Detailed information for compound 263756

Basic information

Technical information
  • TDR Targets ID: 263756
  • Name: 2-[4-[3-(dimethylamino)propyl]piperazin-1-yl] -3-methylnaphthalene-1,4-dione
  • MW: 341.447 | Formula: C20H27N3O2
  • H donors: 0 H acceptors: 2 LogP: 2.36 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCCN1CCN(CC1)C1=C(C)C(=O)c2c(C1=O)cccc2)C
  • InChi: 1S/C20H27N3O2/c1-15-18(20(25)17-8-5-4-7-16(17)19(15)24)23-13-11-22(12-14-23)10-6-9-21(2)3/h4-5,7-8H,6,9-14H2,1-3H3
  • InChiKey: VMDGMWAVABVYDW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-[3-(dimethylamino)propyl]piperazin-1-yl]-3-methyl-naphthalene-1,4-dione
  • 2-[4-[3-(dimethylamino)propyl]-1-piperazinyl]-3-methylnaphthalene-1,4-dione
  • 2-[4-[3-(dimethylamino)propyl]piperazino]-3-methyl-1,4-naphthoquinone
  • 2-[4-(3-dimethylaminopropyl)piperazin-1-yl]-3-methylnaphthalene-1,4-dione
  • 2-[4-(3-dimethylaminopropyl)piperazin-1-yl]-3-methyl-naphthalene-1,4-dione
  • 2-[4-(3-dimethylaminopropyl)-1-piperazinyl]-3-methylnaphthalene-1,4-dione
  • 2-[4-(3-dimethylaminopropyl)piperazin-1-yl]-3-methyl-1,4-naphthoquinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase 0.0038 0.0181 0.0669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Loa Loa (eye worm) hypothetical protein 0.0133 0.0749 0.2809
Entamoeba histolytica hypothetical protein 0.0022 0.009 0.0621
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0103 0.0721
Echinococcus granulosus methionine tRNA synthetase 0.0033 0.0155 0.0331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.1098 0.1098
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0181 0.0861
Brugia malayi protein ZK524.3 0.0033 0.0155 0.0572
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0026 0.0026
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0063 0.0402
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0022 0.009 0.009
Trypanosoma brucei Replication factor A protein 1 0.0218 0.1252 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0009 0.0013 0.0038
Brugia malayi nuclear receptor NHR-88 0.0012 0.0026 0.0087
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0181 0.0861
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Onchocerca volvulus 0.0038 0.0181 0.0671
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.2352 0.2352
Echinococcus granulosus eukaryotic translation elongation factor 1 0.0011 0.0023 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0023 0.0075
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0107 0.0758
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0455 0.2659 1
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) 0.0022 0.009 0.0175
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0063 0.0402
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0022 0.009 0.0622
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0008 0.0003 0.0003
Echinococcus granulosus lysyl tRNA synthetase 0.0022 0.009 0.0193
Mycobacterium ulcerans lipase LipD 0.0038 0.0181 1
Loa Loa (eye worm) MBCTL1 0.0054 0.028 0.1044
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0033 0.0155 0.7737
Giardia lamblia Methionyl-tRNA synthetase 0.0033 0.0155 0.4188
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0051
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0214 0.1618
Brugia malayi nuclear hormone receptor 0.0012 0.0026 0.0087
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0192 0.1482
Loa Loa (eye worm) hypothetical protein 0.0044 0.0219 0.0812
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0181 0.0181
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0026 0.0014
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0241 0.0514
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0026 0.0087
Entamoeba histolytica hypothetical protein 0.0024 0.0103 0.0724
Loa Loa (eye worm) hypothetical protein 0.0025 0.0107 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Schistosoma mansoni aspartyl-tRNA synthetase 0.0022 0.009 0.0193
Treponema pallidum leucyl-tRNA synthetase 0.0033 0.0155 0.0776
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.1387 1
Schistosoma mansoni ap endonuclease 0.0019 0.0067 0.0143
Loa Loa (eye worm) hypothetical protein 0.0038 0.0181 0.0669
Schistosoma mansoni protein phosphatase type 1 0.0009 0.0013 0.0028
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0107 0.0758
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0026 0.0087
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0026 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0063 0.0402
Schistosoma mansoni aspartyl-tRNA synthetase 0.0022 0.009 0.0193
Toxoplasma gondii hypothetical protein 0.0048 0.0241 0.1837
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0241 0.0514
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0026 0.0014
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0026 0.0014
Toxoplasma gondii aspartate-tRNA ligase 0.0022 0.009 0.0622
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0498 0.1063
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0026 0.0026
Echinococcus granulosus microtubule associated protein 2 0.0797 0.4688 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.028 0.1044
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.028 0.0598
Entamoeba histolytica replication factor A, putative 0.0044 0.0219 0.1707
Loa Loa (eye worm) hypothetical protein 0.0038 0.0181 0.0669
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0063 0.0402
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.009 0.0328
Giardia lamblia Lysyl-tRNA synthetase 0.0022 0.009 0.2274
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.028 0.1044
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0214 0.0456
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0067 0.0241
Schistosoma mansoni hypothetical protein 0.0008 0.0003 0.0007
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0133 0.0749 0.1598
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0026 0.0056
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0087
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0063 0.0402
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0011 0.0011
Toxoplasma gondii elongation factor 1-gamma, putative 0.0011 0.0023 0.008
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0022 0.009 0.009
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0022 0.009 0.0193
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0063 0.0402
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0087
Schistosoma mansoni aspartyl-tRNA synthetase 0.0022 0.009 0.0193
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.0009 0.0013 0.0013
Schistosoma mansoni cpg binding protein 0.0029 0.013 0.0277
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0107 0.0758
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0022 0.009 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0067 0.0241
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0498 0.1063
Treponema pallidum methionyl-tRNA synthetase 0.0209 0.1201 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.083 0.083
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0022 0.009 0.2031
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0024 0.0024
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0181 0.1354
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0026 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0026 0.0087
Trichomonas vaginalis protein phosphatase-1, putative 0.0009 0.0013 0.0038
Schistosoma mansoni protein phosphatase type 1 0.0009 0.0013 0.0028
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0241 0.0896
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0103 0.0103
Leishmania major leucyl-tRNA synthetase, putative 0.0033 0.0155 0.1146
Brugia malayi lysyl-tRNA synthetase 0.0022 0.009 0.0328
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.0022 0.009 0.0621
Loa Loa (eye worm) hypothetical protein 0.0021 0.0082 0.0297
Loa Loa (eye worm) hypothetical protein 0.0209 0.1201 0.4511
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0026 0.0056
Schistosoma mansoni cpg binding protein 0.0031 0.014 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0026 0.0087
Schistosoma mansoni apoptosis regulator bax 0.0133 0.0749 0.1598
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0063 0.0403
Echinococcus granulosus intestinal type alkaline phosphatase 0.0188 0.1072 0.2287
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0163 0.0923 0.3465
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0063 0.0134
Schistosoma mansoni hypothetical protein 0.0098 0.0536 0.1144
Entamoeba histolytica hypothetical protein 0.0022 0.009 0.0621
Schistosoma mansoni elongation factor 1-gamma 0.0011 0.0023 0.0049
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0181 0.0669
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0011 0.0023 0.008
Plasmodium falciparum methionine--tRNA ligase, putative 0.0033 0.0155 0.1146
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0011 0.0028
Plasmodium vivax asparagine--tRNA ligase, putative 0.0022 0.009 0.0622
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0026 0.0056
Schistosoma mansoni hypothetical protein 0.0011 0.0024 0.0052
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0214 0.0793
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Leishmania major lysyl-tRNA synthetase, putative 0.0022 0.009 0.0622
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0022 0.009 0.0328
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0026 0.0056
Schistosoma mansoni methionine-tRNA synthetase 0.0209 0.1201 0.2562
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0026 0.0087
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0133 0.0749 0.2809
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0107 0.0758
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0017 0.0051
Plasmodium falciparum methionine--tRNA ligase 0.0033 0.0155 0.1146
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0294 0.1706 0.3638
Schistosoma mansoni hypothetical protein 0.0133 0.0749 0.1598
Schistosoma mansoni lysyl-tRNA synthetase 0.0022 0.009 0.0193
Loa Loa (eye worm) hypothetical protein 0.0038 0.0181 0.0669
Echinococcus granulosus alkaline phosphatase 0.0188 0.1072 0.2287
Brugia malayi steroid hormone receptor 0.0012 0.0026 0.0087
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0011 0.0022
Trichomonas vaginalis protein phosphatase, caeel, putative 0.0009 0.0013 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0026 0.0026
Brugia malayi Serine/threonine protein phosphatase F56C9.1 in chromosomeIII 0.0009 0.0013 0.0038
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0026 0.0056
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0188 0.1072 0.1072
Leishmania major asparaginyl-tRNA synthetase, putative 0.0022 0.009 0.0622
Schistosoma mansoni protein phosphatase-1 0.0009 0.0013 0.0028
Plasmodium falciparum elongation factor 1-gamma, putative 0.0011 0.0023 0.008
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.0022 0.009 0.0622
Mycobacterium ulcerans beta-lactamase 0.0038 0.0181 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0022 0.009 0.0622
Giardia lamblia Aspartyl-tRNA synthetase 0.0022 0.009 0.2274
Loa Loa (eye worm) hypothetical protein 0.0038 0.0181 0.0669
Onchocerca volvulus 0.0048 0.0241 0.0927
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0026 0.0056
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0087
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0181 1
Echinococcus multilocularis eukaryotic translation elongation factor 1 0.0011 0.0023 0.0023
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0181 0.0861
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0087
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0022 0.009 0.0622
Schistosoma mansoni hypothetical protein 0.0022 0.009 0.0193
Plasmodium falciparum asparagine--tRNA ligase 0.0022 0.009 0.0622
Loa Loa (eye worm) hypothetical protein 0.0048 0.0241 0.0896
Leishmania major lysyl-tRNA synthetase, putative 0.0022 0.009 0.0622
Schistosoma mansoni aspartyl-tRNA synthetase 0.0022 0.009 0.0193
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0009 0.0013 0.0038
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0181 0.1354
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0026 0.0087
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0181 1
Brugia malayi Aspartyl-tRNA synthetase 0.0022 0.009 0.0328
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0067 0.0436
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0067 0.334
Plasmodium falciparum lysine--tRNA ligase 0.0022 0.009 0.0622
Leishmania major elongation factor-1 gamma 0.0011 0.0023 0.008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.001 0.0017 0.0051
Plasmodium falciparum asparagine--tRNA ligase 0.0022 0.009 0.0622
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0009 0.0013 0.0038
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0103 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0026 0.0087
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0033 0.0155 0.1146
Toxoplasma gondii tRNA ligases class I (M) protein 0.0033 0.0155 0.1146
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0498 0.0498
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.028 0.028
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0241 0.0241
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0026 0.0087
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.028 0.028
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0181 0.0386
Loa Loa (eye worm) hypothetical protein 0.0038 0.0181 0.0669
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.001 0.0017 0.0017
Echinococcus multilocularis alkaline phosphatase 0.0188 0.1072 0.1072
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0026 0.0056
Schistosoma mansoni hypothetical protein 0.0133 0.0749 0.1598
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0063 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0181 0.0669
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0026 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0026 0.0087
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0103 0.0219
Onchocerca volvulus 0.0038 0.0181 0.0671
Schistosoma mansoni microtubule-associated protein tau 0.0797 0.4688 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0181 0.0861
Brugia malayi glycyl-tRNA synthetase 0.0163 0.0923 0.3465
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0103 0.0374
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0241 0.0241
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0063 0.0225
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0748 0.44 0.9385
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0026 0.0087
Trypanosoma brucei elongation factor 1 gamma, putative 0.0011 0.0023 0.008
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0181 0.0669
Loa Loa (eye worm) 63kd antigen 0.0022 0.009 0.0328
Giardia lamblia Elongation factor 1-gamma 0.0011 0.0023 0.0292
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0022 0.009 0.0622
Leishmania major replication Factor A 28 kDa subunit, putative 0.0022 0.009 0.0622
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0188 0.1072 0.2287
Brugia malayi mbt repeat family protein 0.0048 0.0241 0.0896
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0181 0.0669
Schistosoma mansoni leucyl-tRNA synthetase 0.0033 0.0155 0.0331
Schistosoma mansoni aspartyl-tRNA synthetase 0.0022 0.009 0.0193
Toxoplasma gondii methionyl-tRNA synthetase 0.0033 0.0155 0.1146
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0455 0.2659 0.5671
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0022 0.009 0.0622
Echinococcus granulosus serine:threonine protein phosphatase PP1 beta 0.0009 0.0013 0.0028
Loa Loa (eye worm) hypothetical protein 0.0033 0.0155 0.0572
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0181 0.0669
Onchocerca volvulus 0.0038 0.0181 0.0671
Leishmania major hypothetical protein, conserved 0.0038 0.0181 0.1354
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0192 0.1446
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0181 0.0861
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0087
Schistosoma mansoni aspartyl-tRNA synthetase 0.0022 0.009 0.0193
Treponema pallidum aspartyl-tRNA synthetase 0.0022 0.009 0.0204
Echinococcus multilocularis lysyl tRNA synthetase 0.0022 0.009 0.009
Entamoeba histolytica replication factor A protein 1, putative 0.0196 0.1119 0.9305
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0022 0.009 0.0328
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0026 0.0056
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0498 0.0498
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0067 0.0436
Schistosoma mansoni hypothetical protein 0.0133 0.0749 0.1598
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0241 0.0514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0026 0.0056
Echinococcus multilocularis serine:threonine protein phosphatase PP1 beta 0.0009 0.0013 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0498 0.1063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0026 0.0056
Schistosoma mansoni lysyl-tRNA synthetase 0.0022 0.009 0.0193
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0009 0.0013 0.0038
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0067 0.0426
Echinococcus granulosus stringent starvation protein A 0.0011 0.0023 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0011 0.0023 0.008
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0022 0.009 0.0622
Loa Loa (eye worm) hypothetical protein 0.0033 0.0155 0.0572
Loa Loa (eye worm) acetyltransferase 0.0147 0.083 0.3112
Trypanosoma brucei elongation factor 1 gamma, putative 0.0011 0.0023 0.008
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0067 0.0436
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0022 0.009 0.0622
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0063 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0103 0.0374
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0498 0.1864
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0022 0.009 0.0193
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0011 0.0023 0.008
Schistosoma mansoni cpg binding protein 0.0031 0.014 0.0298
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0133 0.0749 0.1598
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0188 0.1072 0.2287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0033 0.0155 1
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.0218 0.1252 1
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0022 0.009 0.0622
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0192 0.5284
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0163 0.0923 0.3465
Schistosoma mansoni replication factor A 1 rfa1 0.0455 0.2659 0.5671
Loa Loa (eye worm) BRCA2 repeat family protein 0.0092 0.0503 0.1881
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0063 0.0134
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0063 0.0134
Leishmania major hypothetical protein, conserved 0.0025 0.0107 0.0758
Echinococcus granulosus cpg binding protein 0.0031 0.014 0.0298
Echinococcus multilocularis protein phosphatase 1 catalytic subunit 0.0009 0.0013 0.0013
Brugia malayi replication factor A 73 kDa subunit 0.0455 0.2659 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.028 0.0598
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0026 0.0087
Plasmodium vivax aspartate--tRNA ligase, putative 0.0022 0.009 0.0622
Echinococcus multilocularis glutathione S transferase 0.0011 0.0023 0.0023
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.0009 0.0013 0.0013
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0044 0.0219 0.0833
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.028 0.0598
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0067 0.0143
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0024 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0067 0.0436
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0026 0.0087
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0022 0.009 0.0622
Trichomonas vaginalis esterase, putative 0.0038 0.0181 0.0669
Treponema pallidum asparaginyl-tRNA synthetase 0.0022 0.009 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Loa Loa (eye worm) apoptosis regulator protein 0.0133 0.0749 0.2809
Brugia malayi hypothetical protein 0.0011 0.0023 0.0075
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0107 0.0758
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.013 0.0477
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0403 0.2352 0.5018
Onchocerca volvulus 0.0029 0.013 0.0454
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0011 0.0023 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0026 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0024 0.0077
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0218 0.1252 0.4703
Toxoplasma gondii OB-fold nucleic acid binding domain-containing protein 0.0114 0.0636 0.5027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Brugia malayi methionyl-tRNA synthetase 0.0209 0.1201 0.4511
Giardia lamblia Asparaginyl-tRNA synthetase 0.0022 0.009 0.2274
Brugia malayi BRCA2 repeat family protein 0.0092 0.0503 0.1881
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.0009 0.0013 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0026 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Schistosoma mansoni aspartyl-tRNA synthetase 0.0022 0.009 0.0193
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0181 0.1354
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0017 0.0051
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0067 0.1593
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0241 0.0514
Mycobacterium tuberculosis Conserved protein 0.0038 0.0181 0.0861
Brugia malayi Glutathione S-transferase, N-terminal domain containing protein 0.0011 0.0023 0.0075
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0026 0.0056
Mycobacterium tuberculosis Conserved protein 0.0038 0.0181 0.0861
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0033 0.0155 0.0666
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0407 0.2375 1
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.001 0.0025
Echinococcus multilocularis serine:threonine protein phosphatase PP1 isozyme 0.0009 0.0013 0.0013
Giardia lamblia GTOR 0.0018 0.0063 0.1468
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0181 0.0386
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0026 0.0056
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0067 0.0436
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0455 0.2659 1
Brugia malayi Elongation factor 1 gamma, conserved domain containing protein 0.0011 0.0023 0.0075
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0026 0.0087
Mycobacterium ulcerans aspartyl-tRNA synthetase 0.0022 0.009 0.2031
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0063 0.0403
Toxoplasma gondii exonuclease III APE 0.0019 0.0067 0.0436
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0011 0.0024 0.0084
Schistosoma mansoni coup transcription factor 0.0012 0.0026 0.0056
Schistosoma mansoni alkaline phosphatase 0.0188 0.1072 0.2287
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0026 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0026 0.0087
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.0009 0.0013 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0017 0.0051
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0063 0.0402
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0748 0.44 0.44
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0011 0.0023 0.008
Chlamydia trachomatis methionine--tRNA ligase 0.0209 0.1201 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0063 0.0225
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0181 0.0669
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0022 0.009 0.0328
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0432 0.2525 0.9498
Plasmodium vivax replication protein A1, large subunit, putative 0.0218 0.1252 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0324 0.0691
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0063 0.039
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0063 0.0402
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.0805 0.1718
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0075
Echinococcus multilocularis glycyl tRNA synthetase 0.0163 0.0923 0.0923
Trypanosoma cruzi Replication factor A protein 1 0.0218 0.1252 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.001 0.0017 0.0036
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) 0.0022 0.009 0.0175
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0181 0.0861
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0498 0.1864
Brugia malayi Serine/threonine protein phosphatase PP1-beta catalytic subunit 0.0009 0.0013 0.0038
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0455 0.2659 1
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0011 0.0023 0.008
Leishmania major elongation factor 1-gamma, putative 0.0011 0.0023 0.008
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0241 0.0514
Echinococcus multilocularis leucyl tRNA synthetase 0.0033 0.0155 0.0155
Leishmania major replication factor A, 51kDa subunit, putative 0.0218 0.1252 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0063 0.0063
Brugia malayi beta-lactamase family protein 0.0038 0.0181 0.0669
Echinococcus multilocularis cpg binding protein 0.0031 0.014 0.014
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0214 0.0793
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0008 0.0003 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0155 0.1146
Leishmania major aspartyl-tRNA synthetase, putative 0.0022 0.009 0.0622
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0033 0.0155 0.7161
Echinococcus multilocularis methionine tRNA synthetase 0.0033 0.0155 0.0155
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0455 0.2659 0.2659
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0026 0.0087
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0306 0.2364
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0063 0.0225
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0011 0.0023 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Trypanosoma cruzi replication Factor A 28 kDa subunit, putative 0.0022 0.009 0.0622
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0209 0.1201 1
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0188 0.1072 0.1072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0024 0.0077
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-beta catalytic subunit 0.0009 0.0013 0.0038
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0063 0.0134
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0181 0.0669
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0022 0.009 0.009
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0026 0.0087
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0214 0.1618
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.083 0.3112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0063 0.0402
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0063 0.0402
Mycobacterium leprae Probable lipase LipE 0.0038 0.0181 1
Mycobacterium ulcerans hypothetical protein 0.0038 0.0181 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0022 0.009 0.0622
Plasmodium falciparum replication protein A1, large subunit 0.0218 0.1252 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0063 0.0402
Schistosoma mansoni fkbp-rapamycin associated protein 0.001 0.0017 0.0036
Brugia malayi hypothetical protein 0.0016 0.0054 0.0191
Schistosoma mansoni ap endonuclease 0.0019 0.0067 0.0143
Toxoplasma gondii ABC1 family protein 0.0038 0.0181 0.1354
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0181 0.0861
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0033 0.0155 0.1146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Brugia malayi CXXC zinc finger family protein 0.0029 0.013 0.0477
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0498 0.1063
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.0022 0.009 0.0621
Giardia lamblia Leucyl-tRNA synthetase 0.0033 0.0155 0.4188
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0087
Brugia malayi methionyl-tRNA synthetase 0.0033 0.0155 0.0572
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0181 0.0386
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0067 0.0436
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0063 0.0402
Schistosoma mansoni protein phosphatase-1 0.0009 0.0013 0.0028
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0033 0.0155 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0063 0.0402
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0033 0.0155 0.0572
Brugia malayi hypothetical protein 0.0025 0.0107 0.0391
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0022 0.009 0.009
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0026 0.0087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0087
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0026 0.0056
Plasmodium vivax methionine--tRNA ligase, putative 0.0033 0.0155 0.1146
Leishmania major methionyl-tRNA synthetase, putative 0.0033 0.0155 0.1146
Brugia malayi mbt repeat family protein 0.0048 0.0241 0.0896
Echinococcus granulosus glycyl tRNA synthetase 0.0163 0.0923 0.1969
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0022 0.009 0.0622
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.083 0.177
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0209 0.1201 0.2562
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0017 0.0051
Giardia lamblia Hypothetical protein 0.0067 0.0352 1
Brugia malayi beta-lactamase family protein 0.0038 0.0181 0.0669
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0063 0.0225
Schistosoma mansoni aspartyl-tRNA synthetase 0.0022 0.009 0.0193
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0163 0.0923 0.3465
Schistosoma mansoni glycyl-tRNA synthetase 0.0163 0.0923 0.1969
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0026 0.0087
Loa Loa (eye worm) beta-lactamase 0.0038 0.0181 0.0669
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0017 0.0051
Loa Loa (eye worm) hypothetical protein 0.0022 0.009 0.0328
Loa Loa (eye worm) hypothetical protein 0.0009 0.0013 0.0038
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0067 0.0241
Echinococcus granulosus dnaJ subfamily B 0.0403 0.2352 0.5018
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0209 0.1201 0.1201
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.009 0.0622
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0067 0.0067
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0022 0.009 0.2031
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0188 0.1072 0.1072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0498 0.1063
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0022 0.009 0.0193
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0067 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0026 0.0087
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0181 0.0861
Chlamydia trachomatis leucine--tRNA ligase 0.0033 0.0155 0.0584
Schistosoma mansoni alkaline phosphatase 0.0188 0.1072 0.2287
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0087
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0103 0.0721
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0077
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0033 0.0155 0.7737
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0241 0.0927
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0181 0.1354
Toxoplasma gondii lysine-tRNA ligase 0.0022 0.009 0.0622
Plasmodium vivax methionine--tRNA ligase, putative 0.0033 0.0155 0.1146
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0133 0.0749 0.0749
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0026 0.0087
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0026 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.0009 0.0013 0.0028
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0063 0.0402
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0026 0.0056
Plasmodium falciparum aspartate--tRNA ligase 0.0022 0.009 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0017 0.0051
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.1098 0.2343
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0011 0.0024 0.0084
Wolbachia endosymbiont of Brugia malayi aspartyl-tRNA synthetase 0.0022 0.009 0.5088
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0026 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0225
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0107 0.0758
Schistosoma mansoni methionine-tRNA synthetase 0.0033 0.0155 0.0331
Plasmodium vivax elongation factor 1-gamma, putative 0.0011 0.0023 0.008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0026 0.0056
Plasmodium falciparum nucleic acid binding protein, putative 0.0022 0.009 0.0622
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0214 0.1618
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0017 0.0051
Loa Loa (eye worm) hypothetical protein 0.0038 0.0181 0.0669
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0082 0.0557
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0063 0.0402
Plasmodium vivax asparagine--tRNA ligase, putative 0.0022 0.009 0.0622
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0022 0.009 0.0622
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.001 0.0017 0.0029
Echinococcus granulosus glutathione S transferase 0.0011 0.0023 0.0049
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0103 0.0721
Brugia malayi ecdysteroid receptor 0.0012 0.0026 0.0087
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0033 0.0155 0.0572
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0026 0.0056
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0026 0.0026
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0022 0.009 0.0622
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0026 0.0087
Echinococcus multilocularis microtubule associated protein 2 0.0797 0.4688 0.4688
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0022 0.009 0.0622
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0181 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0063 0.0402
Schistosoma mansoni aspartyl-tRNA synthetase 0.0022 0.009 0.0193
Onchocerca volvulus 0.0012 0.0026 0.0014
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0176 0.1003 0.3765
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0107 0.0758
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0026 0.0026
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0026 0.0056
Echinococcus granulosus protein phosphatase 1, catalytic subunit, beta isozyme 0.0009 0.0013 0.0028
Leishmania major aspartyl-tRNA synthetase, putative 0.0022 0.009 0.0622

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 12.5 uM In vitro antiparasitic activity against L. infantum was tested by sigmoidal regression analysis ChEMBL. 11170645
ED50 (functional) > 12.5 uM In vitro antiparasitic activity against Trypanosoma cruzi was tested by sigmoidal regression analysis ChEMBL. 11170645
ED50 (functional) > 12.5 uM In vitro antiparasitic activity against Trypanosoma brucei was tested by sigmoidal regression analysis ChEMBL. 11170645
ED50 (functional) > 12.5 uM In vitro antiparasitic activity against L. infantum was tested by sigmoidal regression analysis ChEMBL. 11170645
ED50 (functional) > 12.5 uM In vitro antiparasitic activity against Trypanosoma cruzi was tested by sigmoidal regression analysis ChEMBL. 11170645
ED50 (functional) > 12.5 uM In vitro antiparasitic activity against Trypanosoma brucei was tested by sigmoidal regression analysis ChEMBL. 11170645
IC50 (binding) > 57 uM Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2. ChEMBL. 11170645
IC50 (binding) > 57 uM Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2. ChEMBL. 11170645

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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