Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase, putative | 492 aa | 548 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0076 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0076 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0076 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0026 | 0 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0076 | 1 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0026 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0076 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0076 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0026 | 0 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0026 | 0 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0076 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0076 | 1 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0026 | 0 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0076 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0026 | 0 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0076 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0076 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0076 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0076 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0026 | 0 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0076 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0026 | 0 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0026 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 2.6 uM | In vitro antiparasitic activity against Trypanosoma brucei was tested by sigmoidal regression analysis | ChEMBL. | 11170645 |
ED50 (functional) | = 2.6 uM | In vitro antiparasitic activity against Trypanosoma brucei was tested by sigmoidal regression analysis | ChEMBL. | 11170645 |
ED50 (functional) | = 4 uM | In vitro antiparasitic activity against Trypanosoma cruzi was tested by sigmoidal regression analysis | ChEMBL. | 11170645 |
ED50 (functional) | = 4 uM | In vitro antiparasitic activity against Trypanosoma cruzi was tested by sigmoidal regression analysis | ChEMBL. | 11170645 |
ED50 (functional) | = 5.4 uM | In vitro antiparasitic activity against L. donavani was tested by sigmoidal regression analysis | ChEMBL. | 11170645 |
IC50 (binding) | = 1.7 uM | Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2. | ChEMBL. | 11170645 |
IC50 (binding) | = 1.7 uM | Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2. | ChEMBL. | 11170645 |
k cat/Km (binding) | = 4.8 10e4 M-1 s-1 | The second order rate constant of the TcTR (Trypanosoma cruzi trypanothione reductase) catalyzed NADH oxidation . | ChEMBL. | 11170645 |
k cat/Km (binding) | = 4.8 10e4 M-1 s-1 | The second order rate constant of the TcTR (Trypanosoma cruzi trypanothione reductase) catalyzed NADH oxidation . | ChEMBL. | 11170645 |
Km (binding) | = 21 uM | The Michaelis-Menten constant for NADPH oxidation by TcTR (Trypanosoma cruzi trypanothione reductase) | ChEMBL. | 11170645 |
Km (binding) | = 21 uM | The Michaelis-Menten constant for NADPH oxidation by TcTR (Trypanosoma cruzi trypanothione reductase) | ChEMBL. | 11170645 |
Vmax (binding) | = 1.2 uM min-1mg-1 | Vmax is the maximum velocity of the TcTR (Trypanosoma cruzi trypanothione reductase) catalyzed NADH oxidation . | ChEMBL. | 11170645 |
Vmax (binding) | = 1.2 uM min-1mg-1 | Vmax is the maximum velocity of the TcTR (Trypanosoma cruzi trypanothione reductase) catalyzed NADH oxidation . | ChEMBL. | 11170645 |
x fold (binding) | = 1725 uM | Rate of NADPH oxidation by TcTR in presence of 25 microM NQ was determined in comparison to intrinsic oxidase activity | ChEMBL. | 11170645 |
x fold (binding) | = 1725 uM | Rate of NADPH oxidation by TcTR in presence of 25 microM NQ was determined in comparison to intrinsic oxidase activity | ChEMBL. | 11170645 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.