Detailed information for compound 264095

Basic information

Technical information
  • TDR Targets ID: 264095
  • Name: 4-[(4-fluorophenoxy)-phenylmethyl]piperidine
  • MW: 285.356 | Formula: C18H20FNO
  • H donors: 1 H acceptors: 0 LogP: 3.84 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)OC(c1ccccc1)C1CCNCC1
  • InChi: 1S/C18H20FNO/c19-16-6-8-17(9-7-16)21-18(14-4-2-1-3-5-14)15-10-12-20-13-11-15/h1-9,15,18,20H,10-13H2
  • InChiKey: LTJYRADDZMINOQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(4-fluorophenoxy)-phenyl-methyl]piperidine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine transporter Starlite/ChEMBL References
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL References
Rattus norvegicus Norepinephrine transporter Starlite/ChEMBL References
Rattus norvegicus Serotonin transporter Starlite/ChEMBL References
Rattus norvegicus Serotonin 2a (5-HT2a) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative Norepinephrine transporter   597 aa 579 aa 22.1 %
Echinococcus granulosus sodium and chloride dependent glycine Norepinephrine transporter   597 aa 507 aa 38.9 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Norepinephrine transporter   597 aa 595 aa 34.0 %
Schistosoma japonicum ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative Norepinephrine transporter   597 aa 545 aa 41.7 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Onchocerca volvulus Norepinephrine transporter   597 aa 548 aa 24.8 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Plasmodium knowlesi transporter, putative Serotonin transporter   630 aa 514 aa 20.2 %
Brugia malayi Sodium:neurotransmitter symporter family protein Norepinephrine transporter   597 aa 581 aa 34.6 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Echinococcus multilocularis sodium and chloride dependent glycine Norepinephrine transporter   597 aa 507 aa 38.9 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Neospora caninum sodium-dependent transporter, putative Norepinephrine transporter   597 aa 507 aa 30.4 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Plasmodium vivax amine transporter, putative Norepinephrine transporter   597 aa 483 aa 21.1 %
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter Norepinephrine transporter   597 aa 549 aa 41.9 %
Onchocerca volvulus Norepinephrine transporter   597 aa 570 aa 38.6 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Serotonin 2a (5-HT2a) receptor   471 aa 405 aa 25.4 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Onchocerca volvulus High affinity copper uptake protein 1 homolog Norepinephrine transporter   597 aa 551 aa 47.4 %
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Norepinephrine transporter   597 aa 501 aa 39.7 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Toxoplasma gondii Sodium:neurotransmitter symporter family protein Norepinephrine transporter   597 aa 522 aa 22.0 %
Schistosoma mansoni sodium/chloride dependent transporter Norepinephrine transporter   597 aa 534 aa 41.0 %
Toxoplasma gondii Sodium:neurotransmitter symporter family protein Norepinephrine transporter   597 aa 508 aa 32.7 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Serotonin 2a (5-HT2a) receptor   471 aa 435 aa 23.0 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Plasmodium yoelii hypothetical protein Norepinephrine transporter   597 aa 478 aa 19.7 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Echinococcus granulosus sodium and chloride dependent glycine Norepinephrine transporter   597 aa 529 aa 42.5 %
Onchocerca volvulus Norepinephrine transporter   597 aa 554 aa 38.6 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Echinococcus multilocularis sodium and chloride dependent glycine Norepinephrine transporter   597 aa 529 aa 42.0 %
Onchocerca volvulus Norepinephrine transporter   597 aa 540 aa 46.3 %
Drosophila melanogaster CG1698 gene product from transcript CG1698-RA Norepinephrine transporter   597 aa 513 aa 38.4 %
Plasmodium vivax hypothetical protein, conserved Serotonin transporter   630 aa 528 aa 21.2 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Norepinephrine transporter   597 aa 579 aa 35.1 %
Loa Loa (eye worm) hypothetical protein Norepinephrine transporter   597 aa 551 aa 25.0 %
Schistosoma mansoni sodium/chloride dependent transporter Norepinephrine transporter   597 aa 529 aa 41.6 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Drosophila melanogaster CG13796 gene product from transcript CG13796-RD Norepinephrine transporter   597 aa 569 aa 24.8 %
Onchocerca volvulus Transmembrane protein 120 homolog Norepinephrine transporter   597 aa 577 aa 34.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni dihydrofolate reductase 0.0052 0.0526 0.0526
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0292 1 1
Onchocerca volvulus 0.0129 0.3539 0.3539
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0411 0.0411
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0411 0.0411
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0411 0.0411
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.005 0.0411 0.0411
Echinococcus granulosus thymidylate synthase 0.0129 0.3539 0.3539
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0067 0.111 0.111
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0411 0.0411
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0411 0.0411
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0411 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0871 0.5
Schistosoma mansoni sodium-dependent amino acid transporter 0.005 0.0411 0.0411
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0411 0.0411
Loa Loa (eye worm) serotonin transporter b 0.0292 1 1
Brugia malayi hypothetical protein 0.0061 0.0871 0.0871
Schistosoma mansoni sodium/chloride dependent transporter 0.0292 1 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0411 0.0411
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0099 0.2358 0.2358
Loa Loa (eye worm) hypothetical protein 0.0099 0.2358 0.2358
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0073 0.1326 0.1326
Chlamydia trachomatis dihydrofolate reductase 0.0052 0.0526 1
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.005 0.0411 0.0411
Echinococcus granulosus dihydrofolate reductase 0.0052 0.0526 0.0526
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0181 0.5614 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0411 0.0411
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0091 0.206 0.206
Treponema pallidum sodium- and chloride- dependent transporter 0.0292 1 0.5
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0411 0.0411
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0181 0.5614 0.5
Loa Loa (eye worm) hypothetical protein 0.005 0.0411 0.0411
Brugia malayi Metabotropic glutamate receptor precursor. 0.008 0.1625 0.1625
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0129 0.3539 1
Onchocerca volvulus 0.005 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.005 0.0411 0.0411
Schistosoma mansoni biogenic amine (5HT) receptor 0.0186 0.5817 0.5817
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.005 0.0411 0.0411
Brugia malayi hypothetical protein 0.005 0.0411 0.0411
Echinococcus multilocularis dihydrofolate reductase 0.0052 0.0526 0.0526
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.005 0.0411 0.0411
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0129 0.3539 1
Loa Loa (eye worm) hypothetical protein 0.0186 0.5817 0.5817
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0411 0.0411
Echinococcus granulosus serotonin transporter 0.0292 1 1
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0181 0.5614 0.5
Loa Loa (eye worm) norepinephrine transporter 0.0292 1 1
Loa Loa (eye worm) thymidylate synthase 0.0129 0.3539 0.3539
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0181 0.5614 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0411 0.0411
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0129 0.3539 0.3539
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0411 0.0411
Loa Loa (eye worm) dihydrofolate reductase 0.0052 0.0526 0.0526
Loa Loa (eye worm) hypothetical protein 0.005 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.005 0.0411 0.0411
Onchocerca volvulus 0.0292 1 1
Onchocerca volvulus 0.005 0.0411 0.0411
Brugia malayi dihydrofolate reductase family protein 0.0052 0.0526 0.0526
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.005 0.0411 0.0411
Echinococcus multilocularis serotonin transporter 0.0292 1 1
Loa Loa (eye worm) hypothetical protein 0.0186 0.5817 0.5817
Echinococcus granulosus biogenic amine 5HT receptor 0.0186 0.5817 0.5817
Echinococcus multilocularis serotonin receptor 0.0186 0.5817 0.5817
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0411 0.0411
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0181 0.5614 1
Echinococcus granulosus metabotropic glutamate receptor 2 0.0067 0.111 0.111
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0292 1 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0292 1 1
Onchocerca volvulus 0.005 0.0411 0.0411
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0411 0.0411
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0411 0.0411
Loa Loa (eye worm) glutamate receptor 0.008 0.1625 0.1625
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0411 0.0411
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.005 0.0411 0.0411
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0411 0.0411
Brugia malayi thymidylate synthase 0.0129 0.3539 0.3539
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0181 0.5614 1
Mycobacterium ulcerans thymidylate synthase 0.0129 0.3539 1
Schistosoma mansoni metabotropic glutamate receptor 0.0067 0.111 0.111
Loa Loa (eye worm) hypothetical protein 0.0292 1 1
Echinococcus granulosus metabotropic glutamate receptor 5 0.0099 0.2358 0.2358
Loa Loa (eye worm) hypothetical protein 0.0292 1 1
Echinococcus multilocularis serotonin receptor 0.0186 0.5817 0.5817
Mycobacterium tuberculosis Hypothetical protein 0.0061 0.0871 0.1148
Echinococcus multilocularis thymidylate synthase 0.0129 0.3539 0.3539
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.005 0.0411 0.0411
Brugia malayi Dihydrofolate reductase 0.0052 0.0526 0.0526
Loa Loa (eye worm) hypothetical protein 0.005 0.0411 0.0411
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0411 0.0411
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0411 0.0411

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 1000 nM Binding affinity against 5-hydroxytryptamine 1A receptor (5-HT1A) by displacement of [3H]-8-OH-DPAT from rat hippocampus membranes ChEMBL. 14640559
IC50 (binding) > 1000 nM Binding affinity against 5-hydroxytryptamine 2A receptor by displacement of [3H]-ketanserin from rat prefrontal cerebral cortex mambranes ChEMBL. 14640559
IC50 (binding) > 1000 nM Binding affinity against norepinephrine transporter (NET) by displacement of [3H]-nisoxatine in male wistar rats ChEMBL. 14640559
IC50 (binding) > 1000 nM Binding affinity against 5-hydroxytryptamine 1A receptor (5-HT1A) by displacement of [3H]-8-OH-DPAT from rat hippocampus membranes ChEMBL. 14640559
IC50 (binding) > 1000 nM Binding affinity against 5-hydroxytryptamine 2A receptor by displacement of [3H]-ketanserin from rat prefrontal cerebral cortex mambranes ChEMBL. 14640559
IC50 (binding) > 1000 nM Binding affinity against norepinephrine transporter (NET) by displacement of [3H]-nisoxatine in male wistar rats ChEMBL. 14640559
Ki (binding) = 0.4 nM Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]-paroxetine in male wistar rats ChEMBL. 14640559
Ki (binding) = 0.4 nM Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]-paroxetine in male wistar rats ChEMBL. 14640559
Ki (binding) = 1.1 nM Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]-paroxetine in male wistar rats ChEMBL. 14640559
Ki (binding) = 1.1 nM Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]-paroxetine in male wistar rats ChEMBL. 14640559
Ki (binding) = 45.9 nM Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]-paroxetine in male wistar rats ChEMBL. 14640559
Ki (binding) = 45.9 nM Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]-paroxetine in male wistar rats ChEMBL. 14640559
Ki (binding) = 111.4 nM Binding affinity against norepinephrine transporter (NET) by displacement of [3H]-nisoxatine in male wistar rats ChEMBL. 14640559
Ki (binding) = 111.4 nM Binding affinity against norepinephrine transporter (NET) by displacement of [3H]-nisoxatine in male wistar rats ChEMBL. 14640559
Ki (binding) = 253.4 nM Binding affinity against dopamine ransporter (DAT) by displacement of [3H]-WIN-35,428 in male wistar rats ChEMBL. 14640559
Ki (binding) = 253.4 nM Binding affinity against dopamine ransporter (DAT) by displacement of [3H]-WIN-35,428 in male wistar rats ChEMBL. 14640559
Ki (binding) = 821 nM Binding affinity against dopamine ransporter (DAT) by displacement of [3H]-WIN-35,428 in male wistar rats ChEMBL. 14640559
Ki (binding) = 821 nM Binding affinity against dopamine ransporter (DAT) by displacement of [3H]-WIN-35,428 in male wistar rats ChEMBL. 14640559
Ratio (binding) = 247.6 Ratio of NET to that of SERT ChEMBL. 14640559

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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