Detailed information for compound 26286

Basic information

Technical information
  • TDR Targets ID: 26286
  • Name: 4-[[amino(hydrazinyl)methylidene]amino]butano ic acid
  • MW: 160.174 | Formula: C5H12N4O2
  • H donors: 4 H acceptors: 2 LogP: -3.71 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: NNC(=N)NCCCC(=O)O
  • InChi: 1S/C5H12N4O2/c6-5(9-7)8-3-1-2-4(10)11/h1-3,7H2,(H,10,11)(H3,6,8,9)
  • InChiKey: QFLMWQCNEKACKS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[amino(hydrazino)methylene]amino]butanoic acid
  • 4-[[azanyl(hydrazinyl)methylidene]amino]butanoic acid
  • 4-[[amino(hydrazino)methylene]amino]butyric acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.1801 0.4238 0.9274
Trypanosoma brucei fructose-1,6-bisphosphatase 0.1238 0.2869 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.0112 0.011
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Loa Loa (eye worm) TK/FER protein kinase 0.008 0.0053 0.0053
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Echinococcus multilocularis hemicentin 1 0.0104 0.0112 0.011
Echinococcus granulosus hypothetical protein 0.0127 0.0167 0.0165
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.008 0.0053 0.0781
Echinococcus multilocularis cyclin dependent kinase 0.0139 0.0197 0.0195
Echinococcus granulosus roundabout 2 0.0107 0.0117 0.0115
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.013 0.0175 0.0601
Brugia malayi Probable tyrosine-protein kinase kin-31 0.008 0.0053 0.0051
Loa Loa (eye worm) hypothetical protein 0.0259 0.0488 0.0488
Schistosoma mansoni tyrosine kinase 0.0437 0.0921 0.0919
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0053 0.2626
Echinococcus multilocularis tyrosine protein kinase pr2 0.008 0.0053 0.0051
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Loa Loa (eye worm) hypothetical protein 0.0059 0.0002 0.0002
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.013 0.0175 0.0601
Onchocerca volvulus 0.0059 0.0002 0.0004
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.008 0.0053 0.0051
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.1238 0.2869 0.2867
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0197 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0107 0.0117 0.0115
Echinococcus multilocularis 0.0127 0.0167 0.0165
Echinococcus multilocularis protein KINase family member (kin 25) 0.008 0.0053 0.0051
Entamoeba histolytica tyrosin kinase, putative 0.008 0.0053 0.0781
Leishmania major protein kinase, putative 0.013 0.0175 0.0601
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0187 0.0313 0.0311
Echinococcus granulosus tyrosine kinase 0.0139 0.0197 0.0195
Schistosoma mansoni protein kinase 0.0084 0.0062 0.006
Loa Loa (eye worm) TK protein kinase 0.008 0.0053 0.0053
Schistosoma mansoni tyrosine kinase 0.2267 0.5371 0.537
Brugia malayi hypothetical protein 0.0139 0.0197 0.0195
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Echinococcus granulosus Immunoglobulin 0.0213 0.0375 0.0373
Schistosoma mansoni tyrosine-protein kinase fps85d 0.008 0.0053 0.0051
Trypanosoma brucei Pseudokinase, putative 0.008 0.0053 0.0178
Entamoeba histolytica protein kinase, putative 0.0063 0.001 0.0126
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.046 0.0978 0.3403
Loa Loa (eye worm) hypothetical protein 0.008 0.0053 0.0053
Entamoeba histolytica hypothetical protein, conserved 0.008 0.0053 0.0781
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0059 0.0002 0.0002
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0437 0.0921 0.0919
Onchocerca volvulus 0.008 0.0053 0.0117
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Echinococcus multilocularis neuroglian 0.0107 0.0117 0.0115
Onchocerca volvulus 0.008 0.0053 0.0117
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Echinococcus granulosus tyrosine kinase 0.008 0.0053 0.0051
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0146 0.0214 0.0212
Brugia malayi Protein kinase domain containing protein 0.0191 0.0323 0.0321
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Entamoeba histolytica protein kinase, putative 0.008 0.0053 0.0781
Loa Loa (eye worm) TK/KIN16 protein kinase 0.2152 0.5092 0.5092
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Echinococcus multilocularis heat shock protein 70 0.008 0.0053 0.0051
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0104 0.0112 0.0112
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0107 0.0117 0.0117
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.008 0.0053 0.0781
Echinococcus granulosus tyrosine protein kinase Src42A 0.0437 0.0921 0.0919
Echinococcus granulosus protein tyrosine kinase 0.008 0.0053 0.0051
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.008 0.0053 0.0781
Loa Loa (eye worm) hypothetical protein 0.0213 0.0375 0.0375
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Echinococcus multilocularis retinal guanylyl cyclase 2 0.008 0.0053 0.0051
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0139 0.0197 0.2964
Echinococcus multilocularis tyrosine protein kinase csk 0.008 0.0053 0.0051
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0084 0.0062 0.003
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.008 0.0053 0.0117
Echinococcus granulosus cyclin dependent kinase 1 0.0139 0.0197 0.0195
Schistosoma mansoni ephrin receptor 0.0083 0.0059 0.0057
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.2267 0.5371 0.537
Loa Loa (eye worm) TK/CSK protein kinase 0.008 0.0053 0.0053
Echinococcus granulosus cyclin dependent kinase 5 0.0139 0.0197 0.0195
Onchocerca volvulus 0.008 0.0053 0.0117
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0389 0.0805 0.0803
Echinococcus granulosus tyrosine protein kinase otk 0.0104 0.0112 0.011
Entamoeba histolytica tyrosine kinase, putative 0.008 0.0053 0.0781
Schistosoma mansoni tyrosine-protein kinase fps85d 0.008 0.0053 0.0051
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.013 0.0175 0.0601
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.046 0.0978 0.3403
Loa Loa (eye worm) hypothetical protein 0.008 0.0053 0.0053
Entamoeba histolytica tyrosine kinase, putative 0.008 0.0053 0.0781
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.008 0.0053 0.0051
Entamoeba histolytica hypothetical protein 0.008 0.0053 0.0781
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.008 0.0053 0.2626
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Schistosoma mansoni nephrin 0.0261 0.0494 0.0492
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0107 0.0117 0.0115
Loa Loa (eye worm) hypothetical protein 0.0087 0.0069 0.0069
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0104 0.0112 0.011
Brugia malayi Fibronectin type III domain containing protein 0.0215 0.0381 0.0379
Brugia malayi Protein kinase domain containing protein 0.0139 0.0197 0.0195
Echinococcus granulosus cyclin dependent kinase 0.0139 0.0197 0.0195
Echinococcus multilocularis ephrin type A receptor 4 A 0.0153 0.0229 0.0227
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Loa Loa (eye worm) SH2 domain-containing protein 0.0059 0.0002 0.0002
Echinococcus granulosus retinal guanylyl cyclase 2 0.008 0.0053 0.0051
Loa Loa (eye worm) TK/FER protein kinase 0.0139 0.0197 0.0197
Brugia malayi Protein kinase domain containing protein 0.0139 0.0197 0.0195
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Loa Loa (eye worm) TK/FER protein kinase 0.0139 0.0197 0.0197
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0068 0.0022 0.002
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.008 0.0053 0.0781
Entamoeba histolytica tyrosine kinase, putative 0.008 0.0053 0.0781
Loa Loa (eye worm) TK/INSR protein kinase 0.1371 0.3193 0.3193
Entamoeba histolytica tyrosine kinase, putative 0.008 0.0053 0.0781
Brugia malayi Sex muscle abnormal protein 5 0.0107 0.0117 0.0115
Echinococcus multilocularis c src tyrosine kinase 0.0187 0.0313 0.0311
Brugia malayi Protein kinase domain containing protein 0.032 0.0636 0.0635
Onchocerca volvulus 0.0139 0.0197 0.0432
Echinococcus multilocularis raf serine:threonine protein kinase 0.008 0.0053 0.0051
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0084 0.0062 0.0207
Echinococcus granulosus expressed conserved protein 0.0087 0.007 0.0068
Loa Loa (eye worm) CMGC/CLK protein kinase 0.013 0.0175 0.0175
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.008 0.0053 0.0051
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.008 0.0053 0.0781
Loa Loa (eye worm) TK protein kinase 0.008 0.0053 0.0053
Entamoeba histolytica tyrosine kinase, putative 0.008 0.0053 0.0781
Echinococcus multilocularis epidermal growth factor receptor 0.417 1 1
Schistosoma mansoni vesicular amine transporter 0.0213 0.0375 0.0373
Loa Loa (eye worm) TK/RYK protein kinase 0.008 0.0053 0.0053
Schistosoma mansoni serine/threonine RGC 0.008 0.0053 0.0051
Echinococcus multilocularis activin receptor type 0.0084 0.0062 0.006
Schistosoma mansoni tyrosine kinase 0.1371 0.3193 0.3192
Schistosoma mansoni tyrosine kinase 0.008 0.0053 0.0051
Echinococcus multilocularis NCK adaptor protein 0.0107 0.0117 0.0115
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0187 0.0313 0.0311
Entamoeba histolytica protein kinase, putative 0.008 0.0053 0.0781
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0191 0.0323 0.1118
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Brugia malayi Prion-like- 0.0104 0.0112 0.011
Brugia malayi Protein kinase domain containing protein 0.0139 0.0197 0.0195
Echinococcus granulosus roundabout 2 0.0319 0.0635 0.0633
Loa Loa (eye worm) hypothetical protein 0.0139 0.0197 0.0197
Brugia malayi SH2 domain containing protein 0.0139 0.0197 0.0195
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.008 0.0053 0.0051
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0107 0.0117 0.0115
Brugia malayi Guanylyl cyclase protein 23 0.008 0.0053 0.0051
Echinococcus granulosus tyrosine protein kinase csk 0.008 0.0053 0.0051
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Echinococcus multilocularis Immunoglobulin 0.0213 0.0375 0.0373
Schistosoma mansoni hypothetical protein 0.008 0.0053 0.0051
Brugia malayi Immunoglobulin I-set domain containing protein 0.2152 0.5092 0.5091
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0175 0.0173
Trypanosoma brucei protein kinase, putative 0.0084 0.0062 0.0207
Brugia malayi C-terminal src kinase protein 1 0.008 0.0053 0.0051
Loa Loa (eye worm) TK protein kinase 0.008 0.0053 0.0053
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Echinococcus multilocularis dual specificity protein kinase clk2 0.013 0.0175 0.0173
Echinococcus multilocularis protein kinase 0.008 0.0053 0.0051
Entamoeba histolytica cell division protein kinase 2, putative 0.0139 0.0197 0.2955
Schistosoma mansoni nck2/grb4 0.0107 0.0117 0.0115
Echinococcus multilocularis lachesin 0.0104 0.0112 0.011
Entamoeba histolytica hypothetical protein 0.008 0.0053 0.0781
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.008 0.0053 0.0178
Loa Loa (eye worm) TK/KIN6 protein kinase 0.008 0.0053 0.0053
Loa Loa (eye worm) TK protein kinase 0.033 0.0661 0.0661
Loa Loa (eye worm) hypothetical protein 0.0059 0.0002 0.0002
Brugia malayi Tyrosine-protein kinase PR2 0.008 0.0053 0.0051
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.008 0.0053 0.0781
Loa Loa (eye worm) hypothetical protein 0.0107 0.0117 0.0117
Echinococcus granulosus activated cdc42 kinase 1 0.008 0.0053 0.0051
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0107 0.0117 0.0115
Entamoeba histolytica protein kinase, putative 0.008 0.0053 0.0781
Echinococcus granulosus tyrosine protein kinase shark 0.0139 0.0197 0.0195
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.008 0.0053 0.0781
Entamoeba histolytica protein kinase, putative 0.0191 0.0323 0.4866
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Entamoeba histolytica tyrosine kinase, putative 0.008 0.0053 0.0781
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0084 0.0062 0.0207
Schistosoma mansoni growth factor receptor-bound protein 0.0107 0.0117 0.0115
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Brugia malayi Variant SH3 domain containing protein 0.0107 0.0117 0.0115
Schistosoma mansoni roundabout 0.0104 0.0112 0.011
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0437 0.0921 0.0919
Brugia malayi SH2 domain containing protein 0.0417 0.0873 0.0871
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Schistosoma mansoni fructose-16-bisphosphatase-related 0.1238 0.2869 0.2867
Entamoeba histolytica protein kinase, putative 0.008 0.0053 0.0781
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0291 0.0565 0.0563
Brugia malayi Tyrosine-protein kinase abl-1 0.0187 0.0313 0.0311
Plasmodium falciparum protein kinase 5 0.0139 0.0197 1
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Echinococcus granulosus natriuretic peptide receptor 1 0.008 0.0053 0.0051
Loa Loa (eye worm) hypothetical protein 0.0259 0.0488 0.0488
Entamoeba histolytica protein kinase, putative 0.008 0.0053 0.0781
Loa Loa (eye worm) TK/ROR protein kinase 0.0127 0.0166 0.0166
Schistosoma mansoni tyrosine kinase 0.008 0.0053 0.0051
Loa Loa (eye worm) hypothetical protein 0.0127 0.0167 0.0167
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0059 0.0002 0.0004
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.1238 0.2869 0.2869
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0213 0.0375 0.0373
Echinococcus multilocularis tyrosine protein kinase Blk 0.0389 0.0805 0.0803
Echinococcus granulosus kinase suppressor of Ras 1 0.008 0.0053 0.0051
Echinococcus multilocularis roundabout 2 0.0319 0.0635 0.0633
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.008 0.0053 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0053 0.0051
Entamoeba histolytica tyrosin kinase, putative 0.008 0.0053 0.0781
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Entamoeba histolytica protein kinase, putative 0.008 0.0053 0.0781
Trichomonas vaginalis TK family protein kinase 0.008 0.0053 0.2626
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0139 0.0197 0.0509
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.008 0.0053 0.0051
Onchocerca volvulus 0.0139 0.0197 0.0432
Entamoeba histolytica protein kinase domain containing protein 0.0084 0.0062 0.0907
Loa Loa (eye worm) hypothetical protein 0.008 0.0053 0.0053
Schistosoma mansoni tyrosine kinase 0.008 0.0053 0.0051
Loa Loa (eye worm) protein kinase domain-containing protein 0.008 0.0053 0.0053
Loa Loa (eye worm) TK/FER protein kinase 0.0139 0.0197 0.0197
Entamoeba histolytica protein kinase, putative 0.008 0.0053 0.0781
Giardia lamblia Kinase, CMGC CDK 0.0139 0.0197 1
Entamoeba histolytica protein kinase, putative 0.0191 0.0323 0.4866
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.008 0.0053 0.0781
Loa Loa (eye worm) TK protein kinase 0.008 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.008 0.0053 0.0053
Trypanosoma brucei Flagellum attachment zone protein 20 0.008 0.0053 0.0178
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0437 0.0921 0.0919
Entamoeba histolytica hypothetical protein 0.008 0.0053 0.0781
Echinococcus granulosus tyrosine protein kinase csk 0.008 0.0053 0.0051
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.008 0.0053 0.0053
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Schistosoma mansoni tyrosine kinase 0.008 0.0053 0.0051
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Brugia malayi Protein kinase domain containing protein 0.1371 0.3193 0.3192
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.008 0.0053 0.0051
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Echinococcus multilocularis tyrosine kinase 0.008 0.0053 0.0051
Loa Loa (eye worm) hypothetical protein 0.0211 0.0371 0.0371
Echinococcus multilocularis tyrosine protein kinase otk 0.0104 0.0112 0.011
Entamoeba histolytica tyrosine kinase, putative 0.008 0.0053 0.0781
Schistosoma mansoni protein kinase 0.0084 0.0062 0.006
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.013 0.0175 0.0601
Echinococcus granulosus protein kinase 0.008 0.0053 0.0051
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Brugia malayi Immunoglobulin I-set domain containing protein 0.0107 0.0117 0.0115
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.008 0.0053 0.2626
Loa Loa (eye worm) TK/Met protein kinase 0.008 0.0053 0.0053
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0107 0.0117 0.0115
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Loa Loa (eye worm) hypothetical protein 0.0107 0.0117 0.0117
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.008 0.0053 0.0051
Schistosoma mansoni tyrosine kinase 0.008 0.0053 0.0051
Echinococcus multilocularis dual specificity 0.0191 0.0323 0.0321
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0541 0.1173 0.1172
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0053 0.2626
Echinococcus granulosus tyrosine protein kinase Srms 0.0139 0.0197 0.0195
Schistosoma mansoni serine/threonine protein kinase 0.0139 0.0197 0.0195
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.008 0.0053 0.0053
Schistosoma mansoni tyrosine kinase 0.008 0.0053 0.0051
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Entamoeba histolytica ankyrin repeat protein 0.008 0.0053 0.0781
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.006 0.0004 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0053 0.2626
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Schistosoma mansoni hypothetical protein 0.0087 0.007 0.0068
Schistosoma mansoni tyrosine kinase 0.0187 0.0313 0.0311
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0437 0.0921 0.0919
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.0112 0.011
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Entamoeba histolytica hypothetical protein 0.0191 0.0323 0.4866
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1238 0.2869 1
Echinococcus multilocularis insulin receptor 0.1371 0.3193 0.3192
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Entamoeba histolytica tyrosine kinase, putative 0.008 0.0053 0.0781
Echinococcus multilocularis tyrosine protein kinase shark 0.0139 0.0197 0.0195
Entamoeba histolytica hypothetical protein 0.008 0.0053 0.0781
Trypanosoma cruzi cdc2-related kinase 1 0.0139 0.0197 0.0678
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0059 0.0002 0.0002
Brugia malayi Probable tyrosine-protein kinase kin-31 0.008 0.0053 0.0051
Schistosoma mansoni tyrosine kinase 0.008 0.0053 0.0051
Schistosoma mansoni tyrosine kinase 0.0139 0.0197 0.0195
Plasmodium vivax protein kinase Crk2 0.0139 0.0197 1
Brugia malayi Protein kinase domain containing protein 0.0139 0.0197 0.0195
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Loa Loa (eye worm) TK/FER protein kinase 0.0139 0.0197 0.0197
Entamoeba histolytica ankyrin repeat protein 0.008 0.0053 0.0781
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0053 0.0051
Entamoeba histolytica receptor protein kinase, putative 0.008 0.0053 0.0781
Echinococcus granulosus insulin receptor 0.1371 0.3193 0.3192
Loa Loa (eye worm) hypothetical protein 0.008 0.0053 0.0053
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.008 0.0053 0.0051
Trichomonas vaginalis STE family protein kinase 0.008 0.0053 0.2626
Schistosoma mansoni protein kinase 0.008 0.0053 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0053 0.2626
Loa Loa (eye worm) RGC/RGC protein kinase 0.008 0.0053 0.0053
Schistosoma mansoni tyrosine kinase 0.417 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.008 0.0053 0.0053
Entamoeba histolytica tyrosine kinase, putative 0.008 0.0053 0.0781
Brugia malayi Protein kinase domain containing protein 0.0139 0.0197 0.0195
Loa Loa (eye worm) TK/EGFR protein kinase 0.417 1 1
Echinococcus granulosus defective proboscis extension response 0.0213 0.0375 0.0373
Loa Loa (eye worm) RGC/RGC protein kinase 0.008 0.0053 0.0053
Entamoeba histolytica serine/threonine kinase, putative 0.008 0.0053 0.0781
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0191 0.0323 0.1118
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0139 0.0197 0.0197
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Entamoeba histolytica tyrosine kinase, putative 0.008 0.0053 0.0781
Loa Loa (eye worm) hypothetical protein 0.0104 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.008 0.0053 0.0053
Onchocerca volvulus 0.008 0.0053 0.0117
Loa Loa (eye worm) hypothetical protein 0.0087 0.0069 0.0069
Brugia malayi Variant SH3 domain containing protein 0.0107 0.0117 0.0115
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Schistosoma mansoni protein kinase 0.008 0.0053 0.0051
Loa Loa (eye worm) hypothetical protein 0.0317 0.0629 0.0629
Entamoeba histolytica protein kinase, putative 0.008 0.0053 0.0781
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Loa Loa (eye worm) TK/FER protein kinase 0.008 0.0053 0.0053
Brugia malayi hypothetical protein 0.008 0.0053 0.0051
Schistosoma mansoni protein kinase 0.008 0.0053 0.0051
Entamoeba histolytica tyrosine kinase, putative 0.008 0.0053 0.0781
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0107 0.0117 0.0115
Brugia malayi Protein kinase domain containing protein 0.013 0.0175 0.0173
Loa Loa (eye worm) hypothetical protein 0.0104 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0104 0.0112 0.0112
Trichomonas vaginalis protein tyrosine kinase, putative 0.008 0.0053 0.2626
Echinococcus granulosus tyrosine protein kinase csk 0.008 0.0053 0.0051
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0213 0.0375 0.0373
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.008 0.0053 0.0053
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Echinococcus multilocularis roundabout 2 0.0107 0.0117 0.0115
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0127 0.0166 0.0165
Echinococcus multilocularis cyclin dependent kinase 5 0.0139 0.0197 0.0195
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.008 0.0053 0.0051
Schistosoma mansoni src-type protein tyrosine kinase-related 0.008 0.0053 0.0051
Entamoeba histolytica hypothetical protein 0.008 0.0053 0.0781
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.008 0.0053 0.0781
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0104 0.0112 0.011
Entamoeba histolytica protein kinase, putative 0.008 0.0053 0.0781
Echinococcus multilocularis FL cytokine receptor 0.008 0.0053 0.0051
Echinococcus multilocularis cyclin dependent kinase 1 0.0139 0.0197 0.0195
Brugia malayi Immunoglobulin I-set domain containing protein 0.0107 0.0117 0.0115
Onchocerca volvulus 0.008 0.0053 0.0117
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.008 0.0053 0.0051
Entamoeba histolytica serine/threonine kinase, putative 0.008 0.0053 0.0781
Loa Loa (eye worm) hypothetical protein 0.0059 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0215 0.0381 0.0381
Echinococcus multilocularis expressed conserved protein 0.0087 0.007 0.0068
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Giardia lamblia Kinase, CMGC CLK 0.013 0.0175 0.8467
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0197 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0437 0.0921 0.0919
Echinococcus granulosus peroxidasin 0.0104 0.0112 0.011
Echinococcus granulosus ephrin type A receptor 4 A 0.0153 0.0229 0.0227
Schistosoma mansoni neuroglian 0.0107 0.0117 0.0115
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Echinococcus granulosus tyrosine kinase 0.0389 0.0805 0.0803
Loa Loa (eye worm) TK/FER protein kinase 0.0139 0.0197 0.0197
Schistosoma mansoni ephrin receptor 0.0139 0.0195 0.0193
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0084 0.0062 0.006
Trichomonas vaginalis serine-threonine protein kinase, putative 0.008 0.0053 0.2626
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Loa Loa (eye worm) hypothetical protein 0.0104 0.0112 0.0112
Echinococcus multilocularis activated cdc42 kinase 1 0.008 0.0053 0.0051
Echinococcus multilocularis tyrosine protein kinase csk 0.008 0.0053 0.0051
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Loa Loa (eye worm) hypothetical protein 0.0059 0.0002 0.0002
Echinococcus granulosus contactin 0.0116 0.0141 0.0139
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0139 0.0197 0.0197
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0139 0.0197 0.0195
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0191 0.0323 0.1118
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.008 0.0053 0.0117
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.008 0.0053 0.0781
Echinococcus granulosus receptor type guanylyl cyclase 0.008 0.0053 0.0051
Schistosoma mansoni tyrosine kinase 0.008 0.0053 0.0051
Loa Loa (eye worm) TK/ACK protein kinase 0.008 0.0053 0.0053
Entamoeba histolytica protein kinase, putative 0.033 0.0661 1
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0139 0.0197 0.0197
Schistosoma mansoni adapter molecule crk 0.0107 0.0117 0.0115
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0437 0.0921 0.0919
Loa Loa (eye worm) TK/FAK protein kinase 0.008 0.0053 0.0053
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.008 0.0053 0.0781
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Loa Loa (eye worm) TK/FER protein kinase 0.008 0.0053 0.0053
Loa Loa (eye worm) SH2 domain-containing protein 0.0059 0.0002 0.0002
Echinococcus multilocularis epidermal growth factor receptor 0.2267 0.5371 0.537
Entamoeba histolytica protein kinase, putative 0.008 0.0053 0.0781
Echinococcus granulosus tyrosine protein kinase Src42A 0.0309 0.061 0.0608
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.008 0.0053 0.0781
Schistosoma mansoni tyrosine kinase 0.008 0.0053 0.0051
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.008 0.0053 0.2626
Schistosoma mansoni cell adhesion molecule 0.0104 0.0112 0.011
Leishmania major protein kinase, putative 0.008 0.0053 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0053 0.2626
Trypanosoma cruzi cdc2-related kinase 3 0.0139 0.0197 0.0678
Plasmodium falciparum protein kinase, putative 0.0084 0.0062 0.058
Schistosoma mansoni tyrosine kinase 0.008 0.0053 0.0051
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0107 0.0117 0.0117
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Entamoeba histolytica serine/threonine kinase, putative 0.008 0.0053 0.0781
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.011 0.0126 0.0126
Schistosoma mansoni titin 0.0114 0.0135 0.0133
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0059 0.0002 0.0002
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Brugia malayi bone morphogenetic protein type 1 receptor 0.008 0.0053 0.0051
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0541 0.1173 0.1172
Loa Loa (eye worm) hypothetical protein 0.0104 0.0112 0.0112
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Loa Loa (eye worm) STAT protein 0.0059 0.0002 0.0002
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0291 0.0565 0.0563
Schistosoma mansoni tyrosine kinase 0.0187 0.0313 0.0311
Entamoeba histolytica receptor protein kinase, putative 0.008 0.0053 0.0781
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Schistosoma mansoni cell adhesion molecule 0.0107 0.0117 0.0115
Echinococcus granulosus twitchin 0.0263 0.0497 0.0495
Echinococcus granulosus tyrosine protein kinase ABL1 0.0139 0.0197 0.0195
Schistosoma mansoni protein kinase 0.008 0.0053 0.0051
Onchocerca volvulus 0.008 0.0053 0.0117
Brugia malayi ephrin receptor 1 precursor 0.0108 0.012 0.0118
Echinococcus granulosus neuroglian 0.0259 0.0488 0.0486
Loa Loa (eye worm) TK/FER protein kinase 0.0139 0.0197 0.0197
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0107 0.0117 0.0115
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0309 0.061 0.0608
Echinococcus multilocularis roundabout 2 0.0107 0.0117 0.0115
Echinococcus granulosus tyrosine protein kinase HCK 0.033 0.0661 0.0659
Schistosoma mansoni tyrosine kinase 0.0437 0.0921 0.0919
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.1238 0.2869 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0053 0.0053
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Trypanosoma cruzi cdc2-related kinase 1 0.0139 0.0197 0.0678
Schistosoma mansoni protein tyrosine kinase 0.008 0.0053 0.0051
Loa Loa (eye worm) TK protein kinase 0.008 0.0053 0.0053
Entamoeba histolytica protein kinase, putative 0.008 0.0053 0.0781
Brugia malayi Protein kinase domain containing protein 0.0139 0.0197 0.0195
Brugia malayi Immunoglobulin I-set domain containing protein 0.0107 0.0117 0.0115
Echinococcus multilocularis tyrosine protein kinase Abl 0.0187 0.0313 0.0311
Leishmania major 0.1238 0.2869 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0389 0.0805 0.0803
Schistosoma mansoni tyrosine kinase 0.1371 0.3193 0.3192
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.0112 0.011
Entamoeba histolytica protein kinase, putative 0.008 0.0053 0.0781
Echinococcus granulosus tyrosine protein kinase Blk 0.0389 0.0805 0.0803
Schistosoma mansoni septate junction protein 0.0104 0.0112 0.011
Entamoeba histolytica tyrosin kinase, putative 0.008 0.0053 0.0781
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0146 0.0214 0.0212
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Loa Loa (eye worm) RGC/RGC protein kinase 0.008 0.0053 0.0053
Echinococcus granulosus integrin linked protein kinase 0.008 0.0053 0.0051
Echinococcus granulosus Down syndrome cell adhesion molecule 0.006 0.0004 0.0002
Brugia malayi Immunoglobulin I-set domain containing protein 0.006 0.0004 0.0002
Entamoeba histolytica serine/threonine kinase, putative 0.008 0.0053 0.0781
Loa Loa (eye worm) hypothetical protein 0.008 0.0053 0.0053
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Schistosoma mansoni growth factor receptor-bound protein 0.0107 0.0117 0.0115
Onchocerca volvulus 0.008 0.0053 0.0117
Onchocerca volvulus 0.0059 0.0002 0.0004
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0059 0.0002 0.0004
Echinococcus granulosus activated cdc42 kinase 1 0.008 0.0053 0.0051
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0139 0.0197 0.0678
Brugia malayi SRC-1 0.0437 0.0921 0.0919
Echinococcus multilocularis tyrosine protein kinase csk 0.008 0.0053 0.0051
Loa Loa (eye worm) TK/FER protein kinase 0.0139 0.0197 0.0197
Schistosoma mansoni cell adhesion molecule 0.0107 0.0117 0.0115
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0053 0.2626
Onchocerca volvulus 0.0059 0.0002 0.0004
Echinococcus granulosus fructose 16 bisphosphatase 1 0.1238 0.2869 0.2867
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Loa Loa (eye worm) hypothetical protein 0.008 0.0053 0.0053
Schistosoma mansoni tyrosine kinase 0.008 0.0053 0.0051
Brugia malayi hypothetical protein 0.0068 0.0022 0.002
Toxoplasma gondii fructose-bisphospatase I 0.046 0.0978 0.3283
Entamoeba histolytica protein kinase, putative 0.008 0.0053 0.0781
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0104 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.008 0.0053 0.0053
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Echinococcus granulosus tyrosine protein kinase Fyn 0.0437 0.0921 0.0919
Echinococcus granulosus activin receptor type 0.0084 0.0062 0.006
Trichomonas vaginalis CMGC family protein kinase 0.013 0.0175 0.887
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.008 0.0053 0.0051
Plasmodium falciparum protein serine/threonine kinase-1 0.013 0.0175 0.8467
Loa Loa (eye worm) TK/FER protein kinase 0.008 0.0053 0.0053
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0139 0.0197 0.0195
Schistosoma mansoni tyrosine protein kinase 0.008 0.0053 0.0051
Entamoeba histolytica protein kinase, putative 0.008 0.0053 0.0781
Echinococcus multilocularis kinase suppressor of Ras 1 0.008 0.0053 0.0051
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Brugia malayi hypothetical protein 0.0259 0.0488 0.0486
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.0112 0.011
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0063 0.001 0.0126
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Schistosoma mansoni protein kinase 0.008 0.0053 0.0051
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.008 0.0053 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0128 0.0169 0.0167
Loa Loa (eye worm) TK/FER protein kinase 0.008 0.0053 0.0053
Onchocerca volvulus 0.0059 0.0002 0.0004
Echinococcus multilocularis protein kinase 0.008 0.0053 0.0051
Echinococcus granulosus tyrosine protein kinase Src64B 0.0437 0.0921 0.0919
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.0112 0.011
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0437 0.0921 0.0919
Loa Loa (eye worm) hypothetical protein 0.0104 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0188 0.0314 0.0314
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.006 0.0004 0.0002
Entamoeba histolytica protein kinase, putative 0.008 0.0053 0.0781
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Entamoeba histolytica hypothetical protein 0.008 0.0053 0.0781
Echinococcus granulosus roundabout 2 0.0107 0.0117 0.0115
Schistosoma mansoni tyrosine kinase 0.008 0.0053 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0175 0.0173
Brugia malayi integrin-linked kinase 0.008 0.0053 0.0051
Echinococcus granulosus hemicentin 1 0.0114 0.0135 0.0133
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.008 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0104 0.0112 0.0112
Echinococcus multilocularis protein tyrosine kinase 0.008 0.0053 0.0051
Brugia malayi hypothetical protein 0.0087 0.0069 0.0067
Echinococcus multilocularis transfer RNA-Thr 0.008 0.0053 0.0051
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Loa Loa (eye worm) hypothetical protein 0.008 0.0053 0.0053
Echinococcus granulosus dual specificity protein kinase clk2 0.013 0.0175 0.0173
Loa Loa (eye worm) RGC/RGC protein kinase 0.008 0.0053 0.0053
Brugia malayi SH2 domain containing protein 0.0139 0.0197 0.0195
Loa Loa (eye worm) hypothetical protein 0.0136 0.0188 0.0188
Echinococcus multilocularis growth factor receptor bound protein 2 0.0107 0.0117 0.0115
Schistosoma mansoni protein kinase 0.008 0.0053 0.0051
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0541 0.1173 0.1172
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0213 0.0375 0.0373
Loa Loa (eye worm) hypothetical protein 0.0059 0.0002 0.0002
Entamoeba histolytica protein kinase, putative 0.008 0.0053 0.0781
Trypanosoma cruzi cdc2-related kinase 3 0.0139 0.0197 0.0678
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.008 0.0053 0.0781
Schistosoma mansoni protein kinase 0.0084 0.0062 0.006
Echinococcus granulosus tyrosine protein kinase Fyn 0.0437 0.0921 0.0919
Echinococcus granulosus retinal guanylyl cyclase 2 0.008 0.0053 0.0051
Echinococcus multilocularis hemicentin 1 0.0114 0.0135 0.0133
Echinococcus granulosus tyrosine protein kinase Btk29A 0.008 0.0053 0.0051
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Loa Loa (eye worm) hypothetical protein 0.0059 0.0002 0.0002
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.013 0.0175 0.0601
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Entamoeba histolytica hypothetical protein 0.008 0.0053 0.0781
Echinococcus multilocularis peroxidasin 0.0104 0.0112 0.011
Brugia malayi Peroxidasin 0.0104 0.0112 0.011
Onchocerca volvulus 0.008 0.0053 0.0117
Entamoeba histolytica serine/threonine kinase, putative 0.008 0.0053 0.0781
Entamoeba histolytica serine/threonine kinase, putative 0.008 0.0053 0.0781
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0107 0.0117 0.0115
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0437 0.0921 0.0919
Toxoplasma gondii fructose-bisphospatase II 0.1238 0.2869 1
Giardia lamblia Kinase, CMGC CDK 0.0139 0.0197 1
Loa Loa (eye worm) TK protein kinase 0.0337 0.0678 0.0678
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0191 0.0323 0.0323
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.008 0.0053 0.0051
Loa Loa (eye worm) hypothetical protein 0.0059 0.0002 0.0002
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.008 0.0053 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0053 0.2626
Loa Loa (eye worm) SH2 domain-containing protein 0.0059 0.0002 0.0002
Brugia malayi Immunoglobulin I-set domain containing protein 0.0337 0.0678 0.0676
Trichomonas vaginalis AGC family protein kinase 0.008 0.0053 0.2626
Entamoeba histolytica hypothetical protein 0.008 0.0053 0.0781
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Onchocerca volvulus 0.0139 0.0197 0.0432
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1374 0.3199 0.3197
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Echinococcus multilocularis tyrosine protein kinase Srms 0.0389 0.0805 0.0803
Loa Loa (eye worm) TK protein kinase 0.008 0.0053 0.0053
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0127 0.0166 0.0165
Echinococcus multilocularis tyrosine protein kinase 0.008 0.0053 0.0051
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Loa Loa (eye worm) TK protein kinase 0.0389 0.0805 0.0805
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Leishmania major hypothetical protein, conserved 0.008 0.0053 0.0178
Loa Loa (eye worm) hypothetical protein 0.0213 0.0375 0.0375
Trypanosoma cruzi protein kinase, putative 0.008 0.0053 0.0178
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0114 0.0135 0.0296
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Loa Loa (eye worm) TK/FER protein kinase 0.0139 0.0197 0.0197
Loa Loa (eye worm) TK/DDR protein kinase 0.008 0.0053 0.0053
Entamoeba histolytica hypothetical protein 0.008 0.0053 0.0781
Loa Loa (eye worm) hypothetical protein 0.0188 0.0314 0.0314
Echinococcus granulosus tyrosine protein kinase 0.008 0.0053 0.0051
Echinococcus multilocularis tyrosine protein kinase HCK 0.033 0.0661 0.0659
Echinococcus granulosus raf serine:threonine protein kinase 0.008 0.0053 0.0051
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1374 0.3199 0.3197
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Echinococcus multilocularis 0.1273 0.2954 0.2953
Entamoeba histolytica protein kinase domain containing protein 0.0191 0.0323 0.4866
Echinococcus granulosus retinal guanylyl cyclase 2 0.008 0.0053 0.0051
Loa Loa (eye worm) hypothetical protein 0.0541 0.1173 0.1173
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0437 0.0921 0.0919
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Entamoeba histolytica hypothetical protein 0.008 0.0053 0.0781
Entamoeba histolytica tyrosine kinase, putative 0.008 0.0053 0.0781
Entamoeba histolytica cell division protein kinase 2, putative 0.0139 0.0197 0.2955
Entamoeba histolytica tyrosine kinase, putative 0.008 0.0053 0.0781
Schistosoma mansoni tyrosine kinase 0.008 0.0053 0.0051
Schistosoma mansoni tyrosine kinase 0.0291 0.0565 0.0563
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Schistosoma mansoni serine/threonine protein kinase 0.0139 0.0197 0.0195
Echinococcus multilocularis cyclin dependent kinase 1 0.0139 0.0197 0.0195
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.008 0.0053 0.0781
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.046 0.0978 0.3403
Leishmania major protein kinase, putative 0.013 0.0175 0.0601
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Brugia malayi Immunoglobulin I-set domain containing protein 0.0215 0.0381 0.0379
Schistosoma mansoni eyes absent homolog 0.0087 0.0069 0.0067
Onchocerca volvulus 0.0059 0.0002 0.0004
Schistosoma mansoni tyrosine kinase 0.008 0.0053 0.0051
Brugia malayi hypothetical protein 0.0215 0.0381 0.0379
Schistosoma mansoni septate junction protein 0.0104 0.0112 0.011
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0053 0.2626
Echinococcus multilocularis neuroglian 0.0259 0.0488 0.0486
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.0323 0.0321
Entamoeba histolytica protein kinase, putative 0.008 0.0053 0.0781
Onchocerca volvulus 0.0059 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0327 0.0653 0.0653
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.046 0.0978 0.3283
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0437 0.0921 0.0919
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Loa Loa (eye worm) hypothetical protein 0.0059 0.0002 0.0002
Echinococcus granulosus NCK adaptor protein 0.0107 0.0117 0.0115
Echinococcus multilocularis natriuretic peptide receptor 1 0.008 0.0053 0.0051
Echinococcus multilocularis tyrosine protein kinase csk 0.008 0.0053 0.0051
Schistosoma mansoni protein kinase 0.008 0.0053 0.0051
Trypanosoma brucei cdc2-related kinase 1 0.0139 0.0197 0.0678
Echinococcus granulosus c src tyrosine kinase 0.0187 0.0313 0.0311
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Loa Loa (eye worm) hypothetical protein 0.008 0.0053 0.0053
Brugia malayi Raf kinase 0.008 0.0053 0.0051
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.008 0.0053 0.0053
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0053 0.0051
Schistosoma mansoni nephrin 0.0107 0.0117 0.0115
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.0112 0.011
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.008 0.0053 0.0051
Loa Loa (eye worm) TK protein kinase 0.008 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0059 0.0002 0.0002
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0139 0.0197 0.0195
Plasmodium vivax serine/threonine kinase-1, putative 0.013 0.0175 0.8467
Echinococcus granulosus epidermal growth factor receptor 0.417 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0139 0.0197 0.0197
Brugia malayi protein-tyrosine kinase 0.0389 0.0805 0.0803
Loa Loa (eye worm) hypothetical protein 0.0417 0.0873 0.0873
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0107 0.0117 0.0117
Trichomonas vaginalis CMGC family protein kinase 0.0139 0.0197 1
Schistosoma mansoni tyrosine kinase 0.0139 0.0197 0.0195
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0437 0.0921 0.0919
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.008 0.0053 0.0781
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0084 0.0062 0.006
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.008 0.0053 0.0051
Entamoeba histolytica tyrosine kinase, putative 0.008 0.0053 0.0781
Schistosoma mansoni tyrosine kinase 0.2187 0.5176 0.5175
Loa Loa (eye worm) TK/EPH protein kinase 0.0155 0.0234 0.0234
Onchocerca volvulus 0.0139 0.0197 0.0432
Schistosoma mansoni tyrosine kinase 0.008 0.0053 0.0051
Echinococcus multilocularis retinal guanylyl cyclase 2 0.008 0.0053 0.0051
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0139 0.0197 0.0678
Schistosoma mansoni tyrosine kinase 0.2187 0.5176 0.5175
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.008 0.0053 0.0051
Onchocerca volvulus 0.0139 0.0197 0.0432
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Schistosoma mansoni tyrosine kinase 0.0185 0.0307 0.0305
Loa Loa (eye worm) hypothetical protein 0.0059 0.0002 0.0002
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0271 0.0516 0.0514
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0187 0.0313 0.0311
Echinococcus granulosus dual specificity 0.0191 0.0323 0.0321
Onchocerca volvulus 0.008 0.0053 0.0117
Echinococcus granulosus neuroglian 0.0107 0.0117 0.0115
Echinococcus multilocularis retinal guanylyl cyclase 2 0.008 0.0053 0.0051
Loa Loa (eye worm) hypothetical protein 0.0215 0.0381 0.0381
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0291 0.0565 0.0563
Schistosoma mansoni tyrosine kinase 0.008 0.0053 0.0051
Echinococcus granulosus fibroblast growth factor receptor 4 0.0291 0.0565 0.0563
Entamoeba histolytica hypothetical protein 0.008 0.0053 0.0781
Brugia malayi hypothetical protein 0.008 0.0053 0.0051
Schistosoma mansoni tyrosine kinase 0.008 0.0053 0.0051
Trichomonas vaginalis protein kinase atn1, putative 0.008 0.0053 0.2626
Loa Loa (eye worm) serine/threonine protein kinase 0.008 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0271 0.0516 0.0516
Plasmodium vivax protein kinase, putative 0.0085 0.0065 0.0778
Loa Loa (eye worm) hypothetical protein 0.0215 0.0381 0.0381
Entamoeba histolytica tyrosine kinase, putative 0.008 0.0053 0.0781
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0437 0.0921 0.0919
Loa Loa (eye worm) SRC-1 0.0437 0.0921 0.0921
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0084 0.0062 0.0207
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0191 0.0323 0.1118
Schistosoma mansoni tyrosine kinase 0.2267 0.5371 0.537
Onchocerca volvulus Tyrosine kinase homolog 0.1937 0.457 1
Echinococcus multilocularis integrin linked protein kinase 0.008 0.0053 0.0051
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Echinococcus granulosus tyrosine protein kinase Lyn 0.044 0.0929 0.0927
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.008 0.0053 0.0051
Loa Loa (eye worm) TK/FER protein kinase 0.008 0.0053 0.0053
Echinococcus granulosus lachesin 0.0104 0.0112 0.011
Loa Loa (eye worm) TK/ALK protein kinase 0.032 0.0636 0.0636
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.013 0.0175 0.0431
Schistosoma mansoni tyrosine kinase 0.008 0.0053 0.0051
Loa Loa (eye worm) TK/ABL protein kinase 0.0139 0.0197 0.0197
Entamoeba histolytica tyrosine kinase, putative 0.008 0.0053 0.0781
Trypanosoma brucei cdc2-related kinase 3 0.0139 0.0197 0.0678
Trypanosoma cruzi protein kinase, putative 0.008 0.0053 0.0178
Schistosoma mansoni protein kinase 0.008 0.0053 0.0051
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0139 0.0197 0.0195
Echinococcus granulosus epidermal growth factor receptor 0.2267 0.5371 0.537
Onchocerca volvulus 0.0139 0.0197 0.0432
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Loa Loa (eye worm) hypothetical protein 0.0059 0.0002 0.0002
Echinococcus multilocularis receptor type guanylyl cyclase 0.008 0.0053 0.0051
Brugia malayi fructose-1,6-bisphosphatase 0.1238 0.2869 0.2867
Schistosoma mansoni cell adhesion molecule 0.0273 0.0522 0.052
Loa Loa (eye worm) hypothetical protein 0.0059 0.0002 0.0002
Leishmania major protein kinase, putative 0.0084 0.0062 0.0207
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.013 0.0175 0.0601
Brugia malayi Receptor family ligand binding region containing protein 0.008 0.0053 0.0051
Entamoeba histolytica tyrosine kinase, putative 0.008 0.0053 0.0781
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.008 0.0053 0.0781
Loa Loa (eye worm) TK/FER protein kinase 0.0139 0.0197 0.0197
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0059 0.0002 0.0002
Brugia malayi Protein kinase domain containing protein 0.008 0.0053 0.0051
Entamoeba histolytica tyrosin kinase, putative 0.008 0.0053 0.0781
Echinococcus granulosus tyrosine protein kinase pr2 0.008 0.0053 0.0051
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Loa Loa (eye worm) hypothetical protein 0.0213 0.0375 0.0375
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0053 0.0781
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.008 0.0053 0.0053
Entamoeba histolytica protein kinase, putative 0.008 0.0053 0.0781
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Entamoeba histolytica cysteine surface protein, putative 0.008 0.0053 0.0781
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1742 0.4095 0.4094
Trichomonas vaginalis TKL family protein kinase 0.008 0.0053 0.2626
Schistosoma mansoni tyrosine kinase 0.2187 0.5176 0.5175
Brugia malayi cell division control protein 2 homolog 0.0139 0.0197 0.0195
Echinococcus multilocularis tyrosine kinase 0.0139 0.0197 0.0195
Loa Loa (eye worm) hypothetical protein 0.0059 0.0002 0.0002
Echinococcus multilocularis Immunoglobulin 0.0213 0.0375 0.0373

Activities

Activity type Activity value Assay description Source Reference
MISS T/C (functional) = 1.14 In vivo blood glucose was determined in obese, hyperglycemic, hyperinsulinemic, insulin-resistant KKAy mice after a dose of 500 mg/kg for 4 days ChEMBL. 11312923

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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