Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0365 | 0.1534 | 1 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0185 | 0.0684 | 0.0666 |
Echinococcus granulosus | carboxylesterase 5A | 0.216 | 1 | 1 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0285 | 0.1156 | 0.1156 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0111 | 0.0335 | 0.2088 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0365 | 0.1534 | 0.1534 |
Leishmania major | trypanothione reductase | 0.0044 | 0.0019 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.216 | 1 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.01 | 0.0283 | 0.1742 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0365 | 0.1534 | 0.1534 |
Brugia malayi | Carboxylesterase family protein | 0.0365 | 0.1534 | 0.1518 |
Echinococcus multilocularis | acetylcholinesterase | 0.216 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0044 | 0.0019 | 0.5 |
Onchocerca volvulus | 0.0365 | 0.1534 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.216 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0044 | 0.0019 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0365 | 0.1534 | 0.1518 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0365 | 0.1534 | 0.1534 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.014 | 0.0472 | 0.0454 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0365 | 0.1534 | 0.1534 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.01 | 0.0283 | 0.1742 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0044 | 0.0019 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0365 | 0.1534 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.216 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0044 | 0.0019 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0365 | 0.1534 | 0.1534 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 0.1534 | 0.1534 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0365 | 0.1534 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0111 | 0.0335 | 0.2088 |
Schistosoma mansoni | integrin alpha-ps | 0.0043 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0472 | 0.0472 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0365 | 0.1534 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0365 | 0.1534 | 0.1518 |
Echinococcus multilocularis | integrin alpha 3 | 0.0142 | 0.0481 | 0.0481 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 0.1534 | 0.1534 |
Echinococcus granulosus | integrin alpha 3 | 0.0142 | 0.0481 | 0.0481 |
Echinococcus multilocularis | neuroligin | 0.0365 | 0.1534 | 0.1534 |
Plasmodium falciparum | glutathione reductase | 0.0044 | 0.0019 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0365 | 0.1534 | 0.1534 |
Onchocerca volvulus | 0.0365 | 0.1534 | 0.5 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0365 | 0.1534 | 0.1534 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.01 | 0.0283 | 0.1742 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 0.1534 | 0.1534 |
Mycobacterium tuberculosis | Probable reductase | 0.01 | 0.0283 | 0.1742 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0044 | 0.0019 | 0.0019 |
Schistosoma mansoni | acetylcholinesterase | 0.0365 | 0.1534 | 0.1534 |
Echinococcus granulosus | neuroligin | 0.0365 | 0.1534 | 0.1534 |
Echinococcus granulosus | integrin alpha ps | 0.0083 | 0.0203 | 0.0203 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0365 | 0.1534 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0365 | 0.1534 | 0.1518 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 0.1534 | 0.1534 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0365 | 0.1534 | 0.1534 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 0.1534 | 0.1534 |
Brugia malayi | Carboxylesterase family protein | 0.216 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.216 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.216 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.216 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.216 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0497 | 0.0497 |
Schistosoma mansoni | integrin alpha-ps | 0.0083 | 0.0203 | 0.0203 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0365 | 0.1534 | 0.1534 |
Onchocerca volvulus | 0.0365 | 0.1534 | 0.5 | |
Echinococcus multilocularis | integrin alpha ps | 0.0083 | 0.0203 | 0.0203 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0044 | 0.0022 | 0.0022 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0044 | 0.0022 | 0.0022 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0365 | 0.1534 | 0.1534 |
Echinococcus multilocularis | carboxylesterase 5A | 0.216 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0111 | 0.0335 | 1 |
Schistosoma mansoni | integrin alpha | 0.0185 | 0.0684 | 0.0684 |
Loa Loa (eye worm) | carboxylesterase | 0.0365 | 0.1534 | 0.1534 |
Plasmodium vivax | glutathione reductase, putative | 0.0044 | 0.0019 | 0.5 |
Echinococcus multilocularis | integrin alpha ps | 0.0083 | 0.0203 | 0.0203 |
Loa Loa (eye worm) | glutathione reductase | 0.0044 | 0.0019 | 0.0019 |
Echinococcus granulosus | acetylcholinesterase | 0.216 | 1 | 1 |
Onchocerca volvulus | 0.0365 | 0.1534 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0365 | 0.1534 | 0.1518 |
Schistosoma mansoni | gliotactin | 0.0365 | 0.1534 | 0.1534 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 0.1534 | 0.1534 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0293 | 0.0293 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0365 | 0.1534 | 0.1534 |
Onchocerca volvulus | 0.0365 | 0.1534 | 0.5 | |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.01 | 0.0283 | 0.1742 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0365 | 0.1534 | 0.1534 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0111 | 0.0335 | 0.2088 |
Toxoplasma gondii | thioredoxin reductase | 0.0044 | 0.0019 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0016 | 0.0016 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.01 | 0.0283 | 0.1742 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 0.1534 | 0.1534 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0365 | 0.1534 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.