Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0057 | 0 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.01 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.01 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.01 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.01 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0057 | 0 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.01 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.01 | 1 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0057 | 0 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0057 | 0 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0057 | 0 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.01 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0057 | 0 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0057 | 0 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.01 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.01 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.01 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.01 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.01 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0057 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.01 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0057 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0057 | 0 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.01 | 1 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0057 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 85 uM | Tested for competitive binding inhibition against phenylalanine hydroxylase in rat liver | ChEMBL. | 6834389 |
Ki (binding) | = 85 uM | Tested for competitive binding inhibition against phenylalanine hydroxylase in rat liver | ChEMBL. | 6834389 |
Km (binding) | 0 uM | Michaelis Menton constant was determined for the compound; ND denotes no data | ChEMBL. | 6834389 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.