Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | peroxidasin | 0.0342 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0342 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0342 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0342 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0342 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0342 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0342 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0342 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0342 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0342 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0342 | 0.5 | 0.5 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0342 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0342 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0342 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0342 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0342 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0342 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0342 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0342 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0342 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0342 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0342 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0342 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0342 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0342 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 1 ug ml-1 | Cytotoxicity against chronic myelogenous leukemia cell line K-562 was determined by measuring [3H]-thymidine incorporation after 48 h | ChEMBL. | 11844673 |
IC50 (functional) | > 1 ug ml-1 | Concentration that reduces [3H]-thymidine incorporation by 50% in chronic myelogenous leukemia cell line K-562 after 5 h | ChEMBL. | 11844673 |
IC50 (functional) | > 1 ug ml-1 | Cytotoxicity against chronic myelogenous leukemia cell line K-562 was determined by measuring [3H]-thymidine incorporation after 48 h | ChEMBL. | 11844673 |
IC50 (functional) | > 1 ug ml-1 | Concentration that reduces [3H]-thymidine incorporation by 50% in chronic myelogenous leukemia cell line K-562 after 5 h | ChEMBL. | 11844673 |
Inhibition (functional) | 0 % | Cytotoxicity against chronic myelogenous leukemia cell line K-562 was determined by measuring [3H]-thymidine incorporation at a concentration 10 microg/mL after 48 h; Not determined | ChEMBL. | 11844673 |
Inhibition (functional) | 0 % | Cytotoxicity against chronic myelogenous leukemia cell line K-562 was determined by measuring [3H]-thymidine incorporation at a concentration of 10 microg/mL after 5 h; Not determined | ChEMBL. | 11844673 |
Inhibition (functional) | = 0.3 % | Cytotoxicity against chronic myelogenous leukemia cell line K-562 was determined by measuring [3H]-thymidine incorporation at a concentration of 1 microg/mL after 5 h | ChEMBL. | 11844673 |
Inhibition (functional) | = 0.3 % | Cytotoxicity against chronic myelogenous leukemia cell line K-562 was determined by measuring [3H]-thymidine incorporation at a concentration of 1 microg/mL after 5 h | ChEMBL. | 11844673 |
Inhibition (functional) | = 0.8 % | Cytotoxicity against chronic myelogenous leukemia cell line K-562 was determined by measuring [3H]-thymidine incorporation at a concentration 1 microg/mL after 48 h | ChEMBL. | 11844673 |
Inhibition (functional) | = 0.8 % | Cytotoxicity against chronic myelogenous leukemia cell line K-562 was determined by measuring [3H]-thymidine incorporation at a concentration 1 microg/mL after 48 h | ChEMBL. | 11844673 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 11844673 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.