Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | Starlite/ChEMBL | References |
Homo sapiens | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 0.2895 | 0.2895 |
Schistosoma mansoni | hypothetical protein | 0.0311 | 0.2083 | 0.1626 |
Echinococcus multilocularis | slit 2 protein | 0.0311 | 0.2083 | 0.2065 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0964 | 1 | 1 |
Echinococcus multilocularis | protein jagged 1 | 0.0311 | 0.2083 | 0.2065 |
Echinococcus multilocularis | notch | 0.0311 | 0.2083 | 0.2065 |
Onchocerca volvulus | 0.0964 | 1 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0964 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0311 | 0.2083 | 0.1626 |
Echinococcus granulosus | delta-like protein 1 | 0.0311 | 0.2083 | 0.2065 |
Loa Loa (eye worm) | hypothetical protein | 0.0964 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0964 | 1 | 1 |
Echinococcus granulosus | slit 2 protein | 0.0311 | 0.2083 | 0.2065 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Brugia malayi | Peroxidasin | 0.0964 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0311 | 0.2083 | 0.2065 |
Schistosoma mansoni | notch | 0.0311 | 0.2083 | 0.1626 |
Loa Loa (eye worm) | hypothetical protein | 0.0964 | 1 | 1 |
Schistosoma mansoni | notch | 0.0311 | 0.2083 | 0.1626 |
Brugia malayi | Animal haem peroxidase family protein | 0.0964 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0964 | 1 | 1 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0311 | 0.2083 | 0.1626 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0311 | 0.2083 | 0.2083 |
Echinococcus multilocularis | neural cadherin | 0.0311 | 0.2083 | 0.2065 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Loa Loa (eye worm) | hypothetical protein | 0.0964 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0964 | 1 | 1 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0378 | 0.2895 | 0.2895 |
Onchocerca volvulus | 0.0964 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Loa Loa (eye worm) | hypothetical protein | 0.0964 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Brugia malayi | EGF-like domain containing protein | 0.0311 | 0.2083 | 0.2083 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.1705 | 0.1686 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0185 | 0.0546 | 0.0546 |
Schistosoma mansoni | hypothetical protein | 0.0311 | 0.2083 | 0.1626 |
Echinococcus granulosus | fibropellin Ia | 0.0311 | 0.2083 | 0.2065 |
Loa Loa (eye worm) | hypothetical protein | 0.0964 | 1 | 1 |
Echinococcus granulosus | protein jagged 2 | 0.0311 | 0.2083 | 0.2065 |
Echinococcus multilocularis | fibropellin Ia | 0.0311 | 0.2083 | 0.2065 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0311 | 0.2083 | 0.2083 |
Loa Loa (eye worm) | hypothetical protein | 0.0964 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0964 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0964 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0964 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0311 | 0.2083 | 0.1626 |
Brugia malayi | EGF-like domain containing protein | 0.0311 | 0.2083 | 0.2083 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0311 | 0.2083 | 0.2065 |
Echinococcus granulosus | peroxidasin | 0.0964 | 1 | 1 |
Brugia malayi | Muscle positioning protein 4 | 0.0311 | 0.2083 | 0.2083 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Brugia malayi | EGF-like domain containing protein | 0.0311 | 0.2083 | 0.2083 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Giardia lamblia | High cysteine protein | 0.0311 | 0.2083 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0964 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0311 | 0.2083 | 0.1626 |
Onchocerca volvulus | Peroxidasin homolog | 0.0964 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0311 | 0.2083 | 0.1626 |
Loa Loa (eye worm) | hypothetical protein | 0.0964 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0964 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0964 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0311 | 0.2083 | 0.2065 |
Schistosoma mansoni | notch | 0.0311 | 0.2083 | 0.1626 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0311 | 0.2083 | 0.2065 |
Echinococcus multilocularis | protein jagged 2 | 0.0311 | 0.2083 | 0.2065 |
Schistosoma mansoni | septate junction protein | 0.0311 | 0.2083 | 0.1626 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0311 | 0.2083 | 0.2065 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Schistosoma mansoni | slit | 0.0311 | 0.2083 | 0.1626 |
Echinococcus granulosus | protein jagged 1 | 0.0311 | 0.2083 | 0.2065 |
Brugia malayi | notch-like transmembrane receptor | 0.0311 | 0.2083 | 0.2083 |
Schistosoma mansoni | peroxidasin | 0.0964 | 1 | 1 |
Onchocerca volvulus | 0.0964 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0064 | 0.0064 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0311 | 0.2083 | 0.2065 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0311 | 0.2083 | 0.5 |
Brugia malayi | Cadherin domain containing protein | 0.0311 | 0.2083 | 0.2083 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Loa Loa (eye worm) | Notch2 | 0.0311 | 0.2083 | 0.2083 |
Brugia malayi | EGF-like domain containing protein | 0.0311 | 0.2083 | 0.2083 |
Brugia malayi | EGF-like domain containing protein | 0.0311 | 0.2083 | 0.2083 |
Schistosoma mansoni | notch | 0.0311 | 0.2083 | 0.1626 |
Brugia malayi | Animal haem peroxidase family protein | 0.0964 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0964 | 1 | 1 |
Loa Loa (eye worm) | notch protein | 0.0311 | 0.2083 | 0.2083 |
Brugia malayi | EGF-like domain containing protein | 0.0311 | 0.2083 | 0.2083 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0311 | 0.2083 | 0.2065 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0311 | 0.2083 | 0.2065 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.1705 | 0.1686 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0311 | 0.2083 | 0.2083 |
Loa Loa (eye worm) | hypothetical protein | 0.0964 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0964 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0964 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Loa Loa (eye worm) | hypothetical protein | 0.0964 | 1 | 1 |
Echinococcus granulosus | notch | 0.0311 | 0.2083 | 0.2065 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0964 | 1 | 1 |
Echinococcus multilocularis | protein jagged 1 | 0.0311 | 0.2083 | 0.2065 |
Echinococcus granulosus | protein jagged 2 | 0.0311 | 0.2083 | 0.2065 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0964 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0964 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Brugia malayi | EGF-like domain containing protein | 0.0311 | 0.2083 | 0.2083 |
Echinococcus granulosus | protein jagged 1 | 0.0311 | 0.2083 | 0.2065 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0311 | 0.2083 | 0.2065 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Schistosoma mansoni | hypothetical protein | 0.0311 | 0.2083 | 0.1626 |
Brugia malayi | Cadherin domain containing protein | 0.0311 | 0.2083 | 0.2083 |
Loa Loa (eye worm) | hypothetical protein | 0.0964 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0964 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Onchocerca volvulus | Peroxidase homolog | 0.0964 | 1 | 1 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.1008 | 0.0489 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0964 | 1 | 1 |
Schistosoma mansoni | notch | 0.0311 | 0.2083 | 0.1626 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0285 | 0.1759 | 0.1759 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.2083 | 0.2083 |
Schistosoma mansoni | notch | 0.0311 | 0.2083 | 0.1626 |
Brugia malayi | Delta serrate ligand family protein | 0.0311 | 0.2083 | 0.2083 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0311 | 0.2083 | 0.2083 |
Echinococcus granulosus | neural cadherin | 0.0311 | 0.2083 | 0.2065 |
Schistosoma mansoni | cell polarity protein | 0.0311 | 0.2083 | 0.1626 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0311 | 0.2083 | 0.2065 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0311 | 0.2083 | 0.1626 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0311 | 0.2083 | 0.2083 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2100 nM | Inhibition of ADP-induced platelet aggregation in human platelet-rich plasma. | ChEMBL. | 10052962 |
IC50 (functional) | = 2100 nM | Inhibition of ADP-induced platelet aggregation in human platelet-rich plasma. | ChEMBL. | 10052962 |
Ki (binding) | = 290 nM | Fibrinogen receptor binding affinity was determined by assaying for inhibition of [3H]-1 binding to purified Fibrinogen Receptor isolated from human platelets and reconstituted in liposomes | ChEMBL. | 10052962 |
Ki (binding) | = 290 nM | Fibrinogen receptor binding affinity was determined by assaying for inhibition of [3H]-1 binding to purified Fibrinogen Receptor isolated from human platelets and reconstituted in liposomes | ChEMBL. | 10052962 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 10052962 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.