Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0035 | 0 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0271 | 0.8717 | 1 |
Treponema pallidum | flavodoxin | 0.0117 | 0.3033 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0117 | 0.3033 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0155 | 0.4458 | 0.4458 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0155 | 0.4458 | 0.4458 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0305 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0151 | 0.4316 | 0.968 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0102 | 0.2487 | 0.2487 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0155 | 0.4458 | 0.4458 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0189 | 0.5684 | 0.5684 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0151 | 0.4316 | 0.4316 |
Leishmania major | cytochrome P450 reductase, putative | 0.0271 | 0.8717 | 0.8717 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0155 | 0.4458 | 0.2046 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0117 | 0.3033 | 0.3033 |
Leishmania major | hypothetical protein, conserved | 0.0117 | 0.3033 | 0.3033 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0305 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0155 | 0.4458 | 0.4458 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0305 | 1 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0189 | 0.5684 | 0.5684 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0155 | 0.4458 | 0.4458 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0155 | 0.4458 | 0.4458 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0102 | 0.2487 | 0.2487 |
Giardia lamblia | Hypothetical protein | 0.0271 | 0.8717 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0155 | 0.4458 | 0.4458 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0155 | 0.4458 | 0.2046 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0155 | 0.4458 | 1 |
Leishmania major | p450 reductase, putative | 0.0305 | 1 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0117 | 0.3033 | 0.3033 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0035 | 0 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0155 | 0.4458 | 0.4458 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0117 | 0.3033 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0155 | 0.4458 | 0.4458 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0305 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0154 | 0.4402 | 0.4402 |
Brugia malayi | MAP kinase sur-1 | 0.0155 | 0.4458 | 0.4458 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0305 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0271 | 0.8717 | 0.8159 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0102 | 0.2487 | 0.2487 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0305 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0305 | 1 | 1 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0088 | 0.1958 | 0.1958 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0117 | 0.3033 | 0.3033 |
Echinococcus granulosus | methionine synthase reductase | 0.0189 | 0.5684 | 0.5684 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0117 | 0.3033 | 0.3033 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0155 | 0.4458 | 0.4458 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0155 | 0.4458 | 0.5114 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0035 | 0 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0305 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0189 | 0.5684 | 0.5684 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0305 | 1 | 1 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0117 | 0.3033 | 0.3033 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0305 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0117 | 0.3033 | 0.3033 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0305 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0305 | 1 | 1 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0117 | 0.3033 | 0.3033 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0155 | 0.4458 | 0.2046 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0305 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0155 | 0.4458 | 0.4458 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0155 | 0.4458 | 0.2046 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0305 | 1 | 1 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0035 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0117 | 0.3033 | 0.5 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0271 | 0.8717 | 0.8717 |
Chlamydia trachomatis | sulfite reductase | 0.0189 | 0.5684 | 1 |
Brugia malayi | flavodoxin family protein | 0.0117 | 0.3033 | 0.3033 |
Giardia lamblia | Kinase, AGC AKT | 0.0088 | 0.1958 | 0.2246 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0155 | 0.4458 | 0.4458 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0305 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0117 | 0.3033 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0151 | 0.4316 | 0.968 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0305 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0305 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0305 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0305 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0305 | 1 | 1 |
Brugia malayi | ribosomal protein S6 kinase alpha 3 | 0.0088 | 0.1958 | 0.1958 |
Brugia malayi | FAD binding domain containing protein | 0.0189 | 0.5684 | 0.5684 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0155 | 0.4458 | 0.4458 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0117 | 0.3033 | 0.3033 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0305 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0155 | 0.4458 | 0.4458 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0102 | 0.2487 | 0.2487 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0117 | 0.3033 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.