Detailed information for compound 263069

Basic information

Technical information
  • TDR Targets ID: 263069
  • Name: 7-chloro-N-[3-[4-[3-(cyclohexylmethylamino)pr opyl]piperazin-1-yl]propyl]quinolin-4-amine
  • MW: 458.082 | Formula: C26H40ClN5
  • H donors: 2 H acceptors: 1 LogP: 5.31 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)nccc2NCCCN1CCN(CC1)CCCNCC1CCCCC1
  • InChi: 1S/C26H40ClN5/c27-23-8-9-24-25(10-13-30-26(24)20-23)29-12-5-15-32-18-16-31(17-19-32)14-4-11-28-21-22-6-2-1-3-7-22/h8-10,13,20,22,28H,1-7,11-12,14-19,21H2,(H,29,30)
  • InChiKey: UXGGOTXAZVUPLC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-chloro-N-[3-[4-[3-(cyclohexylmethylamino)propyl]-1-piperazinyl]propyl]-4-quinolinamine
  • (7-chloro-4-quinolyl)-[3-[4-[3-(cyclohexylmethylamino)propyl]piperazino]propyl]amine
  • 3-[4-[3-[(7-chloro-4-quinolyl)amino]propyl]piperazin-1-yl]propyl-(cyclohexylmethyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cruzipain precursor, putative 0.00898577 0.0254029 0.0249195
Echinococcus granulosus neuropeptide s receptor 0.0266185 0.0878853 0.10804
Loa Loa (eye worm) hypothetical protein 0.00317063 0.00479669 0.00609112
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.00298304 0.00413195 0.00449537
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0266185 0.0878853 0.123434
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.00207973 0.000931034 0.000435452
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Brugia malayi Protein kinase domain containing protein 0.00298304 0.00413195 0.00515222
Loa Loa (eye worm) TK/ABL protein kinase 0.00298304 0.00413195 0.00515222
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00898577 0.0254029 0.0249195
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Entamoeba histolytica cysteine protease, putative 0.00239425 0.00204554 0.0175929
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0110824 0.0328325 0.0323527
Plasmodium falciparum cysteine proteinase falcipain 1 0.00239425 0.00204554 0.00155051
Echinococcus granulosus histone deacetylase 7 0.028607 0.0949319 0.116751
Loa Loa (eye worm) hypothetical protein 0.0150665 0.0469502 0.0656303
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022507 0.00153686 0.00147046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Brugia malayi Cathepsin L-like precursor 0.00426815 0.00868582 0.0115843
Trichomonas vaginalis conserved hypothetical protein 0.00195691 0.000495798 0.0014859
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.201752 0.70848 1
Brugia malayi Papain family cysteine protease containing protein 0.00239425 0.00204554 0.0022053
Schistosoma mansoni tyrosine kinase 0.00986359 0.0285136 0.039574
Entamoeba histolytica cysteine proteinase, putative 0.00239425 0.00204554 0.0175929
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Schistosoma mansoni tyrosine kinase 0.00662512 0.0170379 0.023365
Schistosoma mansoni cathepsin D (A01 family) 0.0280687 0.0930243 0.130693
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00898577 0.0254029 0.0249195
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0266185 0.0878853 0.123449
Trypanosoma cruzi major cysteine proteinase, putative 0.0058342 0.0142352 0.0137462
Schistosoma mansoni biogenic amine receptor 0.0266185 0.0878853 0.123434
Echinococcus multilocularis roundabout 2 0.00317063 0.00479669 0.00531719
Leishmania major histone deacetylase, putative 0.028607 0.0949319 0.094483
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Loa Loa (eye worm) hypothetical protein 0.00195691 0.000495798 0.0000163762
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Echinococcus granulosus dro:myosuppressin receptor 0.0266185 0.0878853 0.10804
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Echinococcus granulosus rhodopsin orphan GPCR 0.0266185 0.0878853 0.10804
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Trichomonas vaginalis histone deacetylase, putative 0.0268159 0.088585 0.265488
Brugia malayi RE15519p 0.0266185 0.0878853 0.123449
Trypanosoma brucei Replication factor A protein 1 0.00424961 0.00862011 0.00812834
Brugia malayi histone deacetylase 1 (HD1) 0.0268159 0.088585 0.124437
Onchocerca volvulus 0.00298304 0.00413195 0.00513593
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Brugia malayi Protein kinase domain containing protein 0.00298304 0.00413195 0.00515222
Brugia malayi replication factor A 73 kDa subunit 0.00906098 0.0256695 0.0355726
Brugia malayi ORL1-like opioid receptor 0.0266185 0.0878853 0.123449
Brugia malayi bone morphogenetic protein type 1 receptor 0.00195691 0.000495798 0.0000163762
Echinococcus granulosus tyrosine protein kinase Fyn 0.00298304 0.00413195 0.00449537
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Brugia malayi cathepsin L-like precursor 0.00299049 0.00415836 0.00518952
Plasmodium vivax aspartyl protease, putative 0.0022507 0.00153686 0.00104158
Schistosoma mansoni memapsin-2 (A01 family) 0.0022507 0.00153686 0.00147046
Schistosoma mansoni histone deacetylase hda2 0.0294655 0.0979739 0.137684
Echinococcus granulosus histone deacetylase 6 0.028607 0.0949319 0.116751
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.012394 0.0374801 0.0522544
Onchocerca volvulus 0.0266185 0.0878853 0.123434
Brugia malayi Cathepsin L-like precursor 0.00299049 0.00415836 0.00518952
Plasmodium falciparum histone deacetylase 1 0.0268159 0.088585 0.0881329
Onchocerca volvulus 0.201752 0.70848 1
Trypanosoma cruzi histone deacetylase, putative 0.0135406 0.0415432 0.0410677
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022507 0.00153686 0.00147046
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Loa Loa (eye worm) aspartic protease BmAsp-2 0.00951984 0.0272955 0.0378692
Schistosoma mansoni replication factor A 1 rfa1 0.00906098 0.0256695 0.0355568
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00298304 0.00413195 0.00449537
Echinococcus multilocularis cathepsin L cysteine protease 0.00426815 0.00868582 0.0101253
Brugia malayi cathepsin B-like cysteine proteinase 0.0109278 0.0322846 0.0449161
Echinococcus multilocularis 0.00460345 0.00987395 0.0115942
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.00889233 0.0250718 0.07514
Trypanosoma brucei histone deacetylase 2 0.0135406 0.0415432 0.0410677
Giardia lamblia Cathepsin B precursor 0.00515047 0.0118124 0.128467
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0266185 0.0878853 0.10804
Plasmodium vivax histone deacetylase 1, putative 0.0268159 0.088585 0.0881329
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Entamoeba histolytica cell division protein kinase 2, putative 0.00885023 0.0249227 0.277297
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.28402 1 1
Entamoeba histolytica cysteine protease, putative 0.00239425 0.00204554 0.0175929
Echinococcus granulosus sex peptide receptor 0.0266185 0.0878853 0.10804
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00239425 0.00204554 0.00155051
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Giardia lamblia Cathepsin B precursor 0.00515047 0.0118124 0.128467
Brugia malayi hypothetical protein 0.095979 0.333668 0.470602
Schistosoma mansoni tyrosine kinase 0.00298304 0.00413195 0.00513593
Echinococcus granulosus tyrosine protein kinase shark 0.00298304 0.00413195 0.00449537
Brugia malayi neuropeptide F receptor 0.0266185 0.0878853 0.123449
Echinococcus multilocularis allatostatin A receptor 0.0266185 0.0878853 0.10804
Echinococcus multilocularis epidermal growth factor receptor 0.00986359 0.0285136 0.0346383
Trypanosoma brucei histone deacetylase, putative 0.028607 0.0949319 0.094483
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.00198071 0.000580137 0.000104269
Onchocerca volvulus 0.00298304 0.00413195 0.00513593
Loa Loa (eye worm) RGC/RGC protein kinase 0.00195691 0.000495798 0.0000163762
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0110824 0.0328325 0.0399778
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.00515047 0.0118124 0.0113222
Trypanosoma brucei protein kinase, putative 0.00207973 0.000931034 0.000435452
Onchocerca volvulus 0.0266185 0.0878853 0.123434
Echinococcus multilocularis tyrosine protein kinase Fgr 0.00298304 0.00413195 0.00449537
Toxoplasma gondii cathepsin CPL 0.00426815 0.00868582 0.00819408
Chlamydia trachomatis 1,4-alpha-glucan branching enzyme 0.0026484 0.00294613 0.00587221
Echinococcus multilocularis neuropeptide Y receptor 0.0266185 0.0878853 0.10804
Plasmodium falciparum plasmepsin III 0.0022507 0.00153686 0.00104158
Plasmodium vivax aspartyl protease, putative 0.0022507 0.00153686 0.00104158
Loa Loa (eye worm) hypothetical protein 0.00426815 0.00868582 0.0115843
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.00515047 0.0118124 0.0354015
Loa Loa (eye worm) TK protein kinase 0.00298304 0.00413195 0.00515222
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0109278 0.0322846 0.0449004
Brugia malayi SRC-1 0.00298304 0.00413195 0.00515222
Echinococcus multilocularis cathepsin b 0.0109278 0.0322846 0.0393004
Entamoeba histolytica cysteine protease, putative 0.00239425 0.00204554 0.0175929
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0266185 0.0878853 0.10804
Brugia malayi aspartic protease BmAsp-1, identical 0.0022507 0.00153686 0.00148681
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0266185 0.0878853 0.123449
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0266185 0.0878853 0.123434
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.00272434 0.00321522 0.00272077
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0266185 0.0878853 0.123434
Loa Loa (eye worm) TK/INSR protein kinase 0.00662512 0.0170379 0.023381
Brugia malayi Cathepsin L-like precursor 0.00426815 0.00868582 0.0115843
Plasmodium vivax histone deacetylase 2, putative 0.028607 0.0949319 0.094483
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus granulosus fmrfamide receptor 0.0266185 0.0878853 0.10804
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Onchocerca volvulus 0.00299049 0.00415836 0.00517322
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022507 0.00153686 0.00147046
Plasmodium falciparum protein kinase 5 0.00885023 0.0249227 0.024439
Brugia malayi Papain family cysteine protease containing protein 0.00239425 0.00204554 0.0022053
Echinococcus granulosus segment polarity protein dishevelled 0.012394 0.0374801 0.0457237
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.00707142 0.0186193 0.0255988
Trypanosoma brucei cysteine peptidase C (CPC) 0.00515047 0.0118124 0.0113222
Loa Loa (eye worm) histone deacetylase 0.028607 0.0949319 0.133402
Toxoplasma gondii histone deacetylase HDAC2 0.0268159 0.088585 0.0881329
Onchocerca volvulus 0.0266185 0.0878853 0.123434
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.00195691 0.000495798 0.0000163762
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Trypanosoma cruzi cdc2-related kinase 3 0.00885023 0.0249227 0.024439
Echinococcus granulosus c src tyrosine kinase 0.00298304 0.00413195 0.00449537
Onchocerca volvulus 0.0266185 0.0878853 0.123434
Trichomonas vaginalis CAMK family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0266185 0.0878853 0.10804
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0110824 0.0328325 0.0323527
Trypanosoma cruzi cysteine protease, putative 0.00239425 0.00204554 0.00155051
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus multilocularis neuropeptide Y receptor 0.0266185 0.0878853 0.10804
Brugia malayi hypothetical protein 0.0266185 0.0878853 0.123449
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Loa Loa (eye worm) TK/FER protein kinase 0.00298304 0.00413195 0.00515222
Echinococcus granulosus cathepsin l cysteine peptidase 0.00426815 0.00868582 0.0101253
Schistosoma mansoni neuropeptide receptor 0.0416096 0.141007 0.198467
Schistosoma mansoni tyrosine kinase 0.00790669 0.0215792 0.0297794
Loa Loa (eye worm) TK/EGFR protein kinase 0.0167453 0.0528994 0.0740333
Onchocerca volvulus 0.0266185 0.0878853 0.123434
Echinococcus multilocularis dro:myosuppressin receptor 0.0266185 0.0878853 0.10804
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Echinococcus multilocularis neuropeptide receptor 0.0416096 0.141007 0.173714
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0266185 0.0878853 0.123434
Echinococcus granulosus neuropeptides capa receptor 0.0266185 0.0878853 0.10804
Brugia malayi integrin-linked kinase 0.00195691 0.000495798 0.0000163762
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Plasmodium falciparum replication protein A1, large subunit 0.00424961 0.00862011 0.00812834
Schistosoma mansoni tyrosine kinase 0.00790669 0.0215792 0.0297794
Echinococcus granulosus cyclin dependent kinase 1 0.00885023 0.0249227 0.0301989
Echinococcus granulosus cysteine protease 0.00239425 0.00204554 0.00191595
Echinococcus multilocularis neuropeptide s receptor 0.0266185 0.0878853 0.10804
Entamoeba histolytica cysteine protease, putative 0.00239425 0.00204554 0.0175929
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus granulosus cathepsin l1 0.00426815 0.00868582 0.0101253
Echinococcus granulosus tyrosine protein kinase Fyn 0.00298304 0.00413195 0.00449537
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Giardia lamblia Cathepsin B precursor 0.00515047 0.0118124 0.128467
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Onchocerca volvulus Neuropeptide F receptor homolog 0.0266185 0.0878853 0.123434
Brugia malayi hypothetical protein 0.0022507 0.00153686 0.00148681
Brugia malayi SH2 domain containing protein 0.00298304 0.00413195 0.00515222
Echinococcus granulosus alpha 1A adrenergic receptor 0.0266185 0.0878853 0.10804
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0266185 0.0878853 0.10804
Echinococcus granulosus potassium voltage gated channel subfamily H 0.00198071 0.000580137 0.000104269
Loa Loa (eye worm) RGC/RGC protein kinase 0.00195691 0.000495798 0.0000163762
Echinococcus granulosus cathepsin b 0.0109278 0.0322846 0.0393004
Brugia malayi Histone deacetylase 1 0.0268159 0.088585 0.124437
Echinococcus multilocularis Immunoglobulin 0.00317063 0.00479669 0.00531719
Loa Loa (eye worm) melatonin receptor type 1A 0.0266185 0.0878853 0.123449
Echinococcus granulosus neuroglian 0.00317063 0.00479669 0.00531719
Schistosoma mansoni voltage-gated potassium channel 0.00218377 0.00129968 0.00113546
Echinococcus multilocularis somatostatin receptor 0.0266185 0.0878853 0.10804
Onchocerca volvulus 0.00298304 0.00413195 0.00513593
Loa Loa (eye worm) TK protein kinase 0.00195691 0.000495798 0.0000163762
Onchocerca volvulus 0.0266185 0.0878853 0.123434
Echinococcus granulosus tyrosine protein kinase Btk29A 0.00298304 0.00413195 0.00449537
Echinococcus multilocularis tyrosine protein kinase shark 0.00298304 0.00413195 0.00449537
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.201752 0.70848 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00298304 0.00413195 0.00449537
Schistosoma mansoni hypothetical protein 0.0266185 0.0878853 0.123434
Loa Loa (eye worm) hypothetical protein 0.00195691 0.000495798 0.0000163762
Loa Loa (eye worm) hypothetical protein 0.00317063 0.00479669 0.00609112
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.00195691 0.000495798 0.0014859
Brugia malayi histone deacetylase 11 0.0359319 0.120888 0.170063
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0109278 0.0322846 0.0449004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Plasmodium falciparum histone deacetylase, putative 0.028607 0.0949319 0.094483
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0266185 0.0878853 0.123434
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Plasmodium vivax replication protein A1, large subunit, putative 0.00424961 0.00862011 0.00812834
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Trichomonas vaginalis histone deacetylase, putative 0.0268159 0.088585 0.265488
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00951984 0.0272955 0.0378535
Onchocerca volvulus 0.00426815 0.00868582 0.0115681
Loa Loa (eye worm) TK protein kinase 0.00195691 0.000495798 0.0000163762
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0022507 0.00153686 0.00104158
Trichomonas vaginalis alpha-amylase, putative 0.00771315 0.0208934 0.0626172
Loa Loa (eye worm) hypothetical protein 0.00299049 0.00415836 0.00518952
Echinococcus multilocularis activin receptor type 0.00207973 0.000931034 0.000538082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00898577 0.0254029 0.0249195
Loa Loa (eye worm) TK protein kinase 0.00195691 0.000495798 0.0000163762
Onchocerca volvulus 0.0266185 0.0878853 0.123434
Echinococcus granulosus rhodopsin orphan GPCR 0.0266185 0.0878853 0.10804
Brugia malayi hypothetical protein 0.124304 0.43404 0.612371
Leishmania major cathepsin L-like protease 0.00426815 0.00868582 0.00819408
Echinococcus granulosus thymidylate synthase 0.201752 0.70848 0.87528
Loa Loa (eye worm) hypothetical protein 0.00317063 0.00479669 0.00609112
Brugia malayi Serotonin receptor 0.0266185 0.0878853 0.123449
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00898577 0.0254029 0.0249195
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus multilocularis tyrosine kinase 0.00298304 0.00413195 0.00449537
Loa Loa (eye worm) hypothetical protein 0.00195691 0.000495798 0.0000163762
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus multilocularis g protein coupled receptor 0.0266185 0.0878853 0.10804
Loa Loa (eye worm) hypothetical protein 0.0109278 0.0322846 0.0449161
Onchocerca volvulus 0.00426815 0.00868582 0.0115681
Echinococcus granulosus twitchin 0.00329346 0.00523193 0.00585527
Brugia malayi follicle stimulating hormone receptor 0.0266185 0.0878853 0.123449
Echinococcus multilocularis g-protein coupled receptor 0.0266185 0.0878853 0.10804
Loa Loa (eye worm) hypothetical protein 0.0159249 0.0499921 0.0699269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00239425 0.00204554 0.00613047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00898577 0.0254029 0.0249195
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.00662512 0.0170379 0.0204509
Entamoeba histolytica cysteine proteinase, putative 0.00239425 0.00204554 0.0175929
Onchocerca volvulus Histone deacetylase 10 homolog 0.0135406 0.0415432 0.0579778
Plasmodium vivax histone deacetylase, putative 0.0359319 0.120888 0.120452
Echinococcus granulosus histone deacetylase 0.028607 0.0949319 0.116751
Giardia lamblia Histone deacetylase 0.0268159 0.088585 1
Brugia malayi Raf kinase 0.00195691 0.000495798 0.0000163762
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus granulosus tyrosine protein kinase Fyn 0.00298304 0.00413195 0.00449537
Toxoplasma gondii OB-fold nucleic acid binding domain-containing protein 0.00212229 0.00108183 0.00058632
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Trypanosoma cruzi histone deacetylase 1, putative 0.0268159 0.088585 0.0881329
Toxoplasma gondii alpha amylase, catalytic domain-containing protein 0.0026484 0.00294613 0.00245155
Echinococcus granulosus rhodopsin orphan GPCR 0.0266185 0.0878853 0.10804
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.00424961 0.00862011 0.0258344
Toxoplasma gondii histone deacetylase HDAC3 0.0268159 0.088585 0.0881329
Echinococcus multilocularis g protein coupled receptor 0.0266185 0.0878853 0.10804
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00239425 0.00204554 0.00218896
Trichomonas vaginalis conserved hypothetical protein 0.00195691 0.000495798 0.0014859
Echinococcus granulosus peptide allatostatin:somatostatin 0.0266185 0.0878853 0.10804
Plasmodium falciparum plasmepsin I 0.00951984 0.0272955 0.026813
Plasmodium vivax plasmepsin IV, putative 0.00951984 0.0272955 0.026813
Trichomonas vaginalis amylase, putative 0.00771315 0.0208934 0.0626172
Echinococcus granulosus epidermal growth factor receptor 0.00986359 0.0285136 0.0346383
Toxoplasma gondii glycosyltransferase 0.0026484 0.00294613 0.00245155
Echinococcus granulosus allatostatin A receptor 0.0266185 0.0878853 0.10804
Schistosoma mansoni tyrosine kinase 0.00790669 0.0215792 0.0297794
Echinococcus multilocularis rhodopsin orphan GPCR 0.0266185 0.0878853 0.10804
Entamoeba histolytica histone deacetylase, putative 0.0268159 0.088585 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.00195691 0.000495798 0.0000163762
Schistosoma mansoni vesicular amine transporter 0.00333435 0.00537683 0.00689427
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0266185 0.0878853 0.10804
Brugia malayi histone deacetylase 3 (HD3) 0.0268159 0.088585 0.124437
Schistosoma mansoni growth hormone secretagogue receptor 0.0266185 0.0878853 0.123434
Schistosoma mansoni cathepsin D (A01 family) 0.0280687 0.0930243 0.130693
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Loa Loa (eye worm) hypothetical protein 0.00195691 0.000495798 0.0000163762
Echinococcus multilocularis segment polarity protein dishevelled 0.012394 0.0374801 0.0457237
Brugia malayi Cathepsin L-like precursor 0.00426815 0.00868582 0.0115843
Brugia malayi Protein kinase domain containing protein 0.00298304 0.00413195 0.00515222
Trichomonas vaginalis alpha-amylase, putative 0.00771315 0.0208934 0.0626172
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Echinococcus multilocularis rhodopsin orphan GPCR 0.0266185 0.0878853 0.10804
Schistosoma mansoni histone deacetylase 4 5 0.028607 0.0949319 0.133387
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Loa Loa (eye worm) TYRA-2 protein 0.0266185 0.0878853 0.123449
Loa Loa (eye worm) hypothetical protein 0.00317063 0.00479669 0.00609112
Schistosoma mansoni nephrin 0.00317063 0.00479669 0.00607485
Brugia malayi Dopamine receptor protein 1 0.0266185 0.0878853 0.123449
Trypanosoma brucei cdc2-related kinase 3 0.00885023 0.0249227 0.024439
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0268159 0.088585 0.265488
Echinococcus multilocularis thymidylate synthase 0.201752 0.70848 0.87528
Loa Loa (eye worm) hypothetical protein 0.0135406 0.0415432 0.0579932
Trichomonas vaginalis CMGC family protein kinase 0.00885023 0.0249227 0.074693
Schistosoma mansoni histone deacetylase 0.0268159 0.088585 0.124423
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Schistosoma mansoni tyrosine kinase 0.00986359 0.0285136 0.039574
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00898577 0.0254029 0.0249195
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0266185 0.0878853 0.10804
Trichomonas vaginalis AGC family protein kinase 0.00195691 0.000495798 0.0014859
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0022507 0.00153686 0.00148681
Loa Loa (eye worm) TK/ALK protein kinase 0.00195691 0.000495798 0.0000163762
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.00906098 0.0256695 0.0311222
Echinococcus granulosus tm gpcr rhodopsin 0.230221 0.809362 1
Brugia malayi Fibronectin type III domain containing protein 0.00317063 0.00479669 0.00609112
Loa Loa (eye worm) TK protein kinase 0.00195691 0.000495798 0.0000163762
Entamoeba histolytica cysteine protease, putative 0.00239425 0.00204554 0.0175929
Schistosoma mansoni Neurotrimin precursor (hNT) 0.00317063 0.00479669 0.00607485
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Schistosoma mansoni myosin xvIII 0.0266185 0.0878853 0.123434
Loa Loa (eye worm) G-protein coupled receptor 0.0266185 0.0878853 0.123449
Echinococcus multilocularis histone deacetylase 6 0.0294655 0.0979739 0.120512
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0266185 0.0878853 0.123434
Echinococcus granulosus rhodopsin orphan GPCR 0.0266185 0.0878853 0.10804
Echinococcus multilocularis neuroglian 0.00317063 0.00479669 0.00531719
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Brugia malayi Probable tyrosine-protein kinase kin-31 0.00195691 0.000495798 0.0000163762
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0266185 0.0878853 0.123434
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus multilocularis neuropeptide receptor A26 0.0266185 0.0878853 0.10804
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.00207973 0.000931034 0.000435452
Trypanosoma cruzi histone deacetylase 1, putative 0.0268159 0.088585 0.0881329
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.00317063 0.00479669 0.00607485
Brugia malayi Immunoglobulin I-set domain containing protein 0.00512754 0.0117311 0.0158856
Echinococcus multilocularis histone deacetylase 6 0.028607 0.0949319 0.116751
Brugia malayi Cathepsin L-like precursor 0.00426815 0.00868582 0.0115843
Schistosoma mansoni opsin-like receptor 0.0266185 0.0878853 0.123434
Echinococcus granulosus tm gpcr rhodopsin 0.0266185 0.0878853 0.10804
Plasmodium falciparum plasmepsin IX 0.0022507 0.00153686 0.00104158
Echinococcus multilocularis cathepsin l cysteine peptidase 0.00426815 0.00868582 0.0101253
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0110824 0.0328325 0.0323527
Plasmodium falciparum plasmepsin VII 0.0022507 0.00153686 0.00104158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00299049 0.00415836 0.0124625
Brugia malayi ephrin receptor 1 precursor 0.00195691 0.000495798 0.0000163762
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.00298304 0.00413195 0.00449537
Brugia malayi dihydrofolate reductase family protein 0.0822677 0.285082 0.401976
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus granulosus tyrosine protein kinase Src42A 0.00298304 0.00413195 0.00449537
Onchocerca volvulus 0.0266185 0.0878853 0.123434
Echinococcus granulosus g protein coupled receptor 0.0266185 0.0878853 0.10804
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.00885023 0.0249227 0.024439
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0266185 0.0878853 0.123449
Entamoeba histolytica cysteine protease, putative 0.00239425 0.00204554 0.0175929
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0335571 0.112473 0.138437
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus granulosus biogenic amine 5HT receptor 0.0266185 0.0878853 0.10804
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Loa Loa (eye worm) TK/CSK protein kinase 0.00195691 0.000495798 0.0000163762
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00898577 0.0254029 0.0249195
Loa Loa (eye worm) papain family cysteine protease containing protein 0.00426815 0.00868582 0.0115843
Echinococcus multilocularis histone deacetylase 3 0.0268159 0.088585 0.108905
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0110824 0.0328325 0.0456743
Loa Loa (eye worm) histone deacetylase 7A 0.028607 0.0949319 0.133402
Schistosoma mansoni histone deacetylase hda2 0.0135406 0.0415432 0.0579778
Brugia malayi Cathepsin L-like cysteine proteinase 0.00299049 0.00415836 0.00518952
Brugia malayi Tachykinin-like peptides receptor 99D 0.0266185 0.0878853 0.123449
Giardia lamblia Kinase, CMGC CDK 0.00885023 0.0249227 0.277297
Echinococcus granulosus cyclin dependent kinase 5 0.00885023 0.0249227 0.0301989
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Brugia malayi Dihydrofolate reductase 0.0822677 0.285082 0.401976
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0110824 0.0328325 0.04569
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0266185 0.0878853 0.123434
Brugia malayi Probable tyrosine-protein kinase kin-31 0.00195691 0.000495798 0.0000163762
Echinococcus granulosus rhodopsin orphan GPCR 0.0266185 0.0878853 0.10804
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0266185 0.0878853 0.123449
Echinococcus multilocularis dihydrofolate reductase 0.0822677 0.285082 0.351833
Trypanosoma cruzi cdc2-related kinase 1 0.00885023 0.0249227 0.024439
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0266185 0.0878853 0.123434
Loa Loa (eye worm) hypothetical protein 0.00195691 0.000495798 0.0000163762
Mycobacterium tuberculosis 1,4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme) 0.0026484 0.00294613 0.00235654
Brugia malayi G-protein coupled receptor 0.0266185 0.0878853 0.123449
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00299049 0.00415836 0.0124625
Brugia malayi Cathepsin L-like precursor 0.00426815 0.00868582 0.0115843
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Loa Loa (eye worm) TK/FER protein kinase 0.00298304 0.00413195 0.00515222
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Brugia malayi hypothetical protein 0.0266185 0.0878853 0.123449
Loa Loa (eye worm) TK/FER protein kinase 0.00298304 0.00413195 0.00515222
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Echinococcus multilocularis rhodopsin orphan GPCR 0.0266185 0.0878853 0.10804
Toxoplasma gondii 1,4-alpha-glucan-branching enzyme 0.0026484 0.00294613 0.00245155
Schistosoma mansoni amine GPCR 0.0266185 0.0878853 0.123434
Loa Loa (eye worm) RGC/RGC protein kinase 0.00195691 0.000495798 0.0000163762
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0266185 0.0878853 0.10804
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0266185 0.0878853 0.123449
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.00195691 0.000495798 0.0014859
Mycobacterium ulcerans glycogen branching protein 0.0026484 0.00294613 0.00235654
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Echinococcus granulosus cathepsin b 0.0109278 0.0322846 0.0393004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0266185 0.0878853 0.10804
Plasmodium vivax vivapain-2 0.00426815 0.00868582 0.00819408
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Brugia malayi hypothetical protein 0.0266185 0.0878853 0.123449
Echinococcus granulosus g protein coupled receptor 0.0266185 0.0878853 0.10804
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.28402 1 1
Loa Loa (eye worm) hypothetical protein 0.00317063 0.00479669 0.00609112
Echinococcus multilocularis fmrfamide receptor 0.0266185 0.0878853 0.10804
Chlamydia trachomatis dihydrofolate reductase 0.0822677 0.285082 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00898577 0.0254029 0.0249195
Plasmodium vivax protein kinase Crk2 0.00885023 0.0249227 0.024439
Plasmodium falciparum plasmepsin X 0.0022507 0.00153686 0.00104158
Brugia malayi hypothetical protein 0.0266185 0.0878853 0.123449
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.00317063 0.00479669 0.00531719
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00239425 0.00204554 0.00218896
Loa Loa (eye worm) histone deacetylase 1 0.0268159 0.088585 0.124437
Onchocerca volvulus 0.0266185 0.0878853 0.123434
Onchocerca volvulus 0.0022507 0.00153686 0.00147046
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Brugia malayi Receptor family ligand binding region containing protein 0.00195691 0.000495798 0.0000163762
Plasmodium falciparum plasmepsin V 0.0022507 0.00153686 0.00104158
Echinococcus granulosus roundabout 2 0.00317063 0.00479669 0.00531719
Loa Loa (eye worm) TK/FER protein kinase 0.00298304 0.00413195 0.00515222
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.00906098 0.0256695 0.0769311
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.00195691 0.000495798 0.0000163762
Loa Loa (eye worm) hypothetical protein 0.00317063 0.00479669 0.00609112
Plasmodium vivax vivapain-3 0.00239425 0.00204554 0.00155051
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0268159 0.088585 0.265488
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.00239425 0.00204554 0.00155051
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00298304 0.00413195 0.00449537
Loa Loa (eye worm) hypothetical protein 0.00317063 0.00479669 0.00609112
Leishmania major cathepsin L-like protease 0.00898577 0.0254029 0.0249195
Schistosoma mansoni neuropeptide f receptor 76f 0.0266185 0.0878853 0.123434
Plasmodium vivax plasmepsin V, putative 0.0022507 0.00153686 0.00104158
Trypanosoma cruzi cysteine peptidase, putative 0.00898577 0.0254029 0.0249195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00239425 0.00204554 0.00155051
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.201752 0.70848 1
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.00298304 0.00413195 0.00513593
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.00298304 0.00413195 0.00449537
Schistosoma mansoni alpha-1 adrenergic receptor 0.0266185 0.0878853 0.123434
Echinococcus multilocularis histone deacetylase 7 0.028607 0.0949319 0.116751
Entamoeba histolytica cell division protein kinase 2, putative 0.00885023 0.0249227 0.277297
Trichomonas vaginalis conserved hypothetical protein 0.095979 0.333668 1
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.00804652 0.0220746 0.0304793
Schistosoma mansoni amine GPCR 0.0266185 0.0878853 0.123434
Trypanosoma brucei histone deacetylase 4 0.028607 0.0949319 0.094483
Entamoeba histolytica cysteine protease, putative 0.00239425 0.00204554 0.0175929
Echinococcus multilocularis histone deacetylase 6 0.028607 0.0949319 0.116751
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.28402 1 1
Schistosoma mansoni amine GPCR 0.0266185 0.0878853 0.123434
Trypanosoma cruzi cysteine proteinase, putative 0.00239425 0.00204554 0.00155051
Entamoeba histolytica cysteine protease, putative 0.00239425 0.00204554 0.0175929
Schistosoma mansoni adenoreceptor 0.0266185 0.0878853 0.123434
Echinococcus multilocularis tyrosine protein kinase Src64B 0.00298304 0.00413195 0.00449537
Mycobacterium ulcerans thymidylate synthase 0.201752 0.70848 1
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Schistosoma mansoni dishevelled 0.0110526 0.0327267 0.045525
Schistosoma mansoni amine GPCR 0.0266185 0.0878853 0.123434
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0266185 0.0878853 0.123449
Loa Loa (eye worm) TK/KIN16 protein kinase 0.00512754 0.0117311 0.0158856
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Loa Loa (eye worm) TK/FER protein kinase 0.00195691 0.000495798 0.0000163762
Echinococcus multilocularis rhodopsin orphan GPCR 0.0266185 0.0878853 0.10804
Echinococcus multilocularis cyclin dependent kinase 5 0.00885023 0.0249227 0.0301989
Leishmania major dihydrofolate reductase-thymidylate synthase 0.28402 1 1
Schistosoma mansoni neuropeptide receptor 0.0266185 0.0878853 0.123434
Plasmodium vivax unspecified product 0.00239425 0.00204554 0.00155051
Trichomonas vaginalis CMGC family protein kinase 0.00885023 0.0249227 0.074693
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0266185 0.0878853 0.123434
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.00885023 0.0249227 0.0345178
Echinococcus granulosus histone deacetylase 3 0.0268159 0.088585 0.108905
Onchocerca volvulus 0.00426815 0.00868582 0.0115681
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0109278 0.0322846 0.0449004
Echinococcus multilocularis cathepsin l cysteine peptidase 0.00426815 0.00868582 0.0101253
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Echinococcus granulosus neuropeptide Y receptor 0.0266185 0.0878853 0.10804
Plasmodium falciparum plasmepsin II 0.00951984 0.0272955 0.026813
Brugia malayi Papain family cysteine protease containing protein 0.00426815 0.00868582 0.0115843
Schistosoma mansoni protein kinase 0.00207973 0.000931034 0.000614755
Plasmodium vivax aspartyl protease, putative 0.0022507 0.00153686 0.00104158
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Plasmodium vivax histone deacetylase, putative 0.028607 0.0949319 0.094483
Leishmania major histone deacetylase, putative 0.0268159 0.088585 0.0881329
Leishmania major histone deacetylase, putative 0.0268159 0.088585 0.0881329
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Schistosoma mansoni protein kinase 0.00207973 0.000931034 0.000614755
Echinococcus granulosus tyrosine protein kinase ABL1 0.00298304 0.00413195 0.00449537
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0266185 0.0878853 0.123449
Echinococcus multilocularis rhodopsin orphan GPCR 0.0266185 0.0878853 0.10804
Echinococcus granulosus cathepsin L 0.00239425 0.00204554 0.00191595
Brugia malayi cell division control protein 2 homolog 0.00885023 0.0249227 0.0345178
Schistosoma mansoni tyrosine kinase 0.00662512 0.0170379 0.023365
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0266185 0.0878853 0.123434
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0266185 0.0878853 0.123434
Echinococcus multilocularis sex peptide receptor 0.0266185 0.0878853 0.10804
Echinococcus granulosus histone deacetylase 1 0.0268159 0.088585 0.108905
Echinococcus multilocularis basement membrane specific heparan sulfate 0.00317063 0.00479669 0.00531719
Leishmania major cathepsin L-like protease 0.00426815 0.00868582 0.00819408
Onchocerca volvulus 0.0266185 0.0878853 0.123434
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.230221 0.809362 1
Brugia malayi putative neuropeptide receptor NPR1 0.0266185 0.0878853 0.123449
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.00195691 0.000495798 0.0014859
Entamoeba histolytica cysteine proteinase, putative 0.00239425 0.00204554 0.0175929
Echinococcus multilocularis glucan (1,4 alpha), branching enzyme 1 0.0026484 0.00294613 0.00302935
Schistosoma mansoni neuropeptide receptor 0.0266185 0.0878853 0.123434
Echinococcus multilocularis neuropeptides capa receptor 0.0266185 0.0878853 0.10804
Plasmodium vivax aspartyl proteinase, putative 0.00951984 0.0272955 0.026813
Echinococcus granulosus g protein coupled receptor 0.0266185 0.0878853 0.10804
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Echinococcus granulosus neuropeptide FF receptor 2 0.0266185 0.0878853 0.10804
Brugia malayi Eukaryotic aspartyl protease family protein 0.0022507 0.00153686 0.00148681
Loa Loa (eye worm) histone deacetylase 11 0.0359319 0.120888 0.170063
Echinococcus multilocularis epidermal growth factor receptor 0.0167453 0.0528994 0.0647865
Loa Loa (eye worm) TK/FAK protein kinase 0.00195691 0.000495798 0.0000163762
Trichomonas vaginalis histone deacetylase, putative 0.0268159 0.088585 0.265488
Loa Loa (eye worm) TK/FER protein kinase 0.00195691 0.000495798 0.0000163762
Echinococcus multilocularis histone deacetylase 0.028607 0.0949319 0.116751
Loa Loa (eye worm) hypothetical protein 0.0022507 0.00153686 0.00148681
Loa Loa (eye worm) hypothetical protein 0.00195691 0.000495798 0.0000163762
Trichomonas vaginalis conserved hypothetical protein 0.00195691 0.000495798 0.0014859
Echinococcus granulosus cathepsin l1 0.00299049 0.00415836 0.00452802
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0335571 0.112473 0.138437
Schistosoma mansoni protein kinase 0.00207973 0.000931034 0.000614755
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Loa Loa (eye worm) hypothetical protein 0.00195691 0.000495798 0.0000163762
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Schistosoma mansoni tyrosine kinase 0.00298304 0.00413195 0.00513593
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Loa Loa (eye worm) TK/ACK protein kinase 0.00195691 0.000495798 0.0000163762
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.00951984 0.0272955 0.0818042
Trypanosoma brucei histone deacetylase 3 0.028607 0.0949319 0.094483
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Trichomonas vaginalis conserved hypothetical protein 0.00195691 0.000495798 0.0014859
Loa Loa (eye worm) hypothetical protein 0.00951984 0.0272955 0.0378692
Trichomonas vaginalis STE family protein kinase 0.00195691 0.000495798 0.0014859
Brugia malayi aspartic protease BmAsp-2, identical 0.0022507 0.00153686 0.00148681
Echinococcus granulosus cyclin dependent kinase 0.00885023 0.0249227 0.0301989
Echinococcus granulosus insulin receptor 0.00662512 0.0170379 0.0204509
Plasmodium falciparum cysteine proteinase falcipain 3 0.00426815 0.00868582 0.00819408
Loa Loa (eye worm) TK/ROR protein kinase 0.00195691 0.000495798 0.0000163762
Echinococcus multilocularis serotonin receptor 0.0266185 0.0878853 0.10804
Trichomonas vaginalis histone deacetylase, putative 0.0268159 0.088585 0.265488
Echinococcus granulosus Immunoglobulin 0.00317063 0.00479669 0.00531719
Brugia malayi G protein-coupled receptor 0.0266185 0.0878853 0.123449
Echinococcus multilocularis cathepsin L 0.00239425 0.00204554 0.00191595
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Echinococcus granulosus segment polarity protein dishevelled 0.012394 0.0374801 0.0457237
Echinococcus granulosus cathepsin L cysteine protease 0.00239425 0.00204554 0.00191595
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus multilocularis cysteine protease 0.00426815 0.00868582 0.0101253
Schistosoma mansoni tyrosine kinase 0.0167453 0.0528994 0.0740181
Loa Loa (eye worm) serine/threonine protein kinase 0.00195691 0.000495798 0.0000163762
Brugia malayi C-terminal src kinase protein 1 0.00195691 0.000495798 0.0000163762
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.00195691 0.000495798 0.0000163762
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.00951984 0.0272955 0.0331324
Loa Loa (eye worm) hypothetical protein 0.00195691 0.000495798 0.0000163762
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022507 0.00153686 0.00147046
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.00198071 0.000580137 0.0001355
Trichomonas vaginalis TK family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus granulosus tyrosine protein kinase Srms 0.00298304 0.00413195 0.00449537
Schistosoma mansoni cathepsin F (C01 family) 0.00426815 0.00868582 0.0115681
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0266185 0.0878853 0.123434
Echinococcus granulosus 7TM GPCR rhodopsin 0.0266185 0.0878853 0.10804
Brugia malayi hypothetical protein 0.0266185 0.0878853 0.123449
Echinococcus multilocularis cyclin dependent kinase 0.00885023 0.0249227 0.0301989
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus multilocularis cathepsin b 0.0109278 0.0322846 0.0393004
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0266185 0.0878853 0.10804
Loa Loa (eye worm) hypothetical protein 0.00195691 0.000495798 0.0000163762
Echinococcus granulosus activin receptor type 0.00207973 0.000931034 0.000538082
Trichomonas vaginalis amylase, putative 0.0026484 0.00294613 0.00882953
Trichomonas vaginalis starch branching enzyme II, putative 0.0026484 0.00294613 0.00882953
Echinococcus granulosus rhodopsin orphan GPCR 0.0266185 0.0878853 0.10804
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Trypanosoma cruzi histone deacetylase, putative 0.0135406 0.0415432 0.0410677
Trypanosoma cruzi cdc2-related kinase 3 0.00885023 0.0249227 0.024439
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Brugia malayi hypothetical protein 0.0022507 0.00153686 0.00148681
Brugia malayi Guanylyl cyclase protein 23 0.00195691 0.000495798 0.0000163762
Onchocerca volvulus 0.0022507 0.00153686 0.00147046
Loa Loa (eye worm) TK/DDR protein kinase 0.00195691 0.000495798 0.0000163762
Echinococcus granulosus biogenic amine 5HT receptor 0.0266185 0.0878853 0.10804
Brugia malayi Histone deacetylase family protein 0.028607 0.0949319 0.133402
Loa Loa (eye worm) TK protein kinase 0.00195691 0.000495798 0.0000163762
Loa Loa (eye worm) hypothetical protein 0.00299049 0.00415836 0.00518952
Loa Loa (eye worm) thymidylate synthase 0.201752 0.70848 1
Loa Loa (eye worm) TK/FER protein kinase 0.00195691 0.000495798 0.0000163762
Toxoplasma gondii aspartyl protease ASP1 0.00951984 0.0272955 0.026813
Brugia malayi Dopamine receptor 0.0266185 0.0878853 0.123449
Loa Loa (eye worm) histone deacetylase 3 0.0268159 0.088585 0.124437
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.00885023 0.0249227 0.0301989
Trypanosoma cruzi cysteine peptidase, putative 0.00898577 0.0254029 0.0249195
Onchocerca volvulus 0.00426815 0.00868582 0.0115681
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0266185 0.0878853 0.123449
Entamoeba histolytica 1,4-alpha-glucan branching enzyme, putative 0.0026484 0.00294613 0.0278165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Echinococcus multilocularis serotonin receptor 0.0266185 0.0878853 0.10804
Brugia malayi hypothetical protein 0.00195691 0.000495798 0.0000163762
Loa Loa (eye worm) hypothetical protein 0.00299049 0.00415836 0.00518952
Echinococcus multilocularis neuropeptides capa receptor 0.0266185 0.0878853 0.10804
Schistosoma mansoni tyrosine kinase 0.00298304 0.00413195 0.00513593
Echinococcus granulosus neuropeptide receptor 0.0416096 0.141007 0.173714
Trypanosoma cruzi cdc2-related kinase 1 0.00885023 0.0249227 0.024439
Mycobacterium tuberculosis Hypothetical protein 0.095979 0.333668 0.470006
Entamoeba histolytica alpha-amylase family protein 0.00771315 0.0208934 0.231556
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0266185 0.0878853 0.10804
Onchocerca volvulus 0.0266185 0.0878853 0.123434
Echinococcus multilocularis segment polarity protein dishevelled 0.012394 0.0374801 0.0457237
Leishmania major protein kinase, putative 0.00207973 0.000931034 0.000435452
Echinococcus granulosus serotonin receptor 0.0266185 0.0878853 0.10804
Entamoeba histolytica cysteine proteinase 1, putative 0.00239425 0.00204554 0.0175929
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0266185 0.0878853 0.123434
Echinococcus multilocularis orexin receptor type 2 0.0266185 0.0878853 0.10804
Trichomonas vaginalis conserved hypothetical protein 0.00195691 0.000495798 0.0014859
Brugia malayi Cathepsin L-like precursor 0.00299049 0.00415836 0.00518952
Brugia malayi Immunoglobulin I-set domain containing protein 0.00195691 0.000495798 0.0000163762
Loa Loa (eye worm) hypothetical protein 0.0223913 0.0729061 0.102291
Loa Loa (eye worm) hypothetical protein 0.012394 0.0374801 0.0522544
Echinococcus granulosus neuropeptide receptor A26 0.0266185 0.0878853 0.10804
Schistosoma mansoni voltage-gated potassium channel 0.00218377 0.00129968 0.00113546
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0266185 0.0878853 0.10804
Entamoeba histolytica cysteine protease, putative 0.00239425 0.00204554 0.0175929
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Loa Loa (eye worm) TK/RYK protein kinase 0.00195691 0.000495798 0.0000163762
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.00195691 0.000495798 0.0000163762
Leishmania major replication factor A, 51kDa subunit, putative 0.00424961 0.00862011 0.00812834
Brugia malayi GnHR receptor homolog 0.0266185 0.0878853 0.123449
Brugia malayi hypothetical protein 0.0266185 0.0878853 0.123449
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00898577 0.0254029 0.0249195
Loa Loa (eye worm) TK/FER protein kinase 0.00298304 0.00413195 0.00515222
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Loa Loa (eye worm) hypothetical protein 0.00317063 0.00479669 0.00609112
Loa Loa (eye worm) TK/FER protein kinase 0.00195691 0.000495798 0.0000163762
Trichomonas vaginalis histone deacetylase, putative 0.0268159 0.088585 0.265488
Echinococcus granulosus neuropeptide Y receptor 0.0266185 0.0878853 0.10804
Echinococcus multilocularis dual specificity testis specific protein kinase 0.00207973 0.000931034 0.000538082
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0266185 0.0878853 0.10804
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus granulosus dual specificity testis-specific protein kinase 0.00207973 0.000931034 0.000538082
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Echinococcus multilocularis neuropeptide receptor 0.0266185 0.0878853 0.10804
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0266185 0.0878853 0.123449
Trichomonas vaginalis conserved hypothetical protein 0.00195691 0.000495798 0.0014859
Plasmodium falciparum plasmepsin IV 0.00951984 0.0272955 0.026813
Onchocerca volvulus 0.00426815 0.00868582 0.0115681
Echinococcus granulosus histone deacetylase 6 0.0294655 0.0979739 0.120512
Echinococcus granulosus rhodopsin orphan GPCR 0.0266185 0.0878853 0.10804
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00239425 0.00204554 0.00218896
Plasmodium vivax vivapain-1 0.00239425 0.00204554 0.00155051
Echinococcus granulosus hypothetical protein 0.0266185 0.0878853 0.10804
Loa Loa (eye worm) hypothetical protein 0.0022507 0.00153686 0.00148681
Plasmodium falciparum plasmepsin VIII, putative 0.0022507 0.00153686 0.00104158
Brugia malayi hypothetical protein 0.0266185 0.0878853 0.123449
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.00298304 0.00413195 0.00449537
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Onchocerca volvulus 0.00426815 0.00868582 0.0115681
Loa Loa (eye worm) RGC/RGC protein kinase 0.00195691 0.000495798 0.0000163762
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0266185 0.0878853 0.123434
Loa Loa (eye worm) TK/FER protein kinase 0.00298304 0.00413195 0.00515222
Loa Loa (eye worm) TK/FER protein kinase 0.00298304 0.00413195 0.00515222
Echinococcus multilocularis G-protein coupled receptor, putative 0.0266185 0.0878853 0.10804
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Leishmania major cathepsin L-like protease 0.00426815 0.00868582 0.00819408
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022507 0.00153686 0.00147046
Loa Loa (eye worm) G-protein coupled receptor 0.0266185 0.0878853 0.123449
Schistosoma mansoni biogenic amine receptor 0.0266185 0.0878853 0.123434
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.00885023 0.0249227 0.024439
Loa Loa (eye worm) hypothetical protein 0.00195691 0.000495798 0.0000163762
Onchocerca volvulus 0.0266185 0.0878853 0.123434
Brugia malayi Pepsin A precursor 0.0022507 0.00153686 0.00148681
Loa Loa (eye worm) dihydrofolate reductase 0.0822677 0.285082 0.401976
Onchocerca volvulus 0.00426815 0.00868582 0.0115681
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022507 0.00153686 0.00147046
Plasmodium vivax aspartyl proteinase, putative 0.0022507 0.00153686 0.00104158
Entamoeba histolytica cysteine protease, putative 0.00239425 0.00204554 0.0175929
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0266185 0.0878853 0.123434
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus granulosus defective proboscis extension response 0.00317063 0.00479669 0.00531719
Schistosoma mansoni opsin-like receptor 0.0266185 0.0878853 0.123434
Onchocerca volvulus 0.0266185 0.0878853 0.123434
Brugia malayi Cathepsin L-like precursor 0.00426815 0.00868582 0.0115843
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0268159 0.088585 0.265488
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0822677 0.285082 0.401303
Echinococcus granulosus neuropeptides capa receptor 0.0266185 0.0878853 0.10804
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.00906098 0.0256695 0.0769311
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.00198071 0.000580137 0.0001355
Loa Loa (eye worm) TK/Met protein kinase 0.00195691 0.000495798 0.0000163762
Leishmania major cathepsin L-like protease 0.00426815 0.00868582 0.00819408
Echinococcus granulosus cathepsin L cysteine proteinase 0.00426815 0.00868582 0.0101253
Echinococcus granulosus tm gpcr rhodopsin 0.0266185 0.0878853 0.10804
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Trypanosoma cruzi histone deacetylase, putative 0.028607 0.0949319 0.094483
Schistosoma mansoni tyrosine kinase 0.00298304 0.00413195 0.00513593
Onchocerca volvulus 0.0266185 0.0878853 0.123434
Echinococcus granulosus tyrosine protein kinase Lyn 0.00310586 0.00456719 0.00503345
Schistosoma mansoni neuropeptide F-like receptor 0.0266185 0.0878853 0.123434
Plasmodium vivax vivapain-2 0.00426815 0.00868582 0.00819408
Loa Loa (eye worm) TK protein kinase 0.00195691 0.000495798 0.0000163762
Onchocerca volvulus Cathepsin L homolog 0.00426815 0.00868582 0.0115681
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Leishmania major cysteine peptidase A (CPA) 0.00426815 0.00868582 0.00819408
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.00298304 0.00413195 0.00449537
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Loa Loa (eye worm) hypothetical protein 0.00317063 0.00479669 0.00609112
Brugia malayi 1,4-alpha-glucan branching enzyme 0.0026484 0.00294613 0.00347733
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0266185 0.0878853 0.10804
Trypanosoma cruzi histone deacetylase, putative 0.028607 0.0949319 0.094483
Echinococcus granulosus epidermal growth factor receptor 0.0167453 0.0528994 0.0647865
Echinococcus granulosus tyrosine protein kinase Fps85D 0.00298304 0.00413195 0.00449537
Echinococcus multilocularis tyrosine protein kinase Src42A 0.00298304 0.00413195 0.00449537
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0110824 0.0328325 0.0323527
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.00207973 0.000931034 0.000435452
Echinococcus granulosus orexin receptor type 2 0.0266185 0.0878853 0.10804
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0266185 0.0878853 0.10804
Schistosoma mansoni cathepsin F (C01 family) 0.00426815 0.00868582 0.0115681
Trichomonas vaginalis alpha-amylase, putative 0.00710865 0.0187513 0.0561973
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.28402 1 1
Echinococcus granulosus g-protein coupled receptor 0.0266185 0.0878853 0.10804
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.00321393 0.00495014 0.00519025
Schistosoma mansoni hypothetical protein 0.0266185 0.0878853 0.123434
Toxoplasma gondii histone deacetylase HDAC4 0.0359319 0.120888 0.120452
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Entamoeba histolytica cysteine protease, putative 0.00239425 0.00204554 0.0175929
Brugia malayi hypothetical protein 0.0266185 0.0878853 0.123449
Loa Loa (eye worm) cysteine protease 0.00426815 0.00868582 0.0115843
Echinococcus multilocularis cyclin dependent kinase 1 0.00885023 0.0249227 0.0301989
Loa Loa (eye worm) TK/FER protein kinase 0.00298304 0.00413195 0.00515222
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Trichomonas vaginalis serine-threonine protein kinase, putative 0.00195691 0.000495798 0.0014859
Brugia malayi Histone deacetylase family protein 0.028607 0.0949319 0.133402
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Trypanosoma brucei cdc2-related kinase 1 0.00885023 0.0249227 0.024439
Echinococcus granulosus tyrosine kinase 0.00298304 0.00413195 0.00449537
Plasmodium falciparum histone deacetylase 2 0.028607 0.0949319 0.094483
Trichomonas vaginalis protein tyrosine kinase, putative 0.00195691 0.000495798 0.0014859
Loa Loa (eye worm) SRC-1 0.00298304 0.00413195 0.00515222
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Onchocerca volvulus 0.00298304 0.00413195 0.00513593
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0110824 0.0328325 0.0399778
Echinococcus granulosus dihydrofolate reductase 0.0822677 0.285082 0.351833
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.00195691 0.000495798 0.0000163762
Toxoplasma gondii cathepsin B 0.00515047 0.0118124 0.0113222
Schistosoma mansoni cell adhesion molecule 0.00317063 0.00479669 0.00607485
Loa Loa (eye worm) TK protein kinase 0.00195691 0.000495798 0.0000163762
Loa Loa (eye worm) TK/EPH protein kinase 0.00195691 0.000495798 0.0000163762
Trichomonas vaginalis protein kinase atn1, putative 0.00195691 0.000495798 0.0014859
Brugia malayi hypothetical protein 0.00298304 0.00413195 0.00515222
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus multilocularis cysteine protease 0.00426815 0.00868582 0.0101253
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.00195691 0.000495798 0.0000163762
Brugia malayi Protein kinase domain containing protein 0.00662512 0.0170379 0.023381
Loa Loa (eye worm) cathepsin B 0.00515047 0.0118124 0.0160003
Schistosoma mansoni dishevelled 0.012394 0.0374801 0.0522389
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.28402 1 1
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.00424961 0.00862011 0.00812834
Loa Loa (eye worm) hypothetical protein 0.00298304 0.00413195 0.00515222
Echinococcus granulosus tachykinin peptides receptor 99D 0.0425187 0.144229 0.177697
Schistosoma mansoni histone deacetylase 1 2 3 0.0135406 0.0415432 0.0579778
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Echinococcus multilocularis G protein coupled receptor 139 0.0416096 0.141007 0.173714
Brugia malayi Melatonin receptor type 1A 0.0266185 0.0878853 0.123449
Trichomonas vaginalis CMGC family protein kinase 0.00885023 0.0249227 0.074693
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.00207973 0.000931034 0.000435452
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.00906098 0.0256695 0.0311222
Loa Loa (eye worm) hypothetical protein 0.0026484 0.00294613 0.00347733
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0266185 0.0878853 0.10804
Brugia malayi protein-tyrosine kinase 0.00298304 0.00413195 0.00515222
Trichomonas vaginalis histone deacetylase, putative 0.0268159 0.088585 0.265488
Trichomonas vaginalis alpha-amylase, putative 0.00771315 0.0208934 0.0626172
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Plasmodium falciparum plasmepsin VI 0.00951984 0.0272955 0.026813
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00298304 0.00413195 0.00449537
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.00195691 0.000495798 0.0000163762
Entamoeba histolytica alpha-amylase family protein 0.00771315 0.0208934 0.231556
Echinococcus multilocularis Immunoglobulin 0.00317063 0.00479669 0.00531719
Brugia malayi Serotonin receptor 0.0266185 0.0878853 0.123449
Schistosoma mansoni biogenic amine (5HT) receptor 0.0266185 0.0878853 0.123434
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.00890431 0.0251143 0.0337029
Echinococcus multilocularis c src tyrosine kinase 0.00298304 0.00413195 0.00449537
Brugia malayi Protein kinase domain containing protein 0.00885023 0.0249227 0.0345178
Schistosoma mansoni neuropeptide receptor 0.0266185 0.0878853 0.123434
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022507 0.00153686 0.00147046
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Brugia malayi SH2 domain containing protein 0.00298304 0.00413195 0.00515222
Schistosoma mansoni serine/threonine protein kinase 0.00885023 0.0249227 0.034502
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0266185 0.0878853 0.123434
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0110824 0.0328325 0.0323527
Brugia malayi Protein kinase domain containing protein 0.00298304 0.00413195 0.00515222
Schistosoma mansoni cathepsin F (C01 family) 0.00299049 0.00415836 0.00517322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00239425 0.00204554 0.00613047
Schistosoma mansoni tyrosine kinase 0.00298304 0.00413195 0.00513593
Loa Loa (eye worm) hypothetical protein 0.00195691 0.000495798 0.0000163762
Trypanosoma cruzi Replication factor A protein 1 0.00424961 0.00862011 0.00812834
Schistosoma mansoni hypothetical protein 0.0266185 0.0878853 0.123434
Echinococcus granulosus glucan 14 alpha branching enzyme 1 0.0026484 0.00294613 0.00302935
Onchocerca volvulus Cathepsin L homolog 0.00426815 0.00868582 0.0115681
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0266185 0.0878853 0.123449
Toxoplasma gondii aspartyl protease 0.0022507 0.00153686 0.00104158
Echinococcus multilocularis histone deacetylase 8 0.0135406 0.0415432 0.0507468
Brugia malayi hypothetical protein 0.00195691 0.000495798 0.0000163762
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Schistosoma mansoni amine GPCR 0.0266185 0.0878853 0.123434
Leishmania major cathepsin L-like protease 0.00426815 0.00868582 0.00819408
Echinococcus granulosus insulin growth factor 1 receptor beta 0.00662512 0.0170379 0.0204509
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0110824 0.0328325 0.5
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Schistosoma mansoni neuropeptide F-like receptor 0.0266185 0.0878853 0.123434
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0110824 0.0328325 0.0323527
Plasmodium falciparum cysteine proteinase falcipain 2a 0.00426815 0.00868582 0.00819408
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.095979 0.333668 0.333338
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Giardia lamblia Kinase, CMGC CDK 0.00885023 0.0249227 0.277297
Entamoeba histolytica cysteine proteinase, putative 0.00426815 0.00868582 0.0929741
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.00885023 0.0249227 0.0345178
Trypanosoma cruzi histone deacetylase, putative 0.028607 0.0949319 0.094483
Schistosoma mansoni serine/threonine protein kinase 0.00885023 0.0249227 0.034502
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0077081 0.0208755 0.0203898
Loa Loa (eye worm) TK/KIN6 protein kinase 0.00195691 0.000495798 0.0000163762
Echinococcus multilocularis rhodopsin orphan GPCR 0.0266185 0.0878853 0.10804
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus multilocularis cyclin dependent kinase 1 0.00885023 0.0249227 0.0301989
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0109278 0.0322846 0.0449004
Onchocerca volvulus 0.00298304 0.00413195 0.00513593
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Entamoeba histolytica SH2-protein kinase domain containing protein 0.00298304 0.00413195 0.0412781
Brugia malayi thymidylate synthase 0.201752 0.70848 1
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.00298304 0.00413195 0.00449537
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.00951984 0.0272955 0.026813
Toxoplasma gondii histone deacetylase HDAC1 0.028607 0.0949319 0.094483
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Schistosoma mansoni tyrosine kinase 0.00298304 0.00413195 0.00513593
Loa Loa (eye worm) neuropeptide F receptor 0.0266185 0.0878853 0.123449
Onchocerca volvulus 0.0266185 0.0878853 0.123434
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.00515047 0.0118124 0.0113222
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.00515047 0.0118124 0.0159842
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0266185 0.0878853 0.123434
Loa Loa (eye worm) TK/FER protein kinase 0.00298304 0.00413195 0.00515222
Onchocerca volvulus 0.0266185 0.0878853 0.123434
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Brugia malayi Tyrosine-protein kinase PR2 0.00195691 0.000495798 0.0000163762
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Loa Loa (eye worm) fibroinase 0.00426815 0.00868582 0.0115843
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.00298304 0.00413195 0.00449537
Brugia malayi Furin-like cysteine rich region family protein 0.0167453 0.0528994 0.0740333
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.00195691 0.000495798 0.0000163762
Leishmania major histone deacetylase, putative 0.028607 0.0949319 0.094483
Echinococcus multilocularis insulin receptor 0.00662512 0.0170379 0.0204509
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0266185 0.0878853 0.123434
Echinococcus multilocularis fmrfamide receptor 0.0266185 0.0878853 0.10804
Leishmania major cathepsin L-like protease 0.00898577 0.0254029 0.0249195
Entamoeba histolytica cysteine protease, putative 0.00239425 0.00204554 0.0175929
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00898577 0.0254029 0.0249195
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0022507 0.00153686 0.00147046
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus multilocularis tyrosine protein kinase Abl 0.00298304 0.00413195 0.00449537
Giardia lamblia 1,4-alpha-glucan branching enzyme 0.0026484 0.00294613 0.0278165
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.00195691 0.000495798 0.0000163762
Brugia malayi Protein kinase domain containing protein 0.00298304 0.00413195 0.00515222
Loa Loa (eye worm) neuropeptide F receptor 0.0266185 0.0878853 0.123449
Schistosoma mansoni histone deacetylase 4 5 0.028607 0.0949319 0.133387
Trichomonas vaginalis alpha-amylase, putative 0.00771315 0.0208934 0.0626172
Entamoeba histolytica protein kinase domain containing protein 0.00207973 0.000931034 0.00494086
Echinococcus granulosus tyrosine kinase 0.00298304 0.00413195 0.00449537
Plasmodium falciparum cysteine proteinase falcipain 2b 0.00426815 0.00868582 0.00819408
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0266185 0.0878853 0.123434
Loa Loa (eye worm) TK/FER protein kinase 0.00195691 0.000495798 0.0000163762
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.00890431 0.0251143 0.5
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0266185 0.0878853 0.10804
Trichomonas vaginalis amylase, putative 0.00771315 0.0208934 0.0626172
Loa Loa (eye worm) TK/FER protein kinase 0.00195691 0.000495798 0.0000163762
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Loa Loa (eye worm) DIX domain-containing protein 0.0024206 0.00213892 0.00233719
Loa Loa (eye worm) aspartyl protease 6 0.0022507 0.00153686 0.00148681
Trypanosoma cruzi cysteine peptidase, putative 0.00898577 0.0254029 0.0249195
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.00885023 0.0249227 0.0345178
Plasmodium falciparum protein kinase, putative 0.00207973 0.000931034 0.000435452
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.00890431 0.0251143 0.0337029
Brugia malayi Dopamine receptor protein 2 0.0266185 0.0878853 0.123449
Loa Loa (eye worm) hypothetical protein 0.0268159 0.088585 0.124437
Brugia malayi hypothetical protein 0.00317063 0.00479669 0.00609112
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus granulosus tyrosine protein kinase Src64B 0.00298304 0.00413195 0.00449537
Brugia malayi sulfakinin receptor protein 0.124304 0.43404 0.612371
Echinococcus granulosus histone deacetylase 8 0.0135406 0.0415432 0.0507468
Entamoeba histolytica cysteine proteinase, putative 0.00426815 0.00868582 0.0929741
Entamoeba histolytica cysteine proteinase 2 0.00239425 0.00204554 0.0175929
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Trypanosoma cruzi cysteine proteinase, putative 0.00239425 0.00204554 0.00155051
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Brugia malayi Tyrosine-protein kinase abl-1 0.00298304 0.00413195 0.00515222
Brugia malayi Immunoglobulin I-set domain containing protein 0.00317063 0.00479669 0.00609112
Loa Loa (eye worm) hypothetical protein 0.124304 0.43404 0.612371
Schistosoma mansoni histamine h1 receptor 0.0266185 0.0878853 0.123434
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.00885023 0.0249227 0.024439
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0110824 0.0328325 0.111179
Echinococcus multilocularis cathepsin L cysteine protease 0.00426815 0.00868582 0.0101253
Leishmania major cathepsin L-like protease 0.00898577 0.0254029 0.0249195
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.00986359 0.0285136 0.0346383
Brugia malayi neuropeptide F receptor 0.0266185 0.0878853 0.123449
Entamoeba histolytica cysteine protease, putative 0.00426815 0.00868582 0.0929741
Trypanosoma cruzi cysteine peptidase, putative 0.00426815 0.00868582 0.00819408
Echinococcus multilocularis tyrosine protein kinase Blk 0.00298304 0.00413195 0.00449537
Loa Loa (eye worm) hypothetical protein 0.00872741 0.0244874 0.0339031
Loa Loa (eye worm) TK protein kinase 0.00195691 0.000495798 0.0000163762
Loa Loa (eye worm) TK/FER protein kinase 0.00298304 0.00413195 0.00515222
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Entamoeba histolytica cysteine protease, putative 0.00239425 0.00204554 0.0175929
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.00298304 0.00413195 0.00449537
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0266185 0.0878853 0.10804
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.00906098 0.0256695 0.0355726
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Onchocerca volvulus Cathepsin F homolog 0.00426815 0.00868582 0.0115681
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.00890431 0.0251143 0.0337029
Brugia malayi DIX domain containing protein 0.0024206 0.00213892 0.00233719
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0266185 0.0878853 0.10804
Schistosoma mansoni histone deacetylase 0.0268159 0.088585 0.124423
Brugia malayi G-protein coupled receptor 0.0266185 0.0878853 0.123449
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Entamoeba histolytica cysteine proteinase, putative 0.00239425 0.00204554 0.0175929
Loa Loa (eye worm) protein kinase domain-containing protein 0.00195691 0.000495798 0.0000163762
Onchocerca volvulus 0.00298304 0.00413195 0.00513593
Loa Loa (eye worm) TK protein kinase 0.00195691 0.000495798 0.0000163762
Schistosoma mansoni opsin-like receptor 0.0266185 0.0878853 0.123434
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0822677 0.285082 0.401303
Entamoeba histolytica replication factor A protein 1, putative 0.00408096 0.00802249 0.0854439
Loa Loa (eye worm) ctsf protein 0.00426815 0.00868582 0.0115843
Schistosoma mansoni hypothetical protein 0.0266185 0.0878853 0.123434
Echinococcus multilocularis tyrosine protein kinase Srms 0.00298304 0.00413195 0.00449537
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0109278 0.0322846 0.0318046
Echinococcus granulosus neuropeptide receptor 0.0266185 0.0878853 0.10804
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.00951984 0.0272955 0.0331324
Trypanosoma cruzi cysteine peptidase, putative 0.00239425 0.00204554 0.00155051
Schistosoma mansoni starch branching enzyme II 0.0026484 0.00294613 0.00346101
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Echinococcus granulosus 7tm_1 domain containing protein 0.0266185 0.0878853 0.10804
Toxoplasma gondii aspartyl protease ASP3 0.0022507 0.00153686 0.00104158
Echinococcus granulosus somatostatin receptor 0.0266185 0.0878853 0.10804
Brugia malayi AKH receptor 0.0266185 0.0878853 0.123449
Loa Loa (eye worm) TK/FER protein kinase 0.00195691 0.000495798 0.0000163762
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0110824 0.0328325 0.04569
Echinococcus multilocularis g protein coupled receptor 0.0266185 0.0878853 0.10804
Brugia malayi Protein kinase domain containing protein 0.00195691 0.000495798 0.0000163762
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.00426815 0.00868582 0.0115843
Echinococcus multilocularis rhodopsin orphan GPCR 0.0266185 0.0878853 0.10804
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0266185 0.0878853 0.123434
Schistosoma mansoni biogenic amine receptor 0.0266185 0.0878853 0.123434
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Schistosoma mansoni biogenic amine (5HT) receptor 0.0266185 0.0878853 0.123434
Brugia malayi larval opioid receptor 0.0266185 0.0878853 0.123449
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0266185 0.0878853 0.123434
Echinococcus multilocularis tyrosine protein kinase ABL1 0.00298304 0.00413195 0.00449537
Echinococcus granulosus histone deacetylase 6 0.028607 0.0949319 0.116751
Toxoplasma gondii histone deacetylase HDAC5 0.0135406 0.0415432 0.0410677
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00898577 0.0254029 0.0249195
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.00890431 0.0251143 0.0752673
Echinococcus granulosus tyrosine protein kinase Blk 0.00298304 0.00413195 0.00449537
Trichomonas vaginalis conserved hypothetical protein 0.00195691 0.000495798 0.0014859
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0266185 0.0878853 0.123434
Trypanosoma brucei histone deacetylase 1 0.0268159 0.088585 0.0881329
Echinococcus multilocularis neuropeptide FF receptor 2 0.0266185 0.0878853 0.10804
Echinococcus multilocularis histone deacetylase 1 0.0268159 0.088585 0.108905
Echinococcus granulosus G protein coupled receptor 139 0.0266185 0.0878853 0.10804
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0425187 0.144229 0.177697
Brugia malayi G protein-coupled receptor F59B2.13 0.0266185 0.0878853 0.123449
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0822677 0.285082 0.401303
Brugia malayi hypothetical protein 0.0266185 0.0878853 0.123449
Entamoeba histolytica cysteine proteinase, putative 0.00299049 0.00415836 0.0415778
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00426815 0.00868582 0.0260313
Brugia malayi putative neuropeptide receptor 0.0266185 0.0878853 0.123449
Onchocerca volvulus 0.0266185 0.0878853 0.123434
Loa Loa (eye worm) hypothetical protein 0.00195691 0.000495798 0.0000163762
Trichomonas vaginalis TKL family protein kinase 0.00195691 0.000495798 0.0014859
Schistosoma mansoni dihydrofolate reductase 0.0822677 0.285082 0.401966
Entamoeba histolytica 1,4-alpha-glucan branching enzyme, putative 0.0026484 0.00294613 0.0278165
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0266185 0.0878853 0.10804
Loa Loa (eye worm) hypothetical protein 0.0266185 0.0878853 0.123449

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) = 5.5 uM Cytotoxicity was tested on human diploid embryonic lung cell line (MRC-5) (in vitro) ChEMBL. 12570376
CC50 (functional) = 5.5 uM Cytotoxicity was tested on human diploid embryonic lung cell line (MRC-5) (in vitro) ChEMBL. 12570376
CD50 (ADMET) = 5.5 uM Cytotoxicity against human MRC5 cells ChEMBL. 19361896
IC50 (functional) = 43 nM Antimalarial activity was determined by its inhibition of Plasmodium falciparum FcB1 strain (in vitro) ChEMBL. 12570376
IC50 (functional) = 43 nM Antimalarial activity was determined by its inhibition of Plasmodium falciparum FcB1 strain (in vitro) ChEMBL. 12570376
IC50 (functional) = 43 nM Antimalarial activity against Plasmodium falciparum FcB1/Columbia erythrocytes infected human MRC5 cells ChEMBL. 19361896

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 12570376

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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