Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0287 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0287 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0287 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0287 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0287 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0287 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0287 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0177 | 0.2291 | 0.2291 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0287 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0287 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0287 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0287 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0287 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0287 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0287 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0287 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0287 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0287 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0287 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0254 | 0.7709 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0287 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0287 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0254 | 0.7709 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0287 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0177 | 0.2291 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (binding) | = 42 % | Inhibition of PGH synthase by measuring oxygen consumption with a Clark oxygen electrode at 100 uM | ChEMBL. | 3102742 |
Control (binding) | = 42 % | Inhibition of PGH synthase by measuring oxygen consumption with a Clark oxygen electrode at 100 uM | ChEMBL. | 3102742 |
Control (binding) | = 78 % | Inhibition of PGH synthase was determined by measuring oxygen consumption with a Clark oxygen electrode at 25 microM | ChEMBL. | 3102742 |
Control (binding) | = 78 % | Inhibition of PGH synthase was determined by measuring oxygen consumption with a Clark oxygen electrode at 25 microM | ChEMBL. | 3102742 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.