Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0055 | 0.1003 | 0.1572 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0032 | 0.0169 | 0.0202 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0097 | 0.2574 | 0.3947 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0048 | 0.0755 | 0.1115 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0097 | 0.2574 | 0.3947 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0194 | 0.617 | 1 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0055 | 0.1003 | 0.1501 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0164 | 0.507 | 0.8206 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0048 | 0.0755 | 0.096 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0032 | 0.0169 | 0.013 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0755 | 0.1115 |
Loa Loa (eye worm) | MBCTL1 | 0.0055 | 0.1003 | 0.1501 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.004 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0032 | 0.0169 | 0.0212 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0169 | 0.0202 |
Brugia malayi | ecdysteroid receptor | 0.0032 | 0.0169 | 0.0202 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0032 | 0.0169 | 0.0212 |
Schistosoma mansoni | nuclear hormone receptor | 0.0032 | 0.0169 | 0.013 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 0.507 | 0.5051 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0132 | 0.3865 | 0.624 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0097 | 0.2574 | 0.4172 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0032 | 0.0169 | 0.0202 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0755 | 0.1115 |
Schistosoma mansoni | coup transcription factor | 0.0032 | 0.0169 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0169 | 0.0202 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0032 | 0.0169 | 0.0202 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0032 | 0.0169 | 0.0212 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.646 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.5327 | 0.5308 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0755 | 0.0719 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0032 | 0.0169 | 0.0212 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0032 | 0.0169 | 0.013 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0032 | 0.0169 | 0.0212 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0032 | 0.0169 | 0.0202 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0032 | 0.0169 | 0.0174 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0032 | 0.0169 | 0.0274 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0097 | 0.2574 | 0.4172 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.5327 | 0.5308 |
Brugia malayi | steroid hormone receptor | 0.0032 | 0.0169 | 0.0202 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0055 | 0.1003 | 0.1626 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 0.507 | 0.5051 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.2574 | 0.2544 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.2574 | 0.2544 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0169 | 0.0202 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0032 | 0.0169 | 0.0202 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0032 | 0.0169 | 0.0202 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0194 | 0.617 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0032 | 0.0169 | 0.0202 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0032 | 0.0169 | 0.0202 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0169 | 0.0202 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0032 | 0.0169 | 0.0202 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0132 | 0.3865 | 0.6264 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0032 | 0.0169 | 0.0202 |
Onchocerca volvulus | 0.023 | 0.7496 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0132 | 0.3865 | 0.3841 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0032 | 0.0169 | 0.0274 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0032 | 0.0169 | 0.0274 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0032 | 0.0169 | 0.0174 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0032 | 0.0169 | 0.0202 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0032 | 0.0169 | 0.0212 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0032 | 0.0169 | 0.013 |
Brugia malayi | nuclear receptor NHR-88 | 0.0032 | 0.0169 | 0.0202 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0055 | 0.1003 | 0.1572 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0032 | 0.0169 | 0.0202 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.2574 | 0.2544 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0032 | 0.0169 | 0.0202 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0032 | 0.0169 | 0.0274 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0097 | 0.2574 | 0.4134 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0032 | 0.0169 | 0.013 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0055 | 0.1003 | 0.0968 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0032 | 0.0169 | 0.0274 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0048 | 0.0755 | 0.1224 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0032 | 0.0169 | 0.0212 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0032 | 0.0169 | 0.0202 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0032 | 0.0169 | 0.013 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0032 | 0.0169 | 0.013 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0032 | 0.0169 | 0.013 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0755 | 0.1115 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0032 | 0.0169 | 0.013 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0048 | 0.0755 | 0.1224 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0032 | 0.0169 | 0.0202 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0032 | 0.0169 | 0.0202 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0032 | 0.0169 | 0.0174 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0097 | 0.2574 | 0.4134 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0048 | 0.0755 | 0.1168 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0032 | 0.0169 | 0.0202 |
Trichomonas vaginalis | set domain proteins, putative | 0.023 | 0.7496 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.004 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0032 | 0.0169 | 0.0274 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0032 | 0.0169 | 0.0202 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0032 | 0.0169 | 0.0274 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0032 | 0.0169 | 0.0274 |
Onchocerca volvulus | 0.0048 | 0.0755 | 0.096 | |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0169 | 0.0202 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0055 | 0.1003 | 0.1626 |
Echinococcus granulosus | FTZ F1 alpha | 0.0032 | 0.0169 | 0.0274 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0032 | 0.0169 | 0.0202 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0032 | 0.0169 | 0.0202 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0169 | 0.0202 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0032 | 0.0169 | 0.0202 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0048 | 0.0755 | 0.1168 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0032 | 0.0169 | 0.0202 |
Echinococcus granulosus | geminin | 0.0171 | 0.5327 | 0.8634 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.646 | 1 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0048 | 0.0755 | 0.0719 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0755 | 0.0719 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0032 | 0.0169 | 0.0202 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0169 | 0.0202 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.004 | 0.0064 |
Onchocerca volvulus | 0.0032 | 0.0169 | 0.0174 | |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0032 | 0.0169 | 0.0202 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0032 | 0.0169 | 0.013 |
Echinococcus multilocularis | geminin | 0.0171 | 0.5327 | 0.8625 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1003 | 0.1501 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0169 | 0.0202 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0032 | 0.0169 | 0.0202 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0032 | 0.0169 | 0.0212 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4.5 uM | In vitro antimalarial activity against Plasmodium falciparum. | ChEMBL. | 1995879 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.