Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | peroxidasin | 0.0966 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0966 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0966 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0966 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0966 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0966 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0966 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0966 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0966 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0966 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0966 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0966 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0966 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0966 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0966 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0966 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0966 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0966 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0966 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0966 | 0.5 | 0.5 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0966 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0966 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0966 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0966 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0966 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0966 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0966 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0966 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0966 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0966 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0966 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0966 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0966 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0966 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0966 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0966 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0966 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0966 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0966 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 4.98 | Calculated partition coefficient (clogP) | ChEMBL. | 12477356 |
Ki (binding) | = 0.13 nM | Binding affinity towards Dopamine receptor D3 of rat using [3H]-spiroperidol as radioligand | ChEMBL. | 12477356 |
Ki (binding) | = 110 nM | Binding affinity towards Alpha-1 adrenergic receptor from rat cortical membranes | ChEMBL. | 12477356 |
Ki (binding) | = 184 nM | Binding affinity towards 5-hydroxytryptamine 1A receptor from rat hippocampal membranes | ChEMBL. | 12477356 |
Ki (binding) | = 373 nM | Binding affinity towards human Dopamine receptor D2 using [3H]-spiroperidol as radioligand | ChEMBL. | 12477356 |
Ki (binding) | = 720 nM | Binding affinity towards human Dopamine receptor D4 using [3H]-spiroperidol as radioligand | ChEMBL. | 12477356 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.