Detailed information for compound 263755

Basic information

Technical information
  • TDR Targets ID: 263755
  • Name: 2-(2,3,3-triiodoprop-2-enyl)tetrazole
  • MW: 487.807 | Formula: C4H3I3N4
  • H donors: 0 H acceptors: 3 LogP: 3.2 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: IC(=C(Cn1nncn1)I)I
  • InChi: 1S/C4H3I3N4/c5-3(4(6)7)1-11-9-2-8-10-11/h2H,1H2
  • InChiKey: VVMCWIWSUYPHAI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2,3,3-triiodoallyl)tetrazole
  • 2-(2,3,3-triiodoprop-2-enyl)-1,2,3,4-tetrazole
  • 2-(2,3,3-triiodoallyl)-2H-tetrazole
  • 87427-25-6
  • ME 1401
  • AIDS154255
  • AIDS-154255
  • 2H-Tetrazole, 2-(2,3,3-triiodo-2-propenyl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.006 0.0101
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0204 0.0446
Loa Loa (eye worm) hypothetical protein 0.0039 0.0144 0.0324
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0022 0.0015
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0039 0.0144 0.0324
Brugia malayi mbt repeat family protein 0.005 0.0204 0.0491
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0034 0.0112 0.0508
Toxoplasma gondii serine/threonine phosophatase PP1 0.0029 0.0086 0.0358
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.0029 0.0086 0.0086
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0685 0.3837 0.3837
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0055 0.0236 0.056
Echinococcus granulosus serine protein kinase ATM 0.0025 0.006 0.0132
Brugia malayi Aspartyl-tRNA synthetase 0.0034 0.0112 0.0251
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0018 0.0022 0.0003
Plasmodium falciparum lysine--tRNA ligase 0.0034 0.0112 0.0494
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0144 0.0319
Toxoplasma gondii aspartate-tRNA ligase 0.0034 0.0112 0.0508
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0069 0.0267
Brugia malayi Elongation factor 1 gamma, conserved domain containing protein 0.0018 0.0024 0.0022
Giardia lamblia Ser/Thr protein phosphatase PP1-alpha 2 catalytic subunit 0.0029 0.0086 0.1354
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) 0.0034 0.0112 0.0648
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.0985 0.2155
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0034 0.0112 0.0245
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0026 0.0023
Loa Loa (eye worm) hypothetical protein 0.0039 0.0144 0.0324
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0055 0.0236 1
Loa Loa (eye worm) MBCTL1 0.0057 0.0243 0.0585
Schistosoma mansoni protein phosphatase-1 0.0029 0.0086 0.0187
Entamoeba histolytica replication factor A, putative 0.0066 0.0299 0.1467
Schistosoma mansoni hypothetical protein 0.0813 0.457 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.006 0.0217
Loa Loa (eye worm) glycyl-tRNA synthetase 0.027 0.1464 0.3783
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0034 0.0112 0.0245
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0034 0.0112 0.0236
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0069 0.0267
Trichomonas vaginalis protein phosphatase, caeel, putative 0.0029 0.0086 0.0167
Entamoeba histolytica hypothetical protein 0.0025 0.006 0.0204
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0018 0.0024 0.0014
Onchocerca volvulus 0.0057 0.0245 0.065
Leishmania major elongation factor 1-gamma, putative 0.0018 0.0024 0.0014
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0019 0.0007
Toxoplasma gondii ABC1 family protein 0.0039 0.0144 0.0685
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0144 0.0324
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.006 0.0132
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0034 0.0112 0.0251
Leishmania major serine/threonine protein phosphatase pp1(5.9), putative 0.0018 0.0022 0.0003
Trypanosoma brucei protein phosphatase 1 0.0018 0.0022 0.0003
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0144 0.0884
Brugia malayi Serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0018 0.0022 0.0017
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0055 0.0236 0.1204
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0066 0.0299 0.0806
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0034 0.0112 0.4105
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0018 0.0022 0.0003
Echinococcus granulosus glycyl tRNA synthetase 0.027 0.1464 0.3203
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.0985 0.2155
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0144 0.0884
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0144 0.0884
Schistosoma mansoni hypothetical protein 0.0034 0.0112 0.0245
Brugia malayi Glutathione S-transferase, N-terminal domain containing protein 0.0018 0.0024 0.0022
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.002 0.0044
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0779 0.4379 0.4379
Giardia lamblia Elongation factor 1-gamma 0.0018 0.0024 0.0053
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0144 0.0672
Schistosoma mansoni elongation factor 1-gamma 0.0018 0.0024 0.0054
Echinococcus granulosus dnaJ subfamily B 0.0813 0.457 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0236 0.0565
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0034 0.0112 0.0494
Loa Loa (eye worm) hypothetical protein 0.0139 0.0714 0.1818
Toxoplasma gondii hypothetical protein 0.0072 0.033 0.1738
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0144 0.0144
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0034 0.0112 0.0508
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0186 0.0985 0.2528
Plasmodium vivax lysine--tRNA ligase, putative 0.0034 0.0112 0.0494
Chlamydia trachomatis leucine--tRNA ligase 0.0055 0.0236 0.0688
Trypanosoma cruzi serine/threonine protein phosphatase catalytic subunit, putative 0.0029 0.0086 0.0358
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0029 0.0086 0.0167
Brugia malayi glycyl-tRNA synthetase 0.027 0.1464 0.3789
Mycobacterium tuberculosis Conserved protein 0.0039 0.0144 0.0884
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0018 0.0022 0.0017
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0034 0.0112 0.0112
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0144 0.0884
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0022 0.0048
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.0034 0.0112 0.0478
Echinococcus multilocularis serine:threonine protein phosphatase PP1 beta 0.0029 0.0086 0.0086
Toxoplasma gondii FATC domain-containing protein 0.0025 0.006 0.0217
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0144 0.0685
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0144 0.0319
Schistosoma mansoni aspartyl-tRNA synthetase 0.0034 0.0112 0.0245
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0069 0.0267
Loa Loa (eye worm) hypothetical protein 0.0029 0.0086 0.0172
Echinococcus granulosus lysyl tRNA synthetase 0.0034 0.0112 0.0245
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.006 0.006
Schistosoma mansoni aspartyl-tRNA synthetase 0.0034 0.0112 0.0245
Schistosoma mansoni leucyl-tRNA synthetase 0.0055 0.0236 0.0516
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0144 0.0314
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0018 0.0022 0.0003
Onchocerca volvulus 0.0039 0.0144 0.035
Echinococcus multilocularis glycyl tRNA synthetase 0.027 0.1464 0.1464
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0245 0.0591
Loa Loa (eye worm) hypothetical protein 0.0039 0.0144 0.0324
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0026 0.0026
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0139 0.0714 0.0714
Mycobacterium ulcerans aspartyl-tRNA synthetase 0.0034 0.0112 0.4105
Leishmania major hypothetical protein, conserved 0.0026 0.0069 0.0267
Trichomonas vaginalis esterase, putative 0.0039 0.0144 0.0319
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0034 0.0112 0.0508
Loa Loa (eye worm) hypothetical protein 0.0055 0.0236 0.0565
Treponema pallidum asparaginyl-tRNA synthetase 0.0034 0.0112 0.0457
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.0985 0.2155
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0204 0.0527
Plasmodium falciparum nucleic acid binding protein, putative 0.0034 0.0112 0.0494
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0034 0.0112 0.0112
Echinococcus granulosus endonuclease exonuclease phosphatase 0.02 0.1063 0.2326
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0243 0.0532
Schistosoma mansoni aspartyl-tRNA synthetase 0.0034 0.0112 0.0245
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.0029 0.0086 0.0086
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.027 0.1464 0.3789
Chlamydia trachomatis methionine--tRNA ligase 0.0347 0.1908 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0026 0.0026
Schistosoma mansoni ap endonuclease 0.0019 0.0026 0.0057
Trypanosoma brucei protein phosphatase 1, putative 0.0029 0.0086 0.0358
Brugia malayi mbt repeat family protein 0.005 0.0204 0.0491
Brugia malayi Serine/threonine protein phosphatase F56C9.1 in chromosomeIII 0.0029 0.0086 0.0182
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0026 0.0011
Echinococcus granulosus stringent starvation protein A 0.0018 0.0024 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.0985 0.0985
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0012
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0069 0.0254
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0139 0.0714 0.1562
Toxoplasma gondii tRNA ligases class I (M) protein 0.0055 0.0236 0.1204
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0144 0.0319
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0204 0.0446
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0022 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0055 0.0236 0.1191
Schistosoma mansoni ap endonuclease 0.0019 0.0026 0.0057
Schistosoma mansoni methionine-tRNA synthetase 0.0055 0.0236 0.0516
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0243 0.0243
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0069 0.0254
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0144 0.0334
Entamoeba histolytica hypothetical protein 0.0034 0.0112 0.0478
Trypanosoma brucei Replication factor A protein 1 0.0328 0.1797 1
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.0029 0.0086 0.0187
Echinococcus multilocularis eukaryotic translation elongation factor 1 0.0018 0.0024 0.0024
Wolbachia endosymbiont of Brugia malayi aspartyl-tRNA synthetase 0.0034 0.0112 0.4151
Loa Loa (eye worm) hypothetical protein 0.005 0.0204 0.0482
Brugia malayi BRCA2 repeat family protein 0.0138 0.071 0.1817
Brugia malayi methionyl-tRNA synthetase 0.0347 0.1908 0.4951
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0204 0.0446
Toxoplasma gondii elongation factor 1-gamma, putative 0.0018 0.0024 0.0014
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0139 0.0714 0.1826
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0018 0.0022 0.0001
Treponema pallidum leucyl-tRNA synthetase 0.0055 0.0236 0.1113
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0144 0.0314
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-gamma catalytic subunit 0.0018 0.0022 0.0007
Schistosoma mansoni aspartyl-tRNA synthetase 0.0034 0.0112 0.0245
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0022 0.0001
Schistosoma mansoni apoptosis regulator bax 0.0139 0.0714 0.1562
Plasmodium falciparum aspartate--tRNA ligase 0.0034 0.0112 0.0494
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0034 0.0112 0.0508
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0018 0.0024 0.0014
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0018 0.0024 0.0014
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0144 0.5606
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0186 0.0985 0.2535
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0054
Onchocerca volvulus 0.005 0.0204 0.0527
Brugia malayi beta-lactamase family protein 0.0039 0.0144 0.0334
Echinococcus multilocularis serine:threonine protein phosphatase PP1 isozyme 0.0029 0.0086 0.0086
Trichomonas vaginalis protein phosphatase, caeel, putative 0.0018 0.0022 0.0001
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0018 0.0024 0.0014
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0204 0.0446
Loa Loa (eye worm) hypothetical protein 0.0039 0.0144 0.0324
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0022 0.0001
Mycobacterium tuberculosis Conserved protein 0.0039 0.0144 0.0884
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-beta catalytic subunit 0.0029 0.0086 0.0172
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.02 0.1063 0.1063
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0034 0.0112 0.0508
Schistosoma mansoni aspartyl-tRNA synthetase 0.0034 0.0112 0.0245
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0029 0.0086 0.0167
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0243 0.0532
Trypanosoma cruzi serine/threonine-protein phosphatase PP1 alpha 0.0018 0.0022 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0112 0.0508
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) 0.0034 0.0112 0.0648
Echinococcus multilocularis leucyl tRNA synthetase 0.0055 0.0236 0.0236
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0034 0.0112 0.0508
Plasmodium vivax aspartate--tRNA ligase, putative 0.0034 0.0112 0.0494
Schistosoma mansoni protein phosphatase type 1 0.0029 0.0086 0.0187
Mycobacterium ulcerans beta-lactamase 0.0039 0.0144 0.5606
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0026 0.0023
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0018 0.0022 0.0003
Loa Loa (eye worm) hypothetical protein 0.0039 0.0144 0.0324
Mycobacterium ulcerans lipase LipD 0.0039 0.0144 0.5606
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.0029 0.0086 0.0187
Leishmania major asparaginyl-tRNA synthetase, putative 0.0034 0.0112 0.0508
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0034 0.0112 0.0241
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0243 0.0532
Trypanosoma cruzi Replication factor A protein 1 0.0328 0.1797 1
Plasmodium vivax methionine--tRNA ligase, putative 0.0055 0.0236 0.1191
Trichomonas vaginalis protein phosphatase-1, putative 0.0029 0.0086 0.0167
Schistosoma mansoni protein phosphatase-1 0.0018 0.0022 0.0049
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0139 0.0714 0.1562
Toxoplasma gondii OB-fold nucleic acid binding domain-containing protein 0.0172 0.0903 0.4966
Brugia malayi Serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0018 0.0022 0.0017
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0018 0.0024 0.0014
Trichomonas vaginalis protein phosphatase-5, putative 0.0018 0.0022 0.0001
Schistosoma mansoni protein phosphatase type 1 0.0018 0.0022 0.0049
Treponema pallidum methionyl-tRNA synthetase 0.0347 0.1908 1
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0055 0.0236 0.1204
Trypanosoma cruzi replication Factor A 28 kDa subunit, putative 0.0034 0.0112 0.0508
Leishmania major hypothetical protein, conserved 0.0039 0.0144 0.0685
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0034 0.0112 0.0508
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.006 0.0217
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0685 0.3837 1
Leishmania major replication factor A, 51kDa subunit, putative 0.0328 0.1797 1
Brugia malayi replication factor A 73 kDa subunit 0.0685 0.3837 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0034 0.0112 0.0508
Leishmania major lysyl-tRNA synthetase, putative 0.0034 0.0112 0.0508
Plasmodium falciparum serine/threonine protein phosphatase PP1 0.0029 0.0086 0.0345
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0034 0.0112 0.0508
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0144 0.0884
Entamoeba histolytica hypothetical protein 0.0034 0.0112 0.0478
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.0985 0.2155
Plasmodium falciparum methionine--tRNA ligase, putative 0.0055 0.0236 0.1191
Schistosoma mansoni cpg binding protein 0.006 0.0264 0.0578
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0018 0.0022 0.0007
Giardia lamblia Aspartyl-tRNA synthetase 0.0034 0.0112 0.1918
Trypanosoma brucei elongation factor 1 gamma, putative 0.0018 0.0024 0.0014
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0144 0.5606
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.0985 0.0985
Loa Loa (eye worm) apoptosis regulator protein 0.0139 0.0714 0.1818
Schistosoma mansoni aspartyl-tRNA synthetase 0.0034 0.0112 0.0245
Schistosoma mansoni protein phosphatase type 1 0.0029 0.0086 0.0187
Trypanosoma brucei elongation factor 1 gamma, putative 0.0018 0.0024 0.0014
Plasmodium vivax replication protein A1, large subunit, putative 0.0328 0.1797 1
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0055 0.0236 1
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0018 0.0022 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.0985 0.2155
Schistosoma mansoni hypothetical protein 0.0306 0.1672 0.3659
Echinococcus granulosus protein phosphatase 1, catalytic subunit, beta isozyme 0.0029 0.0086 0.0187
Treponema pallidum aspartyl-tRNA synthetase 0.0034 0.0112 0.0457
Trichomonas vaginalis protein phosphatase-1, putative 0.0018 0.0022 0.0001
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0243 0.0243
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0022 0.0005
Schistosoma mansoni lysyl-tRNA synthetase 0.0034 0.0112 0.0245
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0022 0.0015
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0026 0.0022
Schistosoma mansoni protein phosphatase-1 0.0029 0.0086 0.0187
Leishmania major leucyl-tRNA synthetase, putative 0.0055 0.0236 0.1204
Mycobacterium leprae Probable lipase LipE 0.0039 0.0144 0.2546
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0144 0.0314
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.0029 0.0086 0.0187
Echinococcus granulosus eukaryotic translation elongation factor 1 0.0018 0.0024 0.0054
Echinococcus multilocularis dnaJ subfamily B 0.0813 0.457 0.457
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0022 0.0048
Toxoplasma gondii methionyl-tRNA synthetase 0.0055 0.0236 0.1204
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0018 0.0024 0.0014
Schistosoma mansoni cpg binding protein 0.0057 0.0245 0.0537
Echinococcus granulosus cpg binding protein 0.006 0.0264 0.0578
Schistosoma mansoni cpg binding protein 0.006 0.0264 0.0578
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0034 0.0112 0.0245
Schistosoma mansoni replication factor A 1 rfa1 0.0685 0.3837 0.8396
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0612 0.1338
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0007
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0026 0.0009
Onchocerca volvulus 0.0039 0.0144 0.035
Echinococcus granulosus methionine tRNA synthetase 0.0055 0.0236 0.0516
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0204 0.0482
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0034 0.0112 0.0236
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0613 0.3426 1
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0018 0.0022 0.0003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0026 0.0023
Giardia lamblia Leucyl-tRNA synthetase 0.0055 0.0236 0.4546
Brugia malayi beta-lactamase family protein 0.0039 0.0144 0.0334
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0055 0.0236 1
Plasmodium vivax asparagine--tRNA ligase, putative 0.0034 0.0112 0.0494
Echinococcus multilocularis glutathione S transferase 0.0018 0.0024 0.0024
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.002 0.002
Schistosoma mansoni glycyl-tRNA synthetase 0.027 0.1464 0.3203
Loa Loa (eye worm) hypothetical protein 0.0026 0.0069 0.013
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.006 0.0116
Brugia malayi Serine/threonine protein phosphatase PP1 isozyme 1, putative 0.0018 0.0022 0.0017
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0018 0.0024 0.0014
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0026 0.0011
Toxoplasma gondii lysine-tRNA ligase 0.0034 0.0112 0.0508
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0144 0.0319
Brugia malayi CXXC zinc finger family protein 0.0057 0.0245 0.06
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0034 0.0112 0.4105
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0347 0.1908 0.4175
Loa Loa (eye worm) hypothetical protein 0.0057 0.0243 0.0585
Schistosoma mansoni hypothetical protein 0.0139 0.0714 0.1562
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0026 0.0023
Entamoeba histolytica replication factor A protein 1, putative 0.0294 0.1604 0.8387
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0651 0.3644 0.9494
Echinococcus multilocularis protein phosphatase 1 catalytic subunit 0.0029 0.0086 0.0086
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0018 0.0022 0.0007
Schistosoma mansoni aspartyl-tRNA synthetase 0.0034 0.0112 0.0245
Plasmodium falciparum asparagine--tRNA ligase 0.0034 0.0112 0.0494
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0779 0.4379 0.9581
Loa Loa (eye worm) beta-lactamase 0.0039 0.0144 0.0324
Brugia malayi lysyl-tRNA synthetase 0.0034 0.0112 0.0251
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0292 0.1591 0.4116
Trypanosoma brucei protein phosphatase 1 0.0018 0.0022 0.0003
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0018 0.0022 0.0001
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0144 0.0319
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0055 0.0236 0.1578
Plasmodium vivax serine/threonine protein phosphatase PP1, putative 0.0029 0.0086 0.0345
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0055 0.0236 0.0565
Brugia malayi methionyl-tRNA synthetase 0.0055 0.0236 0.0575
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0055 0.0236 1
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.0034 0.0112 0.0478
Schistosoma mansoni protein phosphatase-1 0.0018 0.0022 0.0049
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0685 0.3837 0.8396
Plasmodium falciparum methionine--tRNA ligase 0.0055 0.0236 0.1191
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0034 0.0112 0.0508
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-alpha catalytic subunit 0.0018 0.0022 0.0007
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0034 0.0112 0.0508
Echinococcus granulosus glutathione S transferase 0.0018 0.0024 0.0054
Brugia malayi beta-lactamase 0.0039 0.0144 0.0334
Entamoeba histolytica serine/threonine protein phosphatase PP1, putative 0.0018 0.0022 0.0003
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0026 0.0009
Loa Loa (eye worm) hypothetical protein 0.0034 0.0112 0.0241
Brugia malayi hypothetical protein 0.0026 0.0069 0.014
Trichomonas vaginalis protein phosphatase-1, putative 0.0018 0.0022 0.0001
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0034 0.0112 0.0508
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0041 0.0105
Brugia malayi protein ZK524.3 0.0055 0.0236 0.0575
Echinococcus multilocularis lysyl tRNA synthetase 0.0034 0.0112 0.0112
Giardia lamblia Methionyl-tRNA synthetase 0.0055 0.0236 0.4546
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0022 0.0048
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0022 0.0048
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0034 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0007
Loa Loa (eye worm) BRCA2 repeat family protein 0.0138 0.071 0.1808
Onchocerca volvulus 0.0039 0.0144 0.035
Schistosoma mansoni aspartyl-tRNA synthetase 0.0034 0.0112 0.0245
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0034 0.0112 0.0112
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0026 0.0016
Plasmodium vivax asparagine--tRNA ligase, putative 0.0034 0.0112 0.0494
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0026 0.0057
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0347 0.1908 0.1908
Mycobacterium tuberculosis Conserved protein 0.0039 0.0144 0.0884
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0069 0.0267
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.0328 0.1797 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0026 0.0077
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0029 0.0086 0.0167
Plasmodium falciparum replication protein A1, large subunit 0.0328 0.1797 1
Loa Loa (eye worm) serine/threonine protein phosphatase PP1 isozyme 1 0.0018 0.0022 0.0007
Loa Loa (eye worm) hypothetical protein 0.0066 0.0299 0.073
Plasmodium vivax methionine--tRNA ligase, putative 0.0055 0.0236 0.1191
Leishmania major serine/threonine-protein phosphatase PP1, putative 0.0018 0.0022 0.0003
Leishmania major methionyl-tRNA synthetase, putative 0.0055 0.0236 0.1204
Giardia lamblia Asparaginyl-tRNA synthetase 0.0034 0.0112 0.1918
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0069 0.0254
Schistosoma mansoni methionine-tRNA synthetase 0.0347 0.1908 0.4175
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.0034 0.0112 0.0508
Mycobacterium ulcerans hypothetical protein 0.0039 0.0144 0.5606
Schistosoma mansoni hypothetical protein 0.0139 0.0714 0.1562
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0144 0.0884
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0034 0.0112 0.0508
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.027 0.1464 0.3783
Leishmania major replication Factor A 28 kDa subunit, putative 0.0034 0.0112 0.0508
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0022 0.0022
Toxoplasma gondii exonuclease III APE 0.0019 0.0026 0.0023
Trypanosoma brucei serine threonine-protein phosphatase PP1, putative 0.0018 0.0022 0.0003
Giardia lamblia Hypothetical protein 0.01 0.0492 1
Leishmania major aspartyl-tRNA synthetase, putative 0.0034 0.0112 0.0508
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0144 0.2546
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0018 0.0022 0.0003
Loa Loa (eye worm) 63kd antigen 0.0034 0.0112 0.0241
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0144 0.0685
Brugia malayi putative serine/threonine phosphatase 0.0018 0.0022 0.0017
Giardia lamblia Lysyl-tRNA synthetase 0.0034 0.0112 0.1918
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0243 0.0594
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0328 0.1797 0.4653
Brugia malayi Serine/threonine protein phosphatase PP1-beta catalytic subunit 0.0029 0.0086 0.0182
Leishmania major lysyl-tRNA synthetase, putative 0.0034 0.0112 0.0508
Leishmania major aspartyl-tRNA synthetase, putative 0.0034 0.0112 0.0508
Brugia malayi hypothetical protein 0.0018 0.0024 0.0022
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0026 0.0088
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0018 0.0022 0.0003
Schistosoma mansoni lysyl-tRNA synthetase 0.0034 0.0112 0.0245
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0204 0.0446
Echinococcus multilocularis methionine tRNA synthetase 0.0055 0.0236 0.0236
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0022 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0144 0.0685
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0204 0.0204
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0347 0.1908 1
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0029 0.0086 0.0167
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.0538 0.2905
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0251 0.1354 1
Leishmania major elongation factor-1 gamma 0.0018 0.0024 0.0014
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0018 0.0022 0.0001
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0685 0.3837 1
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0144 0.0884
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0055 0.0236 1
Leishmania major serine/threonine protein phosphatase catalytic subunit, putative 0.0029 0.0086 0.0358
Echinococcus multilocularis cpg binding protein 0.006 0.0264 0.0264
Schistosoma mansoni aspartyl-tRNA synthetase 0.0034 0.0112 0.0245
Plasmodium falciparum asparagine--tRNA ligase 0.0034 0.0112 0.0494
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0685 0.3837 1
Echinococcus granulosus serine:threonine protein phosphatase PP1 beta 0.0029 0.0086 0.0187
Trypanosoma cruzi serine/threonine-protein phosphatase PP1, putative 0.0018 0.0022 0.0003
Schistosoma mansoni hypothetical protein 0.0139 0.0714 0.1562
Loa Loa (eye worm) hypothetical protein 0.0347 0.1908 0.4946

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.1 ug ml-1 Antifungal activity towards Trichophyton mentagrophytes 530324 strain ChEMBL. 3546691
MIC (functional) = 0.1 ug ml-1 Antifungal activity towards Trichophyton interdigitale ChEMBL. 3546691
MIC (functional) = 0.2 ug ml-1 Antifungal activity against Candida albicans C-A-24 strain ChEMBL. 3546691
MIC (functional) = 0.2 ug ml-1 Antifungal activity against Aspergillus fumigatus Saito strain ChEMBL. 3546691
MIC (functional) = 0.2 ug ml-1 Antifungal activity against Candida albicans C-A-24 strain ChEMBL. 3546691
MIC (functional) = 0.78 ug ml-1 Antifungal activity against Cryptococcus neoformans Cr-1 strain ChEMBL. 3546691
MIC (functional) = 0.78 ug ml-1 Antifungal activity against Cryptococcus neoformans Cr-1 strain ChEMBL. 3546691

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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