Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | trypanothione reductase | 0.0111 | 0.0049 | 0.0066 |
Echinococcus multilocularis | caspase 2 | 0.0181 | 0.0131 | 0.0132 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.1375 | 0.1523 | 0.2401 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0188 | 0.014 | 0.0141 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0188 | 0.014 | 0.0141 |
Trichomonas vaginalis | conserved hypothetical protein | 0.4128 | 0.4733 | 0.747 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.0166 | 0.0164 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1617 | 0.1805 | 0.1837 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0211 | 0.0166 | 0.0164 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0211 | 0.0166 | 0.0167 |
Toxoplasma gondii | hypothetical protein | 0.1553 | 0.173 | 0.3654 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.2774 | 0.3154 | 1 |
Trichomonas vaginalis | cAMP/cGMP cyclic nucleotide phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Loa Loa (eye worm) | PDE1B protein | 0.8492 | 0.9819 | 0.9819 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.04 | 0.0386 | 0.0384 |
Toxoplasma gondii | GAF domain-containing protein | 0.1553 | 0.173 | 0.3654 |
Schistosoma mansoni | nuclear hormone receptor | 0.0188 | 0.014 | 0.0141 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.04 | 0.0386 | 0.0384 |
Trypanosoma brucei | 3', 5'-cyclic nucleotide phosphodiesterase, putative | 0.1375 | 0.1523 | 0.2395 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0281 | 0.0248 | 0.118 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0188 | 0.014 | 0.0138 |
Mycobacterium ulcerans | putative regulatory protein | 0.1553 | 0.173 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.04 | 0.0386 | 0.0391 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.1375 | 0.1523 | 0.2401 |
Trichomonas vaginalis | cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative | 0.1375 | 0.1523 | 0.2401 |
Plasmodium vivax | hypothetical protein, conserved | 0.1553 | 0.173 | 0.7422 |
Brugia malayi | Cell death protein 3 precursor | 0.0181 | 0.0131 | 0.0129 |
Mycobacterium tuberculosis | Probable reductase | 0.0253 | 0.0215 | 0.0984 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.04 | 0.0386 | 0.0384 |
Echinococcus multilocularis | FTZ F1 alpha | 0.04 | 0.0386 | 0.0391 |
Trypanosoma brucei | hypothetical protein, conserved | 0.1375 | 0.1523 | 0.2395 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.2068 | 0.2331 | 0.2372 |
Trichomonas vaginalis | cGMP-inhibited 3,5-cyclic phosphodiesterase, putative | 0.1375 | 0.1523 | 0.2401 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0188 | 0.014 | 0.0138 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0253 | 0.0215 | 0.0984 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.2928 | 0.3333 | 0.3393 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0188 | 0.014 | 0.0141 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0408 | 0.0396 | 0.0402 |
Leishmania major | hypothetical protein, conserved | 0.1375 | 0.1523 | 0.2395 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.04 | 0.0386 | 0.0391 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.1399 | 0.1551 | 0.1578 |
Onchocerca volvulus | 0.04 | 0.0386 | 0.0728 | |
Trypanosoma cruzi | cAMP-specific phosphodiesterase, putative | 0.1375 | 0.1523 | 0.2404 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.1375 | 0.1523 | 0.3215 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.04 | 0.0386 | 0.0391 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.014 | 0.0138 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1553 | 0.173 | 0.2729 |
Brugia malayi | nuclear receptor RXR | 0.0211 | 0.0166 | 0.0164 |
Trichomonas vaginalis | cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative | 0.395 | 0.4525 | 0.7142 |
Loa Loa (eye worm) | hypothetical protein | 0.7272 | 0.8397 | 0.8397 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0147 | 0.0092 | 0.0133 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.04 | 0.0386 | 0.0384 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.1375 | 0.1523 | 0.1549 |
Trichomonas vaginalis | conserved hypothetical protein | 0.4128 | 0.4733 | 0.747 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0188 | 0.014 | 0.0141 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.1375 | 0.1523 | 0.3215 |
Echinococcus granulosus | microtubule associated protein 2 | 0.1617 | 0.1805 | 0.1837 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0281 | 0.0248 | 0.118 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0147 | 0.0092 | 0.009 |
Loa Loa (eye worm) | hypothetical protein | 0.1375 | 0.1523 | 0.1521 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.2928 | 0.3333 | 0.3332 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.04 | 0.0386 | 0.0391 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.04 | 0.0386 | 0.0391 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Trypanosoma cruzi | cAMP phosphodiesterase A, putative | 0.2068 | 0.2331 | 0.3679 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0147 | 0.0092 | 0.009 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.1375 | 0.1523 | 0.3215 |
Plasmodium falciparum | glutathione reductase | 0.0111 | 0.0049 | 0.0274 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.014 | 0.0138 |
Brugia malayi | ecdysteroid receptor | 0.04 | 0.0386 | 0.0384 |
Trichomonas vaginalis | conserved hypothetical protein | 0.4128 | 0.4733 | 0.747 |
Brugia malayi | Thioredoxin reductase | 0.0111 | 0.0049 | 0.0047 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.1375 | 0.1523 | 0.2401 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.4386 | 0.5033 | 0.5032 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0211 | 0.0166 | 0.0167 |
Echinococcus granulosus | carbonic anhydrase II | 0.0147 | 0.0092 | 0.0092 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.04 | 0.0386 | 0.0391 |
Schistosoma mansoni | high-affinity cgmp-specific 35-cyclic phosphodiesterase | 0.1375 | 0.1523 | 0.1549 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0253 | 0.0215 | 0.0984 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0188 | 0.014 | 0.0141 |
Schistosoma mansoni | high-affinity choline transporter | 0.0408 | 0.0396 | 0.0402 |
Echinococcus multilocularis | high affinity cAMP specific 3',5' cyclic | 0.1375 | 0.1523 | 0.1549 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.2928 | 0.3333 | 0.3393 |
Schistosoma mansoni | nuclear receptor | 0.0188 | 0.014 | 0.0141 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.2774 | 0.3154 | 0.321 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0188 | 0.014 | 0.0141 |
Brugia malayi | hypothetical protein | 0.0211 | 0.0166 | 0.0164 |
Brugia malayi | steroid hormone receptor | 0.04 | 0.0386 | 0.0384 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.04 | 0.0386 | 0.0728 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.0166 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.0386 | 0.0384 |
Schistosoma mansoni | high-affinity cgmp-specific 35-cyclic phosphodiesterase | 0.1375 | 0.1523 | 0.1549 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.04 | 0.0386 | 0.0384 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.04 | 0.0386 | 0.0384 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.014 | 0.0138 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.1375 | 0.1523 | 0.2401 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0188 | 0.014 | 0.0261 |
Echinococcus multilocularis | high affinity cgmp specific 3' 5' cyclic | 0.1375 | 0.1523 | 0.1549 |
Plasmodium falciparum | phosphodiesterase delta, putative | 0.1375 | 0.1523 | 0.8799 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0281 | 0.0248 | 0.118 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.014 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.8647 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.0386 | 0.0384 |
Plasmodium falciparum | 3',5'-cyclic nucleotide phosphodiesterase, putative | 0.1375 | 0.1523 | 0.8799 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0253 | 0.0215 | 0.0984 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.04 | 0.0386 | 0.0391 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0181 | 0.0131 | 0.0132 |
Echinococcus multilocularis | dual 3',5' cyclic AMP and GMP phosphodiesterase | 0.5503 | 0.6335 | 0.6451 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.04 | 0.0386 | 0.0391 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0188 | 0.014 | 0.0138 |
Echinococcus granulosus | high affinity cgmp specific 3' 5' cyclic | 0.1375 | 0.1523 | 0.1549 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.1375 | 0.1523 | 0.2401 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1375 | 0.1523 | 0.2404 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0188 | 0.014 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.0386 | 0.0384 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.04 | 0.0386 | 0.0384 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.04 | 0.0386 | 0.0391 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0147 | 0.0092 | 0.009 |
Brugia malayi | nuclear receptor NHR-88 | 0.0188 | 0.014 | 0.0138 |
Plasmodium vivax | 3',5'-cyclic nucleotide phosphodiesterase, putative | 0.1375 | 0.1523 | 0.653 |
Loa Loa (eye worm) | hypothetical protein | 0.1553 | 0.173 | 0.1729 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DosT | 0.1553 | 0.173 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0188 | 0.014 | 0.0138 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0188 | 0.014 | 0.0141 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0211 | 0.0166 | 0.0164 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.1375 | 0.1523 | 0.3215 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.1375 | 0.1523 | 0.3215 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.04 | 0.0386 | 0.0391 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.1375 | 0.1523 | 0.3215 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.2068 | 0.2331 | 0.4923 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.0386 | 0.0384 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.1375 | 0.1523 | 0.3215 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0188 | 0.014 | 0.0138 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0188 | 0.014 | 0.0141 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.04 | 0.0386 | 0.0384 |
Plasmodium falciparum | cGMP-specific phosphodiesterase | 0.1375 | 0.1523 | 0.8799 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.0386 | 0.0384 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.8492 | 0.9819 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.2068 | 0.2331 | 0.2372 |
Schistosoma mansoni | thyroid hormone receptor | 0.04 | 0.0386 | 0.0391 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.04 | 0.0386 | 0.0391 |
Toxoplasma gondii | hypothetical protein | 0.4128 | 0.4733 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.04 | 0.0386 | 0.0384 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.0386 | 0.0384 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.014 | 0.0138 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.1375 | 0.1523 | 0.3215 |
Onchocerca volvulus | Bile acid receptor homolog | 0.04 | 0.0386 | 0.0728 |
Mycobacterium ulcerans | putative regulatory protein | 0.1553 | 0.173 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0075 | 0.0008 | 0.0012 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0408 | 0.0396 | 0.0402 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.04 | 0.0386 | 0.0391 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.2774 | 0.3154 | 0.321 |
Schistosoma mansoni | calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase | 0.8492 | 0.9819 | 1 |
Brugia malayi | GH02984p | 0.0408 | 0.0396 | 0.0394 |
Trypanosoma cruzi | cyclic nucleotide phosphodiesterase | 0.1375 | 0.1523 | 0.2404 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0131 | 0.0129 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Plasmodium vivax | phosphodiesterase gamma, putative | 0.1375 | 0.1523 | 0.653 |
Trypanosoma brucei | cAMP-specific phosphodiesterase | 0.5503 | 0.6335 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.04 | 0.0386 | 0.0391 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.04 | 0.0386 | 0.0384 |
Echinococcus granulosus | high affinity cAMP specific 3'5' cyclic | 0.1375 | 0.1523 | 0.1549 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0147 | 0.0092 | 0.0133 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.2068 | 0.2331 | 0.4923 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.0068 | 0.0067 |
Onchocerca volvulus | 0.0188 | 0.014 | 0.0261 | |
Onchocerca volvulus | 0.0188 | 0.014 | 0.0261 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1375 | 0.1523 | 0.2404 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1617 | 0.1805 | 0.1837 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.2928 | 0.3333 | 0.526 |
Trypanosoma cruzi | cAMP phosphodiesterase A, putative | 0.2068 | 0.2331 | 0.3679 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0211 | 0.0166 | 0.0164 |
Trypanosoma brucei | cAMP-specific phosphodiesterase | 0.5503 | 0.6335 | 1 |
Brugia malayi | tailless protein | 0.0188 | 0.014 | 0.0138 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0147 | 0.0092 | 0.0092 |
Plasmodium falciparum | cGMP-specific phosphodiesterase | 0.1375 | 0.1523 | 0.8799 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1375 | 0.1523 | 0.2404 |
Brugia malayi | hypothetical protein | 0.0127 | 0.0068 | 0.0066 |
Echinococcus granulosus | dual 3'5' cyclic AMP and GMP phosphodiesterase | 0.5503 | 0.6335 | 0.6451 |
Mycobacterium ulcerans | two component sensor histidine kinase DevS | 0.1553 | 0.173 | 0.5 |
Echinococcus granulosus | caspase 2 | 0.0181 | 0.0131 | 0.0132 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.1375 | 0.1523 | 0.3215 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.1375 | 0.1523 | 0.1521 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.04 | 0.0386 | 0.0384 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.014 | 0.0138 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.04 | 0.0386 | 0.0391 |
Schistosoma mansoni | nuclear receptor | 0.0188 | 0.014 | 0.0141 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0188 | 0.014 | 0.0261 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0188 | 0.014 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.0386 | 0.0384 |
Trypanosoma brucei | 3', 5'-cyclic nucleotide phosphodiesterase, putative | 0.1375 | 0.1523 | 0.2395 |
Plasmodium vivax | 3',5'-cyclic nucleotide phosphodiesterase, putative | 0.2068 | 0.2331 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.1399 | 0.1551 | 0.1578 |
Toxoplasma gondii | thioredoxin reductase | 0.0111 | 0.0049 | 0.01 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0111 | 0.0049 | 0.0204 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.2774 | 0.3154 | 0.321 |
Brugia malayi | nuclear hormone receptor | 0.04 | 0.0386 | 0.0384 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0281 | 0.0248 | 0.0217 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.04 | 0.0386 | 0.0391 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0211 | 0.0166 | 0.0167 |
Brugia malayi | ecdysone receptor | 0.0188 | 0.014 | 0.0138 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.4597 | 0.5279 | 1 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Plasmodium falciparum | phosphodiesterase gamma, putative | 0.1375 | 0.1523 | 0.8799 |
Trypanosoma brucei | cAMP phosphodiesterase A, putative | 0.2068 | 0.2331 | 0.3672 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0188 | 0.014 | 0.0141 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.395 | 0.4525 | 0.7143 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.0396 | 0.0394 |
Loa Loa (eye worm) | hypothetical protein | 0.3423 | 0.3911 | 0.391 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative | 0.1375 | 0.1523 | 0.2401 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.1375 | 0.1523 | 0.2401 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.04 | 0.0386 | 0.0384 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1375 | 0.1523 | 0.2404 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.1399 | 0.1551 | 0.155 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.04 | 0.0386 | 0.0384 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0188 | 0.014 | 0.0141 |
Schistosoma mansoni | high-affinity cgmp-specific 35-cyclic phosphodiesterase | 0.1375 | 0.1523 | 0.1549 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0253 | 0.0215 | 0.0984 |
Brugia malayi | nuclear receptor NHR-67 | 0.0188 | 0.014 | 0.0138 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0111 | 0.0049 | 0.0047 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DevS | 0.1553 | 0.173 | 1 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.2774 | 0.3154 | 0.321 |
Brugia malayi | nuclear hormone receptor | 0.4386 | 0.5033 | 0.5032 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.04 | 0.0386 | 0.0391 |
Trypanosoma brucei | cAMP-specific phosphodiesterase, putative | 0.1375 | 0.1523 | 0.2395 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.04 | 0.0386 | 0.0384 |
Schistosoma mansoni | coup transcription factor | 0.04 | 0.0386 | 0.0391 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0075 | 0.0008 | 0.0012 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Brugia malayi | hypothetical protein | 0.0188 | 0.014 | 0.0138 |
Leishmania major | cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 | 0.2068 | 0.2331 | 0.3672 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0127 | 0.0068 | 0.0067 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0075 | 0.0008 | 0.0012 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0075 | 0.0008 | 0.0012 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative | 0.8492 | 0.9819 | 0.9819 |
Schistosoma mansoni | cgmp-dependent 35-cyclic phosphodiesterase | 0.3423 | 0.3911 | 0.3981 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.04 | 0.0386 | 0.0391 |
Toxoplasma gondii | hypothetical protein | 0.1553 | 0.173 | 0.3654 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.04 | 0.0386 | 0.0384 |
Plasmodium falciparum | 3',5'-cyclic nucleotide phosphodiesterase, putative | 0.1375 | 0.1523 | 0.8799 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0188 | 0.014 | 0.0141 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Plasmodium vivax | cyclic nucleotide phosphodiesterase, putative | 0.1375 | 0.1523 | 0.653 |
Loa Loa (eye worm) | calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase | 0.1375 | 0.1523 | 0.1521 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.04 | 0.0386 | 0.0391 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0188 | 0.014 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.2774 | 0.3154 | 0.3152 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0188 | 0.014 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.014 | 0.0138 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0147 | 0.0092 | 0.009 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.04 | 0.0386 | 0.0384 |
Plasmodium vivax | glutathione reductase, putative | 0.0111 | 0.0049 | 0.0204 |
Trichomonas vaginalis | conserved hypothetical protein | 0.5503 | 0.6335 | 1 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0181 | 0.0131 | 0.0245 |
Brugia malayi | nuclear receptor NHR-88 | 0.04 | 0.0386 | 0.0384 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.0166 | 0.0164 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.1375 | 0.1523 | 0.3215 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.014 | 0.0138 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.04 | 0.0386 | 0.0391 |
Schistosoma mansoni | nuclear hormone receptor | 0.0188 | 0.014 | 0.0141 |
Brugia malayi | nuclear receptor RXR | 0.0188 | 0.014 | 0.0138 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.04 | 0.0386 | 0.0384 |
Loa Loa (eye worm) | glutathione reductase | 0.0111 | 0.0049 | 0.0047 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.04 | 0.0386 | 0.0384 |
Leishmania major | cAMP-specific phosphodiesterase, putative | 0.1375 | 0.1523 | 0.2395 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1375 | 0.1523 | 0.2401 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.1375 | 0.1523 | 0.1521 |
Echinococcus granulosus | FTZ F1 alpha | 0.04 | 0.0386 | 0.0391 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1375 | 0.1523 | 0.2404 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.04 | 0.0386 | 0.0384 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.2928 | 0.3333 | 0.526 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0147 | 0.0092 | 0.0145 |
Plasmodium falciparum | GAF domain-related protein, putative | 0.1553 | 0.173 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.014 | 0.0138 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.2774 | 0.3154 | 0.6662 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.04 | 0.0386 | 0.0384 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.1399 | 0.1551 | 0.155 |
Loa Loa (eye worm) | DR-78 | 0.0188 | 0.014 | 0.0138 |
Brugia malayi | hypothetical protein | 0.0188 | 0.014 | 0.0138 |
Brugia malayi | glutathione reductase | 0.0111 | 0.0049 | 0.0047 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0147 | 0.0092 | 0.0092 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.04 | 0.0386 | 0.0384 |
Loa Loa (eye worm) | hypothetical protein | 0.4197 | 0.4813 | 0.4812 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.1375 | 0.1523 | 0.1549 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0147 | 0.0092 | 0.0092 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.1375 | 0.1523 | 0.1549 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1375 | 0.1523 | 0.2401 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0188 | 0.014 | 0.0141 |
Onchocerca volvulus | 0.0127 | 0.0068 | 0.0125 | |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0111 | 0.0049 | 0.0048 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.04 | 0.0386 | 0.0384 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.014 | 0.0138 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.04 | 0.0386 | 0.0384 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.04 | 0.0386 | 0.0391 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.1375 | 0.1523 | 0.3215 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.0166 | 0.0164 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0188 | 0.014 | 0.0141 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0253 | 0.0215 | 0.0984 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0147 | 0.0092 | 0.0145 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.1375 | 0.1523 | 0.3215 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.0166 | 0.0164 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0211 | 0.0166 | 0.0167 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0111 | 0.0049 | 0.0048 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.04 | 0.0386 | 0.0384 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.0386 | 0.0384 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Trichomonas vaginalis | cGMP-inhibited 3,5-cyclic phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.04 | 0.0386 | 0.0391 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.014 | 0.0138 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.1375 | 0.1523 | 0.2401 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.04 | 0.0386 | 0.0391 |
Plasmodium falciparum | thioredoxin reductase | 0.0111 | 0.0049 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.0068 | 0.0066 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.1375 | 0.1523 | 0.3215 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0188 | 0.014 | 0.0141 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.027 | 0.0235 | 0.1106 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0111 | 0.0049 | 0.0078 |
Mycobacterium leprae | conserved hypothetical protein | 0.1553 | 0.173 | 1 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.395 | 0.4525 | 0.7142 |
Schistosoma mansoni | nuclear hormone receptor | 0.04 | 0.0386 | 0.0391 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0188 | 0.014 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.014 | 0.0138 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0908 | 0.0979 | 0.0995 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Leishmania major | trypanothione reductase | 0.0111 | 0.0049 | 0.0066 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.3423 | 0.3911 | 0.391 |
Schistosoma mansoni | camp-specific cyclic nucleotide phosphodiesterase | 0.1375 | 0.1523 | 0.1549 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.014 | 0.0138 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.04 | 0.0386 | 0.0391 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.1375 | 0.1523 | 0.3215 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.2774 | 0.3154 | 0.321 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.1375 | 0.1523 | 0.3215 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.04 | 0.0386 | 0.0391 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Schistosoma mansoni | camp/cgmp cyclic nucleotide phosphodiesterase | 0.5503 | 0.6335 | 0.6451 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.5503 | 0.6335 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.8492 | 0.9819 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.04 | 0.0386 | 0.0391 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0127 | 0.0068 | 0.0067 |
Schistosoma mansoni | zinc finger protein | 0.0188 | 0.014 | 0.0141 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.04 | 0.0386 | 0.0391 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.2928 | 0.3333 | 0.526 |
Brugia malayi | hypothetical protein | 0.0211 | 0.0166 | 0.0164 |
Leishmania major | hypothetical protein, conserved | 0.1375 | 0.1523 | 0.2395 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1375 | 0.1523 | 0.2404 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 140 nM | Dissociation constant against human carbonic anhydrase II at 37 degree centigrade | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.