Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 2 (5-HT2) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0332 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0332 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0332 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0332 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0332 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0332 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0332 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0332 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0332 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0332 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0332 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0332 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0332 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0332 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0332 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0332 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0332 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0332 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0332 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0332 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0332 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0332 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0332 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0332 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0332 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 15 mg kg-1 | Antipsychotic activity at a dose 10 times the ED50 value for CAR block for production of catalepsy in the rat (following i.p. dosing) | ChEMBL. | 1346653 |
Ki (binding) | = 436 nM | The compound was tested for its binding affinity towards Alpha-1 adrenergic receptor by displacing [3H]-WB-4101 radioligand in rat cerebral cortex | ChEMBL. | 1346653 |
Ki (binding) | = 436 nM | The compound was tested for its binding affinity towards Alpha-1 adrenergic receptor by displacing [3H]-WB-4101 radioligand in rat cerebral cortex | ChEMBL. | 1346653 |
Ki (binding) | > 1000 nM | Binding affinity towards dopamine receptor D2 by displacing [3H]-spiperone radioligand in rat striatum | ChEMBL. | 1346653 |
Ki (binding) | > 1000 nM | The compound was tested for its binding affinity towards 5-hydroxytryptamine 2 receptor by displacing [3H]-ketanserin radioligand in rat cerebral cortex | ChEMBL. | 1346653 |
Ki (binding) | > 1000 nM | Binding affinity towards dopamine receptor D2 by displacing [3H]-spiperone radioligand in rat striatum | ChEMBL. | 1346653 |
Ki (binding) | > 1000 nM | The compound was tested for its binding affinity towards 5-hydroxytryptamine 2 receptor by displacing [3H]-ketanserin radioligand in rat cerebral cortex | ChEMBL. | 1346653 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.