Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.724 | 0.7519 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0071 | 0.9628 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0071 | 0.9628 | 0.9589 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0071 | 0.9628 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0535 | 0.0556 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0535 | 0.0556 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0071 | 0.9628 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.6205 | 0.5801 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.724 | 0.7519 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.6205 | 0.6444 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.2951 | 0.3065 |
Leishmania major | cytochrome p450-like protein | 0.0071 | 0.9628 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0071 | 0.9628 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0071 | 0.9628 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.0071 | 0.9628 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0071 | 0.9628 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.6205 | 0.6444 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.6205 | 0.6444 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0071 | 0.9628 | 0.5 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0071 | 0.9628 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.9628 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0071 | 0.9628 | 0.5 |
Echinococcus multilocularis | 0.0071 | 0.9628 | 1 | |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.6205 | 0.6373 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.2951 | 0.3065 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4163 | 0.4209 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0071 | 0.9628 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0071 | 0.9628 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0071 | 0.9628 | 0.9589 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0071 | 0.9628 | 0.5 |
Brugia malayi | cytochrome P450 | 0.0071 | 0.9628 | 0.9589 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0071 | 0.9628 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0071 | 0.9628 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0071 | 0.9628 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0071 | 0.9628 | 0.9589 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.6205 | 0.6444 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0071 | 0.9628 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0071 | 0.9628 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.6205 | 0.6444 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0071 | 0.9628 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 | 0.0071 | 0.9628 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0071 | 0.9628 | 1 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0071 | 0.9628 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.3378 | 0.2673 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0071 | 0.9628 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3391 | 0.3391 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0071 | 0.9628 | 0.5 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0071 | 0.9628 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0071 | 0.9628 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.6205 | 0.6444 |
Trypanosoma brucei | cytochrome P450, putative | 0.0071 | 0.9628 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0071 | 0.9628 | 0.9589 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0071 | 0.9628 | 0.5 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0071 | 0.9628 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.7886 | 0.819 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0071 | 0.9628 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.9228 | 0.9576 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.3818 | 0.3843 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0071 | 0.9628 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0071 | 0.9628 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0535 | 0.0556 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0071 | 0.9628 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0071 | 0.9628 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.6205 | 0.6444 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0191 | 0.0198 |
Leishmania major | cytochrome p450-like protein | 0.0071 | 0.9628 | 0.5 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0071 | 0.9628 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0071 | 0.9628 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0071 | 0.9628 | 1 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0071 | 0.9628 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0071 | 0.9628 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0071 | 0.9628 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta TC (functional) | = -29 % | Acute in vivo activity measured by total plasma cholesterol concentration levels (TC) at 30 mg/kg dose | ChEMBL. | 8632431 |
IC50 (binding) | = 31 uM | In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 in microsomes of rat liver | ChEMBL. | 8632431 |
IC50 (binding) | = 31 uM | In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 in microsomes of rat liver | ChEMBL. | 8632431 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.