Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | 0.0032 | 0.107 | 0.3119 |
Giardia lamblia | ABC transporter, putative | 0.003 | 0.0988 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0895 | 0.0895 |
Onchocerca volvulus | 0.0029 | 0.0895 | 0.5 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.3227 | 1 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0895 | 0.2561 |
Toxoplasma gondii | hypothetical protein | 0.018 | 1 | 1 |
Echinococcus granulosus | multidrug resistance associated protein 4 | 0.0023 | 0.0565 | 0.175 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.003 | 0.0988 | 1 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.0988 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.003 | 0.0988 | 0.5 |
Trypanosoma brucei | p-glycoprotein | 0.003 | 0.0988 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0895 | 0.2561 |
Entamoeba histolytica | ABC transporter, putative | 0.003 | 0.0988 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0973 | 0.0973 |
Loa Loa (eye worm) | multidrug resistance-associated protein | 0.0024 | 0.0579 | 0.0579 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.003 | 0.0988 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.003 | 0.0988 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3227 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.018 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3227 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.3227 | 1 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.3227 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.0988 | 0.0399 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.003 | 0.0988 | 0.0988 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0863 | 0.0863 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.003 | 0.0988 | 0.306 |
Echinococcus multilocularis | lamin | 0.0029 | 0.0895 | 0.2772 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3227 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.003 | 0.0988 | 0.5 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.003 | 0.0988 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0032 | 0.107 | 0.107 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.0988 | 0.0399 |
Brugia malayi | multidrug resistance related protein 1 | 0.003 | 0.0988 | 0.2857 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.003 | 0.0988 | 0.306 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.0988 | 0.0399 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.003 | 0.0988 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0895 | 0.0895 |
Onchocerca volvulus | 0.0029 | 0.0895 | 0.5 | |
Leishmania major | ABC-thiol transporter | 0.003 | 0.0988 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0895 | 0.2772 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.3227 | 1 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.003 | 0.0988 | 0.306 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.003 | 0.0988 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0895 | 0.0895 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.003 | 0.0988 | 0.5 |
Trypanosoma brucei | multidrug resistance protein E | 0.003 | 0.0988 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 4 | 0.0023 | 0.0565 | 0.175 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.003 | 0.0988 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.3227 | 0.3227 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0988 | 0.0988 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.003 | 0.0988 | 0.5 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.003 | 0.0988 | 0.2857 |
Brugia malayi | RNA binding protein | 0.0068 | 0.3227 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0895 | 0.2772 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.003 | 0.0988 | 1 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.003 | 0.0988 | 0.5 |
Schistosoma mansoni | multidrug resistance protein | 0.003 | 0.0988 | 0.0399 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.003 | 0.0988 | 0.5 |
Leishmania major | p-glycoprotein e | 0.003 | 0.0988 | 0.5 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0895 | 0.2772 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.003 | 0.0988 | 0.306 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.3227 | 0.3227 |
Echinococcus granulosus | lamin | 0.0029 | 0.0895 | 0.2772 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.003 | 0.0988 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.3227 | 0.3227 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0092 | 0.0092 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3227 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Giardia lamblia | MRP-like ABC transporter | 0.003 | 0.0988 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.3227 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0988 | 0.0988 |
Leishmania major | pentamidine resistance protein 1 | 0.003 | 0.0988 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0895 | 0.2772 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.003 | 0.0988 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Concentration (functional) | = 1.2 ug ml-1 | Concentration for 100% inhibition of growth of dapsone sensitive Mycobacterium smegmatis 607 strain in vitro | ChEMBL. | 3279207 |
Concentration (functional) | = 6 ug ml-1 | 100% inhibition of growth of rifampicin resistant Mycobacterium smegmatis 607 strain in vitro | ChEMBL. | 3279207 |
Concentration (functional) | = 16 ug ml-1 | 100% inhibition of growth of clofazimine resistant Mycobacterium smegmatis 607 strain in vitro | ChEMBL. | 3279207 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.