.1412	0.2667	0.2667
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0279	0.0486	0.0486
Onchocerca volvulus		0.0053	0.0051	0.0598
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0053	0.0051	0.016
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0279	0.0486	0.1516
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0279	0.0486	0.0486
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.1691	0.3203	0.3203
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.1691	0.3203	0.3203
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0513	0.0936	0.0936
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.1631	0.3088	0.964
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.1691	0.3203	0.3203
Echinococcus granulosus	tyrosine protein kinase Blk	0.0034	0.0015	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0014	0.0033
Loa Loa (eye worm)	oxidoreductase	0.0354	0.063	0.2029
Loa Loa (eye worm)	hypothetical protein	0.0513	0.0936	0.3023
Schistosoma mansoni	sodium/chloride dependent transporter	0.0053	0.0051	0.016
Trypanosoma brucei	hypothetical protein, conserved	0.0279	0.0486	0.1516
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0038	0.0023	0.0071
Loa Loa (eye worm)	thrombospondin type 1 domain-containing protein	0.0073	0.009	0.0278
Plasmodium falciparum	amino acid transporter, putative	0.0053	0.0051	0.0051
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0279	0.0486	0.0486
Mycobacterium ulcerans	putative regulatory protein	0.0513	0.0936	0.0936
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.1691	0.3203	0.3203
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0279	0.0486	0.0486
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0038	0.0023	0.0071
Mycobacterium leprae	3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI	0.0354	0.063	0.063
Loa Loa (eye worm)	hypothetical protein	0.0354	0.063	0.2029
Plasmodium falciparum	GAF domain-related protein, putative	0.0513	0.0936	0.0936
Onchocerca volvulus		0.0073	0.009	0.1226
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0014	0.0045
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.1691	0.3203	0.3203
Plasmodium vivax	amine transporter, putative	0.0053	0.0051	0.0051
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0792	0.1473	0.4598
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0034	0.0014	0.0045
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0354	0.063	0.063
Trichomonas vaginalis	conserved hypothetical protein	0.0513	0.0936	0.0936
Giardia lamblia	hypothetical protein	0.0279	0.0486	1
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0053	0.0051	0.016
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0051	0.0153
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0279	0.0486	0.1516
Brugia malayi	protein-tyrosine kinase	0.0034	0.0015	0.005
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0279	0.0486	0.0486
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0053	0.0051	0.016
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0279	0.0486	0.1516
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0031	0.0008	0.0025
Toxoplasma gondii	thioredoxin reductase	0.0076	0.0096	0.0096
Schistosoma mansoni	tyrosine kinase	0.0038	0.0023	0.0071
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0279	0.0486	0.1516
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0053	0.0051	0.016
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0279	0.0486	0.0486
Mycobacterium ulcerans	short chain dehydrogenase	0.0354	0.063	0.063
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0354	0.063	0.063
Loa Loa (eye worm)	TK protein kinase	0.0031	0.0008	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0014	0.0033
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0034	0.0015	0.0048
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.1691	0.3203	0.3203
Trichomonas vaginalis	conserved hypothetical protein	0.1412	0.2667	0.2667
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0312	0.055	0.177
Toxoplasma gondii	short chain dehydrogenase family protein, putative	0.0354	0.063	0.063
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0014	0.0045
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0279	0.0486	0.0486
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0279	0.0486	0.1516
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0053	0.0051	0.016
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0053	0.0051	0.016
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.1691	0.3203	0.3203
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.1691	0.3203	0.3203
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0038	0.0023	0.0071
Echinococcus granulosus	tyrosine kinase	0.0034	0.0015	0.0048
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0053	0.0051	0.016
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0354	0.063	0.063
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0279	0.0486	0.1516
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0279	0.0486	0.1516
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0051	0.0153
Mycobacterium tuberculosis	Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase)	0.0354	0.063	0.063
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0279	0.0486	0.1516
Schistosoma mansoni	hypothetical protein	0.0073	0.009	0.0281
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.5223	1	1
Leishmania major	oxidoreductase-like protein	0.0354	0.063	0.1966
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0279	0.0486	0.1516
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0053	0.0051	0.016
Loa Loa (eye worm)	glutathione reductase	0.0076	0.0096	0.0297
Echinococcus granulosus	sodium and chloride dependent glycine	0.0053	0.0051	0.016
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.1178	0.2216	0.2216
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0038	0.0023	0.0071
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0038	0.0023	0.0071
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0354	0.063	0.063
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0053	0.0051	0.016
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0279	0.0486	0.0486
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0354	0.063	0.063
Mycobacterium ulcerans	short chain dehydrogenase	0.0354	0.063	0.063
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0053	0.0051	0.016
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0279	0.0486	0.1516
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0792	0.1473	0.1473
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0279	0.0486	0.0486
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0279	0.0486	0.0486
Schistosoma mansoni	sodium/chloride dependent transporter	0.0312	0.055	0.1717
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0279	0.0486	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0051	0.0153
Mycobacterium ulcerans	short chain dehydrogenase	0.0354	0.063	0.063
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.1691	0.3203	0.3203
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0051	0.0153
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0279	0.0486	0.0486
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0279	0.0486	0.1516
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.1178	0.2216	0.2216
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0279	0.0486	0.0486
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0034	0.0014	0.0045
Onchocerca volvulus		0.0053	0.0051	0.0598
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0038	0.0023	0.0071
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.1691	0.3203	1
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0279	0.0486	0.1516
Plasmodium vivax	hypothetical protein, conserved	0.0053	0.0051	0.0051
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0354	0.063	0.063
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0354	0.063	0.063
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.1691	0.3203	1
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0279	0.0486	0.1516

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	0 uM	In vitro antiparasitic activity against L. donavani was tested by sigmoidal regression analysis; at 10 microM value is T/	ChEMBL.	11170645
ED50 (functional)	0 uM	In vitro antiparasitic activity against T. cruzi was tested by sigmoidal regression analysis; at 30 microM value is T/	ChEMBL.	11170645
ED50 (functional)	= 10.1 uM	In vitro antiparasitic activity against Trypanosoma brucei was tested by sigmoidal regression analysis	ChEMBL.	11170645
ED50 (functional)	= 10.1 uM	In vitro antiparasitic activity against Trypanosoma brucei was tested by sigmoidal regression analysis	ChEMBL.	11170645
IC50 (binding)	= 0.8 uM	Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.	ChEMBL.	11170645
IC50 (binding)	= 0.8 uM	Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.	ChEMBL.	11170645
Toxic dose (ADMET)	= 10 uM	Compound dose toxic against magrophages of L. donavani	ChEMBL.	11170645
Toxic dose (ADMET)	= 30 uM	Compound dose toxic against magrophages of T. cruzi	ChEMBL.	11170645

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL152787
PubChem: 10580422

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 262724