TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 383.525 | Formula: C27H29NO
H donors: 0 H acceptors: 1 LogP: 7.8 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCn1c2ccccc2c(c1C)C(=O)c1cccc2c1cccc2
InChi: 1S/C27H29NO/c1-3-4-5-6-11-19-28-20(2)26(24-16-9-10-18-25(24)28)27(29)23-17-12-14-21-13-7-8-15-22(21)23/h7-10,12-18H,3-6,11,19H2,1-2H3
InChiKey: OVZJUGLCPQYLFW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cannabinoid receptor 1 (brain)	Starlite/ChEMBL	No references
Homo sapiens	cannabinoid receptor 2 (macrophage)		No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0638	0.0638
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0013	0.0003	0.5
Onchocerca volvulus		0.015	0.1559	0.3627
Schistosoma mansoni	zinc finger protein	0.0015	0.0022	0.0143
Echinococcus multilocularis	glycine receptor subunit beta	0.015	0.1559	0.2216
Schistosoma mansoni	neurotransmitter gated ion channel	0.0081	0.077	0.494
Loa Loa (eye worm)	hypothetical protein	0.0032	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.015	0.1559	0.1559
Echinococcus multilocularis	geminin	0.0071	0.0663	0.0943
Loa Loa (eye worm)	hypothetical protein	0.015	0.1559	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0081	0.077	0.077
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.015	0.1559	0.4905
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0638	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0638	0.0638
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.015	0.1559	0.4905
Schistosoma mansoni	hypothetical protein	0.0071	0.0663	0.4254
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.0068	0.0619	0.0619
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0027	0.0153	0.0392
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.015	0.1559	0.1559
Echinococcus granulosus	glycine receptor subunit beta	0.015	0.1559	0.4905
Brugia malayi	Protein kinase domain containing protein	0.0038	0.028	0.0277
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0013	0.0003	0.5
Echinococcus granulosus	cytochrome P450 2K1	0.0013	0.0003	0.0009
Schistosoma mansoni	neurotransmitter gated ion channel	0.0069	0.0638	0.409
Brugia malayi	map kinase activated protein kinase protein 2	0.0068	0.0619	0.0616
Brugia malayi	hypothetical protein	0.0069	0.0638	0.0635
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0013	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0638	0.0638
Loa Loa (eye worm)	cytochrome P450 family protein	0.0086	0.0832	0.0832
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0038	0.028	0.028
Schistosoma mansoni	hypothetical protein	0.0016	0.0032	0.0204
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0038	0.028	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0638	0.0638
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0069	0.0638	0.0638
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0013	0.0003	0.5
Schistosoma mansoni	hypothetical protein	0.0013	0.0003	0.0017
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.015	0.1559	0.1556
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0013	0.0003	0.5
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0013	0.0003	0.5
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0081	0.077	0.0768
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.028	0.1794
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0638	0.0638
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.015	0.1559	0.1556
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0028	0.0167	0.0238
Onchocerca volvulus		0.015	0.1559	0.3627
Echinococcus multilocularis	nAChR subunit	0.015	0.1559	0.2216
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0013	0.0003	0.5
Schistosoma mansoni	nAChR subunit	0.015	0.1559	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.015	0.1559	0.1556
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0069	0.0638	0.0906
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.015	0.1559	0.2216
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.015	0.1559	0.2216
Echinococcus granulosus	geminin	0.0071	0.0663	0.2087
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0013	0.0003	0.5
Schistosoma mansoni	nAChR subunit	0.015	0.1559	1
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0013	0.0003	0.5
Mycobacterium leprae	putative cytochrome p450	0.0013	0.0003	0.5
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0292	0.3178	0.4517
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0013	0.0003	0.5
Loa Loa (eye worm)	bromodomain containing protein	0.0014	0.0005	0.0005
Echinococcus granulosus	glycine receptor subunit alpha 1	0.015	0.1559	0.4905
Loa Loa (eye worm)	hypothetical protein	0.015	0.1559	0.1559
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.0619	0.3968
Echinococcus granulosus	FAD linked sulfhydryl oxidase ALR	0.0027	0.0153	0.0481
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.015	0.1559	0.1556
Brugia malayi	excitatory GABA receptor EXP-1A	0.015	0.1559	0.1556
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.015	0.1559	0.1556
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0069	0.0638	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0081	0.077	0.077
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.015	0.1559	0.1556
Schistosoma mansoni	nAChR subunit	0.015	0.1559	1
Schistosoma mansoni	nAChR subunit	0.015	0.1559	1
Brugia malayi	hypothetical protein	0.0069	0.0638	0.0635
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0046	0.0378	0.0537
Loa Loa (eye worm)	hypothetical protein	0.015	0.1559	0.1559
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0013	0.0003	0.5
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0046	0.0378	0.1189
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.015	0.1559	0.1556
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0069	0.0638	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0638	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0227	0.0227
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0013	0.0003	0.5
Loa Loa (eye worm)	ACC-1 protein	0.015	0.1559	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0638	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0638	0.0638
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0631	0.7035	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.077	0.077
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.015	0.1559	0.2216
Loa Loa (eye worm)	CYP4Cod1	0.0013	0.0003	0.0003
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0013	0.0003	0.5
Trypanosoma brucei	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.035	0.3837	1
Brugia malayi	hypothetical protein	0.0069	0.0638	0.0635
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0013	0.0003	0.5
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0013	0.0003	0.5
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.015	0.1559	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.015	0.1559	0.4905
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0013	0.0003	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.015	0.1559	0.1556
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0069	0.0638	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0638	0.0638
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0027	0.0153	0.0392
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.0068	0.0619	0.0879
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0018	0.0049	0.0312
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0292	0.3178	0.3176
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0081	0.077	0.0768
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0038	0.028	0.0722
Loa Loa (eye worm)	GABA receptor subunit	0.0081	0.077	0.077
Schistosoma mansoni	acetylcholine receptor-related	0.0069	0.0638	0.409
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0638	0.0638
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0081	0.077	0.0768
Schistosoma mansoni	neurotransmitter gated ion channel	0.0069	0.0638	0.409
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0013	0.0003	0.5
Echinococcus granulosus	zinc finger protein	0.0015	0.0022	0.007
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0069	0.0638	0.0635
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0013	0.0003	0.5
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.015	0.1559	1
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0013	0.0003	0.5
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0038	0.028	0.0722
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.015	0.1559	0.1556
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0013	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.015	0.1559	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0891	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0013	0.0003	0.5
Schistosoma mansoni	nAChR subunit	0.0069	0.0638	0.409
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.015	0.1559	0.1556
Echinococcus granulosus	fetal alzheimer antigen falz	0.0018	0.0049	0.0153
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.015	0.1559	0.1559
Loa Loa (eye worm)	hypothetical protein	0.015	0.1559	0.1559
Schistosoma mansoni	cytochrome P450	0.0013	0.0003	0.0017
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0069	0.0638	0.0635
Mycobacterium leprae	Conserved hypothetical protein	0.0013	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.015	0.1559	0.1559
Brugia malayi	Bromodomain containing protein	0.0058	0.0514	0.0511
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0013	0.0003	0.5
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.015	0.1559	1
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0013	0.0003	0.5
Brugia malayi	hypothetical protein	0.0069	0.0638	0.0635
Echinococcus multilocularis	glycine receptor subunit beta	0.015	0.1559	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0276	0.0276
Schistosoma mansoni	bromodomain containing protein	0.0049	0.041	0.2628
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0003	0.0003
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0013	0.0003	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0013	0.0003	0.5
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.015	0.1559	0.1556
Echinococcus granulosus	glycine receptor subunit beta	0.015	0.1559	0.4905
Plasmodium falciparum	FAD-linked sulfhydryl oxidase ERV1, putative	0.0027	0.0153	0.5
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.015	0.1559	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.015	0.1559	0.1559
Onchocerca volvulus		0.0081	0.077	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0476	0.0476
Echinococcus granulosus	glycine receptor subunit alpha 1	0.015	0.1559	0.4905
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0081	0.077	0.494
Onchocerca volvulus		0.0081	0.077	0.0521
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.015	0.1559	0.2216
Onchocerca volvulus	Putative nachr subunit	0.0292	0.3178	1
Echinococcus multilocularis	zinc finger protein	0.0015	0.0022	0.0032
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.035	0.3837	1
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0013	0.0003	0.5
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0292	0.3178	0.3178
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0069	0.0638	0.0635
Onchocerca volvulus		0.015	0.1559	0.3627
Loa Loa (eye worm)	hypothetical protein	0.015	0.1559	0.1559
Echinococcus multilocularis	dual specificity	0.0038	0.028	0.0398
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0018	0.0049	0.0069
Brugia malayi	hypothetical protein	0.0069	0.0638	0.0635
Trypanosoma cruzi	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0027	0.0153	0.0392
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0292	0.3178	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.077	0.077
Schistosoma mansoni	nAChR subunit	0.015	0.1559	1
Echinococcus multilocularis	nAChR subunit	0.0081	0.077	0.1095
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0638	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0081	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.0081	0.077	0.077
Loa Loa (eye worm)	cytochrome P450	0.0013	0.0003	0.0003
Entamoeba histolytica	hypothetical protein	0.0081	0.077	1
Echinococcus granulosus	dual specificity	0.0038	0.028	0.088
Leishmania major	hypothetical protein, conserved	0.0027	0.0153	0.0392
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.015	0.1559	1
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0013	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.015	0.1559	0.1559
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0069	0.0638	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0638	0.0638
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0013	0.0003	0.5
Brugia malayi	PHD-finger family protein	0.0019	0.007	0.0067
Loa Loa (eye worm)	hypothetical protein	0.015	0.1559	0.1559
Trypanosoma brucei	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0027	0.0153	0.0392
Loa Loa (eye worm)	hepatopoietin HPO2	0.0027	0.0153	0.0153
Toxoplasma gondii	Erv1 / Alr family protein	0.0027	0.0153	1
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0292	0.3178	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.077	0.077
Loa Loa (eye worm)	LGC-31 protein	0.015	0.1559	0.1559
Loa Loa (eye worm)	hypothetical protein	0.015	0.1559	0.1559
Brugia malayi	Cation transporter family protein	0.015	0.1559	0.1556
Loa Loa (eye worm)	hypothetical protein	0.015	0.1559	0.1559
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0013	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.015	0.1559	0.1559
Loa Loa (eye worm)	hypothetical protein	0.015	0.1559	0.1559
Wolbachia endosymbiont of Brugia malayi	malonyl-CoA decarboxylase	0.0891	1	0.5
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.015	0.1559	0.1556
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.015	0.1559	0.1556
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0081	0.077	0.0768
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0638	0.0638
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0069	0.0638	0.2007
Echinococcus multilocularis		0.0013	0.0003	0.0004
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0069	0.0638	0.2007
Echinococcus granulosus	nAChR subunit	0.0081	0.077	0.2423
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0013	0.0003	0.5
Brugia malayi	Cation transporter family protein	0.015	0.1559	0.1556
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0276	0.0276
Schistosoma mansoni	hypothetical protein	0.0071	0.0663	0.4254
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0292	0.3178	0.4517
Loa Loa (eye worm)	hypothetical protein	0.0081	0.077	0.077
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0069	0.0638	0.0906
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0013	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0292	0.3178	0.3178
Loa Loa (eye worm)	hypothetical protein	0.015	0.1559	0.1559
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0013	0.0003	0.5
Schistosoma mansoni	nAChR subunit	0.015	0.1559	1
Leishmania major	malonyl-coa decarboxylase-like protein	0.035	0.3837	1
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0069	0.0638	0.0906
Echinococcus multilocularis	FAD linked sulfhydryl oxidase ALR	0.0027	0.0153	0.0217
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.015	0.1559	1
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0013	0.0003	0.5
Loa Loa (eye worm)	PHD-finger family protein	0.0016	0.0032	0.0032
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.015	0.1559	0.4905
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0013	0.0003	0.5
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0292	0.3178	0.4517
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.015	0.1559	0.2216
Echinococcus granulosus	glycine receptor subunit alpha 1	0.015	0.1559	0.4905
Loa Loa (eye worm)	hypothetical protein	0.015	0.1559	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0638	0.0638
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.015	0.1559	0.1556
Onchocerca volvulus		0.015	0.1559	0.3627
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.015	0.1559	0.2216
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.015	0.1559	0.1559
Brugia malayi	Cation transporter family protein	0.015	0.1559	0.1556
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0013	0.0003	0.5
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0069	0.0638	0.409
Onchocerca volvulus		0.015	0.1559	0.3627
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0013	0.0003	0.5
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0038	0.028	0.0722
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0013	0.0003	0.5
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0292	0.3178	1
Loa Loa (eye worm)	hypothetical protein	0.015	0.1559	0.1559
Brugia malayi	Cytochrome P450 family protein	0.0086	0.0832	0.083
Brugia malayi	Augmenter of liver regeneration	0.0027	0.0153	0.015
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.0068	0.0619	0.1947
Echinococcus granulosus	nAChR subunit	0.015	0.1559	0.4905
Schistosoma mansoni	nAChR subunit	0.0069	0.0638	0.409
Plasmodium vivax	FAD-linked sulfhydryl oxidase ERV1, putative	0.0027	0.0153	0.5
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.015	0.1559	0.1559
Onchocerca volvulus		0.015	0.1559	0.3627
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0028	0.0167	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0081	0.077	0.077
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.015	0.1559	0.2216
Loa Loa (eye worm)	hypothetical protein	0.015	0.1559	0.1559
Toxoplasma gondii	Erv1 / Alr family protein	0.0027	0.0153	1
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0013	0.0003	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.003	0.0189	0.0189
Loa Loa (eye worm)	acetylcholine receptor protein	0.0069	0.0638	0.0638
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.035	0.3837	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.015	0.1559	0.1556
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0013	0.0003	0.5
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.015	0.1559	0.4905
Schistosoma mansoni	nAChR subunit	0.015	0.1559	1
Brugia malayi	Bromodomain containing protein	0.003	0.0188	0.0186
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0081	0.077	0.494
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0013	0.0003	0.5
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0013	0.0003	0.5
Loa Loa (eye worm)	ACC-1 protein	0.015	0.1559	0.1559

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	> 189 uM kg-1	Tested in vivo for cannabimimetic activity in mouse	ChEMBL.	No reference
ED50 (functional)	> 189 uM kg-1	Tested in vivo for cannabimimetic activity in mouse	ChEMBL.	No reference
Ki (binding)	> 10000 nM	Binding affinity was determined in vitro against cannabinoid receptor by ability to displace [3H]- CP-55,940	ChEMBL.	No reference
Ki (binding)	> 10000 nM	Binding affinity was determined in vitro against cannabinoid receptor by ability to displace [3H]- CP-55,940	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL152814

Bibliographic References

No literature references available for this target.

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Detailed information for compound 262750