Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0372 | 1 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0372 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0372 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 1 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0372 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0372 | 1 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0372 | 1 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0372 | 1 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0372 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0372 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0372 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 3.33 uM | Growth inhibition effect of the compound against prostate tumor IGROV cells | ChEMBL. | 14667235 |
GI50 (functional) | = 3.49 uM | Growth inhibition effect of the compound against prostate tumor LN-caP cells | ChEMBL. | 14667235 |
GI50 (functional) | = 3.59 uM | Growth inhibition effect of the compound against leukemia K-652 cells | ChEMBL. | 14667235 |
GI50 (functional) | = 3.86 uM | Growth inhibition effect of the compound against ovarian tumor SK-BR-3 cells | ChEMBL. | 14667235 |
GI50 (functional) | = 4.97 uM | Growth inhibition effect of the compound against ovarian tumor IGROV-ET cells | ChEMBL. | 14667235 |
GI50 (functional) | = 4.99 uM | Growth inhibition effect of the compound against prostate tumor SKOV-3 cells | ChEMBL. | 14667235 |
GI50 (functional) | = 5.1 uM | Growth inhibition effect of the compound against pancreas PANC-1 cells | ChEMBL. | 14667235 |
GI50 (functional) | = 5.2 uM | Growth inhibition effect of the compound against NSCL A-549 cells | ChEMBL. | 14667235 |
GI50 (functional) | = 6.69 uM | Growth inhibition effect of the compound against melanoma MEL-28 cells | ChEMBL. | 14667235 |
GI50 (functional) | = 8.83 uM | Growth inhibition effect of the compound against colon LOVO cells | ChEMBL. | 14667235 |
GI50 (functional) | = 8.84 uM | Growth inhibition effect of the compound against colon LOVO-DOX cells | ChEMBL. | 14667235 |
GI50 (functional) | = 9.31 uM | Growth inhibition effect of the compound against pancreas HT-29 cells | ChEMBL. | 14667235 |
GI50 (functional) | = 10.6 uM | Growth inhibition effect of the compound against prostate tumor DU-145 cells | ChEMBL. | 14667235 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.