Detailed information for compound 264931

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 403.472 | Formula: C28H21NO2
  • H donors: 1 H acceptors: 3 LogP: 6.32 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)C1=CCC(c2c1cc(C#Cc1ccc(cc1)C(=O)O)cc2)(C)C
  • InChi: 1S/C28H21NO2/c1-28(2)16-15-24(22-10-7-21(18-29)8-11-22)25-17-20(9-14-26(25)28)4-3-19-5-12-23(13-6-19)27(30)31/h5-15,17H,16H2,1-2H3,(H,30,31)
  • InChiKey: MBSFTWQYXVUVSD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens retinoic acid receptor, beta Starlite/ChEMBL References
Homo sapiens retinoic acid receptor, gamma Starlite/ChEMBL References
Homo sapiens retinoic acid receptor, alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog Get druggable targets OG5_131607 All targets in OG5_131607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131607 All targets in OG5_131607
Loa Loa (eye worm) nuclear receptor nhr-7B Get druggable targets OG5_131607 All targets in OG5_131607
Brugia malayi nuclear hormone receptor Get druggable targets OG5_131607 All targets in OG5_131607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0108 0.0108
Schistosoma mansoni lamin 0.0028 0.0063 0.0063
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0032 0.0082 0.0082
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0093 0.0422 0.1712
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0023 0.0023
Toxoplasma gondii AGC kinase 0.0443 0.2357 1
Trichomonas vaginalis AGC family protein kinase 0.0041 0.0133 0.0526
Brugia malayi Cytochrome P450 family protein 0.0025 0.0044 0.0101
Leishmania major protein kinase A catalytic subunit 0.0443 0.2357 1
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0019 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.006 0.0236 0.0236
Brugia malayi nuclear hormone receptor 0.0787 0.4256 1
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.006 0.0236 0.0912
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0108 0.0108
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.0041 0.0041
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0107 0.0417
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0107 0.0417
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0097 0.0441 0.1035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0027
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0056 0.0218 0.0886
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0108 0.0251
Echinococcus granulosus cyclin k 0.006 0.0236 0.0236
Echinococcus multilocularis lamin 0.0028 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0247 0.1273 0.5381
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0251
Echinococcus granulosus cyclin G2 0.006 0.0236 0.0236
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0443 0.2357 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0197 0.0997 0.4207
Plasmodium falciparum calcium-dependent protein kinase 2 0.0097 0.0441 0.1839
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0443 0.2357 0.5538
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.006 0.0236 0.0912
Trypanosoma brucei metacaspase MCA3 0.0197 0.0997 0.4207
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0022 0.0054
Trichomonas vaginalis AGC family protein kinase 0.0041 0.0133 0.0526
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0039 0.0122 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0108 0.0251
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0063 0.0145
Echinococcus multilocularis musashi 0.0028 0.0063 0.0063
Schistosoma mansoni cyclin d 0.006 0.0236 0.0236
Trypanosoma cruzi metacaspase, putative 0.0197 0.0997 0.4207
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0097 0.0441 0.0441
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0197 0.0997 0.4174
Echinococcus multilocularis nervana 2 0.002 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0108 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0066 0.0241
Toxoplasma gondii hypothetical protein 0.0188 0.0943 0.3942
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0108 0.0251
Onchocerca volvulus 0.0037 0.0108 0.0245
Toxoplasma gondii cathepsin CPL 0.0036 0.0107 0.0363
Echinococcus granulosus caspase 8 0.0197 0.0997 0.0997
Trichomonas vaginalis cyclins, putative 0.006 0.0236 0.0963
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0107 0.0417
Echinococcus multilocularis apoptotic protease activating factor 1 0.0184 0.0922 0.0922
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0019 0.0011 0.0011
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0107 0.0107
Brugia malayi intermediate filament protein 0.0028 0.0063 0.0145
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0066 0.0241
Echinococcus granulosus Protein kinase C brain isozyme 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0197 0.0997 0.4207
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0236 0.0963
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0097 0.0441 0.1035
Onchocerca volvulus 0.006 0.0236 0.0537
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0108 0.0251
Echinococcus granulosus caspase 0.0522 0.2792 0.2792
Loa Loa (eye worm) CYL-1 protein 0.006 0.0236 0.0551
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0108 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0108 0.0251
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0251
Loa Loa (eye worm) fibroinase 0.0036 0.0107 0.025
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0443 0.2357 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0108 0.0108
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0044 0.0101
Schistosoma mansoni protein kinase 0.0744 0.4023 0.4023
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0434 0.2308 0.2308
Brugia malayi Cyclin, N-terminal domain containing protein 0.006 0.0236 0.0551
Echinococcus granulosus cyclin A3 4 0.006 0.0236 0.0236
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0108 0.0108
Brugia malayi cathepsin L-like precursor 0.0024 0.0041 0.0093
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0097 0.0441 0.1793
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0013 0.0013
Echinococcus granulosus cathepsin L cysteine proteinase 0.0036 0.0107 0.0107
Echinococcus multilocularis cyclin y 0.006 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0093
Schistosoma mansoni serine/threonine protein kinase 0.0443 0.2357 0.2357
Echinococcus multilocularis nervana 2 0.002 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0107 0.0417
Echinococcus granulosus oligomeric golgi complex subunit 3 0.006 0.0236 0.0236
Trypanosoma cruzi mitotic cyclin, putative 0.006 0.0236 0.0963
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0422 0.0422
Echinococcus multilocularis lamin dm0 0.0028 0.0063 0.0063
Trypanosoma brucei metacaspase 0.0197 0.0997 0.4207
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0108 0.0108
Brugia malayi steroid hormone receptor 0.0037 0.0108 0.0251
Echinococcus granulosus caspase 2 0.0381 0.2014 0.2014
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0093 0.0422 0.099
Echinococcus granulosus lamin 0.0028 0.0063 0.0063
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.001 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0108 0.0108
Echinococcus granulosus cathepsin l1 0.0024 0.0041 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0108 0.0251
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.001 0.002
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0056 0.0218 0.0835
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.0273 0.0638
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0108 0.0108
Trypanosoma brucei metacaspase 5, putative 0.0197 0.0997 0.4207
Brugia malayi hypothetical protein 0.0019 0.0013 0.0027
Brugia malayi Cam kinase protein 1 0.0097 0.0441 0.1035
Mycobacterium leprae Possible regulatory protein 0.0056 0.0218 0.5
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0019 0.0011 0.0011
Trichomonas vaginalis AGC family protein kinase 0.0041 0.0133 0.0526
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0168 0.0837 0.3487
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0065 0.0267 0.1095
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0108 0.0108
Brugia malayi Cyclin, N-terminal domain containing protein 0.0527 0.2821 0.6628
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0044 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0107 0.0417
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0097 0.0441 0.0441
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0013 0.0027
Schistosoma mansoni atypical protein kinase C 0.0019 0.0011 0.0011
Onchocerca volvulus 0.0036 0.0107 0.0244
Loa Loa (eye worm) cyclin domain-containing protein 0.006 0.0236 0.0551
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0108 0.0108
Trichomonas vaginalis AGC family protein kinase 0.0041 0.0133 0.0526
Echinococcus granulosus cyclin B 0.0247 0.1273 0.1273
Toxoplasma gondii histone lysine methyltransferase SET1 0.0243 0.1248 0.525
Entamoeba histolytica protein kinase, putative 0.0041 0.0133 0.0523
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0011 0.0007
Trypanosoma cruzi cdc2-related kinase 3 0.0093 0.0422 0.1758
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.0016 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0139 0.0675 0.2832
Schistosoma mansoni g1/s-specific cyclin C 0.006 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0052 0.0194 0.0453
Echinococcus multilocularis cyclin 0.006 0.0236 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0107 0.0417
Entamoeba histolytica protein kinase, putative 0.0039 0.0122 0.0476
Schistosoma mansoni caspase-3 (C14 family) 0.0522 0.2792 0.2792
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0168 0.0837 0.0837
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0145
Brugia malayi Cathepsin L-like precursor 0.0036 0.0107 0.025
Brugia malayi Cathepsin L-like cysteine proteinase 0.0024 0.0041 0.0093
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0108 0.0108
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0108 0.0108
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.0016 0.0016
Onchocerca volvulus 0.0036 0.0107 0.0244
Trypanosoma brucei mitotic cyclin 6 0.0247 0.1273 0.5381
Brugia malayi hypothetical protein 0.0019 0.0013 0.0027
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0097 0.0441 0.1793
Plasmodium vivax metacaspase 1, putative 0.0197 0.0997 0.4207
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0019 0.0011 0.0011
Trichomonas vaginalis AGC family protein kinase 0.0041 0.0133 0.0526
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0107 0.0417
Trichomonas vaginalis guanylate cyclase, putative 0.0056 0.0218 0.0886
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0093 0.0422 0.099
Trichomonas vaginalis cyclins, putative 0.0247 0.1273 0.5381
Echinococcus multilocularis cyclins 0.0247 0.1273 0.1273
Trypanosoma cruzi mitotic cyclin, putative 0.006 0.0236 0.0963
Echinococcus multilocularis protein kinase c iota type 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0197 0.0997 0.4207
Trypanosoma cruzi cysteine peptidase, putative 0.0139 0.0675 0.2832
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0001 0.0001
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0168 0.0837 0.1964
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0107 0.0417
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0248 0.058
Schistosoma mansoni cyclin G2 0.006 0.0236 0.0236
Leishmania major protein kinase, putative 0.0065 0.0267 0.1045
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0168 0.0837 0.3523
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0107 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0107 0.0417
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0443 0.2357 0.2357
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0218 0.0886
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0011 0.0007
Schistosoma mansoni cpg binding protein 0.0135 0.0655 0.0655
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0023 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0236 0.0963
Plasmodium vivax cyclin homologue, putative 0.006 0.0236 0.0963
Echinococcus granulosus apoptotic protease activating factor 1 0.0184 0.0922 0.0922
Echinococcus multilocularis tumor protein p63 0.0356 0.1875 0.1875
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0023 0.0051
Trypanosoma cruzi cyclin, putative 0.0247 0.1273 0.5381
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0044 0.0101
Trichomonas vaginalis AGC family protein kinase 0.0041 0.0133 0.0526
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0056 0.0218 0.0886
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0197 0.0997 0.4207
Onchocerca volvulus 0.0184 0.0922 0.2112
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0168 0.0837 0.0837
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0443 0.2357 0.2357
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.0273 1
Brugia malayi nuclear receptor RXR 0.0019 0.0013 0.0027
Entamoeba histolytica cyclin, domain containing protein 0.006 0.0236 0.0958
Echinococcus granulosus cyclins 0.0247 0.1273 0.1273
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0066 0.0241
Loa Loa (eye worm) hypothetical protein 0.0036 0.0107 0.025
Giardia lamblia Cyclin A 0.0247 0.1273 0.5355
Echinococcus multilocularis cyclin dependent kinase 1 0.0093 0.0422 0.0422
Echinococcus multilocularis G1:S specific cyclin D1 0.006 0.0236 0.0236
Echinococcus multilocularis cyclins 0.0247 0.1273 0.1273
Leishmania major mitotic cyclin, putative 0.006 0.0236 0.0912
Echinococcus granulosus cyclin dependent kinase 5 0.0093 0.0422 0.0422
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0443 0.2357 0.2357
Loa Loa (eye worm) hypothetical protein 0.0247 0.1273 0.2989
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0443 0.2357 1
Entamoeba histolytica protein kinase, putative 0.0097 0.0441 0.183
Echinococcus multilocularis cyclin B 0.0247 0.1273 0.1273
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0027
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0197 0.0997 0.4207
Echinococcus granulosus cyclin y 0.006 0.0236 0.0236
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0273 0.0273
Echinococcus granulosus ubiquitin specific protease 41 0.0168 0.0837 0.0837
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0019 0.0011 0.0024
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0108 0.0108
Toxoplasma gondii AGC kinase 0.0039 0.0122 0.0425
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0065 0.0267 0.1095
Entamoeba histolytica protein kinase, putative 0.0019 0.0011 0.0007
Giardia lamblia Hypothetical protein 0.006 0.0236 0.0912
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0108 0.0245
Schistosoma mansoni protein kinase 0.0744 0.4023 0.4023
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0066 0.0241
Schistosoma mansoni cyclin B 0.0247 0.1273 0.1273
Echinococcus multilocularis cyclin G2 0.006 0.0236 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.0197 0.0997 0.4207
Trypanosoma cruzi metacaspase 5, putative 0.0197 0.0997 0.4207
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0443 0.2357 0.2357
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0066 0.0241
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0093 0.0422 0.0422
Entamoeba histolytica cell division protein kinase 2, putative 0.0093 0.0422 0.175
Entamoeba histolytica protein kinase, putative 0.0097 0.0441 0.183
Schistosoma mansoni cpg binding protein 0.0128 0.0614 0.0614
Onchocerca volvulus 0.0247 0.1273 0.2916
Echinococcus multilocularis cyclins 0.0247 0.1273 0.1273
Echinococcus granulosus cyclin G2 0.006 0.0236 0.0236
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0443 0.2357 0.2357
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0001 0.0001
Echinococcus multilocularis cpg binding protein 0.0135 0.0655 0.0655
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0056 0.0218 0.0509
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0443 0.2357 1
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0108 0.0108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0108 0.0251
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0108 0.0251
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0001 0.0001
Schistosoma mansoni intermediate filament proteins 0.0028 0.0063 0.0063
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0056 0.0218 0.0886
Leishmania major mitotic cyclin, putative 0.006 0.0236 0.0912
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0107 0.0417
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0056 0.0218 0.0218
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0441 0.0441
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0007 0.0007
Schistosoma mansoni serine/threonine-protein kinase 0.0031 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0197 0.0997 0.2341
Trypanosoma cruzi cyclin, putative 0.0247 0.1273 0.5381
Trichomonas vaginalis cyclin D, putative 0.006 0.0236 0.0963
Trichomonas vaginalis cyclin B3, putative 0.006 0.0236 0.0963
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0011 0.0011
Plasmodium vivax vivapain-2 0.0036 0.0107 0.0417
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0273 0.3241
Plasmodium falciparum calcium-dependent protein kinase 5 0.0097 0.0441 0.1839
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0019 0.0011 0.0024
Loa Loa (eye worm) AGC/NDR protein kinase 0.0019 0.0011 0.0024
Echinococcus multilocularis cyclin A3 4 0.006 0.0236 0.0236
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0108 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0197 0.0997 0.4207
Echinococcus granulosus single minded 2 0.0161 0.0794 0.0794
Echinococcus multilocularis ubiquitin specific protease 41 0.0168 0.0837 0.0837
Schistosoma mansoni peptidase 0.0026 0.0047 0.0047
Onchocerca volvulus 0.0036 0.0107 0.0244
Onchocerca volvulus 0.0036 0.0107 0.0244
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0001 0.0001
Leishmania major cathepsin L-like protease 0.0139 0.0675 0.2792
Schistosoma mansoni serine/threonine protein kinase 0.0443 0.2357 0.2357
Brugia malayi F/Y-rich N-terminus family protein 0.0039 0.0122 0.0284
Plasmodium vivax cyclin 4, putative 0.006 0.0236 0.0963
Loa Loa (eye worm) hypothetical protein 0.0085 0.0373 0.0874
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0107 0.0417
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.004 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.0138
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0443 0.2357 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.006 0.0236 0.0551
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0066 0.0241
Echinococcus multilocularis Cyclin L1 0.006 0.0236 0.0236
Schistosoma mansoni single-minded 0.0217 0.1106 0.1106
Brugia malayi hypothetical protein 0.0728 0.3933 0.9242
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0029 0.0065 0.0238
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0107 0.0415
Brugia malayi Cathepsin L-like precursor 0.0036 0.0107 0.025
Brugia malayi cell division control protein 2 homolog 0.0093 0.0422 0.099
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0108 0.0108
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0194 0.0194
Trichomonas vaginalis cyclin D, putative 0.0247 0.1273 0.5381
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0139 0.0675 0.2832
Brugia malayi Cyclin, N-terminal domain containing protein 0.006 0.0236 0.0551
Giardia lamblia Kinase, CMGC CDK 0.0093 0.0422 0.1712
Leishmania major protein kinase, putative 0.0097 0.0441 0.1793
Trypanosoma cruzi metacaspase, putative 0.0197 0.0997 0.4207
Loa Loa (eye worm) CXXC zinc finger family protein 0.0128 0.0614 0.1441
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0251
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0522 0.2792 0.2792
Plasmodium vivax hypothetical protein, conserved 0.006 0.0236 0.0963
Echinococcus granulosus cyclin 0.006 0.0236 0.0236
Trichomonas vaginalis adenylate cyclase, putative 0.0056 0.0218 0.0886
Brugia malayi PAS domain containing protein 0.0217 0.1106 0.2597
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0197 0.0997 0.4174
Leishmania major cathepsin L-like protease 0.0036 0.0107 0.0363
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0066 0.0241
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0107 0.0244
Brugia malayi Hr1 repeat family protein 0.0019 0.0011 0.0024
Toxoplasma gondii hypothetical protein 0.006 0.0236 0.0912
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0127 0.0608 0.2548
Loa Loa (eye worm) cyclin C 0.006 0.0236 0.0551
Trypanosoma cruzi cyclin 9, putative 0.006 0.0236 0.0963
Brugia malayi hypothetical protein 0.006 0.0236 0.0551
Trypanosoma cruzi major cysteine proteinase, putative 0.0109 0.051 0.2131
Echinococcus granulosus cyclins 0.0247 0.1273 0.1273
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0029 0.0065 0.0065
Brugia malayi Protein kinase domain containing protein 0.0093 0.0422 0.099
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0023 0.0056
Leishmania major protein kinase, putative 0.0065 0.0267 0.1045
Onchocerca volvulus 0.0128 0.0614 0.1406
Schistosoma mansoni serine/threonine kinase 0.0019 0.0011 0.0011
Echinococcus granulosus protein kinase c epsilon type 0.0019 0.0011 0.0011
Schistosoma mansoni zinc finger protein 0.0017 0.0001 0.0001
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0247 0.1273 0.1273
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.006 0.0236 0.0236
Trichomonas vaginalis cyclin B, putative 0.0247 0.1273 0.5381
Brugia malayi CXXC zinc finger family protein 0.0128 0.0614 0.1441
Schistosoma mansoni serine/threonine protein kinase 0.0443 0.2357 0.2357
Echinococcus multilocularis cysteine protease 0.0036 0.0107 0.0107
Trichomonas vaginalis CMGC family protein kinase 0.0093 0.0422 0.1758
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0108 0.0108
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0036 0.0107 0.0417
Echinococcus granulosus nervana 2 0.002 0.0016 0.0016
Brugia malayi Cathepsin L-like precursor 0.0036 0.0107 0.025
Echinococcus multilocularis cyclin y 0.006 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0093
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0023 0.0056
Echinococcus multilocularis caspase 8 0.0197 0.0997 0.0997
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0107 0.0417
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0107 0.0417
Loa Loa (eye worm) AGC/PKA protein kinase 0.0443 0.2357 0.5538
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0001 0.0001
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0168 0.0837 0.0837
Entamoeba histolytica PH domain containing protein kinase, putative 0.0031 0.0076 0.0284
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0168 0.0837 0.3523
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.0019 0.0011 0.0024
Loa Loa (eye worm) histone methyltransferase 0.004 0.0125 0.0291
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0197 0.0997 0.0997
Echinococcus granulosus cyclin dependent kinase 0.0093 0.0422 0.0422
Entamoeba histolytica cyclin, domain containing protein 0.006 0.0236 0.0958
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.006 0.0236 0.0551
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0063 0.0145
Trichomonas vaginalis AGC family protein kinase 0.0443 0.2357 1
Leishmania major cathepsin L-like protease 0.0036 0.0107 0.0363
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0139 0.0675 0.2832
Echinococcus multilocularis thyroid hormone receptor alpha 0.0037 0.0108 0.0108
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0197 0.0997 0.4207
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0066 0.0241
Trichomonas vaginalis cyclins, putative 0.0247 0.1273 0.5381
Onchocerca volvulus 0.0036 0.0107 0.0244
Onchocerca volvulus Cyclin L homolog 0.006 0.0236 0.0537
Onchocerca volvulus 0.0056 0.0218 0.0496
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0168 0.0837 0.0837
Echinococcus multilocularis caspase 0.0522 0.2792 0.2792
Trypanosoma brucei cdc2-related kinase 3 0.0093 0.0422 0.1758
Loa Loa (eye worm) AGC/PKN protein kinase 0.0019 0.0011 0.0024
Trichomonas vaginalis helicase, putative 0.0029 0.0066 0.0241
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0023 0.0056
Onchocerca volvulus 0.0024 0.0041 0.0091
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.006 0.0236 0.0963
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0443 0.2357 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0108 0.0108
Plasmodium falciparum protein kinase 5 0.0093 0.0422 0.1758
Echinococcus granulosus cathepsin l cysteine peptidase 0.0036 0.0107 0.0107
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0093 0.0422 0.1712
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0107 0.0417
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0107 0.0417
Entamoeba histolytica cysteine protease, putative 0.0036 0.0107 0.0415
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0044 0.0276
Schistosoma mansoni coup transcription factor 0.0037 0.0108 0.0108
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0107 0.0107
Echinococcus granulosus cysteine protease 0.0019 0.001 0.001
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0247 0.1273 0.1273
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0434 0.2308 0.2308
Trichomonas vaginalis CMGC family protein kinase 0.0093 0.0422 0.1758
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0023 0.5
Leishmania major cysteine peptidase A (CPA) 0.0036 0.0107 0.0363
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0273 0.0273
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0139 0.0675 0.2832
Schistosoma mansoni cyclin G 0.006 0.0236 0.0236
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0168 0.0837 0.0837
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0107 0.0417
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0443 0.2357 1
Plasmodium falciparum metacaspase-like protein 0.0197 0.0997 0.4207
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0787 0.4256 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0108 0.0251
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0011 0.0011
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0108 0.0108
Plasmodium falciparum cysteine proteinase falcipain 3 0.0036 0.0107 0.0417
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0097 0.0441 0.1839
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0056 0.0213 0.0866
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.006 0.0236 0.0236
Onchocerca volvulus Protein CNPPD1 homolog 0.006 0.0236 0.0537
Leishmania major cyclin 9, putative 0.006 0.0236 0.0912
Giardia lamblia Hypothetical protein 0.006 0.0236 0.0912
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0107 0.0107
Trichomonas vaginalis cyclin D, putative 0.0247 0.1273 0.5381
Echinococcus granulosus cathepsin l1 0.0036 0.0107 0.0107
Trypanosoma cruzi cruzipain precursor, putative 0.0139 0.0675 0.2832
Brugia malayi Protein kinase domain containing protein 0.0019 0.0011 0.0024
Echinococcus multilocularis cyclins 0.0247 0.1273 0.1273
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0065 0.0267 0.1095
Plasmodium falciparum calcium-dependent protein kinase 1 0.0097 0.0441 0.1839
Echinococcus multilocularis cysteine protease 0.0036 0.0107 0.0107
Echinococcus granulosus G1:S specific cyclin D1 0.006 0.0236 0.0236
Brugia malayi hypothetical protein 0.006 0.0236 0.0551
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0097 0.0441 0.0441
Trichomonas vaginalis cyclin B, putative 0.0247 0.1273 0.5381
Schistosoma mansoni caspase-7 (C14 family) 0.0381 0.2014 0.2014
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.001 0.002
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0443 0.2357 0.2357
Toxoplasma gondii cyclin 4, putative 0.006 0.0236 0.0912
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0013 0.0013
Echinococcus granulosus cyclins 0.0247 0.1273 0.1273
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0097 0.0441 0.1035
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0044 0.0147
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0168 0.0837 0.3487
Trichomonas vaginalis conserved hypothetical protein 0.0197 0.0997 0.4207
Trichomonas vaginalis cyclins, putative 0.0247 0.1273 0.5381
Echinococcus granulosus cyclin B3 1 0.0247 0.1273 0.1273
Brugia malayi Cytochrome P450 family protein 0.0037 0.0112 0.026
Trypanosoma brucei cdc2-related kinase 1 0.0093 0.0422 0.1758
Leishmania major cathepsin L-like protease 0.0139 0.0675 0.2792
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.006 0.0236 0.0236
Brugia malayi protein kinase C II. 0.0019 0.0011 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0108 0.0251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0107 0.0417
Echinococcus multilocularis caspase 2 0.0381 0.2014 0.2014
Trichomonas vaginalis cyclin B, putative 0.006 0.0236 0.0963
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0251
Trypanosoma cruzi cdc2-related kinase 1 0.0093 0.0422 0.1758
Echinococcus granulosus intermediate filament protein 0.0028 0.0063 0.0063
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.006 0.0236 0.0236
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0108 0.0108
Echinococcus granulosus cyclins 0.0247 0.1273 0.1273
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0056 0.0218 0.0218
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0422 0.0422
Brugia malayi Cyclin, N-terminal domain containing protein 0.006 0.0236 0.0551
Plasmodium falciparum cyclin 0.0247 0.1273 0.5381
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0139 0.0675 0.2832
Loa Loa (eye worm) hypoxia-induced factor 1 0.0672 0.3621 0.8508
Brugia malayi Cyclin, N-terminal domain containing protein 0.0247 0.1273 0.2989
Trichomonas vaginalis AGC family protein kinase 0.0041 0.0133 0.0526
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0197 0.0997 0.2341
Echinococcus multilocularis rac serine:threonine kinase 0.0031 0.0076 0.0076
Echinococcus granulosus mixed lineage leukemia protein mll 0.0032 0.0082 0.0082
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0108 0.0108
Toxoplasma gondii cyclin dependent kinase binding protein 0.006 0.0236 0.0912
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0197 0.0997 0.4174
Loa Loa (eye worm) AGC/PKA protein kinase 0.0443 0.2357 0.5538
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0093 0.0422 0.099
Plasmodium falciparum metacaspase 1 0.0197 0.0997 0.4207
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0066 0.0241
Trypanosoma cruzi cysteine peptidase, putative 0.0139 0.0675 0.2832
Schistosoma mansoni protein kinase 0.0744 0.4023 0.4023
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0056 0.0218 0.0886
Entamoeba histolytica cell division protein kinase 2, putative 0.0093 0.0422 0.175
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0032 0.0082 0.0082
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0032 0.0082 0.0082
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0107 0.0417
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0168 0.0837 0.3523
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0108 0.0245
Trichomonas vaginalis cyclin B, putative 0.0247 0.1273 0.5381
Schistosoma mansoni Cyclin fold protein 0.006 0.0236 0.0236
Schistosoma mansoni nuclear receptor 0.0017 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0107 0.0417
Trypanosoma cruzi cysteine peptidase, putative 0.0139 0.0675 0.2832
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0197 0.0997 0.4207
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0107 0.0244
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0032 0.0082 0.0082
Echinococcus multilocularis cyclins 0.0247 0.1273 0.1273
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.006 0.0236 0.0963
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0443 0.2357 1
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0011 0.0011
Trichomonas vaginalis cyclin A, putative 0.0247 0.1273 0.5381
Plasmodium vivax calcium-dependent protein kinase, putative 0.0097 0.0441 0.1839
Loa Loa (eye worm) AGC/AKT protein kinase 0.0041 0.0133 0.031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0139 0.0675 0.2832
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0139 0.0675 0.2832
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0036 0.0107 0.0417
Entamoeba histolytica PH domain containing protein kinase, putative 0.0445 0.2369 1
Brugia malayi Cytochrome P450 family protein 0.0025 0.0044 0.0101
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.0066 0.0241
Schistosoma mansoni nuclear receptor 0.0017 0.0001 0.0001
Trypanosoma brucei cyclin 3 0.006 0.0236 0.0963
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0044 0.0101
Schistosoma mansoni cyclin l 0.006 0.0236 0.0236
Trypanosoma cruzi CYC2-like cyclin, putative 0.0247 0.1273 0.5381
Trichomonas vaginalis cyclin A, putative 0.006 0.0236 0.0963
Schistosoma mansoni aryl hydrocarbon receptor 0.0217 0.1106 0.1106
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.0066 0.0241
Echinococcus granulosus aryl hydrocarbon receptor 0.0056 0.0218 0.0218
Trichomonas vaginalis cyclin B, putative 0.0247 0.1273 0.5381
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0107 0.0417
Trypanosoma brucei metacaspase MCA2 0.0197 0.0997 0.4207
Leishmania major protein kinase A catalytic subunit isoform 1 0.0443 0.2357 1
Brugia malayi p70 ribosomal S6 kinase beta 0.0039 0.0122 0.0284
Giardia lamblia Hypothetical protein 0.0247 0.1273 0.5355
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0066 0.0241
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0108 0.0108
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0184 0.0922 0.2165
Schistosoma mansoni hypothetical protein 0.006 0.0236 0.0236
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0097 0.0441 0.1839
Entamoeba histolytica PH domain containing protein kinase, putative 0.0445 0.2369 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0108 0.0108
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0108 0.0251
Echinococcus granulosus cyclin dependent kinase 1 0.0093 0.0422 0.0422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0139 0.0675 0.2832
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0107 0.0417
Plasmodium falciparum cyclin 1 0.006 0.0236 0.0963
Plasmodium falciparum calcium-dependent protein kinase 4 0.0097 0.0441 0.1839
Echinococcus granulosus cathepsin L cysteine protease 0.0019 0.001 0.001
Echinococcus multilocularis dnaJ subfamily B 0.1825 1 1
Schistosoma mansoni cyclins 0.0247 0.1273 0.1273
Onchocerca volvulus 0.0161 0.0794 0.1818
Leishmania major cathepsin L-like protease 0.0036 0.0107 0.0363
Onchocerca volvulus Cyclin L homolog 0.006 0.0236 0.0537
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0097 0.0441 0.1035
Brugia malayi Cyclin, N-terminal domain containing protein 0.006 0.0236 0.0551
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0197 0.0997 0.4207
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0097 0.0441 0.1839
Schistosoma mansoni ap endonuclease 0.0021 0.0023 0.0023
Plasmodium vivax protein kinase Crk2 0.0093 0.0422 0.1758
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0168 0.0837 0.0837
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0019 0.0011 0.0024
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0065 0.0267 0.1095
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0023 0.0056
Trypanosoma cruzi cdc2-related kinase 3 0.0093 0.0422 0.1758
Trypanosoma brucei cyclin 9 0.006 0.0236 0.0963
Trypanosoma cruzi Protein kinase B 0.0031 0.0076 0.0285
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0001 0.0001
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0097 0.0441 0.1839
Echinococcus multilocularis cyclin dependent kinase 5 0.0093 0.0422 0.0422
Schistosoma mansoni serine/threonine-protein kinase 0.0031 0.0076 0.0076
Trichomonas vaginalis cyclins, putative 0.0247 0.1273 0.5381
Echinococcus multilocularis serine threonine protein kinase 0.0019 0.0011 0.0011
Entamoeba histolytica PH domain containing protein kinase, putative 0.0031 0.0076 0.0284
Entamoeba histolytica cyclin family protein 0.0247 0.1273 0.5356
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0001 0.0001
Trichomonas vaginalis guanylate cyclase, putative 0.0056 0.0218 0.0886
Brugia malayi nuclear hormone receptor 0.0037 0.0108 0.0251
Leishmania major protein kinase A catalytic subunit isoform 2 0.0443 0.2357 1
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.0016 0.0016
Plasmodium vivax tyrosine kinase-like protein, putative 0.0056 0.0213 0.0866
Trypanosoma cruzi metacaspase, putative 0.0197 0.0997 0.4207
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0066 0.0241
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0056 0.0218 0.0886
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0023 0.0056
Echinococcus multilocularis protein kinase c epsilon type 0.0019 0.0011 0.0011
Echinococcus multilocularis cyclin b3 0.0247 0.1273 0.1273
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0019 0.0011 0.0024
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0031 0.0076 0.0285
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0168 0.0837 0.3523
Echinococcus multilocularis cathepsin L 0.0019 0.001 0.001
Echinococcus multilocularis serine:threonine protein kinase N2 0.0019 0.0011 0.0011
Entamoeba histolytica cyclin, putative 0.0247 0.1273 0.5356
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0769 0.416 0.9775
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0443 0.2357 1
Brugia malayi hypoxia-induced factor 1 0.0672 0.3621 0.8508
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0023 0.0051
Loa Loa (eye worm) hypothetical protein 0.0168 0.0837 0.1964
Brugia malayi Cyclin, N-terminal domain containing protein 0.0247 0.1273 0.2989
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0023 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0197 0.0997 0.4207
Echinococcus granulosus lamin dm0 0.0028 0.0063 0.0063
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0744 0.4023 0.4023
Onchocerca volvulus 0.0052 0.0194 0.0442
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0013 0.0027
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0001 0.0001
Schistosoma mansoni caspase-7 (C14 family) 0.0522 0.2792 0.2792
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0108 0.0251
Trypanosoma cruzi metacaspase 5, putative 0.0197 0.0997 0.4207
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0108 0.0251
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0108 0.0108
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0197 0.0997 0.4207
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0108 0.0251
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.001 0.001
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0806 0.4363 1
Trypanosoma brucei Metacaspase-4 0.0197 0.0997 0.4207
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0108 0.0108
Echinococcus granulosus cyclin y 0.006 0.0236 0.0236
Trichomonas vaginalis cyclins, putative 0.006 0.0236 0.0963
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0247 0.1273 0.2989
Brugia malayi ecdysteroid receptor 0.0037 0.0108 0.0251
Schistosoma mansoni hypothetical protein 0.0184 0.0922 0.0922
Echinococcus multilocularis cyclin dependent kinase 0.0093 0.0422 0.0422
Trichomonas vaginalis cyclin B3, putative 0.006 0.0236 0.0963
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0001 0.0001
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0041 0.0132
Trichomonas vaginalis cyclin B3, putative 0.0247 0.1273 0.5381
Echinococcus multilocularis cyclin B3 1 0.0247 0.1273 0.1273
Brugia malayi Cyclin, N-terminal domain containing protein 0.0247 0.1273 0.2989
Giardia lamblia Kinase, CMGC CDK 0.0093 0.0422 0.1712
Brugia malayi Cell death protein 3 precursor 0.0381 0.2014 0.4731
Brugia malayi Cathepsin L-like precursor 0.0036 0.0107 0.025
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.0107 0.025
Echinococcus granulosus cyclins 0.006 0.0236 0.0236
Leishmania major cathepsin L-like protease 0.0139 0.0675 0.2792
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0168 0.0837 0.3523
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0093 0.0422 0.1712
Echinococcus granulosus nervana 2 0.002 0.0016 0.0016
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0056 0.0218 0.0886
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0023 0.0023
Echinococcus granulosus serine threonine protein kinase nrc 0.0029 0.0065 0.0065
Trypanosoma cruzi cdc2-related kinase 1 0.0093 0.0422 0.1758
Echinococcus multilocularis transfer RNA-Lys 0.0161 0.0794 0.0794
Trypanosoma brucei rac serine-threonine kinase, putative 0.0041 0.0133 0.0526
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0066 0.0241
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0744 0.4023 0.4023
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0107 0.0107
Echinococcus granulosus cyclin t1 0.006 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.006 0.0236 0.0551
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0013 0.0013
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0107 0.0415
Brugia malayi Cyclin C 0.006 0.0236 0.0551
Echinococcus granulosus tumor protein p63 0.0356 0.1875 0.1875
Loa Loa (eye worm) hypothetical protein 0.0443 0.2357 0.5538
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0029 0.0065 0.0065
Leishmania major metacaspase, putative 0.0197 0.0997 0.4174
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0013 0.0027
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0108 0.0108
Loa Loa (eye worm) cyclin domain-containing protein 0.0247 0.1273 0.2989
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0056 0.0218 0.0886
Entamoeba histolytica cyclin family protein 0.0247 0.1273 0.5356
Trichomonas vaginalis CMGC family protein kinase 0.0093 0.0422 0.1758
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0108 0.0251
Echinococcus multilocularis cyclin dependent kinase 1 0.0093 0.0422 0.0422
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0063 0.0145
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0056 0.0218 0.5
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0027
Entamoeba histolytica cyclin, putative 0.0247 0.1273 0.5356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0041 0.0133
Echinococcus multilocularis cyclins 0.0247 0.1273 0.1273
Plasmodium vivax vivapain-2 0.0036 0.0107 0.0417
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0139 0.0675 0.2832
Loa Loa (eye worm) ctsf protein 0.0036 0.0107 0.025
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0247 0.1273 0.5355
Echinococcus multilocularis cyclins 0.0247 0.1273 0.1273
Onchocerca volvulus Cathepsin F homolog 0.0036 0.0107 0.0244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0139 0.0675 0.2832
Trichomonas vaginalis cyclin B, putative 0.0247 0.1273 0.5381
Giardia lamblia Cyclin B-like protein 0.006 0.0236 0.0912
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0066 0.0241
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0648 0.3487 0.8194
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.006 0.0236 0.0963
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0066 0.0241
Onchocerca volvulus 0.0036 0.0107 0.0244
Onchocerca volvulus Cell death protein 3 homolog 0.0381 0.2014 0.4615
Loa Loa (eye worm) cyclin domain-containing protein 0.006 0.0236 0.0551
Toxoplasma gondii AGC kinase 0.0443 0.2357 1
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0108 0.0251
Brugia malayi bHLH-PAS transcription factor 0.0161 0.0794 0.1864
Echinococcus granulosus cyclin b3 0.0247 0.1273 0.1273
Schistosoma mansoni hypothetical protein 0.1825 1 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0023 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0218 0.0886
Loa Loa (eye worm) hypothetical protein 0.0056 0.0218 0.0509
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0251
Entamoeba histolytica protein kinase, putative 0.0041 0.0133 0.0523
Loa Loa (eye worm) hypothetical protein 0.006 0.0236 0.0551
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0108 0.0108
Loa Loa (eye worm) cyclin domain-containing protein 0.006 0.0236 0.0551
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0107 0.0417
Echinococcus granulosus calcium dependent protein kinase 0.0088 0.0392 0.0392
Echinococcus multilocularis cyclin t1 0.006 0.0236 0.0236
Echinococcus granulosus caspase 3 0.0324 0.17 0.17
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0019 0.0011 0.0011
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0168 0.0837 0.3507
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0027
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0044 0.0147
Giardia lamblia G2/mitotic-specific cyclin B 0.0247 0.1273 0.5355
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0522 0.2792 0.2792
Schistosoma mansoni lamin 0.0028 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0251
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.0107 0.0417
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0001 0.0001
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0001 0.0001
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0066 0.0273 0.0273
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0001 0.0001
Schistosoma mansoni cpg binding protein 0.0135 0.0655 0.0655
Echinococcus multilocularis cyclin k 0.006 0.0236 0.0236
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0011 0.0007
Echinococcus multilocularis cyclin G2 0.006 0.0236 0.0236
Onchocerca volvulus 0.0028 0.0063 0.0141
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0108 0.0251
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0093
Trichomonas vaginalis cyclin B, putative 0.006 0.0236 0.0963
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0023 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0108 0.0251
Loa Loa (eye worm) cyclin domain-containing protein 0.006 0.0236 0.0551
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0036 0.0107 0.025
Echinococcus multilocularis serine:threonine protein kinase N2 0.0019 0.0011 0.0011
Echinococcus granulosus NDR protein kinase 0.0019 0.0011 0.0011
Leishmania major cathepsin L-like protease 0.0036 0.0107 0.0363
Giardia lamblia Kinase, AGC PKA 0.0029 0.0065 0.0183
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0107 0.025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0139 0.0675 0.2832
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0381 0.2014 0.4731
Plasmodium falciparum calcium-dependent protein kinase 3 0.0097 0.0441 0.1839
Schistosoma mansoni cyclin k 0.006 0.0236 0.0236
Echinococcus granulosus cathepsin L 0.0019 0.001 0.001
Brugia malayi Protein kinase domain containing protein 0.0041 0.0133 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0168 0.0837 0.3523
Trichomonas vaginalis conserved hypothetical protein 0.0197 0.0997 0.4207
Echinococcus granulosus protein kinase C gamma type 0.0019 0.0011 0.0011
Leishmania major cyclin 0.0247 0.1273 0.5355
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0108 0.0108
Echinococcus multilocularis calcium dependent protein kinase 0.0088 0.0392 0.0392
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.004 0.0125 0.0125
Entamoeba histolytica hypothetical protein 0.006 0.0236 0.0958
Brugia malayi Cathepsin L-like precursor 0.0024 0.0041 0.0093
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0112 0.026
Trichomonas vaginalis cyclins, putative 0.006 0.0236 0.0963
Echinococcus granulosus cyclins 0.0247 0.1273 0.1273
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0108 0.0251
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0272 0.1409 0.1409
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0236 0.0963
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0251
Entamoeba histolytica cyclin C, putative 0.006 0.0236 0.0958
Giardia lamblia Kinase, AGC PKA 0.0443 0.2357 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.0273 0.1071
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0236 0.0963
Echinococcus granulosus protein kinase c iota type 0.0019 0.0011 0.0011
Loa Loa (eye worm) cyclin domain-containing protein 0.006 0.0236 0.0551
Brugia malayi Cathepsin L-like precursor 0.0036 0.0107 0.025
Brugia malayi Cathepsin L-like precursor 0.0024 0.0041 0.0093
Trichomonas vaginalis cyclins, putative 0.0247 0.1273 0.5381
Echinococcus multilocularis serine:threonine protein kinase 38 0.0019 0.0011 0.0011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0108 0.0251
Brugia malayi nuclear receptor NHR-88 0.0037 0.0108 0.0251
Brugia malayi Cathepsin L-like precursor 0.0036 0.0107 0.025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0024
Brugia malayi cyclin fold protein 1 variant b 0.006 0.0236 0.0551
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0107 0.0417
Echinococcus granulosus cpg binding protein 0.0135 0.0655 0.0655
Brugia malayi hypothetical protein 0.0184 0.0922 0.2165
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0443 0.2357 0.2357
Trypanosoma brucei mitotic cyclin 0.006 0.0236 0.0963
Loa Loa (eye worm) cysteine protease 0.0036 0.0107 0.025
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0108 0.0251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0107 0.0417
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0441 0.0441
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0441 0.0441
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0041 0.0133
Echinococcus granulosus serine/threonine protein kinase 0.0031 0.0076 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0236 0.0963
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0066 0.0241
Trypanosoma cruzi cyclin 6, putative 0.0247 0.1273 0.5381
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0441 0.1839
Echinococcus granulosus serine:threonine protein kinase N2 0.0019 0.0011 0.0011
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.006 0.0236 0.0963
Leishmania major cytochrome p450-like protein 0.0025 0.0044 0.0091
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0019 0.0011 0.0011
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0273 0.3241
Brugia malayi Cyclin, N-terminal domain containing protein 0.006 0.0236 0.0551
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0441 0.0441
Onchocerca volvulus 0.0028 0.0063 0.0141
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0001 0.0001
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0097 0.0441 0.1793
Leishmania major cathepsin L-like protease 0.0036 0.0107 0.0363
Trypanosoma cruzi metacaspase, putative 0.0197 0.0997 0.4207
Echinococcus multilocularis caspase 3 0.0324 0.17 0.17
Entamoeba histolytica protein kinase 2, putative 0.0029 0.0065 0.0237
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0001 0.0001
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0108 0.0251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0107 0.0417
Echinococcus multilocularis aryl hydrocarbon receptor 0.0056 0.0218 0.0218
Schistosoma mansoni cyclin B3 0.0247 0.1273 0.1273
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0029 0.0065 0.0238
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0197 0.0997 0.4207
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0648 0.3487 0.8194
Onchocerca volvulus 0.0036 0.0107 0.0244
Echinococcus granulosus Cyclin L1 0.006 0.0236 0.0236
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0443 0.2357 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0056 0.0213 0.0814
Plasmodium vivax hypothetical protein, conserved 0.0197 0.0997 0.4207
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0029 0.0065 0.0238
Schistosoma mansoni ap endonuclease 0.0021 0.0023 0.0023
Giardia lamblia Cyclin fold protein 1, putative 0.006 0.0236 0.0912
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0218 0.0886
Loa Loa (eye worm) hypothetical protein 0.0728 0.3933 0.9242
Loa Loa (eye worm) cyclin domain-containing protein 0.0527 0.2821 0.6628
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0108 0.0108
Mycobacterium ulcerans putative regulatory protein 0.0161 0.0794 1

Activities

Activity type Activity value Assay description Source Reference
Kd (binding) = 14 nM Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assay ChEMBL. 10098666
Kd (binding) = 14 nM Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from beta retinoic acid receptor (beta RAR) using transactivation assay ChEMBL. 10098666
Kd (binding) = 38 nM Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assay ChEMBL. 10098666
Kd (binding) = 38 nM Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from alpha retinoic acid receptor (alpha RAR) using transactivation assay ChEMBL. 10098666
Kd (binding) = 51 nM Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assay ChEMBL. 10098666
Kd (binding) = 51 nM Ability to displace 3[H]-(all-E)-retinoic acid (5 nM) from Retinoic acid receptor gamma using transactivation assay ChEMBL. 10098666

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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