Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0031 | 0.3691 | 0.3691 |
Brugia malayi | hypothetical protein | 0.0023 | 0.2131 | 0.3576 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0022 | 0.2056 | 0.3323 |
Plasmodium falciparum | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0031 | 0.3691 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0023 | 0.2131 | 0.2131 |
Echinococcus multilocularis | homeobox | 0.0029 | 0.3448 | 0.3448 |
Leishmania major | cytochrome p450-like protein | 0.0022 | 0.2056 | 0.3323 |
Echinococcus multilocularis | Phospholipid glycerol acyltransferase | 0.0031 | 0.3691 | 0.3691 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0042 | 0.5959 | 1 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0023 | 0.2131 | 0.2131 |
Echinococcus granulosus | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0031 | 0.3691 | 0.3691 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.2131 | 0.3576 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0023 | 0.2131 | 0.2131 |
Mycobacterium ulcerans | bifunctional transmembrane phospholipid biosynthesis enzyme PlsC | 0.0031 | 0.3691 | 1 |
Toxoplasma gondii | acyltransferase domain-containing protein | 0.0031 | 0.3691 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.0113 | 0.019 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0042 | 0.5959 | 0.5959 |
Loa Loa (eye worm) | doublecortin family protein | 0.0023 | 0.2131 | 0.3576 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.5959 | 0.5 |
Treponema pallidum | lysophosphatidic acid acyltransferase | 0.0031 | 0.3691 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.3691 | 0.6195 |
Echinococcus multilocularis | 0.0012 | 0.0113 | 0.0113 | |
Mycobacterium tuberculosis | Possible transmembrane phospholipid biosynthesis bifunctional enzyme PlsC: putative L-3-phosphoserine phosphatase (O-phosphoseri | 0.0029 | 0.3448 | 0.9319 |
Leishmania major | 1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative | 0.0031 | 0.3691 | 0.6121 |
Schistosoma mansoni | rab6-interacting | 0.0023 | 0.2131 | 0.2131 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.3448 | 0.5786 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0034 | 0.4344 | 0.729 |
Plasmodium vivax | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0031 | 0.3691 | 1 |
Schistosoma mansoni | transcription factor | 0.0029 | 0.3448 | 0.3448 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0042 | 0.5959 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0022 | 0.2056 | 0.345 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0023 | 0.2131 | 0.2131 |
Echinococcus granulosus | Msx-like | 0.0029 | 0.3448 | 0.3448 |
Echinococcus multilocularis | RUN | 0.0023 | 0.2131 | 0.2131 |
Trypanosoma brucei | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0031 | 0.3691 | 0.6121 |
Schistosoma mansoni | lipoxygenase | 0.0063 | 1 | 1 |
Brugia malayi | Doublecortin family protein | 0.0023 | 0.2131 | 0.3576 |
Mycobacterium leprae | POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERI | 0.0031 | 0.3691 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0022 | 0.2056 | 0.3323 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0042 | 0.5959 | 1 |
Mycobacterium ulcerans | 1-acylglycerol-3-phosphate O-acyltransferase | 0.0031 | 0.3691 | 1 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0042 | 0.5959 | 0.5959 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0042 | 0.5959 | 0.5959 |
Schistosoma mansoni | polycystin 1-related | 0.0023 | 0.2131 | 0.2131 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0022 | 0.2056 | 0.5429 |
Schistosoma mansoni | 1-acyl-sn-glycerol-3-phosphate o-acyltransferase | 0.0031 | 0.3691 | 0.3691 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0023 | 0.2131 | 0.2131 |
Echinococcus granulosus | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0031 | 0.3691 | 0.3691 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0022 | 0.2056 | 0.3323 |
Wolbachia endosymbiont of Brugia malayi | 1-acyl-sn-glycerol-3-phosphate acyltransferase | 0.0031 | 0.3691 | 0.5 |
Brugia malayi | cytochrome P450 | 0.0012 | 0.0113 | 0.019 |
Trypanosoma cruzi | 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative | 0.0031 | 0.3691 | 0.6121 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0042 | 0.5959 | 0.5959 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0042 | 0.5959 | 0.5 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0042 | 0.5959 | 1 |
Brugia malayi | hypothetical protein | 0.0023 | 0.2131 | 0.3576 |
Echinococcus granulosus | RUN | 0.0023 | 0.2131 | 0.2131 |
Brugia malayi | Cytochrome P450 family protein | 0.0034 | 0.4344 | 0.729 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0042 | 0.5959 | 0.5959 |
Schistosoma mansoni | rab6-interacting | 0.0023 | 0.2131 | 0.2131 |
Loa Loa (eye worm) | acyltransferase | 0.0031 | 0.3691 | 0.6195 |
Toxoplasma gondii | acyltransferase domain-containing protein | 0.0031 | 0.3691 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.5959 | 1 |
Mycobacterium tuberculosis | 1-acylglycerol-3-phosphate O-acyltransferase | 0.0031 | 0.3691 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0063 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0023 | 0.2131 | 0.2131 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.2056 | 0.345 |
Chlamydia trachomatis | glycerol-3-phosphate acyltransferase | 0.0031 | 0.3691 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.3691 | 0.6195 |
Schistosoma mansoni | loxhd1 | 0.0023 | 0.2131 | 0.2131 |
Schistosoma mansoni | cytochrome P450 | 0.0012 | 0.0113 | 0.0113 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.2056 | 0.345 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0042 | 0.5959 | 1 |
Echinococcus multilocularis | 1 acyl sn glycerol 3 phosphate acyltransferase | 0.0031 | 0.3691 | 0.3691 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.2131 | 0.2131 |
Onchocerca volvulus | 0.0023 | 0.2131 | 1 | |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0042 | 0.5959 | 0.5 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0042 | 0.5959 | 0.5959 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0042 | 0.5959 | 0.5 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0042 | 0.5959 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0042 | 0.5959 | 0.5959 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.2056 | 0.345 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0113 | 0.0113 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0012 | 0.0113 | 0.0113 |
Echinococcus granulosus | Phospholipid glycerol acyltransferase | 0.0031 | 0.3691 | 0.3691 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.2131 | 0.3576 |
Onchocerca volvulus | 0.0023 | 0.2131 | 1 | |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0042 | 0.5959 | 0.5959 |
Brugia malayi | Acyltransferase family protein | 0.0031 | 0.3691 | 0.6195 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0023 | 0.2131 | 0.2131 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.2056 | 0.345 |
Loa Loa (eye worm) | cytochrome P450 | 0.0012 | 0.0113 | 0.019 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 100 % | Percent anticonvulsant activity of the compound against pentylenetetrazole (PTZ)-induced attacks at 10 mg/kg peroral dose | ChEMBL. | 12477354 |
Activity (functional) | = 100 % | Percent anticonvulsant activity of the compound against pentylenetetrazole (PTZ)-induced attacks at 10 mg/kg peroral dose | ChEMBL. | 12477354 |
Activity (functional) | = 149.16 % | Anxiolytic activity in mice using light-dark box and % time spent in light was reported at 10 mg/kg peroral dose | ChEMBL. | 12477354 |
Activity (functional) | = 149.16 % | Anxiolytic activity in mice using light-dark box and % time spent in light was reported at 10 mg/kg peroral dose | ChEMBL. | 12477354 |
No. of falls (functional) | = 0.55 | Motor coordination of mouse as number of falls in 30 sec was reported after 10 mg/kg peroral dose using rotorod test | ChEMBL. | 12477354 |
No. of transfers (functional) | = 27.9 | Anxiolytic activity in mice using light-dark box and no. of transfers between compartments were reported at 10 mg/kg peroral dose | ChEMBL. | 12477354 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.